Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02902:Or5p69'

363621

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5p69

Ensembl Gene

ENSMUSG00000109631

Gene Name

olfactory receptor family 5 subfamily P member 69

Synonyms

GA_x6K02T2PBJ9-10697517-10698461, MOR204-10, Olfr494

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

IGL02902

Quality Score

Status

Chromosome

Chromosomal Location

107966699-107967643 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 107967336 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 213 (T213K)

Ref Sequence

ENSEMBL: ENSMUSP00000147830 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000209743] [ENSMUST00000210291]

AlphaFold

Q8VG07

Predicted Effect

probably damaging
Transcript: ENSMUST00000209743
AA Change: T213K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

Predicted Effect

probably damaging
Transcript: ENSMUST00000210291
AA Change: T213K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2810459M11Rik	G	T	1: 85,974,087 (GRCm39)	V135F	possibly damaging	Het
Aatk	T	C	11: 119,902,603 (GRCm39)	T541A	probably benign	Het
Abcc1	T	C	16: 14,240,991 (GRCm39)	L516P	probably damaging	Het
Actl6a	T	A	3: 32,776,791 (GRCm39)	V350E	possibly damaging	Het
Afm	A	G	5: 90,674,222 (GRCm39)	K245E	possibly damaging	Het
Agr3	T	C	12: 35,996,915 (GRCm39)	V63A	probably damaging	Het
Arhgef28	A	T	13: 98,083,383 (GRCm39)	M1162K	probably damaging	Het
Casq2	T	A	3: 101,994,113 (GRCm39)	C53*	probably null	Het
Ccdc181	T	C	1: 164,107,470 (GRCm39)	V51A	probably benign	Het
Cd101	A	G	3: 100,926,310 (GRCm39)		probably benign	Het
Csdc2	T	C	15: 81,832,801 (GRCm39)	V69A	probably benign	Het
Cyp2c23	A	T	19: 44,009,997 (GRCm39)		probably benign	Het
Dnph1	A	G	17: 46,809,427 (GRCm39)		probably benign	Het
Egf	T	C	3: 129,474,796 (GRCm39)	T1124A	probably benign	Het
Gpr45	A	G	1: 43,072,371 (GRCm39)	E338G	possibly damaging	Het
Grb14	A	C	2: 64,768,762 (GRCm39)	L98R	probably damaging	Het
Gucy1a1	T	C	3: 82,026,224 (GRCm39)	S77G	possibly damaging	Het
Helb	A	G	10: 119,925,390 (GRCm39)	S996P	probably benign	Het
Huwe1	A	G	X: 150,669,762 (GRCm39)	E1405G	probably damaging	Het
Ifi47	T	C	11: 48,986,617 (GRCm39)	I128T	probably benign	Het
Ift140	T	A	17: 25,309,736 (GRCm39)	Y1089N	probably damaging	Het
Ift56	A	C	6: 38,402,097 (GRCm39)	S530R	probably benign	Het
Il1r1	A	T	1: 40,341,569 (GRCm39)	H324L	probably benign	Het
Irx1	C	T	13: 72,107,974 (GRCm39)	R236H	probably benign	Het
Itpr3	T	C	17: 27,323,530 (GRCm39)	V1185A	probably benign	Het
Kif19a	T	C	11: 114,676,396 (GRCm39)	V450A	possibly damaging	Het
Krtap21-1	G	T	16: 89,200,446 (GRCm39)	Y65*	probably null	Het
Ltn1	A	T	16: 87,176,693 (GRCm39)	N1704K	possibly damaging	Het
Med1	T	C	11: 98,047,335 (GRCm39)		probably benign	Het
Meis2	T	A	2: 115,893,804 (GRCm39)	H36L	probably damaging	Het
Mier2	T	C	10: 79,385,456 (GRCm39)	N124S	probably damaging	Het
Mmp20	A	G	9: 7,654,171 (GRCm39)		probably null	Het
Muc4	A	G	16: 32,569,212 (GRCm39)	T91A	possibly damaging	Het
Myo3b	T	A	2: 70,119,745 (GRCm39)	V935E	probably benign	Het
Ndufa7	T	C	17: 34,048,632 (GRCm39)		probably benign	Het
Nipal1	A	G	5: 72,825,405 (GRCm39)	E366G	possibly damaging	Het
Nobox	A	T	6: 43,282,617 (GRCm39)	N263K	probably benign	Het
Notch2	A	G	3: 98,018,890 (GRCm39)	D684G	probably damaging	Het
Odr4	C	A	1: 150,260,179 (GRCm39)		probably null	Het
Or2t1	A	G	14: 14,328,789 (GRCm38)	H226R	probably benign	Het
Or4c12b	T	A	2: 89,647,508 (GRCm39)	Y273*	probably null	Het
Or5w13	T	C	2: 87,523,344 (GRCm39)	N294S	probably damaging	Het
Or6aa1	T	C	7: 86,043,743 (GRCm39)		probably benign	Het
Plau	A	C	14: 20,889,965 (GRCm39)	D270A	possibly damaging	Het
Pof1b	T	C	X: 111,558,809 (GRCm39)		probably null	Het
Pramel23	A	G	4: 143,424,913 (GRCm39)	C177R	probably damaging	Het
Prtn3	A	T	10: 79,717,767 (GRCm39)		probably null	Het
Ptges3	T	A	10: 127,904,616 (GRCm39)	D26E	probably benign	Het
Pxmp2	T	C	5: 110,429,160 (GRCm39)	E99G	probably benign	Het
Rasgef1a	A	G	6: 118,060,068 (GRCm39)	R106G	probably benign	Het
Rnf208	T	C	2: 25,133,774 (GRCm39)	V156A	probably benign	Het
Rps6ka1	A	T	4: 133,599,292 (GRCm39)	I45N	possibly damaging	Het
Rps6ka4	C	T	19: 6,809,623 (GRCm39)		probably null	Het
Rsbn1	G	T	3: 103,860,972 (GRCm39)	C466F	possibly damaging	Het
Shkbp1	A	T	7: 27,042,141 (GRCm39)	C605S	probably damaging	Het
Slc2a10	G	A	2: 165,360,142 (GRCm39)	D531N	probably benign	Het
Sox13	A	G	1: 133,317,204 (GRCm39)	L143P	probably damaging	Het
Stx2	C	T	5: 129,069,285 (GRCm39)	R142Q	probably damaging	Het
Tanc1	T	A	2: 59,623,431 (GRCm39)		probably benign	Het
Tubgcp5	C	T	7: 55,456,355 (GRCm39)	Q316*	probably null	Het
Ubc	A	G	5: 125,463,293 (GRCm39)	V678A	probably benign	Het
Unc5d	G	A	8: 29,365,634 (GRCm39)	T117I	probably damaging	Het
Vmn2r4	T	C	3: 64,314,337 (GRCm39)	I126V	probably benign	Het
Zfp410	T	A	12: 84,378,594 (GRCm39)		probably null	Het

