Incidental Mutation 'IGL02887:Rapgef2'
| ID |
363850 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Rapgef2
|
| Ensembl Gene |
ENSMUSG00000062232 |
| Gene Name |
Rap guanine nucleotide exchange factor (GEF) 2 |
| Synonyms |
CNRasGEF, nRapGEP, 5830453M24Rik, RA-GEF-1, Pdzgef1 |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
IGL02887
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
3 |
| Chromosomal Location |
78969823-79193824 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
C to T
at 78976187 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141542
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000118100]
[ENSMUST00000118340]
[ENSMUST00000195708]
|
| AlphaFold |
Q8CHG7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118100
|
| SMART Domains |
Protein: ENSMUSP00000114119
Gene: ENSMUSG00000062232
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
38 |
62 |
N/A |
INTRINSIC |
|
low complexity region
|
84 |
95 |
N/A |
INTRINSIC |
|
cNMP
|
135 |
253 |
2.48e-15 |
SMART |
|
RasGEFN
|
267 |
380 |
1.3e-31 |
SMART |
|
PDZ
|
395 |
467 |
1.28e-12 |
SMART |
|
RA
|
606 |
692 |
7.59e-23 |
SMART |
|
RasGEF
|
713 |
950 |
6.09e-100 |
SMART |
|
low complexity region
|
1030 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1110 |
1124 |
N/A |
INTRINSIC |
|
low complexity region
|
1140 |
1161 |
N/A |
INTRINSIC |
|
low complexity region
|
1392 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1440 |
1455 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118340
|
| SMART Domains |
Protein: ENSMUSP00000113778
Gene: ENSMUSG00000062232
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
60 |
N/A |
INTRINSIC |
|
low complexity region
|
82 |
93 |
N/A |
INTRINSIC |
|
cNMP
|
133 |
251 |
2.48e-15 |
SMART |
|
RasGEFN
|
265 |
378 |
1.3e-31 |
SMART |
|
PDZ
|
393 |
465 |
1.28e-12 |
SMART |
|
RA
|
604 |
690 |
7.59e-23 |
SMART |
|
RasGEF
|
711 |
948 |
6.09e-100 |
SMART |
|
low complexity region
|
1028 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1108 |
1122 |
N/A |
INTRINSIC |
|
low complexity region
|
1138 |
1159 |
N/A |
INTRINSIC |
|
low complexity region
|
1390 |
1403 |
N/A |
INTRINSIC |
|
low complexity region
|
1438 |
1453 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195708
|
| SMART Domains |
Protein: ENSMUSP00000141542
Gene: ENSMUSG00000062232
| Domain | Start | End | E-Value | Type |
|---|
|
cNMP
|
24 |
131 |
3.9e-4 |
SMART |
|
low complexity region
|
186 |
210 |
N/A |
INTRINSIC |
|
low complexity region
|
232 |
243 |
N/A |
INTRINSIC |
|
cNMP
|
283 |
401 |
1.2e-17 |
SMART |
|
RasGEFN
|
415 |
528 |
6.4e-34 |
SMART |
|
PDZ
|
543 |
615 |
6.4e-15 |
SMART |
|
RA
|
754 |
840 |
4.8e-25 |
SMART |
|
RasGEF
|
861 |
1098 |
3.8e-102 |
SMART |
|
low complexity region
|
1178 |
1194 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1272 |
N/A |
INTRINSIC |
|
low complexity region
|
1288 |
1309 |
N/A |
INTRINSIC |
|
low complexity region
|
1540 |
1553 |
N/A |
INTRINSIC |
|
low complexity region
|
1588 |
1603 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Homozygotes for a null allele die at mid-gestation exhibiting growth arrest and defects in vascular development, neural tube closure and embryo turning. Homozygotes for another null allele show yolk sac vascular defects, impaired cell physiology and heart, primitive gut, liver and brain formation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700017B05Rik |
A |
G |
9: 57,166,168 (GRCm39) |
Y69H |
probably damaging |
Het |
| Afap1l2 |
A |
T |
19: 56,908,995 (GRCm39) |
S310R |
probably damaging |
Het |
| Aldh7a1 |
A |
G |
