Incidental Mutation 'IGL02904:Lcn11'
ID363749
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lcn11
Ensembl Gene ENSMUSG00000069080
Gene Namelipocalin 11
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #IGL02904
Quality Score
Status
Chromosome2
Chromosomal Location25777017-25780279 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 25779266 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 145 (D145G)
Ref Sequence ENSEMBL: ENSMUSP00000088822 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091278] [ENSMUST00000211245]
Predicted Effect probably null
Transcript: ENSMUST00000091278
AA Change: D145G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000088822
Gene: ENSMUSG00000069080
AA Change: D145G

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:Lipocalin 34 172 7.5e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143166
Predicted Effect probably benign
Transcript: ENSMUST00000211245
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik T C 13: 119,484,454 S564P probably damaging Het
A1cf A C 19: 31,934,806 K432N probably damaging Het
Acp7 A T 7: 28,608,003 D476E probably benign Het
Aqp9 T A 9: 71,138,148 I60F probably damaging Het
B2m A C 2: 122,151,161 probably benign Het
B3galt1 T A 2: 68,118,745 V268E probably damaging Het
BC037034 C T 5: 138,260,602 V232I probably benign Het
Cacna1a T C 8: 84,579,520 L1299P probably damaging Het
Ces2e C T 8: 104,931,338 P356L probably benign Het
Crmp1 A T 5: 37,288,918 K639N possibly damaging Het
Ddx17 G A 15: 79,530,437 R510* probably null Het
Dner C T 1: 84,534,944 V301M probably damaging Het
Efr3b T G 12: 3,984,583 I196L probably damaging Het
Fat1 T C 8: 45,040,682 V3955A probably damaging Het
Gid4 T C 11: 60,417,735 I27T probably benign Het
Glis3 A G 19: 28,357,952 F571L possibly damaging Het
Gm4950 T C 18: 51,865,731 I51V probably benign Het
Gm5592 T C 7: 41,288,386 L364P probably damaging Het
Gm884 A C 11: 103,616,361 probably benign Het
Gucy2d G A 7: 98,462,189 probably null Het
Kpna6 A G 4: 129,650,687 I411T probably benign Het
Med12 A G X: 101,294,178 probably null Het
Mtor A G 4: 148,491,612 probably benign Het
Mtor A G 4: 148,452,394 K42E possibly damaging Het
Mybpc2 T C 7: 44,522,341 D55G probably benign Het
Myo1f T A 17: 33,585,658 C445* probably null Het
Naca C T 10: 128,043,290 probably benign Het
Nlgn2 T C 11: 69,825,840 Y625C possibly damaging Het
Nlrp9c A T 7: 26,375,290 C827S probably damaging Het
Nudt12 T A 17: 59,010,352 N100I probably benign Het
Olfr1009 T C 2: 85,721,755 S117P probably damaging Het
Olfr224 T A 11: 58,566,797 T183S possibly damaging Het
Olfr284 A T 15: 98,340,848 L31Q probably null Het
Olfr77 A T 9: 19,921,097 D296V probably damaging Het
Picalm G A 7: 90,176,411 probably benign Het
Pkd1l1 A G 11: 8,868,450 probably benign Het
Scube3 T C 17: 28,167,600 V831A probably benign Het
Slco5a1 A G 1: 12,921,097 I456T probably damaging Het
Snx3 A G 10: 42,534,694 H110R probably damaging Het
Spef2 T C 15: 9,679,346 D635G probably damaging Het
St3gal5 A T 6: 72,147,124 I212L possibly damaging Het
Syvn1 T A 19: 6,049,815 Y192* probably null Het
Tmem2 G A 19: 21,823,843 D775N possibly damaging Het
Tmtc1 A G 6: 148,249,482 probably benign Het
Trip11 T G 12: 101,886,838 E499D probably damaging Het
Ttn A T 2: 76,732,031 N28823K probably damaging Het
Unc13c C A 9: 73,481,067 G2146* probably null Het
Ush2a G T 1: 188,906,506 V4038L probably benign Het
Zc3h7a T G 16: 11,150,666 D483A probably damaging Het
Zfyve19 T C 2: 119,210,472 probably benign Het
Other mutations in Lcn11
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0220:Lcn11 UTSW 2 25777831 missense probably benign 0.02
R0607:Lcn11 UTSW 2 25779293 missense probably benign 0.00
R1104:Lcn11 UTSW 2 25779103 unclassified probably benign
R2021:Lcn11 UTSW 2 25778085 missense probably benign 0.34
R2331:Lcn11 UTSW 2 25780176 missense possibly damaging 0.79
R4295:Lcn11 UTSW 2 25778099 missense possibly damaging 0.83
R6109:Lcn11 UTSW 2 25779296 missense possibly damaging 0.78
R6356:Lcn11 UTSW 2 25778120 nonsense probably null
R6502:Lcn11 UTSW 2 25779091 missense probably benign 0.08
R7754:Lcn11 UTSW 2 25777818 missense probably benign 0.06
Z1176:Lcn11 UTSW 2 25777724 missense probably benign 0.00
Posted On2015-12-18