Other mutations in Or5p69

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01761:Or5p69	APN	7	107,967,525 (GRCm39)	missense	probably damaging	1.00
IGL01934:Or5p69	APN	7	107,967,368 (GRCm39)	missense	probably damaging	0.99
IGL02041:Or5p69	APN	7	107,966,742 (GRCm39)	missense	probably damaging	1.00
IGL02253:Or5p69	APN	7	107,967,261 (GRCm39)	missense	possibly damaging	0.80
R0125:Or5p69	UTSW	7	107,967,576 (GRCm39)	missense	probably damaging	0.98
R0523:Or5p69	UTSW	7	107,967,438 (GRCm39)	missense	probably damaging	1.00
R0650:Or5p69	UTSW	7	107,966,996 (GRCm39)	missense	probably damaging	1.00
R1268:Or5p69	UTSW	7	107,967,002 (GRCm39)	missense	probably benign	0.06
R2036:Or5p69	UTSW	7	107,966,947 (GRCm39)	missense	probably benign	0.00
R2162:Or5p69	UTSW	7	107,966,769 (GRCm39)	missense	probably benign	0.08
R2278:Or5p69	UTSW	7	107,967,288 (GRCm39)	missense	probably benign	0.01
R2368:Or5p69	UTSW	7	107,967,576 (GRCm39)	missense	probably damaging	0.98
R3410:Or5p69	UTSW	7	107,967,551 (GRCm39)	missense	possibly damaging	0.52
R3411:Or5p69	UTSW	7	107,967,551 (GRCm39)	missense	possibly damaging	0.52
R3834:Or5p69	UTSW	7	107,967,279 (GRCm39)	missense	probably damaging	0.98
R4322:Or5p69	UTSW	7	107,967,555 (GRCm39)	missense	probably damaging	1.00
R4625:Or5p69	UTSW	7	107,966,895 (GRCm39)	missense	probably damaging	0.98
R4724:Or5p69	UTSW	7	107,967,205 (GRCm39)	missense	probably benign
R4843:Or5p69	UTSW	7	107,967,350 (GRCm39)	missense	probably benign	0.01
R5525:Or5p69	UTSW	7	107,967,206 (GRCm39)	missense	probably benign
R5954:Or5p69	UTSW	7	107,966,808 (GRCm39)	missense	probably damaging	0.98
R7027:Or5p69	UTSW	7	107,967,557 (GRCm39)	missense	probably damaging	0.98
R8041:Or5p69	UTSW	7	107,966,741 (GRCm39)	missense	probably damaging	1.00
R8237:Or5p69	UTSW	7	107,967,234 (GRCm39)	missense	probably damaging	1.00
R9566:Or5p69	UTSW	7	107,966,783 (GRCm39)	missense	probably benign	0.01
Z1177:Or5p69	UTSW	7	107,967,468 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-12-18