Incidental Mutation 'IGL02896:Senp2'
ID 363413
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Senp2
Ensembl Gene ENSMUSG00000022855
Gene Name SUMO/sentrin specific peptidase 2
Synonyms 4930538C18Rik, 2310007L05Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02896
Quality Score
Status
Chromosome 16
Chromosomal Location 21828234-21868019 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to G at 21837118 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 122 (Y122*)
Ref Sequence ENSEMBL: ENSMUSP00000155909 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023561] [ENSMUST00000231724] [ENSMUST00000232534] [ENSMUST00000232679]
AlphaFold Q91ZX6
Predicted Effect probably null
Transcript: ENSMUST00000023561
AA Change: Y131*
SMART Domains Protein: ENSMUSP00000023561
Gene: ENSMUSG00000022855
AA Change: Y131*

DomainStartEndE-ValueType
low complexity region 23 40 N/A INTRINSIC
low complexity region 101 118 N/A INTRINSIC
low complexity region 325 340 N/A INTRINSIC
Pfam:Peptidase_C48 408 587 1.5e-40 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231724
Predicted Effect probably benign
Transcript: ENSMUST00000231798
Predicted Effect probably null
Transcript: ENSMUST00000232534
AA Change: Y122*
Predicted Effect probably benign
Transcript: ENSMUST00000232679
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]
PHENOTYPE: Homozygous null mice are embryonic lethal due to placental defects resulting from abnormal trophoblast maturation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402J07Rik A G 8: 88,315,648 (GRCm39) D246G probably damaging Het
Adcy2 A G 13: 68,875,991 (GRCm39) S504P probably damaging Het
Adgrv1 A T 13: 81,668,858 (GRCm39) I2566K probably damaging Het
Als2 A G 1: 59,222,946 (GRCm39) V1108A probably benign Het
Atad2b T A 12: 5,008,151 (GRCm39) F466I probably damaging Het
Cyp2a22 T C 7: 26,635,886 (GRCm39) M226V probably damaging Het
D5Ertd579e T C 5: 36,771,326 (GRCm39) D1023G possibly damaging Het
D630003M21Rik T C 2: 158,059,205 (GRCm39) I232V probably benign Het
Dolpp1 T C 2: 30,286,242 (GRCm39) S114P probably damaging Het
Fars2 T A 13: 36,388,825 (GRCm39) S105T probably benign Het
Fndc7 T C 3: 108,770,247 (GRCm39) I560V probably benign Het
Gcn1 T C 5: 115,757,707 (GRCm39) probably benign Het
Gm5134 T C 10: 75,810,058 (GRCm39) L113P possibly damaging Het
Hipk2 G T 6: 38,675,382 (GRCm39) H1066Q probably damaging Het
Katnb1 A G 8: 95,822,656 (GRCm39) probably benign Het
Lrrd1 T A 5: 3,901,473 (GRCm39) S593T probably benign Het
Mastl T C 2: 23,021,779 (GRCm39) R713G probably damaging Het
Meak7 T C 8: 120,489,164 (GRCm39) D373G probably damaging Het
Mrgpra6 T A 7: 46,838,655 (GRCm39) D181V probably benign Het
Mroh7 C T 4: 106,557,013 (GRCm39) V828I possibly damaging Het
Nbeal2 A G 9: 110,468,360 (GRCm39) probably null Het
Nckap5l G T 15: 99,325,091 (GRCm39) Q471K possibly damaging Het
Or12j5 T C 7: 140,083,968 (GRCm39) probably null Het
Or1j15 A T 2: 36,459,217 (GRCm39) L202F possibly damaging Het
Or5an1c A T 19: 12,218,353 (GRCm39) L224* probably null Het
Pfn4 A G 12: 4,825,451 (GRCm39) N96S probably benign Het
Ppp1r3c G A 19: 36,710,865 (GRCm39) P302S probably benign Het
Slc5a7 C A 17: 54,600,045 (GRCm39) G123* probably null Het
Stxbp2 A T 8: 3,691,971 (GRCm39) I538F probably benign Het
Tent2 A T 13: 93,304,945 (GRCm39) N280K probably damaging Het
Th C T 7: 142,449,168 (GRCm39) R289Q probably damaging Het
Tigit C T 16: 43,482,561 (GRCm39) V58I probably benign Het