18: 56,675,288 (GRCm39) |
|
probably benign |
Het |
| Anxa8 |
T |
A |
14: 33,818,481 (GRCm39) |
|
probably null |
Het |
| Ap1ar |
T |
C |
3: 127,602,192 (GRCm39) |
E282G |
probably damaging |
Het |
| Arl6ip6 |
T |
G |
2: 53,092,939 (GRCm39) |
S155A |
probably benign |
Het |
| Armc9 |
T |
C |
1: 86,092,557 (GRCm39) |
F107S |
probably damaging |
Het |
| Ash1l |
C |
A |
3: 88,891,488 (GRCm39) |
D1122E |
probably benign |
Het |
| Atp2b4 |
T |
A |
1: 133,656,512 (GRCm39) |
I713F |
probably damaging |
Het |
| BC005624 |
A |
C |
2: 30,863,317 (GRCm39) |
|
probably benign |
Het |
| Calcrl |
T |
C |
2: 84,169,586 (GRCm39) |
D365G |
probably benign |
Het |
| Ccdc110 |
A |
G |
8: 46,396,221 (GRCm39) |
N704S |
probably benign |
Het |
| Ccr10 |
G |
T |
11: 101,065,492 (GRCm39) |
L13I |
probably benign |
Het |
| Cfap52 |
A |
G |
11: 67,844,341 (GRCm39) |
Y125H |
probably damaging |
Het |
| Cnr2 |
C |
A |
4: 135,644,936 (GRCm39) |
T338K |
possibly damaging |
Het |
| Cntn2 |
T |
A |
1: 132,444,308 (GRCm39) |
D935V |
probably damaging |
Het |
| Cog7 |
T |
C |
7: 121,543,067 (GRCm39) |
K448R |
possibly damaging |
Het |
| Csnk1g2 |
G |
A |
10: 80,474,369 (GRCm39) |
D197N |
probably damaging |
Het |
| Cyp2e1 |
T |
A |
7: 140,343,824 (GRCm39) |
S21T |
probably damaging |
Het |
| Dcaf11 |
T |
C |
14: 55,801,592 (GRCm39) |
F187L |
probably damaging |
Het |
| Dmd |
T |
A |
X: 82,922,110 (GRCm39) |
F1460Y |
probably benign |
Het |
| Dnah11 |
G |
A |
12: 117,874,775 (GRCm39) |
A4030V |
probably damaging |
Het |
| Dnah7a |
A |
G |
1: 53,561,519 (GRCm39) |
V2046A |
possibly damaging |
Het |
| Dnajc6 |
T |
C |
4: 101,496,497 (GRCm39) |
I820T |
probably damaging |
Het |
| Dsel |
T |
C |
1: 111,788,462 (GRCm39) |
D691G |
possibly damaging |
Het |
| Fbp1 |
T |
A |
13: 63,016,894 (GRCm39) |
M203L |
probably benign |
Het |
| Fndc1 |
T |
C |
17: 7,992,470 (GRCm39) |
T409A |
unknown |
Het |
| Golgb1 |
T |
G |
16: 36,746,211 (GRCm39) |
L2930R |
probably damaging |
Het |
| Htr2a |
A |
G |
14: 74,882,583 (GRCm39) |
T190A |
probably benign |
Het |
| Klra4 |
C |
T |
6: 130,021,033 (GRCm39) |
C254Y |
probably damaging |
Het |
| Large1 |
A |
T |
8: 73,858,667 (GRCm39) |
V67E |
probably benign |
Het |
| Lins1 |
T |
C |
7: 66,363,931 (GRCm39) |
S609P |
probably damaging |
Het |
| Magi3 |
T |
C |
3: 104,002,473 (GRCm39) |
E156G |
probably damaging |
Het |
| Mdh1b |
A |
G |
1: 63,754,523 (GRCm39) |
|
probably benign |
Het |
| Mfsd6 |
T |
C |
1: 52,748,037 (GRCm39) |
D276G |
probably benign |
Het |
| Myh9 |
T |
A |
15: 77,680,220 (GRCm39) |
K185* |
probably null |
Het |
| Myof |
T |
C |
19: 37,909,227 (GRCm39) |
|
probably null |
Het |
| Naip2 |
T |
G |
13: 100,298,020 (GRCm39) |
Y672S |
possibly damaging |
Het |
| Nbeal1 |
A |
G |
1: 60,326,603 (GRCm39) |
|
probably benign |
Het |
| Nbeal2 |
T |
A |
9: 110,457,344 (GRCm39) |
H2273L |
probably damaging |
Het |
| Neb |
T |
C |
2: 52,090,733 (GRCm39) |
K1346E |
possibly damaging |
Het |
| Nfatc2 |
T |
C |
2: 168,346,370 (GRCm39) |
D908G |
probably damaging |
Het |
| Nlgn2 |
T |
C |
11: 69,718,080 (GRCm39) |
N375S |
probably benign |
Het |
| Nova1 |
G |
T |
12: 46,767,505 (GRCm39) |
Q139K |
unknown |
Het |
| Opa3 |
A |
T |
7: 18,962,507 (GRCm39) |
Q47L |
probably damaging |
Het |
| Or10g7 |
T |
A |
9: 39,905,109 (GRCm39) |
M1K |
probably null |
Het |
| Or2t47 |
A |
G |
11: 58,442,987 (GRCm39) |
L26P |
probably damaging |
Het |
| Or6c205 |
T |
A |
10: 129,086,794 (GRCm39) |
Y130* |
probably null |
Het |
| Pacs1 |
A |
T |
19: 5,185,138 (GRCm39) |
|
probably benign |
Het |
| Pappa2 |
T |
A |
1: 158,609,829 (GRCm39) |
