Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02900:Zfp608'

363543

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp608

Ensembl Gene

ENSMUSG00000052713

Gene Name

zinc finger protein 608

Synonyms

4932417D18Rik

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.918) question?

Stock #

IGL02900

Quality Score

Status

Chromosome

Chromosomal Location

54888045-54990180 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 54946793 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 307 (T307A)

Ref Sequence

ENSEMBL: ENSMUSP00000068192 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064763]

AlphaFold

Q56A10

Predicted Effect

probably damaging
Transcript: ENSMUST00000064763
AA Change: T307A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000068192
Gene: ENSMUSG00000052713
AA Change: T307A

Domain	Start	End	E-Value	Type
low complexity region	51	61	N/A	INTRINSIC
low complexity region	150	184	N/A	INTRINSIC
low complexity region	214	234	N/A	INTRINSIC
low complexity region	252	266	N/A	INTRINSIC
low complexity region	309	326	N/A	INTRINSIC
low complexity region	428	445	N/A	INTRINSIC
low complexity region	459	471	N/A	INTRINSIC
ZnF_C2H2	552	577	1.86e0	SMART
low complexity region	624	636	N/A	INTRINSIC
low complexity region	706	718	N/A	INTRINSIC
low complexity region	734	773	N/A	INTRINSIC
low complexity region	807	822	N/A	INTRINSIC
low complexity region	833	846	N/A	INTRINSIC
low complexity region	934	956	N/A	INTRINSIC
coiled coil region	1028	1054	N/A	INTRINSIC
low complexity region	1182	1193	N/A	INTRINSIC
low complexity region	1255	1268	N/A	INTRINSIC
low complexity region	1439	1450	N/A	INTRINSIC
low complexity region	1458	1466	N/A	INTRINSIC
low complexity region	1486	1502	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2300003K06Rik	G	T	11: 99,837,948	T23N	possibly damaging	Het
Angpt4	T	A	2: 151,911,471	V47E	probably damaging	Het
Arhgef11	G	A	3: 87,733,160	R1208Q	probably benign	Het
Calb1	T	C	4: 15,895,695		probably benign	Het
Capn11	G	T	17: 45,630,614		probably null	Het
Carmil2	T	A	8: 105,695,519	I1140N	probably damaging	Het
Cnn3	A	T	3: 121,451,494	T23S	probably benign	Het
Colgalt2	C	T	1: 152,508,730	T607M	probably damaging	Het
Cyp46a1	T	G	12: 108,343,091	V93G	probably damaging	Het
Dcaf6	T	C	1: 165,399,775	Y261C	probably damaging	Het
Dnah10	A	G	5: 124,801,822	Y2715C	probably damaging	Het
Dsg1a	G	T	18: 20,328,656		probably benign	Het
Eml4	C	T	17: 83,477,992	P862L	probably benign	Het
Gm13088	A	T	4: 143,655,515	F204I	possibly damaging	Het
Gm5414	T	C	15: 101,627,807	T128A	probably damaging	Het
Gp9	G	T	6: 87,779,433	W143C	probably damaging	Het
Hipk2	T	C	6: 38,729,944	I670V	probably damaging	Het
Hoxa10	T	C	6: 52,232,561	K77R	possibly damaging	Het
Kcna1	T	G	6: 126,643,094	S88R	probably damaging	Het
Kif1b	A	T	4: 149,180,809	S1758T	possibly damaging	Het
Klk11	A	G	7: 43,778,413	T182A	probably damaging	Het
Lrp1	G	A	10: 127,576,647		probably benign	Het
Magi1	A	G	6: 93,686,873	S991P	probably damaging	Het
Mast4	T	A	13: 102,735,676	T2203S	probably benign	Het
Mxra8	A	G	4: 155,841,119	E95G	possibly damaging	Het
Mxra8	A	G	4: 155,841,211		probably null	Het
Nrn1	C	A	13: 36,730,106		probably null	Het
Olfr112	A	G	17: 37,563,849	I154T	possibly damaging	Het
Olfr452	T	A	6: 42,790,874	Y278*	probably null	Het
Olfr967	A	T	9: 39,750,605	H73L	probably benign	Het
Olfr971	T	A	9: 39,839,812	I126N	probably damaging	Het
Pbx4	A	G	8: 69,866,566	E249G	probably damaging	Het
Pkd1l2	T	C	8: 117,024,091	E1727G	probably benign	Het
Plec	T	G	15: 76,186,214	D932A	probably damaging	Het
Raph1	T	C	1: 60,502,863	D364G	probably damaging	Het
Rps29	T	A	12: 69,159,051	H3L	probably damaging	Het
Sema4c	A	T	1: 36,550,745	C509*	probably null	Het
Srgap2	A	T	1: 131,411,796		probably benign	Het
Stam2	A	T	2: 52,708,197	D243E	probably benign	Het
Stxbp4	A	G	11: 90,607,035	L146P	probably benign	Het
Teddm3	G	T	16: 21,153,150	T223K	probably benign	Het
Tfap2d	A	T	1: 19,119,250	N285Y	probably damaging	Het
Tmprss3	T	A	17: 31,184,579	D416V	probably damaging	Het
Vmn1r71	T	A	7: 10,748,674	Y29F	probably benign	Het
Vmn2r84	T	C	10: 130,387,992		probably benign	Het
Washc2	G	T	6: 116,227,474	D362Y	probably damaging	Het
Wbp2nl	T	C	15: 82,313,834	S191P	probably benign	Het
Zfp970	T	C	2: 177,474,817		probably benign	Het

