Incidental Mutation 'IGL02895:Endod1'
ID363389
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Endod1
Ensembl Gene ENSMUSG00000037419
Gene Nameendonuclease domain containing 1
Synonyms2210414F18Rik, 2310067E08Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL02895
Quality Score
Status
Chromosome9
Chromosomal Location14353990-14381507 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 14356870 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 440 (T440S)
Ref Sequence ENSEMBL: ENSMUSP00000127751 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167549]
Predicted Effect probably benign
Transcript: ENSMUST00000167549
AA Change: T440S

PolyPhen 2 Score 0.063 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000127751
Gene: ENSMUSG00000037419
AA Change: T440S

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Endonuclease_NS 61 261 9.04e-1 SMART
NUC 62 264 1.64e-3 SMART
coiled coil region 271 299 N/A INTRINSIC
transmembrane domain 343 365 N/A INTRINSIC
transmembrane domain 430 452 N/A INTRINSIC
transmembrane domain 467 486 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213403
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik A G 15: 8,232,107 probably benign Het
Ahctf1 C T 1: 179,793,811 E130K probably damaging Het
Atf7ip C A 6: 136,560,688 S306R probably damaging Het
Cpd A G 11: 76,785,203 V1208A probably benign Het
Ctsl C T 13: 64,366,512 A195T probably damaging Het
Dennd2c T C 3: 103,137,203 Y367H possibly damaging Het
Gm12695 T C 4: 96,723,949 R526G probably damaging Het
Ighv1-39 T C 12: 114,914,682 T90A probably damaging Het
Kdm2a G A 19: 4,362,902 R19C probably damaging Het
Klra1 C T 6: 130,375,240 E180K possibly damaging Het
Odam A G 5: 87,885,864 Q21R probably benign Het
Olfr1205 A G 2: 88,831,642 Y175C probably damaging Het
Olfr145 G A 9: 37,897,982 V193I probably benign Het
Plk1 A G 7: 122,169,166 E504G possibly damaging Het
Rtl3 T C X: 106,839,544 I37M possibly damaging Het
Srebf2 A G 15: 82,147,467 E22G possibly damaging Het
Tmem74b A G 2: 151,706,391 S13G probably benign Het
Utp14b T C 1: 78,664,607 V74A possibly damaging Het
Znrf3 T C 11: 5,289,085 M93V probably damaging Het
Other mutations in Endod1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00472:Endod1 APN 9 14356753 missense possibly damaging 0.93
IGL01302:Endod1 APN 9 14357239 missense possibly damaging 0.50
IGL02994:Endod1 APN 9 14356887 missense possibly damaging 0.93
IGL03120:Endod1 APN 9 14357035 missense probably damaging 0.98
royal_gorge UTSW 9 14356870 missense probably benign 0.06
R0745:Endod1 UTSW 9 14357117 missense possibly damaging 0.92
R1087:Endod1 UTSW 9 14357193 missense possibly damaging 0.69
R1829:Endod1 UTSW 9 14356926 missense probably damaging 1.00
R1857:Endod1 UTSW 9 14357109 missense probably benign 0.05
R2120:Endod1 UTSW 9 14357653 missense probably benign 0.07
R3906:Endod1 UTSW 9 14380855 missense probably benign 0.12
R4801:Endod1 UTSW 9 14357023 missense probably benign 0.05
R4802:Endod1 UTSW 9 14357023 missense probably benign 0.05
R5017:Endod1 UTSW 9 14356891 nonsense probably null
R6027:Endod1 UTSW 9 14357597 nonsense probably null
R6179:Endod1 UTSW 9 14357461 missense probably benign 0.00
R6279:Endod1 UTSW 9 14356870 missense probably benign 0.06
R6300:Endod1 UTSW 9 14356870 missense probably benign 0.06
R6986:Endod1 UTSW 9 14357310 missense probably damaging 1.00
R7314:Endod1 UTSW 9 14356999 missense probably benign 0.07
Posted On2015-12-18