Ush1c C A 7: 45,847,839 (GRCm39) V810L probably benign Het
Vmn2r120 C A 17: 57,816,008 (GRCm39) K782N probably damaging Het
Other mutations in Senp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00788:Senp2 APN 16 21,837,114 (GRCm39) missense probably damaging 1.00
IGL01562:Senp2 APN 16 21,828,437 (GRCm39) missense probably damaging 1.00
IGL01757:Senp2 APN 16 21,828,414 (GRCm39) missense probably benign 0.13
IGL02593:Senp2 APN 16 21,863,021 (GRCm39) missense probably damaging 1.00
IGL03219:Senp2 APN 16 21,833,014 (GRCm39) splice site probably benign
IGL03244:Senp2 APN 16 21,859,329 (GRCm39) missense probably damaging 0.97
Jessie UTSW 16 21,837,114 (GRCm39) missense probably damaging 1.00
wrangler UTSW 16 21,847,344 (GRCm39) critical splice donor site probably null
wrestler UTSW 16 21,857,372 (GRCm39) missense probably damaging 1.00
PIT1430001:Senp2 UTSW 16 21,832,864 (GRCm39) splice site probably benign
R0410:Senp2 UTSW 16 21,828,444 (GRCm39) missense probably damaging 0.99
R0511:Senp2 UTSW 16 21,855,320 (GRCm39) missense probably benign 0.01
R1186:Senp2 UTSW 16 21,830,254 (GRCm39) missense probably damaging 0.99
R1689:Senp2 UTSW 16 21,845,416 (GRCm39) missense probably damaging 0.98
R1723:Senp2 UTSW 16 21,846,792 (GRCm39) missense probably benign 0.00
R1776:Senp2 UTSW 16 21,861,810 (GRCm39) splice site probably benign
R2056:Senp2 UTSW 16 21,832,949 (GRCm39) missense probably damaging 1.00
R2058:Senp2 UTSW 16 21,832,949 (GRCm39) missense probably damaging 1.00
R2371:Senp2 UTSW 16 21,837,125 (GRCm39) missense possibly damaging 0.86
R3838:Senp2 UTSW 16 21,828,485 (GRCm39) missense probably damaging 0.99
R3839:Senp2 UTSW 16 21,828,485 (GRCm39) missense probably damaging 0.99
R4001:Senp2 UTSW 16 21,847,318 (GRCm39) missense possibly damaging 0.95
R4190:Senp2 UTSW 16 21,865,417 (GRCm39) missense probably damaging 1.00
R4191:Senp2 UTSW 16 21,865,417 (GRCm39) missense probably damaging 1.00
R4193:Senp2 UTSW 16 21,865,417 (GRCm39) missense probably damaging 1.00
R4231:Senp2 UTSW 16 21,830,304 (GRCm39) critical splice donor site probably null
R4435:Senp2 UTSW 16 21,832,991 (GRCm39) missense possibly damaging 0.83
R4847:Senp2 UTSW 16 21,857,386 (GRCm39) missense possibly damaging 0.90
R5207:Senp2 UTSW 16 21,860,130 (GRCm39) missense possibly damaging 0.52
R5509:Senp2 UTSW 16 21,859,272 (GRCm39) missense probably damaging 1.00
R6036:Senp2 UTSW 16 21,847,308 (GRCm39) nonsense probably null
R6036:Senp2 UTSW 16 21,847,308 (GRCm39) nonsense probably null
R6475:Senp2 UTSW 16 21,842,550 (GRCm39) missense probably damaging 1.00
R6517:Senp2 UTSW 16 21,845,474 (GRCm39) missense possibly damaging 0.95
R6923:Senp2 UTSW 16 21,830,326 (GRCm39) intron probably benign
R7287:Senp2 UTSW 16 21,837,114 (GRCm39) missense probably damaging 1.00
R7747:Senp2 UTSW 16 21,857,372 (GRCm39) missense probably damaging 1.00
R7884:Senp2 UTSW 16 21,832,981 (GRCm39) missense probably benign 0.39
R8037:Senp2 UTSW 16 21,832,888 (GRCm39) nonsense probably null
R8393:Senp2 UTSW 16 21,850,864 (GRCm39) missense probably damaging 0.99
R8805:Senp2 UTSW 16 21,846,789 (GRCm39) missense probably benign
R9216:Senp2 UTSW 16 21,847,344 (GRCm39) critical splice donor site probably null
R9426:Senp2 UTSW 16 21,828,491 (GRCm39) missense probably damaging 0.98
R9479:Senp2 UTSW 16 21,842,398 (GRCm39) missense probably damaging 0.99
R9592:Senp2 UTSW 16 21,845,435 (GRCm39) missense possibly damaging 0.54
Z1177:Senp2 UTSW 16 21,828,455 (GRCm39) missense probably benign 0.44
Posted On 2015-12-18