Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02887:Slit2'

363786

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Slit2

Ensembl Gene

ENSMUSG00000031558

Gene Name

slit guidance ligand 2

Synonyms

Drad-1, Slil3, E130320P19Rik, E030015M03Rik

Accession Numbers

Ncbi RefSeq: NM_178804.3; MGI: 1315205

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02887

Quality Score

Status

Chromosome

Chromosomal Location

47983138-48307733 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 48217474 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 361 (T361A)

Ref Sequence

ENSEMBL: ENSMUSP00000033967 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033967] [ENSMUST00000170109] [ENSMUST00000173107] [ENSMUST00000174313] [ENSMUST00000174421]

Predicted Effect

probably benign
Transcript: ENSMUST00000033967
AA Change: T361A

PolyPhen 2 Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000033967
Gene: ENSMUSG00000031558
AA Change: T361A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
LRRNT	27	59	6.53e-9	SMART
LRR	53	77	1.41e2	SMART
LRR_TYP	78	101	1.79e-2	SMART
LRR	102	125	2.45e0	SMART
LRR	126	149	9.96e-1	SMART
LRR	154	173	1.29e2	SMART
LRR_TYP	174	197	2.05e-2	SMART
LRRCT	209	258	3.42e-9	SMART
LRRNT	272	304	4.55e-8	SMART
LRR	298	322	3e1	SMART
LRR_TYP	323	346	1.95e-3	SMART
LRR_TYP	347	370	2.24e-3	SMART
LRR	371	394	1.31e0	SMART
LRR	395	418	2.49e-1	SMART
LRRCT	430	479	1.88e-6	SMART
LRRNT	497	529	1.45e-6	SMART
LRR_TYP	549	572	1.38e-3	SMART
LRR	597	620	9.96e-1	SMART
LRR_TYP	621	644	2.71e-2	SMART
LRRCT	656	705	3.56e-7	SMART
LRRNT	718	750	3.69e-8	SMART
LRR	768	791	7.36e0	SMART
LRR_TYP	792	815	5.59e-4	SMART
LRR_TYP	816	839	7.9e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000170109
AA Change: T365A

PolyPhen 2 Score 0.099 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000127615
Gene: ENSMUSG00000031558
AA Change: T365A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
LRRNT	27	59	6.53e-9	SMART
LRR	53	77	1.41e2	SMART
LRR_TYP	78	101	1.79e-2	SMART
LRR	102	125	2.45e0	SMART
LRR	126	149	9.96e-1	SMART
LRR	154	173	1.29e2	SMART
LRR_TYP	174	197	2.05e-2	SMART
LRRCT	209	258	3.42e-9	SMART
LRRNT	272	304	4.55e-8	SMART
LRR	298	322	3e1	SMART
LRR_TYP	323	346	1.95e-3	SMART
LRR_TYP	347	370	2.24e-3	SMART
LRR	371	394	1.31e0	SMART
LRR	395	418	2.49e-1	SMART
LRRCT	430	479	1.88e-6	SMART
LRRNT	497	529	1.45e-6	SMART
LRR_TYP	549	572	1.38e-3	SMART
LRR	597	620	9.96e-1	SMART
LRR_TYP	621	644	2.71e-2	SMART
LRRCT	656	705	3.56e-7	SMART
LRRNT	718	750	3.69e-8	SMART
LRR	768	791	7.36e0	SMART
LRR_TYP	792	815	5.59e-4	SMART
LRR_TYP	816	839	7.9e-4	SMART
LRRCT	851	900	3.9e-13	SMART
EGF	913	947	3.73e-5	SMART
EGF	952	988	4.35e-6	SMART
EGF_CA	990	1026	2.21e-7	SMART
FOLN	993	1015	5.84e1	SMART
EGF	1031	1066	1.07e-5	SMART
EGF_CA	1068	1104	3.97e-9	SMART
FOLN	1116	1138	2.22e0	SMART
EGF	1116	1149	1.62e-5	SMART
LamG	1172	1308	4.82e-39	SMART
EGF	1327	1360	3.68e-4	SMART
EGF	1366	1399	3.88e-3	SMART
FOLN	1407	1429	3.34e0	SMART
EGF	1407	1440	4.46e-3	SMART
CT	1451	1520	4.23e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000173107
AA Change: T361A

