Incidental Mutation 'IGL02903:Dus3l'
ID363683
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dus3l
Ensembl Gene ENSMUSG00000007603
Gene Namedihydrouridine synthase 3-like (S. cerevisiae)
Synonyms
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.499) question?
Stock #IGL02903
Quality Score
Status
Chromosome17
Chromosomal Location56764751-56770092 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 56768363 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Phenylalanine at position 397 (L397F)
Ref Sequence ENSEMBL: ENSMUSP00000007747 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000007747] [ENSMUST00000168666]
Predicted Effect probably damaging
Transcript: ENSMUST00000007747
AA Change: L397F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000007747
Gene: ENSMUSG00000007603
AA Change: L397F

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
Blast:ZnF_C3H1 109 136 2e-6 BLAST
Blast:ZnF_C3H1 146 172 6e-9 BLAST
Pfam:Dus 295 566 2e-60 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168666
SMART Domains Protein: ENSMUSP00000127457
Gene: ENSMUSG00000090273

DomainStartEndE-ValueType
low complexity region 22 35 N/A INTRINSIC
Pfam:PRR22 58 422 2.3e-169 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000187612
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik G T 15: 8,269,778 R3150M unknown Het
2410089E03Rik G T 15: 8,269,779 R3150S unknown Het
4931417E11Rik A G 6: 73,469,120 Y149H probably damaging Het
Alox5 T G 6: 116,420,335 N296T probably damaging Het
Anks6 C T 4: 47,045,004 E301K probably damaging Het
Astn1 A G 1: 158,688,550 S1237G probably damaging Het
Atf6 G A 1: 170,799,714 P394S probably benign Het
Atp4a G A 7: 30,715,919 M321I probably benign Het
C4bp G A 1: 130,655,985 T82I probably damaging Het
Cask A T X: 13,552,447 probably benign Het
Cenpf A T 1: 189,646,876 S2906T probably damaging Het
Cfl1 T C 19: 5,492,800 F103L probably benign Het
Chrnb3 A T 8: 27,386,806 T83S probably damaging Het
Cmtr2 A G 8: 110,222,878 T607A probably benign Het
Cts7 A T 13: 61,356,626 probably benign Het
Dgkz A T 2: 91,939,962 Y514N possibly damaging Het
Dmrtc1b T A X: 102,713,567 L206Q probably benign Het
Fam159b T A 13: 104,863,610 Y35F probably benign Het
Gm13089 A T 4: 143,699,166 M69K probably benign Het
Gm6356 C T 14: 6,973,735 G27E probably damaging Het
Hkdc1 C T 10: 62,400,191 probably null Het
Kcmf1 A T 6: 72,858,883 V21E possibly damaging Het
Kcnh4 T A 11: 100,757,654 T75S possibly damaging Het
Lemd2 A G 17: 27,193,210 probably benign Het
Magee1 G T X: 105,123,339 R910L probably damaging Het
Mcm3ap T C 10: 76,471,258 probably benign Het
Mfsd4b3 T A 10: 39,947,643 E207V possibly damaging Het
Olfr1354 A G 10: 78,917,416 D192G probably damaging Het
Olfr697 A G 7: 106,741,710 S75P probably damaging Het
Pappa T C 4: 65,261,980 V1026A probably damaging Het
Paxip1 A G 5: 27,748,872 L942P probably damaging Het
Ppp1r12b A T 1: 134,955,649 L45Q probably benign Het
Ptprq T C 10: 107,666,586 T824A possibly damaging Het
Rfwd3 T C 8: 111,278,229 T574A probably benign Het
Rsbn1 T C 3: 103,928,569 S308P probably damaging Het
Smr2 A T 5: 88,108,630 I56F probably benign Het
Wdfy4 C T 14: 33,109,650 R873H probably damaging Het
Other mutations in Dus3l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01145:Dus3l APN 17 56767627 unclassified probably benign
IGL02164:Dus3l APN 17 56767943 unclassified probably benign
IGL02979:Dus3l APN 17 56768140 missense possibly damaging 0.91
R0532:Dus3l UTSW 17 56769308 missense probably damaging 0.98
R1668:Dus3l UTSW 17 56766912 missense possibly damaging 0.73
R3151:Dus3l UTSW 17 56768899 missense probably benign 0.12
R4671:Dus3l UTSW 17 56768566 missense probably benign 0.02
R4737:Dus3l UTSW 17 56767868 missense probably damaging 1.00
R5198:Dus3l UTSW 17 56769574 missense probably benign 0.03
R5613:Dus3l UTSW 17 56767882 missense possibly damaging 0.89
R5930:Dus3l UTSW 17 56769579 missense probably damaging 0.97
R6198:Dus3l UTSW 17 56767858 missense possibly damaging 0.46
R7206:Dus3l UTSW 17 56767807 missense probably damaging 0.98
R7316:Dus3l UTSW 17 56765551 missense possibly damaging 0.90
R8139:Dus3l UTSW 17 56767058 nonsense probably null
Posted On2015-12-18