Incidental Mutation 'IGL02903:Or2ag15'
ID 363693
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2ag15
Ensembl Gene ENSMUSG00000051591
Gene Name olfactory receptor family 2 subfamily AG member 15
Synonyms GA_x6K02T2PBJ9-9119301-9118348, Olfr697, MOR283-5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # IGL02903
Quality Score
Status
Chromosome 7
Chromosomal Location 106340112-106341163 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 106340917 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 75 (S75P)
Ref Sequence ENSEMBL: ENSMUSP00000152039 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050541] [ENSMUST00000217734]
AlphaFold Q8VFM4
Predicted Effect probably damaging
Transcript: ENSMUST00000050541
AA Change: S75P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000055207
Gene: ENSMUSG00000051591
AA Change: S75P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 305 4.7e-7 PFAM
Pfam:7tm_1 41 290 8.7e-26 PFAM
Pfam:7TM_GPCR_Srx 69 306 4.3e-6 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217734
AA Change: S75P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox5 T G 6: 116,397,296 (GRCm39) N296T probably damaging Het
Anks6 C T 4: 47,045,004 (GRCm39) E301K probably damaging Het
Astn1 A G 1: 158,516,120 (GRCm39) S1237G probably damaging Het
Atf6 G A 1: 170,627,283 (GRCm39) P394S probably benign Het
Atp4a G A 7: 30,415,344 (GRCm39) M321I probably benign Het
C4bp G A 1: 130,583,722 (GRCm39) T82I probably damaging Het
Cask A T X: 13,418,686 (GRCm39) probably benign Het
Cenpf A T 1: 189,379,073 (GRCm39) S2906T probably damaging Het
Cfl1 T C 19: 5,542,828 (GRCm39) F103L probably benign Het
Chrnb3 A T 8: 27,876,834 (GRCm39) T83S probably damaging Het
Cmtr2 A G 8: 110,949,510 (GRCm39) T607A probably benign Het
Cplane1 G T 15: 8,299,262 (GRCm39) R3150M unknown Het
Cplane1 G T 15: 8,299,263 (GRCm39) R3150S unknown Het
Cts7 A T 13: 61,504,440 (GRCm39) probably benign Het
Dgkz A T 2: 91,770,307 (GRCm39) Y514N possibly damaging Het
Dmrtc1b T A X: 101,757,173 (GRCm39) L206Q probably benign Het
Dus3l C T 17: 57,075,363 (GRCm39) L397F probably damaging Het
Gm6356 C T 14: 6,973,735 (GRCm38) G27E probably damaging Het
Hkdc1 C T 10: 62,235,970 (GRCm39) probably null Het
Jkampl A G 6: 73,446,103 (GRCm39) Y149H probably damaging Het
Kcmf1 A T 6: 72,835,866 (GRCm39) V21E possibly damaging Het
Kcnh4 T A 11: 100,648,480 (GRCm39) T75S possibly damaging Het
Lemd2 A G 17: 27,412,184 (GRCm39) probably benign Het
Magee1 G T X: 104,166,945 (GRCm39) R910L probably damaging Het
Mcm3ap T C 10: 76,307,092 (GRCm39) probably benign Het
Mfsd4b3-ps T A 10: 39,823,639 (GRCm39) E207V possibly damaging Het
Or7a38 A G 10: 78,753,250 (GRCm39) D192G probably damaging Het
Pappa T C 4: 65,180,217 (GRCm39) V1026A probably damaging Het
Paxip1 A G 5: 27,953,870 (GRCm39) L942P probably damaging Het
Ppp1r12b A T 1: 134,883,387 (GRCm39) L45Q probably benign Het
Pramel23 A T 4: 143,425,736 (GRCm39) M69K probably benign Het
Ptprq T C 10: 107,502,447 (GRCm39) T824A possibly damaging Het
Rfwd3 T C 8: 112,004,861 (GRCm39) T574A probably benign Het
Rsbn1 T C 3: 103,835,885 (GRCm39) S308P probably damaging Het
Shisal2b T A 13: 105,000,118 (GRCm39) Y35F probably benign Het
Smr2 A T 5: 88,256,489 (GRCm39) I56F probably benign Het
Wdfy4 C T 14: 32,831,607 (GRCm39) R873H probably damaging Het
Other mutations in Or2ag15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00226:Or2ag15 APN 7 106,340,908 (GRCm39) missense probably benign 0.20
IGL00937:Or2ag15 APN 7 106,340,364 (GRCm39) missense probably damaging 1.00
IGL01368:Or2ag15 APN 7 106,340,829 (GRCm39) missense probably benign 0.19
IGL01410:Or2ag15 APN 7 106,340,706 (GRCm39) missense probably benign 0.19
IGL01415:Or2ag15 APN 7 106,340,706 (GRCm39) missense probably benign 0.19
IGL01962:Or2ag15 APN 7 106,340,991 (GRCm39) missense probably benign 0.12
IGL02654:Or2ag15 APN 7 106,340,555 (GRCm39) nonsense probably null
IGL03347:Or2ag15 APN 7 106,340,177 (GRCm39) utr 3 prime probably benign
IGL03391:Or2ag15 APN 7 106,340,962 (GRCm39) missense probably damaging 1.00
R0139:Or2ag15 UTSW 7 106,340,832 (GRCm39) missense probably benign 0.05
R0142:Or2ag15 UTSW 7 106,340,972 (GRCm39) missense probably benign 0.36
R1293:Or2ag15 UTSW 7 106,341,058 (GRCm39) missense probably damaging 0.98
R1522:Or2ag15 UTSW 7 106,340,212 (GRCm39) missense probably benign 0.03
R1715:Or2ag15 UTSW 7 106,340,755 (GRCm39) missense probably damaging 1.00
R1959:Or2ag15 UTSW 7 106,340,601 (GRCm39) missense probably damaging 1.00
R1960:Or2ag15 UTSW 7 106,340,601 (GRCm39) missense probably damaging 1.00
R2031:Or2ag15 UTSW 7 106,341,105 (GRCm39) missense probably damaging 1.00
R4790:Or2ag15 UTSW 7 106,340,998 (GRCm39) missense probably benign 0.05
R5550:Or2ag15 UTSW 7 106,340,340 (GRCm39) missense probably benign 0.01
R6232:Or2ag15 UTSW 7 106,340,761 (GRCm39) missense probably damaging 0.96
R6293:Or2ag15 UTSW 7 106,340,613 (GRCm39) missense probably damaging 1.00
R6643:Or2ag15 UTSW 7 106,340,911 (GRCm39) missense probably benign 0.06
R7831:Or2ag15 UTSW 7 106,340,620 (GRCm39) missense probably damaging 0.99
R8013:Or2ag15 UTSW 7 106,340,824 (GRCm39) missense probably benign 0.00
R8014:Or2ag15 UTSW 7 106,340,824 (GRCm39) missense probably benign 0.00
R8883:Or2ag15 UTSW 7 106,340,274 (GRCm39) missense possibly damaging 0.74
R9072:Or2ag15 UTSW 7 106,340,759 (GRCm39) nonsense probably null
RF018:Or2ag15 UTSW 7 106,340,692 (GRCm39) missense probably benign 0.02
X0020:Or2ag15 UTSW 7 106,340,343 (GRCm39) missense probably damaging 0.97
Z1088:Or2ag15 UTSW 7 106,340,350 (GRCm39) missense probably benign 0.21
Posted On 2015-12-18