Incidental Mutation 'IGL02895:Tmem74b'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem74b
Ensembl Gene ENSMUSG00000044364
Gene Nametransmembrane protein 74B
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.081) question?
Stock #IGL02895
Quality Score
Chromosomal Location151702008-151712157 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 151706391 bp
Amino Acid Change Serine to Glycine at position 13 (S13G)
Ref Sequence ENSEMBL: ENSMUSP00000105498 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060196] [ENSMUST00000109872]
Predicted Effect probably benign
Transcript: ENSMUST00000060196
AA Change: S13G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000060017
Gene: ENSMUSG00000044364
AA Change: S13G

Pfam:Neurensin 67 191 7.3e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000109872
AA Change: S13G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000105498
Gene: ENSMUSG00000044364
AA Change: S13G

low complexity region 69 82 N/A INTRINSIC
Pfam:Neurensin 85 186 2.1e-10 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik A G 15: 8,232,107 probably benign Het
Ahctf1 C T 1: 179,793,811 E130K probably damaging Het
Atf7ip C A 6: 136,560,688 S306R probably damaging Het
Cpd A G 11: 76,785,203 V1208A probably benign Het
Ctsl C T 13: 64,366,512 A195T probably damaging Het
Dennd2c T C 3: 103,137,203 Y367H possibly damaging Het
Endod1 T A 9: 14,356,870 T440S probably benign Het
Gm12695 T C 4: 96,723,949 R526G probably damaging Het
Ighv1-39 T C 12: 114,914,682 T90A probably damaging Het
Kdm2a G A 19: 4,362,902 R19C probably damaging Het
Klra1 C T 6: 130,375,240 E180K possibly damaging Het
Odam A G 5: 87,885,864 Q21R probably benign Het
Olfr1205 A G 2: 88,831,642 Y175C probably damaging Het
Olfr145 G A 9: 37,897,982 V193I probably benign Het
Plk1 A G 7: 122,169,166 E504G possibly damaging Het
Rtl3 T C X: 106,839,544 I37M possibly damaging Het
Srebf2 A G 15: 82,147,467 E22G possibly damaging Het
Utp14b T C 1: 78,664,607 V74A possibly damaging Het
Znrf3 T C 11: 5,289,085 M93V probably damaging Het
Other mutations in Tmem74b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0445:Tmem74b UTSW 2 151706959 missense probably damaging 1.00
R1054:Tmem74b UTSW 2 151706419 missense probably benign 0.00
R4658:Tmem74b UTSW 2 151706641 missense probably damaging 1.00
R6018:Tmem74b UTSW 2 151706719 missense probably damaging 1.00
Z1177:Tmem74b UTSW 2 151706569 missense probably damaging 0.98
Z1177:Tmem74b UTSW 2 151706780 nonsense probably null
Posted On2015-12-18