PolyPhen 2 Score 0.105 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000133840
Gene: ENSMUSG00000031558
AA Change: T361A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
LRRNT	27	59	6.53e-9	SMART
LRR	53	77	1.41e2	SMART
LRR_TYP	78	101	1.79e-2	SMART
LRR	102	125	2.45e0	SMART
LRR	126	149	9.96e-1	SMART
LRR	154	173	1.29e2	SMART
LRR_TYP	174	197	2.05e-2	SMART
LRRCT	209	258	3.42e-9	SMART
LRRNT	272	304	4.55e-8	SMART
LRR	298	322	3e1	SMART
LRR_TYP	323	346	1.95e-3	SMART
LRR_TYP	347	370	2.24e-3	SMART
LRR	371	394	1.31e0	SMART
LRR	395	418	2.49e-1	SMART
LRRCT	430	479	1.88e-6	SMART
LRRNT	505	537	1.45e-6	SMART
LRR_TYP	557	580	1.38e-3	SMART
LRR	605	628	9.96e-1	SMART
LRR_TYP	629	652	2.71e-2	SMART
LRRCT	664	713	3.56e-7	SMART
LRRNT	726	758	3.69e-8	SMART
LRR	776	799	7.36e0	SMART
LRR_TYP	800	823	5.59e-4	SMART
LRR_TYP	824	847	7.9e-4	SMART
LRRCT	859	908	3.9e-13	SMART
EGF	921	955	3.73e-5	SMART
EGF	960	996	4.35e-6	SMART
EGF_CA	998	1034	2.21e-7	SMART
FOLN	1001	1023	5.84e1	SMART
EGF	1039	1074	1.07e-5	SMART
EGF_CA	1076	1112	3.97e-9	SMART
FOLN	1124	1146	2.22e0	SMART
EGF	1124	1157	1.62e-5	SMART
LamG	1180	1316	4.82e-39	SMART
EGF	1335	1368	3.68e-4	SMART
EGF	1374	1407	3.88e-3	SMART
FOLN	1415	1437	3.34e0	SMART
EGF	1415	1448	4.46e-3	SMART
CT	1459	1528	4.23e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173303