Other mutations in Zfp608

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00500:Zfp608	APN	18	54988333	missense	probably benign
IGL00920:Zfp608	APN	18	54889831	missense	probably benign	0.00
IGL01088:Zfp608	APN	18	54898087	missense	probably benign	0.03
IGL01447:Zfp608	APN	18	54899011	missense	possibly damaging	0.75
IGL01534:Zfp608	APN	18	54898932	missense	probably damaging	0.99
IGL01547:Zfp608	APN	18	54894449	critical splice donor site	probably null
IGL01933:Zfp608	APN	18	54987799	missense	probably benign
IGL01998:Zfp608	APN	18	54891818	missense	probably damaging	0.99
IGL02167:Zfp608	APN	18	54988224	missense	probably damaging	1.00
IGL02266:Zfp608	APN	18	54897581	missense	probably benign	0.08
IGL02335:Zfp608	APN	18	54897437	nonsense	probably null
IGL02455:Zfp608	APN	18	54899333	missense	probably damaging	1.00
IGL02612:Zfp608	APN	18	54898201	missense	probably damaging	1.00
PIT4243001:Zfp608	UTSW	18	54898024	missense	probably damaging	1.00
PIT4519001:Zfp608	UTSW	18	54946711	missense	possibly damaging	0.71
R0005:Zfp608	UTSW	18	54895520	missense	possibly damaging	0.88
R0010:Zfp608	UTSW	18	54895214	splice site	probably benign
R0010:Zfp608	UTSW	18	54895214	splice site	probably benign
R0064:Zfp608	UTSW	18	54898816	missense	probably benign
R0401:Zfp608	UTSW	18	54898994	missense	probably benign
R0722:Zfp608	UTSW	18	54900234	missense	probably damaging	1.00
R1351:Zfp608	UTSW	18	54898391	missense	probably benign	0.00
R1512:Zfp608	UTSW	18	54946666	missense	probably damaging	1.00
R1554:Zfp608	UTSW	18	54898054	missense	probably damaging	1.00
R1622:Zfp608	UTSW	18	54988294	missense	probably benign	0.07
R1669:Zfp608	UTSW	18	54987739	missense	probably benign	0.09
R1690:Zfp608	UTSW	18	54987634	missense	possibly damaging	0.62
R1721:Zfp608	UTSW	18	54899249	missense	probably benign
R1826:Zfp608	UTSW	18	54898576	missense	probably benign	0.03
R1864:Zfp608	UTSW	18	54897911	missense	probably benign	0.00
R1952:Zfp608	UTSW	18	54897779	nonsense	probably null
R2049:Zfp608	UTSW	18	54895565	missense	probably damaging	1.00
R2051:Zfp608	UTSW	18	54988314	missense	probably benign
R2168:Zfp608	UTSW	18	54898053	nonsense	probably null
R2218:Zfp608	UTSW	18	54987684	missense	probably benign	0.14
R2283:Zfp608	UTSW	18	54988374	missense	probably damaging	1.00
R2399:Zfp608	UTSW	18	54897902	missense	probably damaging	1.00
R2520:Zfp608	UTSW	18	54988506	missense	possibly damaging	0.92
R2961:Zfp608	UTSW	18	54898472	missense	possibly damaging	0.60
R4074:Zfp608	UTSW	18	54898108	missense	probably damaging	1.00
R4076:Zfp608	UTSW	18	54898108	missense	probably damaging	1.00