H1544L |
probably damaging |
Het |
| Pax8 |
A |
G |
2: 24,334,627 (GRCm39) |
S48P |
probably damaging |
Het |
| Pdilt |
T |
C |
7: 119,097,272 (GRCm39) |
N70S |
possibly damaging |
Het |
| Poldip3 |
T |
C |
15: 83,013,469 (GRCm39) |
|
probably benign |
Het |
| Ppp6r1 |
T |
A |
7: 4,645,211 (GRCm39) |
I80F |
probably damaging |
Het |
| Pycr2 |
T |
A |
1: 180,732,304 (GRCm39) |
|
probably null |
Het |
| Rbm44 |
T |
A |
1: 91,080,902 (GRCm39) |
D363E |
probably damaging |
Het |
| Rnf213 |
A |
T |
11: 119,318,336 (GRCm39) |
I1046F |
probably damaging |
Het |
| Ryr2 |
A |
G |
13: 11,606,155 (GRCm39) |
S4476P |
probably damaging |
Het |
| Scara5 |
G |
A |
14: 66,000,278 (GRCm39) |
D483N |
unknown |
Het |
| Scmh1 |
T |
A |
4: 120,325,586 (GRCm39) |
F101Y |
probably damaging |
Het |
| Sgo2a |
T |
A |
1: 58,055,511 (GRCm39) |
V565E |
probably damaging |
Het |
| Simc1 |
T |
C |
13: 54,673,071 (GRCm39) |
M473T |
probably benign |
Het |
| Skint6 |
T |
A |
4: 113,095,381 (GRCm39) |
R93* |
probably null |
Het |
| Skint7 |
T |
C |
4: 111,839,375 (GRCm39) |
V223A |
possibly damaging |
Het |
| Slc25a2 |
T |
C |
18: 37,770,939 (GRCm39) |
I197V |
probably benign |
Het |
| Slit2 |
A |
G |
5: 48,374,816 (GRCm39) |
T361A |
probably benign |
Het |
| Sugp1 |
G |
A |
8: 70,522,776 (GRCm39) |
G492D |
probably damaging |
Het |
| Svep1 |
C |
T |
4: 58,145,301 (GRCm39) |
G388D |
probably damaging |
Het |
| Tbpl2 |
G |
T |
2: 23,983,888 (GRCm39) |
A183E |
probably damaging |
Het |
| Tcerg1l |
G |
T |
7: 137,831,619 (GRCm39) |
P453T |
probably damaging |
Het |
| Tdpoz2 |
T |
C |
3: 93,559,046 (GRCm39) |
T309A |
probably benign |
Het |
| Thbs4 |
T |
A |
13: 92,927,306 (GRCm39) |
Y61F |
probably benign |
Het |
| Tmem117 |
C |
A |
15: 94,992,656 (GRCm39) |
P439T |
probably damaging |
Het |
| Tmem151a |
A |
G |
19: 5,132,993 (GRCm39) |
V71A |
probably benign |
Het |
| Tmem268 |
G |
T |
4: 63,486,691 (GRCm39) |
|
probably benign |
Het |
| Tmem43 |
T |
A |
6: 91,454,356 (GRCm39) |
Y48N |
possibly damaging |
Het |
| Tmigd1 |
T |
C |
11: 76,804,812 (GRCm39) |
V217A |
probably benign |
Het |
| Tmprss11g |
A |
T |
5: 86,645,188 (GRCm39) |
|
probably benign |
Het |
| Tsn |
T |
C |
1: 118,237,551 (GRCm39) |
I38V |
probably benign |
Het |
| Ttc41 |
A |
T |
10: 86,569,518 (GRCm39) |
Y632F |
probably damaging |
Het |
| Vmn2r117 |
C |
T |
17: 23,694,552 (GRCm39) |
|
probably benign |
Het |
| Vmn2r12 |
A |
T |
5: 109,238,351 (GRCm39) |
I463N |
probably benign |
Het |
| Wdsub1 |
T |
A |
2: 59,683,176 (GRCm39) |
N466I |
probably damaging |
Het |
| Zdhhc21 |
A |
T |
4: 82,762,427 (GRCm39) |
I56N |
probably benign |
Het |
| Zfand4 |
A |
G |
6: 116,250,617 (GRCm39) |
T16A |
possibly damaging |
Het |
| Zmym4 |
T |
C |
4: 126,842,268 (GRCm39) |
E15G |
probably damaging |
Het |
|
| Other mutations in Rapgef2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00488:Rapgef2
|
APN |
3 |
78,999,332 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL01024:Rapgef2
|
APN |
3 |
78,977,445 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL01448:Rapgef2
|
APN |
3 |
79,011,269 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01448:Rapgef2
|
APN |
3 |
78,976,244 (GRCm39) |
missense |
probably benign |
|
|
IGL01928:Rapgef2
|
APN |
3 |
79,011,270 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01973:Rapgef2
|
APN |
3 |
78,999,116 (GRCm39) |
splice site |
probably null |
|
|
IGL02015:Rapgef2
|
APN |
3 |
78,999,371 (GRCm39) |
splice site |
probably benign |
|
|
IGL02498:Rapgef2
|
APN |
3 |
78,974,060 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02631:Rapgef2