Predicted Effect

probably benign
Transcript: ENSMUST00000174313
AA Change: T365A

PolyPhen 2 Score 0.099 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000133912
Gene: ENSMUSG00000031558
AA Change: T365A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
LRRNT	27	59	6.53e-9	SMART
LRR	53	77	1.41e2	SMART
LRR_TYP	78	101	1.79e-2	SMART
LRR	102	125	2.45e0	SMART
LRR	126	149	9.96e-1	SMART
LRR	154	173	1.29e2	SMART
LRR_TYP	174	197	2.05e-2	SMART
LRRCT	209	258	3.42e-9	SMART
LRRNT	276	308	4.55e-8	SMART
LRR	302	326	3e1	SMART
LRR_TYP	327	350	1.95e-3	SMART
LRR_TYP	351	374	2.24e-3	SMART
LRR	375	398	1.31e0	SMART
LRR	399	422	2.49e-1	SMART
LRRCT	434	483	1.88e-6	SMART
LRRNT	501	533	1.45e-6	SMART
LRR_TYP	553	576	1.38e-3	SMART
LRR	601	624	9.96e-1	SMART
LRR_TYP	625	648	2.71e-2	SMART
LRRCT	660	709	3.56e-7	SMART
LRRNT	722	754	3.69e-8	SMART
LRR	772	795	7.36e0	SMART
LRR_TYP	796	819	5.59e-4	SMART
LRR_TYP	820	843	7.9e-4	SMART
LRRCT	855	904	3.9e-13	SMART
EGF	917	951	3.73e-5	SMART
EGF	956	992	4.35e-6	SMART
EGF_CA	994	1030	2.21e-7	SMART
FOLN	997	1019	5.84e1	SMART
EGF	1035	1070	1.07e-5	SMART
EGF_CA	1072	1108	3.97e-9	SMART
FOLN	1120	1142	2.22e0	SMART
EGF	1120	1153	1.62e-5	SMART
LamG	1176	1312	4.82e-39	SMART
EGF	1331	1364	3.68e-4	SMART
EGF	1370	1403	3.88e-3	SMART
FOLN	1411	1433	3.34e0	SMART
EGF	1411	1444	4.46e-3	SMART
CT	1455	1524	4.23e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000174421
AA Change: T365A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000134263
Gene: ENSMUSG00000031558
AA Change: T365A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
LRRNT	27	59	6.53e-9	SMART
LRR	53	77	1.41e2	SMART
LRR_TYP	78	101	1.79e-2	SMART
LRR	102	125	2.45e0	SMART
LRR	126	149	9.96e-1	SMART
LRR	154	173	1.29e2	SMART
LRR_TYP	174	197	2.05e-2	SMART
LRRCT	209	258	3.42e-9	SMART
LRRNT	276	308	4.55e-8	SMART
LRR	302	326	3e1	SMART
LRR_TYP	327	350	1.95e-3	SMART
LRR_TYP	351	374	2.24e-3	SMART
LRR	375	398	1.31e0	SMART
LRR	399	422	2.49e-1	SMART
LRRCT	434	483	1.88e-6	SMART
LRRNT	509	541	1.45e-6	SMART
LRR_TYP	561	584	1.38e-3	SMART
LRR	609	632	9.96e-1	SMART
LRR_TYP	633	656	2.71e-2	SMART
LRRCT	668	717	3.56e-7	SMART
LRRNT	730	762	3.69e-8	SMART
LRR	780	803	7.36e0	SMART
LRR_TYP	804	827	5.59e-4	SMART
LRR_TYP	828	851	7.9e-4	SMART
LRRCT	863	912	3.9e-13	SMART
EGF	925	959	3.73e-5	SMART
EGF	964	1000	4.35e-6	SMART
EGF_CA	1002	1047	4.74e-7	SMART
FOLN	1005	1027	5.84e1	SMART
EGF	1052	1087	1.07e-5	SMART
EGF_CA	1089	1125	3.97e-9	SMART
FOLN	1137	1159	2.22e0	SMART
EGF	1137	1170	1.62e-5	SMART
LamG	1193	1329	4.82e-39	SMART
EGF	1348	1381	3.68e-4	SMART
EGF	1387	1420	3.88e-3	SMART
FOLN	1428	1450	3.34e0	SMART
EGF	1428	1461	4.46e-3	SMART
CT	1472	1541	4.23e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000174487

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198260

Coding Region Coverage

Validation Efficiency

MGI Phenotype

Strain: 2179460
FUNCTION: The protein encoded by this gene is a member of the Slit family of secreted glycoproteins, which function as ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. In mammals, members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Mice deficient for this gene exhibit abnormal axonal projections in the embryonic forebrain and develop supernumerary uretic buds that maintain improper connections to the nephric duct. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygous mutants display perinatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and hydroureter. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted(4)

