Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02904:Lcn11'

363749

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lcn11

Ensembl Gene

ENSMUSG00000069080

Gene Name

lipocalin 11

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL02904

Quality Score

Status

Chromosome

Chromosomal Location

25667029-25670291 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 25669278 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 145 (D145G)

Ref Sequence

ENSEMBL: ENSMUSP00000088822 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000091278] [ENSMUST00000211245]

AlphaFold

A2BHR2

Predicted Effect

probably null
Transcript: ENSMUST00000091278
AA Change: D145G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000088822
Gene: ENSMUSG00000069080
AA Change: D145G

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:Lipocalin	34	172	7.5e-23	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143166

Predicted Effect

probably benign
Transcript: ENSMUST00000211245

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833420G17Rik	T	C	13: 119,620,990 (GRCm39)	S564P	probably damaging	Het
A1cf	A	C	19: 31,912,206 (GRCm39)	K432N	probably damaging	Het
Acp7	A	T	7: 28,307,428 (GRCm39)	D476E	probably benign	Het
Aqp9	T	A	9: 71,045,430 (GRCm39)	I60F	probably damaging	Het
B2m	A	C	2: 121,981,642 (GRCm39)		probably benign	Het
B3galt1	T	A	2: 67,949,089 (GRCm39)	V268E	probably damaging	Het
Cacna1a	T	C	8: 85,306,149 (GRCm39)	L1299P	probably damaging	Het
Cemip2	G	A	19: 21,801,207 (GRCm39)	D775N	possibly damaging	Het
Ces2e	C	T	8: 105,657,970 (GRCm39)	P356L	probably benign	Het
Crmp1	A	T	5: 37,446,262 (GRCm39)	K639N	possibly damaging	Het
Ddx17	G	A	15: 79,414,638 (GRCm39)	R510*	probably null	Het
Dner	C	T	1: 84,512,665 (GRCm39)	V301M	probably damaging	Het
Efr3b	T	G	12: 4,034,583 (GRCm39)	I196L	probably damaging	Het
Fat1	T	C	8: 45,493,719 (GRCm39)	V3955A	probably damaging	Het
Gid4	T	C	11: 60,308,561 (GRCm39)	I27T	probably benign	Het
Glis3	A	G	19: 28,335,352 (GRCm39)	F571L	possibly damaging	Het
Gm4950	T	C	18: 51,998,803 (GRCm39)	I51V	probably benign	Het
Gm5592	T	C	7: 40,937,810 (GRCm39)	L364P	probably damaging	Het
Gucy2d	G	A	7: 98,111,396 (GRCm39)		probably null	Het
Kpna6	A	G	4: 129,544,480 (GRCm39)	I411T	probably benign	Het
Lrrc37	A	C	11: 103,507,187 (GRCm39)		probably benign	Het
Med12	A	G	X: 100,337,784 (GRCm39)		probably null	Het
Mtor	A	G	4: 148,536,851 (GRCm39)	K42E	possibly damaging	Het
Mtor	A	G	4: 148,576,069 (GRCm39)		probably benign	Het
Mybpc2	T	C	7: 44,171,765 (GRCm39)	D55G	probably benign	Het
Myo1f	T	A	17: 33,804,632 (GRCm39)	C445*	probably null	Het
Naca	C	T	10: 127,879,159 (GRCm39)		probably benign	Het
Nlgn2	T	C	11: 69,716,666 (GRCm39)	Y625C	possibly damaging	Het
Nlrp9c	A	T	7: 26,074,715 (GRCm39)	C827S	probably damaging	Het
Nudt12	T	A	17: 59,317,347 (GRCm39)	N100I	probably benign	Het
Or2t43	T	A	11: 58,457,623 (GRCm39)	T183S	possibly damaging	Het
Or5g9	T	C	2: 85,552,099 (GRCm39)	S117P	probably damaging	Het
Or7d10	A	T	9: 19,832,393 (GRCm39)	D296V	probably damaging	Het
Or8s5	A	T	15: 98,238,729 (GRCm39)	L31Q	probably null	Het
Picalm	G	A	7: 89,825,619 (GRCm39)		probably benign	Het
Pkd1l1	A	G	11: 8,818,450 (GRCm39)		probably benign	Het
Scube3	T	C	17: 28,386,574 (GRCm39)	V831A	probably benign	Het
Slco5a1	A	G	1: 12,991,321 (GRCm39)	I456T	probably damaging	Het
Snx3	A	G	10: 42,410,690 (GRCm39)	H110R	probably damaging	Het
Spef2	T	C	15: 9,679,432 (GRCm39)	D635G	probably damaging	Het
St3gal5	A	T	6: 72,124,108 (GRCm39)	I212L	possibly damaging	Het
Syvn1	T	A	19: 6,099,845 (GRCm39)	Y192*	probably null	Het
Tmtc1	A	G	6: 148,150,980 (GRCm39)		probably benign	Het
Trappc14	C	T	5: 138,258,864 (GRCm39)	V232I	probably benign	Het
Trip11	T	G	12: 101,853,097 (GRCm39)	E499D	probably damaging	Het
Ttn	A	T	2: 76,562,375 (GRCm39)	N28823K	probably damaging	Het
Unc13c	C	A	9: 73,388,349 (GRCm39)	G2146*	probably null	Het
Ush2a	G	T	1: 188,638,703 (GRCm39)	V4038L	probably benign	Het
Zc3h7a	T	G	16: 10,968,530 (GRCm39)	D483A	probably damaging	Het
Zfyve19	T	C	2: 119,040,953 (GRCm39)		probably benign	Het

Other mutations in Lcn11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0220:Lcn11	UTSW	2	25,667,843 (GRCm39)	missense	probably benign	0.02
R0607:Lcn11	UTSW	2	25,669,305 (GRCm39)	missense	probably benign	0.00
R1104:Lcn11	UTSW	2	25,669,115 (GRCm39)	unclassified	probably benign
R2021:Lcn11	UTSW	2	25,668,097 (GRCm39)	missense	probably benign	0.34
R2331:Lcn11	UTSW	2	25,670,188 (GRCm39)	missense	possibly damaging	0.79
R4295:Lcn11	UTSW	2	25,668,111 (GRCm39)	missense	possibly damaging	0.83
R6109:Lcn11	UTSW	2	25,669,308 (GRCm39)	missense	possibly damaging	0.78
R6356:Lcn11	UTSW	2	25,668,132 (GRCm39)	nonsense	probably null
R6502:Lcn11	UTSW	2	25,669,103 (GRCm39)	missense	probably benign	0.08
R7754:Lcn11	UTSW	2	25,667,830 (GRCm39)	missense	probably benign	0.06
R7920:Lcn11	UTSW	2	25,669,343 (GRCm39)	missense	possibly damaging	0.70
R8389:Lcn11	UTSW	2	25,669,043 (GRCm39)	missense	probably damaging	0.97
R8752:Lcn11	UTSW	2	25,668,138 (GRCm39)	missense	probably damaging	1.00
R8765:Lcn11	UTSW	2	25,668,139 (GRCm39)	missense	probably damaging	1.00
R8881:Lcn11	UTSW	2	25,669,296 (GRCm39)	missense	probably benign	0.33
R8954:Lcn11	UTSW	2	25,669,265 (GRCm39)	missense	probably benign	0.01
Z1176:Lcn11	UTSW	2	25,667,736 (GRCm39)	missense	probably benign	0.00

Posted On

2015-12-18