|
APN |
3 |
78,990,533 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02835:Rapgef2
|
APN |
3 |
79,000,293 (GRCm39) |
splice site |
probably benign |
|
|
IGL03030:Rapgef2
|
APN |
3 |
78,981,614 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03035:Rapgef2
|
APN |
3 |
79,001,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03222:Rapgef2
|
APN |
3 |
78,995,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03227:Rapgef2
|
APN |
3 |
78,999,920 (GRCm39) |
splice site |
probably benign |
|
|
IGL03326:Rapgef2
|
APN |
3 |
78,999,140 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03335:Rapgef2
|
APN |
3 |
79,006,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03384:Rapgef2
|
APN |
3 |
78,990,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Bulge
|
UTSW |
3 |
78,986,439 (GRCm39) |
missense |
probably benign |
0.01 |
|
Hai_phat
|
UTSW |
3 |
78,993,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0022:Rapgef2
|
UTSW |
3 |
78,995,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0022:Rapgef2
|
UTSW |
3 |
78,995,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0038:Rapgef2
|
UTSW |
3 |
78,976,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0117:Rapgef2
|
UTSW |
3 |
78,986,484 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0225:Rapgef2
|
UTSW |
3 |
79,011,412 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0723:Rapgef2
|
UTSW |
3 |
78,986,481 (GRCm39) |
missense |
probably benign |
0.20 |
|
R0788:Rapgef2
|
UTSW |
3 |
79,006,502 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R1311:Rapgef2
|
UTSW |
3 |
78,990,854 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1374:Rapgef2
|
UTSW |
3 |
78,995,275 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1507:Rapgef2
|
UTSW |
3 |
78,988,600 (GRCm39) |
splice site |
probably benign |
|
|
R1523:Rapgef2
|
UTSW |
3 |
79,000,056 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1753:Rapgef2
|
UTSW |
3 |
78,996,098 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R1759:Rapgef2
|
UTSW |
3 |
78,974,038 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1766:Rapgef2
|
UTSW |
3 |
79,000,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2436:Rapgef2
|
UTSW |
3 |
78,996,079 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3033:Rapgef2
|
UTSW |
3 |
78,981,613 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3766:Rapgef2
|
UTSW |
3 |
78,996,057 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4118:Rapgef2
|
UTSW |
3 |
78,976,194 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4416:Rapgef2
|
UTSW |
3 |
78,976,364 (GRCm39) |
nonsense |
probably null |
|
|
R4722:Rapgef2
|
UTSW |
3 |
78,976,480 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4743:Rapgef2
|
UTSW |
3 |
79,080,375 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4780:Rapgef2
|
UTSW |
3 |
79,077,076 (GRCm39) |
splice site |
probably benign |
|
|
R4825:Rapgef2
|
UTSW |
3 |
78,990,534 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4861:Rapgef2
|
UTSW |
3 |
78,981,743 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4861:Rapgef2
|
UTSW |
3 |
78,981,743 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4900:Rapgef2
|
UTSW |
3 |
78,981,670 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4943:Rapgef2
|
UTSW |
3 |
78,971,854 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5291:Rapgef2
|
UTSW |
3 |
78,977,366 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R5369:Rapgef2
|
UTSW |
3 |
78,976,739 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5413:Rapgef2
|
UTSW |
3 |