Other mutations in this stock

Total: 86 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017B05Rik	A	G	9: 57,258,885	Y69H	probably damaging	Het
Afap1l2	A	T	19: 56,920,563	S310R	probably damaging	Het
Aldh7a1	A	G	18: 56,542,216		probably benign	Het
Anxa8	T	A	14: 34,096,524		probably null	Het
Ap1ar	T	C	3: 127,808,543	E282G	probably damaging	Het
Arl6ip6	T	G	2: 53,202,927	S155A	probably benign	Het
Armc9	T	C	1: 86,164,835	F107S	probably damaging	Het
Ash1l	C	A	3: 88,984,181	D1122E	probably benign	Het
Atp2b4	T	A	1: 133,728,774	I713F	probably damaging	Het
BC005624	A	C	2: 30,973,305		probably benign	Het
Calcrl	T	C	2: 84,339,242	D365G	probably benign	Het
Ccdc110	A	G	8: 45,943,184	N704S	probably benign	Het
Ccr10	G	T	11: 101,174,666	L13I	probably benign	Het
Cfap52	A	G	11: 67,953,515	Y125H	probably damaging	Het
Cnr2	C	A	4: 135,917,625	T338K	possibly damaging	Het
Cntn2	T	A	1: 132,516,570	D935V	probably damaging	Het
Cog7	T	C	7: 121,943,844	K448R	possibly damaging	Het
Csnk1g2	G	A	10: 80,638,535	D197N	probably damaging	Het
Cyp2e1	T	A	7: 140,763,911	S21T	probably damaging	Het
Dcaf11	T	C	14: 55,564,135	F187L	probably damaging	Het
Dmd	T	A	X: 83,878,504	F1460Y	probably benign	Het
Dnah11	G	A	12: 117,911,040	A4030V	probably damaging	Het
Dnah7a	A	G	1: 53,522,360	V2046A	possibly damaging	Het
Dnajc6	T	C	4: 101,639,300	I820T	probably damaging	Het
Dsel	T	C	1: 111,860,732	D691G	possibly damaging	Het
Fbp1	T	A	13: 62,869,080	M203L	probably benign	Het
Fndc1	T	C	17: 7,773,638	T409A	unknown	Het
Golgb1	T	G	16: 36,925,849	L2930R	probably damaging	Het
Htr2a	A	G	14: 74,645,143	T190A	probably benign	Het
Klra4	C	T	6: 130,044,070	C254Y	probably damaging	Het
Large1	A	T	8: 73,132,039	V67E	probably benign	Het
Lins1	T	C	7: 66,714,183	S609P	probably damaging	Het
Magi3	T	C	3: 104,095,157	E156G	probably damaging	Het
Mdh1b	A	G	1: 63,715,364		probably benign	Het
Mfsd6	T	C	1: 52,708,878	D276G	probably benign	Het
Myh9	T	A	15: 77,796,020	K185*	probably null	Het
Myof	T	C	19: 37,920,779		probably null	Het
Naip2	T	G	13: 100,161,512	Y672S	possibly damaging	Het
Nbeal1	A	G	1: 60,287,444		probably benign	Het
Nbeal2	T	A	9: 110,628,276	H2273L	probably damaging	Het
Neb	T	C	2: 52,200,721	K1346E	possibly damaging	Het
Nfatc2	T	C	2: 168,504,450	D908G	probably damaging	Het
Nlgn2	T	C	11: 69,827,254	N375S	probably benign	Het
Nova1	G	T	12: 46,720,722	Q139K	unknown	Het
Olfr328	A	G	11: 58,552,161	L26P	probably damaging	Het
Olfr775	T	A	10: 129,250,925	Y130*	probably null	Het
Olfr978	T	A	9: 39,993,813	M1K	probably null	Het
Opa3	A	T	7: 19,228,582	Q47L	probably damaging	Het
Pacs1	A	T	19: 5,135,110		probably benign	Het
Pappa2	T	A	1: 158,782,259	H1544L	probably damaging	Het
Pax8	A	G	2: 24,444,615	S48P	probably damaging	Het
Pdilt	T	C	7: 119,498,049	N70S	possibly damaging	Het
Poldip3	T	C	15: 83,129,268		probably benign	Het
Ppp6r1	T	A	7: 4,642,212	I80F	probably damaging	Het
Pycr2	T	A	1: 180,904,739		probably null	Het
Rapgef2	C	T	3: 79,068,880		probably benign	Het
Rbm44	T	A	1: 91,153,180	D363E	probably damaging	Het
Rnf213	A	T	11: 119,427,510	I1046F	probably damaging	Het
Ryr2	A	G	13: 11,591,269	S4476P	probably damaging	Het
Scara5	G	A	14: 65,762,829	D483N	unknown	Het
Scmh1	T	A	4: 120,468,389	F101Y	probably damaging	Het
Sgo2a	T	A	1: 58,016,352	V565E	probably damaging	Het
Simc1	T	C	13: 54,525,258	M473T	probably benign	Het
Skint6	T	A	4: 113,238,184	R93*	probably null	Het
Skint7	T	C	4: 111,982,178	V223A	possibly damaging	Het
Slc25a2	T	C	18: 37,637,886	I197V	probably benign	Het
Sugp1	G	A	8: 70,070,126	G492D	probably damaging	Het
Svep1	C	T	4: 58,145,301	G388D	probably damaging	Het
Tbpl2	G	T	2: 24,093,876	A183E	probably damaging	Het
Tcerg1l	G	T	7: 138,229,890	P453T	probably damaging	Het
Tdpoz2	T	C	3: 93,651,739	T309A	probably benign	Het
Thbs4	T	A	13: 92,790,798	Y61F	probably benign	Het
Tmem117	C	A	15: 95,094,775	P439T	probably damaging	Het
Tmem151a	A	G	19: 5,082,965	V71A	probably benign	Het
Tmem268	G	T	4: 63,568,454		probably benign	Het
Tmem43	T	A	6: 91,477,374	Y48N	possibly damaging	Het
Tmigd1	T	C	11: 76,913,986	V217A	probably benign	Het
Tmprss11g	A	T	5: 86,497,329		probably benign	Het
Tsn	T	C	1: 118,309,821	I38V	probably benign	Het
Ttc41	A	T	10: 86,733,654	Y632F	probably damaging	Het
Vmn2r117	C	T	17: 23,475,578		probably benign	Het
Vmn2r12	A	T	5: 109,090,485	I463N	probably benign	Het
Wdsub1	T	A	2: 59,852,832	N466I	probably damaging	Het
Zdhhc21	A	T	4: 82,844,190	I56N	probably benign	Het
Zfand4	A	G	6: 116,273,656	T16A	possibly damaging	Het
Zmym4	T	C	4: 126,948,475	E15G	probably damaging	Het

