Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02887:Olfr978'

363775

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr978

Ensembl Gene

ENSMUSG00000044292

Gene Name

olfactory receptor 978

Synonyms

MOR223-3, GA_x6K02T2PVTD-33692287-33693222

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.142) question?

Stock #

IGL02887

Quality Score

Status

Chromosome

Chromosomal Location

39992113-39995095 bp(+) (GRCm38)

Type of Mutation

start codon destroyed

DNA Base Change (assembly)

T to A at 39993813 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 1 (M1K)

Ref Sequence

ENSEMBL: ENSMUSP00000060106 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057161] [ENSMUST00000215523] [ENSMUST00000217600]

AlphaFold

E9Q985

Predicted Effect

probably null
Transcript: ENSMUST00000057161
AA Change: M1K

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000060106
Gene: ENSMUSG00000044292
AA Change: M1K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	303	3.2e-56	PFAM
Pfam:7tm_1	39	287	1.4e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215523

Predicted Effect

probably null
Transcript: ENSMUST00000217600
AA Change: M1K

PolyPhen 2 Score 0.347 (Sensitivity: 0.90; Specificity: 0.89)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 86 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017B05Rik	A	G	9: 57,258,885	Y69H	probably damaging	Het
Afap1l2	A	T	19: 56,920,563	S310R	probably damaging	Het
Aldh7a1	A	G	18: 56,542,216		probably benign	Het
Anxa8	T	A	14: 34,096,524		probably null	Het
Ap1ar	T	C	3: 127,808,543	E282G	probably damaging	Het
Arl6ip6	T	G	2: 53,202,927	S155A	probably benign	Het
Armc9	T	C	1: 86,164,835	F107S	probably damaging	Het
Ash1l	C	A	3: 88,984,181	D1122E	probably benign	Het
Atp2b4	T	A	1: 133,728,774	I713F	probably damaging	Het
BC005624	A	C	2: 30,973,305		probably benign	Het
Calcrl	T	C	2: 84,339,242	D365G	probably benign	Het
Ccdc110	A	G	8: 45,943,184	N704S	probably benign	Het
Ccr10	G	T	11: 101,174,666	L13I	probably benign	Het
Cfap52	A	G	11: 67,953,515	Y125H	probably damaging	Het
Cnr2	C	A	4: 135,917,625	T338K	possibly damaging	Het
Cntn2	T	A	1: 132,516,570	D935V	probably damaging	Het
Cog7	T	C	7: 121,943,844	K448R	possibly damaging	Het
Csnk1g2	G	A	10: 80,638,535	D197N	probably damaging	Het
Cyp2e1	T	A	7: 140,763,911	S21T	probably damaging	Het
Dcaf11	T	C	14: 55,564,135	F187L	probably damaging	Het
Dmd	T	A	X: 83,878,504	F1460Y	probably benign	Het
Dnah11	G	A	12: 117,911,040	A4030V	probably damaging	Het
Dnah7a	A	G	1: 53,522,360	V2046A	possibly damaging	Het
Dnajc6	T	C	4: 101,639,300	I820T	probably damaging	Het
Dsel	T	C	1: 111,860,732	D691G	possibly damaging	Het
Fbp1	T	A	13: 62,869,080	M203L	probably benign	Het
Fndc1	T	C	17: 7,773,638	T409A	unknown	Het
Golgb1	T	G	16: 36,925,849	L2930R	probably damaging	Het
Htr2a	A	G	14: 74,645,143	T190A	probably benign	Het
Klra4	C	T	6: 130,044,070	C254Y	probably damaging	Het
Large1	A	T	8: 73,132,039	V67E	probably benign	Het
Lins1	T	C	7: 66,714,183	S609P	probably damaging	Het
Magi3	T	C	3: 104,095,157	E156G	probably damaging	Het
Mdh1b	A	G	1: 63,715,364		probably benign	Het
Mfsd6	T	C	1: 52,708,878	D276G	probably benign	Het
Myh9	T	A	15: 77,796,020	K185*	probably null	Het
Myof	T	C	19: 37,920,779		probably null	Het
Naip2	T	G	13: 100,161,512	Y672S	possibly damaging	Het
Nbeal1	A	G	1: 60,287,444		probably benign	Het
Nbeal2	T	A	9: 110,628,276	H2273L	probably damaging	Het
Neb	T	C	2: 52,200,721	K1346E	possibly damaging	Het
Nfatc2	T	C	2: 168,504,450	D908G	probably damaging	Het
Nlgn2	T	C	11: 69,827,254	N375S	probably benign	Het
Nova1	G	T	12: 46,720,722	Q139K	unknown	Het
Olfr328	A	G	11: 58,552,161	L26P	probably damaging	Het
Olfr775	T	A	10: 129,250,925	Y130*	probably null	Het
Opa3	A	T	7: 19,228,582	Q47L	probably damaging	Het
Pacs1	A	T	19: 5,135,110		probably benign	Het
Pappa2	T	A	1: 158,782,259	H1544L	probably damaging	Het
Pax8	A	G	2: 24,444,615	S48P	probably damaging	Het
Pdilt	T	C	7: 119,498,049	N70S	possibly damaging	Het
Poldip3	T	C	15: 83,129,268		probably benign	Het
Ppp6r1	T	A	7: 4,642,212	I80F	probably damaging	Het
Pycr2	T	A	1: 180,904,739		probably null	Het
Rapgef2	C	T	3: 79,068,880		probably benign	Het
Rbm44	T	A	1: 91,153,180	D363E	probably damaging	Het
Rnf213	A	T	11: 119,427,510	I1046F	probably damaging	Het
Ryr2	A	G	13: 11,591,269	S4476P	probably damaging	Het
Scara5	G	A	14: 65,762,829	D483N	unknown	Het
Scmh1	T	A	4: 120,468,389	F101Y	probably damaging	Het
Sgo2a	T	A	1: 58,016,352	V565E	probably damaging	Het
Simc1	T	C	13: 54,525,258	M473T	probably benign	Het
Skint6	T	A	4: 113,238,184	R93*	probably null	Het
Skint7	T	C	4: 111,982,178	V223A	possibly damaging	Het
Slc25a2	T	C	18: 37,637,886	I197V	probably benign	Het
Slit2	A	G	5: 48,217,474	T361A	probably benign	Het
Sugp1	G	A	8: 70,070,126	G492D	probably damaging	Het
Svep1	C	T	4: 58,145,301	G388D	probably damaging	Het
Tbpl2	G	T	2: 24,093,876	A183E	probably damaging	Het
Tcerg1l	G	T	7: 138,229,890	P453T	probably damaging	Het
Tdpoz2	T	C	3: 93,651,739	T309A	probably benign	Het
Thbs4	T	A	13: 92,790,798	Y61F	probably benign	Het
Tmem117	C	A	15: 95,094,775	P439T	probably damaging	Het
Tmem151a	A	G	19: 5,082,965	V71A	probably benign	Het
Tmem268	G	T	4: 63,568,454		probably benign	Het
Tmem43	T	A	6: 91,477,374	Y48N	possibly damaging	Het
Tmigd1	T	C	11: 76,913,986	V217A	probably benign	Het
Tmprss11g	A	T	5: 86,497,329		probably benign	Het
Tsn	T	C	1: 118,309,821	I38V	probably benign	Het
Ttc41	A	T	10: 86,733,654	Y632F	probably damaging	Het
Vmn2r117	C	T	17: 23,475,578		probably benign	Het
Vmn2r12	A	T	5: 109,090,485	I463N	probably benign	Het
Wdsub1	T	A	2: 59,852,832	N466I	probably damaging	Het
Zdhhc21	A	T	4: 82,844,190	I56N	probably benign	Het
Zfand4	A	G	6: 116,273,656	T16A	possibly damaging	Het
Zmym4	T	C	4: 126,948,475	E15G	probably damaging	Het

