Incidental Mutation 'IGL02904:Olfr224'
ID363722
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr224
Ensembl Gene ENSMUSG00000059279
Gene Nameolfactory receptor 224
SynonymsGA_x6K02T2NKPP-858022-858862, Olfr327-ps1, MOR275-10_p, GA_x6K02T00261-652-347, MOR275-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock #IGL02904
Quality Score
Status
Chromosome11
Chromosomal Location58565856-58570553 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 58566797 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 183 (T183S)
Ref Sequence ENSEMBL: ENSMUSP00000150268 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081102] [ENSMUST00000215322] [ENSMUST00000216758] [ENSMUST00000217009]
Predicted Effect possibly damaging
Transcript: ENSMUST00000081102
AA Change: T183S

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000079881
Gene: ENSMUSG00000059279
AA Change: T183S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 33 299 5.1e-7 PFAM
Pfam:7tm_1 39 288 4.4e-35 PFAM
Pfam:7tm_4 137 281 5.8e-43 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215322
AA Change: T183S

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216758
AA Change: T183S

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217009
AA Change: T183S

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik T C 13: 119,484,454 S564P probably damaging Het
A1cf A C 19: 31,934,806 K432N probably damaging Het
Acp7 A T 7: 28,608,003 D476E probably benign Het
Aqp9 T A 9: 71,138,148 I60F probably damaging Het
B2m A C 2: 122,151,161 probably benign Het
B3galt1 T A 2: 68,118,745 V268E probably damaging Het
BC037034 C T 5: 138,260,602 V232I probably benign Het
Cacna1a T C 8: 84,579,520 L1299P probably damaging Het
Ces2e C T 8: 104,931,338 P356L probably benign Het
Crmp1 A T 5: 37,288,918 K639N possibly damaging Het
Ddx17 G A 15: 79,530,437 R510* probably null Het
Dner C T 1: 84,534,944 V301M probably damaging Het
Efr3b T G 12: 3,984,583 I196L probably damaging Het
Fat1 T C 8: 45,040,682 V3955A probably damaging Het
Gid4 T C 11: 60,417,735 I27T probably benign Het
Glis3 A G 19: 28,357,952 F571L possibly damaging Het
Gm4950 T C 18: 51,865,731 I51V probably benign Het
Gm5592 T C 7: 41,288,386 L364P probably damaging Het
Gm884 A C 11: 103,616,361 probably benign Het
Gucy2d G A 7: 98,462,189 probably null Het
Kpna6 A G 4: 129,650,687 I411T probably benign Het
Lcn11 A G 2: 25,779,266 D145G probably null Het
Med12 A G X: 101,294,178 probably null Het
Mtor A G 4: 148,452,394 K42E possibly damaging Het
Mtor A G 4: 148,491,612 probably benign Het
Mybpc2 T C 7: 44,522,341 D55G probably benign Het
Myo1f T A 17: 33,585,658 C445* probably null Het
Naca C T 10: 128,043,290 probably benign Het
Nlgn2 T C 11: 69,825,840 Y625C possibly damaging Het
Nlrp9c A T 7: 26,375,290 C827S probably damaging Het
Nudt12 T A 17: 59,010,352 N100I probably benign Het
Olfr1009 T C 2: 85,721,755 S117P probably damaging Het
Olfr284 A T 15: 98,340,848 L31Q probably null Het
Olfr77 A T 9: 19,921,097 D296V probably damaging Het
Picalm G A 7: 90,176,411 probably benign Het
Pkd1l1 A G 11: 8,868,450 probably benign Het
Scube3 T C 17: 28,167,600 V831A probably benign Het
Slco5a1 A G 1: 12,921,097 I456T probably damaging Het
Snx3 A G 10: 42,534,694 H110R probably damaging Het
Spef2 T C 15: 9,679,346 D635G probably damaging Het
St3gal5 A T 6: 72,147,124 I212L possibly damaging Het
Syvn1 T A 19: 6,049,815 Y192* probably null Het
Tmem2 G A 19: 21,823,843 D775N possibly damaging Het
Tmtc1 A G 6: 148,249,482 probably benign Het
Trip11 T G 12: 101,886,838 E499D probably damaging Het
Ttn A T 2: 76,732,031 N28823K probably damaging Het
Unc13c C A 9: 73,481,067 G2146* probably null Het
Ush2a G T 1: 188,906,506 V4038L probably benign Het
Zc3h7a T G 16: 11,150,666 D483A probably damaging Het
Zfyve19 T C 2: 119,210,472 probably benign Het
Other mutations in Olfr224
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00321:Olfr224 APN 11 58566767 missense probably damaging 1.00
IGL02327:Olfr224 APN 11 58566935 missense probably damaging 1.00
IGL02968:Olfr224 APN 11 58567195 missense possibly damaging 0.90
R1704:Olfr224 UTSW 11 58566754 missense probably damaging 0.97
R2055:Olfr224 UTSW 11 58566847 missense probably damaging 0.99
R3925:Olfr224 UTSW 11 58566826 missense probably benign 0.34
R4093:Olfr224 UTSW 11 58566829 missense probably damaging 1.00
R4902:Olfr224 UTSW 11 58566625 missense possibly damaging 0.60
R4955:Olfr224 UTSW 11 58566518 missense probably damaging 1.00
R4956:Olfr224 UTSW 11 58566518 missense probably damaging 1.00
R4957:Olfr224 UTSW 11 58566518 missense probably damaging 1.00
R5436:Olfr224 UTSW 11 58566937 missense probably benign 0.34
R6699:Olfr224 UTSW 11 58567205 missense possibly damaging 0.69
R6825:Olfr224 UTSW 11 58566650 missense possibly damaging 0.89
R7467:Olfr224 UTSW 11 58566462 missense possibly damaging 0.82
R7590:Olfr224 UTSW 11 58567259 missense probably benign 0.09
R7600:Olfr224 UTSW 11 58567336 missense probably benign 0.17
R7725:Olfr224 UTSW 11 58566767 missense probably damaging 1.00
X0026:Olfr224 UTSW 11 58567174 missense possibly damaging 0.50
Posted On2015-12-18