Other mutations in Slit2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00791:Slit2	APN	5	48304032	missense	possibly damaging	0.86
IGL00809:Slit2	APN	5	47989151	missense	possibly damaging	0.88
IGL00811:Slit2	APN	5	47989151	missense	possibly damaging	0.88
IGL00813:Slit2	APN	5	47989151	missense	possibly damaging	0.88
IGL00815:Slit2	APN	5	47989151	missense	possibly damaging	0.88
IGL00816:Slit2	APN	5	47989151	missense	possibly damaging	0.88
IGL00817:Slit2	APN	5	47989151	missense	possibly damaging	0.88
IGL00819:Slit2	APN	5	47989151	missense	possibly damaging	0.88
IGL00820:Slit2	APN	5	47989151	missense	possibly damaging	0.88
IGL00822:Slit2	APN	5	47989151	missense	possibly damaging	0.88
IGL01077:Slit2	APN	5	48217443	splice site	probably null
IGL01375:Slit2	APN	5	48281714	splice site	probably benign
IGL01481:Slit2	APN	5	48302931	missense	probably benign	0.05
IGL01934:Slit2	APN	5	48238405	missense	possibly damaging	0.93
IGL01992:Slit2	APN	5	48238417	missense	probably benign	0.01
IGL02315:Slit2	APN	5	47987871	missense	probably damaging	0.98
IGL02328:Slit2	APN	5	48230304	missense	probably damaging	1.00
IGL02366:Slit2	APN	5	48304068	missense	possibly damaging	0.53
IGL02526:Slit2	APN	5	48304223	nonsense	probably null
IGL02852:Slit2	APN	5	48244672	missense	probably damaging	1.00
IGL03123:Slit2	APN	5	48211339	missense	probably damaging	1.00
IGL03182:Slit2	APN	5	48220053	missense	possibly damaging	0.77
P0025:Slit2	UTSW	5	48304035	missense	probably damaging	0.96
R0032:Slit2	UTSW	5	48256856	missense	probably damaging	0.99
R0032:Slit2	UTSW	5	48256856	missense	probably damaging	0.99
R0055:Slit2	UTSW	5	48281726	nonsense	probably null
R0055:Slit2	UTSW	5	48281726	nonsense	probably null
R0267:Slit2	UTSW	5	48182331	splice site	probably benign
R0552:Slit2	UTSW	5	48238379	missense	probably damaging	1.00
R0610:Slit2	UTSW	5	48275674	missense	possibly damaging	0.77
R0883:Slit2	UTSW	5	48245573	splice site	probably benign
R1390:Slit2	UTSW	5	48217490	missense	probably benign	0.06
R1442:Slit2	UTSW	5	48238383	missense	probably damaging	0.96
R1453:Slit2	UTSW	5	48257051	missense	possibly damaging	0.88
R1508:Slit2	UTSW	5	48192249	missense	probably damaging	0.98
R1639:Slit2	UTSW	5	48259654	missense	probably damaging	1.00
R1705:Slit2	UTSW	5	48189472	missense	probably damaging	0.99
R1828:Slit2	UTSW	5	48304030	missense	probably damaging	1.00
R1897:Slit2	UTSW	5	48238423	missense	probably damaging	1.00
R1908:Slit2	UTSW	5	48281988	missense	probably damaging	1.00
R1919:Slit2	UTSW	5	48191016	unclassified	probably benign