R4206:Zfp608	UTSW	18	54988195	missense	probably damaging	1.00
R4756:Zfp608	UTSW	18	54894472	missense	probably damaging	1.00
R4771:Zfp608	UTSW	18	54988300	missense	probably benign
R4820:Zfp608	UTSW	18	54987684	missense	probably benign	0.14
R4825:Zfp608	UTSW	18	54897969	missense	probably benign	0.01
R4912:Zfp608	UTSW	18	54946591	missense	probably damaging	1.00
R4975:Zfp608	UTSW	18	54889890	missense	probably damaging	1.00
R5138:Zfp608	UTSW	18	54891799	missense	probably damaging	1.00
R5192:Zfp608	UTSW	18	54898497	missense	probably damaging	1.00
R5557:Zfp608	UTSW	18	54987870	missense	possibly damaging	0.81
R5624:Zfp608	UTSW	18	54898272	missense	probably damaging	1.00
R5818:Zfp608	UTSW	18	54895396	missense	probably benign	0.02
R5840:Zfp608	UTSW	18	54898906	missense	probably damaging	1.00
R5992:Zfp608	UTSW	18	54899248	missense	probably benign	0.15
R6106:Zfp608	UTSW	18	54987872	missense	possibly damaging	0.54
R6174:Zfp608	UTSW	18	54988544	start gained	probably benign
R6181:Zfp608	UTSW	18	54895628	missense	possibly damaging	0.56
R6517:Zfp608	UTSW	18	54899078	missense	possibly damaging	0.94
R6567:Zfp608	UTSW	18	54897556	missense	probably damaging	1.00
R6668:Zfp608	UTSW	18	54898019	missense	probably damaging	1.00
R6920:Zfp608	UTSW	18	54988265	missense	probably damaging	1.00
R7061:Zfp608	UTSW	18	54987997	missense	probably benign
R7074:Zfp608	UTSW	18	54897382	missense	possibly damaging	0.69
R7087:Zfp608	UTSW	18	54899397	missense	probably damaging	1.00
R7391:Zfp608	UTSW	18	54897547	missense	possibly damaging	0.49
R7600:Zfp608	UTSW	18	54988020	missense	probably damaging	1.00
R7723:Zfp608	UTSW	18	54897601	missense	probably damaging	1.00
R8054:Zfp608	UTSW	18	54899546	missense	probably benign	0.28
R8236:Zfp608	UTSW	18	54899209	missense	probably damaging	1.00
R8260:Zfp608	UTSW	18	54897749	missense	possibly damaging	0.60
R8732:Zfp608	UTSW	18	54988000	missense	probably benign	0.06
R8781:Zfp608	UTSW	18	54898729	missense	probably damaging	1.00
R8851:Zfp608	UTSW	18	54899122	missense	possibly damaging	0.94
R8940:Zfp608	UTSW	18	54900229	missense	possibly damaging	0.93
R9051:Zfp608	UTSW	18	54899194	missense	probably damaging	1.00
R9091:Zfp608	UTSW	18	54899118	missense	probably damaging	1.00
R9092:Zfp608	UTSW	18	54898576	missense	probably benign	0.03
R9236:Zfp608	UTSW	18	54899282	missense	probably benign	0.39
R9270:Zfp608	UTSW	18	54899118	missense	probably damaging	1.00
R9283:Zfp608	UTSW	18	54897841	missense	possibly damaging	0.50
R9288:Zfp608	UTSW	18	54900269	missense	probably benign	0.39
R9463:Zfp608	UTSW	18	54897202	missense	probably damaging	1.00

Posted On

2015-12-18