Incidental Mutation 'IGL02900:Or14j9'
ID 363538
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or14j9
Ensembl Gene ENSMUSG00000051611
Gene Name olfactory receptor family 14 subfamily J member 9
Synonyms GA_x6K02T2PSCP-2023769-2022807, Olfr112, MOR218-4, 4930580F03Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # IGL02900
Quality Score
Status
Chromosome 17
Chromosomal Location 37874031-37880342 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 37874740 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 154 (I154T)
Ref Sequence ENSEMBL: ENSMUSP00000150904 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085548] [ENSMUST00000174798] [ENSMUST00000208832] [ENSMUST00000213274]
AlphaFold Q8C0S2
Predicted Effect possibly damaging
Transcript: ENSMUST00000085548
AA Change: I154T

PolyPhen 2 Score 0.721 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000082684
Gene: ENSMUSG00000051611
AA Change: I154T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.3e-45 PFAM
Pfam:7TM_GPCR_Srsx 35 305 5.3e-7 PFAM
Pfam:7tm_1 41 290 8.1e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173676
Predicted Effect possibly damaging
Transcript: ENSMUST00000174798
AA Change: I154T

PolyPhen 2 Score 0.721 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000133654
Gene: ENSMUSG00000051611
AA Change: I154T

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 35 296 3.2e-7 PFAM
Pfam:7tm_1 41 290 8.2e-30 PFAM
Pfam:7tm_4 139 283 1.7e-42 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000208832
AA Change: I154T

PolyPhen 2 Score 0.721 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000213274
AA Change: I154T

PolyPhen 2 Score 0.721 (Sensitivity: 0.86; Specificity: 0.92)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300003K06Rik G T 11: 99,728,774 (GRCm39) T23N possibly damaging Het
Angpt4 T A 2: 151,753,391 (GRCm39) V47E probably damaging Het
Arhgef11 G A 3: 87,640,467 (GRCm39) R1208Q probably benign Het
Calb1 T C 4: 15,895,695 (GRCm39) probably benign Het
Capn11 G T 17: 45,941,540 (GRCm39) probably null Het
Carmil2 T A 8: 106,422,151 (GRCm39) I1140N probably damaging Het
Cnn3 A T 3: 121,245,143 (GRCm39) T23S probably benign Het
Colgalt2 C T 1: 152,384,481 (GRCm39) T607M probably damaging Het
Cyp46a1 T G 12: 108,309,350 (GRCm39) V93G probably damaging Het
Dcaf6 T C 1: 165,227,344 (GRCm39) Y261C probably damaging Het
Dnah10 A G 5: 124,878,886 (GRCm39) Y2715C probably damaging Het
Dsg1a G T 18: 20,461,713 (GRCm39) probably benign Het
Eml4 C T 17: 83,785,421 (GRCm39) P862L probably benign Het
Gm5414 T C 15: 101,536,242 (GRCm39) T128A probably damaging Het
Gp9 G T 6: 87,756,415 (GRCm39) W143C probably damaging Het
Hipk2 T C 6: 38,706,879 (GRCm39) I670V probably damaging Het
Hoxa10 T C 6: 52,209,541 (GRCm39) K77R possibly damaging Het
Kcna1 T G 6: 126,620,057 (GRCm39) S88R probably damaging Het
Kif1b A T 4: 149,265,266 (GRCm39) S1758T possibly damaging Het
Klk1b11 A G 7: 43,427,837 (GRCm39) T182A probably damaging Het
Lrp1 G A 10: 127,412,516 (GRCm39) probably benign Het
Magi1 A G 6: 93,663,854 (GRCm39) S991P probably damaging Het
Mast4 T A 13: 102,872,184 (GRCm39) T2203S probably benign Het
Mxra8 A G 4: 155,925,668 (GRCm39) probably null Het
Mxra8 A G 4: 155,925,576 (GRCm39) E95G possibly damaging Het
Nrn1 C A 13: 36,914,080 (GRCm39) probably null Het
Or2f2 T A 6: 42,767,808 (GRCm39) Y278* probably null Het
Or8g2b T A 9: 39,751,108 (GRCm39) I126N probably damaging Het
Or8g4 A T 9: 39,661,901 (GRCm39) H73L probably benign Het
Pbx4 A G 8: 70,319,216 (GRCm39) E249G probably damaging Het
Pkd1l2 T C 8: 117,750,830 (GRCm39) E1727G probably benign Het
Plec T G 15: 76,070,414 (GRCm39) D932A probably damaging Het
Pramel22 A T 4: 143,382,085 (GRCm39) F204I possibly damaging Het
Raph1 T C 1: 60,542,022 (GRCm39) D364G probably damaging Het
Rps29 T A 12: 69,205,825 (GRCm39) H3L probably damaging Het
Sema4c A T 1: 36,589,826 (GRCm39) C509* probably null Het
Srgap2 A T 1: 131,339,534 (GRCm39) probably benign Het
Stam2 A T 2: 52,598,209 (GRCm39) D243E probably benign Het
Stxbp4 A G 11: 90,497,861 (GRCm39) L146P probably benign Het
Teddm3 G T 16: 20,971,900 (GRCm39) T223K probably benign Het
Tfap2d A T 1: 19,189,474 (GRCm39) N285Y probably damaging Het
Tmprss3 T A 17: 31,403,553 (GRCm39) D416V probably damaging Het
Vmn1r71 T A 7: 10,482,601 (GRCm39) Y29F probably benign Het
Vmn2r84 T C 10: 130,223,861 (GRCm39) probably benign Het
Washc2 G T 6: 116,204,435 (GRCm39) D362Y probably damaging Het
Wbp2nl T C 15: 82,198,035 (GRCm39) S191P probably benign Het
Zfp608 T C 18: 55,079,865 (GRCm39) T307A probably damaging Het
Zfp970 T C 2: 177,166,610 (GRCm39) probably benign Het
Other mutations in Or14j9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02270:Or14j9 APN 17 37,874,471 (GRCm39) missense possibly damaging 0.94
IGL03352:Or14j9 APN 17 37,874,681 (GRCm39) missense probably damaging 1.00
R0945:Or14j9 UTSW 17 37,874,278 (GRCm39) missense probably benign 0.00
R2475:Or14j9 UTSW 17 37,874,602 (GRCm39) missense probably benign
R4459:Or14j9 UTSW 17 37,874,365 (GRCm39) missense probably damaging 0.99
R4601:Or14j9 UTSW 17 37,875,076 (GRCm39) missense probably damaging 1.00
R5126:Or14j9 UTSW 17 37,874,719 (GRCm39) missense probably benign 0.22
R6745:Or14j9 UTSW 17 37,874,470 (GRCm39) missense probably damaging 1.00
R7806:Or14j9 UTSW 17 37,875,112 (GRCm39) missense probably damaging 1.00
R9309:Or14j9 UTSW 17 37,875,049 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18