R1982:Slit2	UTSW	5	48249836	missense	probably damaging	1.00
R2013:Slit2	UTSW	5	48302490	missense	probably damaging	1.00
R2136:Slit2	UTSW	5	48304225	missense	probably benign	0.03
R2655:Slit2	UTSW	5	48189575	missense	possibly damaging	0.88
R3402:Slit2	UTSW	5	48283421	missense	probably damaging	0.98
R3724:Slit2	UTSW	5	48256883	critical splice donor site	probably null
R4176:Slit2	UTSW	5	48237244	splice site	probably null
R4306:Slit2	UTSW	5	48302783	missense	possibly damaging	0.83
R4397:Slit2	UTSW	5	48220081	critical splice donor site	probably null
R4525:Slit2	UTSW	5	48249873	missense	probably damaging	1.00
R4688:Slit2	UTSW	5	48257003	splice site	probably null
R5026:Slit2	UTSW	5	48256805	missense	probably damaging	0.99
R5138:Slit2	UTSW	5	48281967	missense	probably damaging	1.00
R5465:Slit2	UTSW	5	48249912	missense	probably damaging	1.00
R5471:Slit2	UTSW	5	48189555	missense	probably damaging	1.00
R5699:Slit2	UTSW	5	48220991	critical splice donor site	probably null
R5735:Slit2	UTSW	5	48259616	missense	probably damaging	1.00
R5834:Slit2	UTSW	5	48259647	missense	probably damaging	1.00
R5967:Slit2	UTSW	5	47985164	missense	probably damaging	0.99
R6150:Slit2	UTSW	5	48304174	missense	probably damaging	1.00
R6219:Slit2	UTSW	5	48302428	missense	possibly damaging	0.53
R6344:Slit2	UTSW	5	48219681	missense	probably benign	0.07
R6408:Slit2	UTSW	5	47984986	unclassified	probably benign
R6479:Slit2	UTSW	5	48231989	missense	probably damaging	1.00
R6526:Slit2	UTSW	5	48304167	missense	probably damaging	0.99
R6959:Slit2	UTSW	5	48238385	missense	possibly damaging	0.83
R7139:Slit2	UTSW	5	48244683	missense	probably benign	0.19
R7201:Slit2	UTSW	5	48237285	missense	probably null	0.85
R7472:Slit2	UTSW	5	48256838	missense	probably damaging	0.97
R7491:Slit2	UTSW	5	48219994	missense	probably benign	0.18
R7566:Slit2	UTSW	5	48249897	missense	probably damaging	0.99
R7622:Slit2	UTSW	5	47985205	missense	probably damaging	0.98
R7831:Slit2	UTSW	5	48244683	missense	probably benign	0.19
R7870:Slit2	UTSW	5	48302307	missense	probably damaging	0.99
R7899:Slit2	UTSW	5	48247185	missense	possibly damaging	0.89
R7969:Slit2	UTSW	5	48304036	missense	possibly damaging	0.47
R7984:Slit2	UTSW	5	48176123	intron	probably benign
R8021:Slit2	UTSW	5	48302492	nonsense	probably null
R8253:Slit2	UTSW	5	48275671	missense	probably benign	0.00
R8321:Slit2	UTSW	5	48230267	missense	probably damaging	1.00
R8426:Slit2	UTSW	5	48224763	missense	probably benign	0.00
R8513:Slit2	UTSW	5	48224708	nonsense	probably null
Z1088:Slit2	UTSW	5	48302353	missense	probably damaging	1.00

Posted On

2015-12-18