Incidental Mutation 'IGL02902:Olfr31'
ID363626
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr31
Ensembl Gene ENSMUSG00000072707
Gene Nameolfactory receptor 31
SynonymsMOR274-1, GA_x6K02T2PLTE-6714644-6715597, MTPCR53
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.170) question?
Stock #IGL02902
Quality Score
Status
Chromosome14
Chromosomal Location14322828-14331791 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 14328789 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Arginine at position 226 (H226R)
Ref Sequence ENSEMBL: ENSMUSP00000149019 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100872] [ENSMUST00000206009] [ENSMUST00000217035]
Predicted Effect probably benign
Transcript: ENSMUST00000100872
AA Change: H226R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000098434
Gene: ENSMUSG00000072707
AA Change: H226R

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 5.7e-50 PFAM
Pfam:7tm_1 40 289 3.1e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000206009
AA Change: H226R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000217035
AA Change: H226R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224991
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810459M11Rik G T 1: 86,046,365 V135F possibly damaging Het
Aatk T C 11: 120,011,777 T541A probably benign Het
Abcc1 T C 16: 14,423,127 L516P probably damaging Het
Actl6a T A 3: 32,722,642 V350E possibly damaging Het
Afm A G 5: 90,526,363 K245E possibly damaging Het
Agr3 T C 12: 35,946,916 V63A probably damaging Het
Arhgef28 A T 13: 97,946,875 M1162K probably damaging Het
BC003331 C A 1: 150,384,428 probably null Het
Casq2 T A 3: 102,086,797 C53* probably null Het
Ccdc181 T C 1: 164,279,901 V51A probably benign Het
Cd101 A G 3: 101,018,994 probably benign Het
Csdc2 T C 15: 81,948,600 V69A probably benign Het
Cyp2c23 A T 19: 44,021,558 probably benign Het
Dnph1 A G 17: 46,498,501 probably benign Het
Egf T C 3: 129,681,147 T1124A probably benign Het
Gm13089 A G 4: 143,698,343 C177R probably damaging Het
Gpr45 A G 1: 43,033,211 E338G possibly damaging Het
Grb14 A C 2: 64,938,418 L98R probably damaging Het
Gucy1a1 T C 3: 82,118,917 S77G possibly damaging Het
Helb A G 10: 120,089,485 S996P probably benign Het
Huwe1 A G X: 151,886,766 E1405G probably damaging Het
Ifi47 T C 11: 49,095,790 I128T probably benign Het
Ift140 T A 17: 25,090,762 Y1089N probably damaging Het
Il1r1 A T 1: 40,302,409 H324L probably benign Het
Irx1 C T 13: 71,959,855 R236H probably benign Het
Itpr3 T C 17: 27,104,556 V1185A probably benign Het
Kif19a T C 11: 114,785,570 V450A possibly damaging Het
Krtap21-1 G T 16: 89,403,558 Y65* probably null Het
Ltn1 A T 16: 87,379,805 N1704K possibly damaging Het
Med1 T C 11: 98,156,509 probably benign Het
Meis2 T A 2: 116,063,323 H36L probably damaging Het
Mier2 T C 10: 79,549,622 N124S probably damaging Het
Mmp20 A G 9: 7,654,170 probably null Het
Muc4 A G 16: 32,750,394 T91A possibly damaging Het
Myo3b T A 2: 70,289,401 V935E probably benign Het
Ndufa7 T C 17: 33,829,658 probably benign Het
Nipal1 A G 5: 72,668,062 E366G possibly damaging Het
Nobox A T 6: 43,305,683 N263K probably benign Het
Notch2 A G 3: 98,111,574 D684G probably damaging Het
Olfr1136 T C 2: 87,693,000 N294S probably damaging Het
Olfr1255 T A 2: 89,817,164 Y273* probably null Het
Olfr303 T C 7: 86,394,535 probably benign Het
Olfr494 C A 7: 108,368,129 T213K probably damaging Het
Plau A C 14: 20,839,897 D270A possibly damaging Het
Pof1b T C X: 112,649,112 probably null Het
Prtn3 A T 10: 79,881,933 probably null Het
Ptges3 T A 10: 128,068,747 D26E probably benign Het
Pxmp2 T C 5: 110,281,294 E99G probably benign Het
Rasgef1a A G 6: 118,083,107 R106G probably benign Het
Rnf208 T C 2: 25,243,762 V156A probably benign Het
Rps6ka1 A T 4: 133,871,981 I45N possibly damaging Het
Rps6ka4 C T 19: 6,832,255 probably null Het
Rsbn1 G T 3: 103,953,656 C466F possibly damaging Het
Shkbp1 A T 7: 27,342,716 C605S probably damaging Het
Slc2a10 G A 2: 165,518,222 D531N probably benign Het
Sox13 A G 1: 133,389,466 L143P probably damaging Het
Stx2 C T 5: 128,992,221 R142Q probably damaging Het
Tanc1 T A 2: 59,793,087 probably benign Het
Ttc26 A C 6: 38,425,162 S530R probably benign Het
Tubgcp5 C T 7: 55,806,607 Q316* probably null Het
Ubc A G 5: 125,386,229 V678A probably benign Het
Unc5d G A 8: 28,875,606 T117I probably damaging Het
Vmn2r4 T C 3: 64,406,916 I126V probably benign Het
Zfp410 T A 12: 84,331,820 probably null Het
Other mutations in Olfr31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02550:Olfr31 APN 14 14328423 missense possibly damaging 0.91
IGL02566:Olfr31 APN 14 14328138 missense probably benign 0.05
IGL03106:Olfr31 APN 14 14328851 missense probably damaging 0.97
IGL03214:Olfr31 APN 14 14328284 missense probably damaging 0.98
R0333:Olfr31 UTSW 14 14328498 missense probably damaging 1.00
R0828:Olfr31 UTSW 14 14328800 missense probably benign 0.00
R1231:Olfr31 UTSW 14 14328515 missense probably benign 0.00
R1725:Olfr31 UTSW 14 14328977 missense probably damaging 1.00
R1823:Olfr31 UTSW 14 14328774 missense probably damaging 1.00
R1824:Olfr31 UTSW 14 14328774 missense probably damaging 1.00
R2026:Olfr31 UTSW 14 14328891 missense probably benign 0.10
R3891:Olfr31 UTSW 14 14328114 start codon destroyed probably null 0.99
R4327:Olfr31 UTSW 14 14328193 missense probably damaging 1.00
R4328:Olfr31 UTSW 14 14328193 missense probably damaging 1.00
R4608:Olfr31 UTSW 14 14328887 missense probably benign 0.06
R4893:Olfr31 UTSW 14 14328852 missense probably damaging 1.00
R5197:Olfr31 UTSW 14 14328462 missense probably damaging 1.00
R5402:Olfr31 UTSW 14 14328878 missense probably damaging 1.00
R5787:Olfr31 UTSW 14 14328725 missense probably damaging 0.98
R5897:Olfr31 UTSW 14 14328120 missense probably benign 0.00
R7340:Olfr31 UTSW 14 14328401 missense possibly damaging 0.90
R7709:Olfr31 UTSW 14 14328384 missense probably damaging 1.00
Posted On2015-12-18