Incidental Mutation 'IGL02895:Tmem74b'
ID363385
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem74b
Ensembl Gene ENSMUSG00000044364
Gene Nametransmembrane protein 74B
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.081) question?
Stock #IGL02895
Quality Score
Status
Chromosome2
Chromosomal Location151702008-151712157 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 151706391 bp
ZygosityHeterozygous
Amino Acid Change Serine to Glycine at position 13 (S13G)
Ref Sequence ENSEMBL: ENSMUSP00000105498 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060196] [ENSMUST00000109872]
Predicted Effect probably benign
Transcript: ENSMUST00000060196
AA Change: S13G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000060017
Gene: ENSMUSG00000044364
AA Change: S13G

DomainStartEndE-ValueType
Pfam:Neurensin 67 191 7.3e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000109872
AA Change: S13G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000105498
Gene: ENSMUSG00000044364
AA Change: S13G

DomainStartEndE-ValueType
low complexity region 69 82 N/A INTRINSIC
Pfam:Neurensin 85 186 2.1e-10 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik A G 15: 8,232,107 probably benign Het
Ahctf1 C T 1: 179,793,811 E130K probably damaging Het
Atf7ip C A 6: 136,560,688 S306R probably damaging Het
Cpd A G 11: 76,785,203 V1208A probably benign Het
Ctsl C T 13: 64,366,512 A195T probably damaging Het
Dennd2c T C 3: 103,137,203 Y367H possibly damaging Het
Endod1 T A 9: 14,356,870 T440S probably benign Het
Gm12695 T C 4: 96,723,949 R526G probably damaging Het
Ighv1-39 T C 12: 114,914,682 T90A probably damaging Het
Kdm2a G A 19: 4,362,902 R19C probably damaging Het
Klra1 C T 6: 130,375,240 E180K possibly damaging Het
Odam A G 5: 87,885,864 Q21R probably benign Het
Olfr1205 A G 2: 88,831,642 Y175C probably damaging Het
Olfr145 G A 9: 37,897,982 V193I probably benign Het
Plk1 A G 7: 122,169,166 E504G possibly damaging Het
Rtl3 T C X: 106,839,544 I37M possibly damaging Het
Srebf2 A G 15: 82,147,467 E22G possibly damaging Het
Utp14b T C 1: 78,664,607 V74A possibly damaging Het
Znrf3 T C 11: 5,289,085 M93V probably damaging Het
Other mutations in Tmem74b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0445:Tmem74b UTSW 2 151706959 missense probably damaging 1.00
R1054:Tmem74b UTSW 2 151706419 missense probably benign 0.00
R4658:Tmem74b UTSW 2 151706641 missense probably damaging 1.00
R6018:Tmem74b UTSW 2 151706719 missense probably damaging 1.00
Z1177:Tmem74b UTSW 2 151706569 missense probably damaging 0.98
Z1177:Tmem74b UTSW 2 151706780 nonsense probably null
Posted On2015-12-18