78,995,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5561:Rapgef2
|
UTSW |
3 |
78,995,950 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5568:Rapgef2
|
UTSW |
3 |
79,011,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5642:Rapgef2
|
UTSW |
3 |
79,002,157 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5783:Rapgef2
|
UTSW |
3 |
78,995,300 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6041:Rapgef2
|
UTSW |
3 |
78,976,469 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6193:Rapgef2
|
UTSW |
3 |
78,976,751 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6324:Rapgef2
|
UTSW |
3 |
78,986,439 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6551:Rapgef2
|
UTSW |
3 |
79,122,342 (GRCm39) |
splice site |
probably null |
|
|
R6688:Rapgef2
|
UTSW |
3 |
78,976,435 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6908:Rapgef2
|
UTSW |
3 |
79,011,370 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6913:Rapgef2
|
UTSW |
3 |
78,993,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6933:Rapgef2
|
UTSW |
3 |
78,993,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7086:Rapgef2
|
UTSW |
3 |
78,993,353 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7106:Rapgef2
|
UTSW |
3 |
78,973,915 (GRCm39) |
missense |
probably benign |
|
|
R7228:Rapgef2
|
UTSW |
3 |
78,976,525 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7242:Rapgef2
|
UTSW |
3 |
78,995,210 (GRCm39) |
nonsense |
probably null |
|
|
R7257:Rapgef2
|
UTSW |
3 |
78,989,934 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7322:Rapgef2
|
UTSW |
3 |
79,053,130 (GRCm39) |
start codon destroyed |
probably null |
0.02 |
|
R7443:Rapgef2
|
UTSW |
3 |
78,988,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7450:Rapgef2
|
UTSW |
3 |
79,080,366 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7472:Rapgef2
|
UTSW |
3 |
78,976,580 (GRCm39) |
missense |
probably benign |
0.45 |
|
R7884:Rapgef2
|
UTSW |
3 |
78,973,933 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7954:Rapgef2
|
UTSW |
3 |
78,977,454 (GRCm39) |
nonsense |
probably null |
|
|
R7957:Rapgef2
|
UTSW |
3 |
79,122,276 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8071:Rapgef2
|
UTSW |
3 |
79,000,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8261:Rapgef2
|
UTSW |
3 |
78,993,325 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8268:Rapgef2
|
UTSW |
3 |
78,993,263 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8309:Rapgef2
|
UTSW |
3 |
78,990,509 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8505:Rapgef2
|
UTSW |
3 |
78,986,349 (GRCm39) |
nonsense |
probably null |
|
|
R8783:Rapgef2
|
UTSW |
3 |
79,005,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8897:Rapgef2
|
UTSW |
3 |
79,019,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8965:Rapgef2
|
UTSW |
3 |
78,999,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9028:Rapgef2
|
UTSW |
3 |
78,981,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9284:Rapgef2
|
UTSW |
3 |
79,000,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9371:Rapgef2
|
UTSW |
3 |
79,082,300 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9479:Rapgef2
|
UTSW |
3 |
79,019,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9493:Rapgef2
|
UTSW |
3 |
79,019,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9494:Rapgef2
|
UTSW |
3 |
79,019,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9500:Rapgef2
|
UTSW |
3 |
78,974,093 (GRCm39) |
missense |
probably benign |
|
|
R9657:Rapgef2
|
UTSW |
3 |
78,999,191 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Posted On |
2015-12-18 |
Incidental Mutation