Incidental Mutation 'IGL02897:Nme5'
ID363460
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nme5
Ensembl Gene ENSMUSG00000035984
Gene NameNME/NM23 family member 5
Synonymsnon-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase), Nm23-M5, 1700019D05Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02897
Quality Score
Status
Chromosome18
Chromosomal Location34562634-34579115 bp(-) (GRCm38)
Type of Mutationintron
DNA Base Change (assembly) A to G at 34569903 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000116092 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079287] [ENSMUST00000134875] [ENSMUST00000154342] [ENSMUST00000155114]
Predicted Effect probably benign
Transcript: ENSMUST00000079287
SMART Domains Protein: ENSMUSP00000078269
Gene: ENSMUSG00000035984

DomainStartEndE-ValueType
NDK 12 150 1.9e-62 SMART
Pfam:Dpy-30 156 197 7.7e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000134875
SMART Domains Protein: ENSMUSP00000118213
Gene: ENSMUSG00000035984

DomainStartEndE-ValueType
NDK 12 113 2.91e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000154342
SMART Domains Protein: ENSMUSP00000117443
Gene: ENSMUSG00000035984

DomainStartEndE-ValueType
NDK 12 113 2.91e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000155114
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mice exhibit hydrocephaly and male spermatogenesis defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700093K21Rik T A 11: 23,517,308 E108D probably benign Het
Abca7 T C 10: 80,001,592 F437L probably damaging Het
Abi2 T C 1: 60,448,194 V134A probably damaging Het
Ablim2 T C 5: 35,833,126 I75T probably damaging Het
Aldh1a3 A G 7: 66,427,327 V29A probably benign Het
Bptf T C 11: 107,047,121 K2715E probably damaging Het
Cd163 A T 6: 124,325,527 S1017C probably damaging Het
Cdc14b T C 13: 64,247,253 I76V probably benign Het
Cers6 T A 2: 68,934,533 C63* probably null Het
Chd9 T C 8: 90,933,868 probably benign Het
Col19a1 T C 1: 24,534,098 N198D unknown Het
Cse1l T C 2: 166,919,708 C61R possibly damaging Het
Cubn T C 2: 13,318,312 T2815A possibly damaging Het
Cyp19a1 G T 9: 54,166,911 T453K possibly damaging Het
Dlg1 G T 16: 31,771,856 probably null Het
Dpp7 T C 2: 25,353,672 Y339C probably damaging Het
Dtl T C 1: 191,541,544 probably benign Het
Gm5591 T C 7: 38,520,042 E469G probably damaging Het
Ing3 T A 6: 21,969,326 V202E probably benign Het
Inpp5j A G 11: 3,500,619 L578P probably damaging Het
Irak4 A G 15: 94,553,991 N155S probably benign Het
Kif2b A T 11: 91,576,219 S413T probably damaging Het
L3mbtl1 A T 2: 162,965,772 Y490F probably damaging Het
Med17 T G 9: 15,267,534 D447A probably damaging Het
Med26 T C 8: 72,496,521 T245A probably benign Het
Nlrc3 A T 16: 3,964,074 S490R possibly damaging Het
Olfr611 T C 7: 103,518,130 R85G probably benign Het
Rnf10 G T 5: 115,248,641 Q530K probably benign Het
Robo3 A T 9: 37,427,502 Y281* probably null Het
Sclt1 T C 3: 41,675,387 I330V probably benign Het
Smim14 A T 5: 65,450,396 probably benign Het
Trank1 T G 9: 111,367,517 H1536Q probably damaging Het
Tspan18 A G 2: 93,220,173 L35P possibly damaging Het
Ubr4 G A 4: 139,472,508 V4568M probably damaging Het
Vmn1r63 A G 7: 5,802,745 V296A possibly damaging Het
Other mutations in Nme5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00983:Nme5 APN 18 34567128 missense probably benign 0.20
IGL01016:Nme5 APN 18 34578659 unclassified probably null
IGL01982:Nme5 APN 18 34569875 missense probably damaging 0.96
IGL02336:Nme5 APN 18 34578677 missense probably benign 0.35
aesthenic UTSW 18 34578685 start codon destroyed probably null 1.00
R1209:Nme5 UTSW 18 34569896 missense probably damaging 1.00
R1221:Nme5 UTSW 18 34571522 missense probably damaging 1.00
R3855:Nme5 UTSW 18 34569831 missense possibly damaging 0.48
R4729:Nme5 UTSW 18 34569837 missense probably benign
R5010:Nme5 UTSW 18 34578685 start codon destroyed probably null 1.00
R6658:Nme5 UTSW 18 34578586 missense probably damaging 1.00
R6820:Nme5 UTSW 18 34571573 missense probably damaging 1.00
R7593:Nme5 UTSW 18 34567148 missense probably benign 0.00
Posted On2015-12-18