Other mutations in Olfr978

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01570:Olfr978	APN	9	39994329	missense	probably damaging	0.99
IGL02429:Olfr978	APN	9	39993842	missense	probably benign
R0190:Olfr978	UTSW	9	39994544	missense	probably benign	0.01
R0355:Olfr978	UTSW	9	39994163	missense	possibly damaging	0.72
R1348:Olfr978	UTSW	9	39993828	missense	probably benign
R1856:Olfr978	UTSW	9	39994359	missense	probably benign	0.29
R3853:Olfr978	UTSW	9	39994154	missense	probably damaging	0.99
R3886:Olfr978	UTSW	9	39994539	missense	probably damaging	1.00
R5678:Olfr978	UTSW	9	39993903	missense	probably benign	0.00
R5994:Olfr978	UTSW	9	39994223	nonsense	probably null
R6185:Olfr978	UTSW	9	39994124	missense	probably benign	0.19
R6721:Olfr978	UTSW	9	39994307	missense	possibly damaging	0.55
R7414:Olfr978	UTSW	9	39994053	missense	possibly damaging	0.53
R7556:Olfr978	UTSW	9	39994682	missense	probably damaging	1.00
R8192:Olfr978	UTSW	9	39994171	missense	probably damaging	1.00
R8422:Olfr978	UTSW	9	39994554	missense	probably damaging	0.99
R9323:Olfr978	UTSW	9	39994064	missense	possibly damaging	0.88
X0025:Olfr978	UTSW	9	39993944	missense	possibly damaging	0.62

Posted On

2015-12-18