Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02926:Trim13'

363877

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trim13

Ensembl Gene

ENSMUSG00000035235

Gene Name

tripartite motif-containing 13

Synonyms

LEU5, RNF77, Rfp2, 3110001L12Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02926

Quality Score

Status

Chromosome

Chromosomal Location

61598247-61605946 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

G to T at 61605244 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000153429 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000039562] [ENSMUST00000051184] [ENSMUST00000165015] [ENSMUST00000225582]

AlphaFold

Q9CYB0

Predicted Effect

probably null
Transcript: ENSMUST00000039562
AA Change: E237*

SMART Domains

Protein: ENSMUSP00000045009
Gene: ENSMUSG00000035235
AA Change: E237*

Domain	Start	End	E-Value	Type
RING	10	57	1.31e-8	SMART
BBOX	89	131	5.55e-12	SMART
transmembrane domain	316	338	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000051184

SMART Domains

Protein: ENSMUSP00000055327
Gene: ENSMUSG00000046168

Domain	Start	End	E-Value	Type
BTB	5	106	8.7e-7	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000165015
AA Change: E237*

SMART Domains

Protein: ENSMUSP00000128509
Gene: ENSMUSG00000035235
AA Change: E237*

Domain	Start	End	E-Value	Type
RING	10	57	1.31e-8	SMART
BBOX	89	131	5.55e-12	SMART
transmembrane domain	316	338	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182259

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182325

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182768

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000183054

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000183066

Predicted Effect

probably null
Transcript: ENSMUST00000225582

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930402H24Rik	C	T	2: 130,712,366	R921K	probably benign	Het
Alms1	A	T	6: 85,641,450	D2826V	probably damaging	Het
Alpl	C	T	4: 137,742,634	A460T	probably damaging	Het
C2cd5	A	G	6: 143,031,237		probably benign	Het
C4b	C	T	17: 34,730,712	R1468Q	possibly damaging	Het
Calu	A	G	6: 29,366,920	T44A	possibly damaging	Het
Cgn	T	C	3: 94,778,016	K399R	probably benign	Het
Cyp2t4	G	A	7: 27,157,803	V356M	probably damaging	Het
D430041D05Rik	T	C	2: 104,214,259	D683G	probably damaging	Het
Dhcr24	T	A	4: 106,586,355	I410N	probably damaging	Het
Dmap1	T	A	4: 117,681,888	E17V	probably benign	Het
Dnah7a	A	G	1: 53,495,950	I2717T	possibly damaging	Het
Epb41l3	G	T	17: 69,247,746	K280N	probably damaging	Het
Espl1	T	A	15: 102,299,855	M432K	probably damaging	Het
Fgf5	C	A	5: 98,262,015	A141E	probably damaging	Het
Fto	T	A	8: 91,485,167	F373L	probably damaging	Het
Gpatch1	T	C	7: 35,308,269	D122G	probably damaging	Het
Ints11	T	C	4: 155,888,111		probably null	Het
Jarid2	A	G	13: 44,902,929	Q398R	probably benign	Het
Kcnh1	A	G	1: 192,276,900	D254G	probably damaging	Het
Lamc3	C	T	2: 31,935,725		probably benign	Het
Lamc3	C	T	2: 31,935,726		probably benign	Het
Ltbp4	T	C	7: 27,328,872		probably null	Het
Mcm6	A	G	1: 128,339,382	Y575H	probably damaging	Het
Myh9	A	C	15: 77,787,626	Y422D	probably damaging	Het
Narfl	A	G	17: 25,782,154	H460R	probably benign	Het
Olfr1260	T	C	2: 89,978,162	L128P	probably damaging	Het
Olfr1458	A	C	19: 13,102,823	N160K	possibly damaging	Het
Olfr911-ps1	T	C	9: 38,523,725		probably benign	Het
Plcb1	T	C	2: 135,364,762		probably benign	Het
Pmfbp1	A	G	8: 109,520,249	E251G	probably damaging	Het
Psg27	A	T	7: 18,557,129	V383E	probably damaging	Het
Ptprn	A	T	1: 75,247,873	H946Q	possibly damaging	Het
Rbl1	A	G	2: 157,167,413	V734A	probably benign	Het
Rspry1	T	A	8: 94,649,811	N320K	probably damaging	Het
Ryr1	A	T	7: 29,061,540	V3219D	probably damaging	Het
Ryr2	C	A	13: 11,759,835	W1145L	probably damaging	Het
Scel	A	T	14: 103,576,247	R319*	probably null	Het
Stxbp2	C	T	8: 3,635,629	T226I	probably benign	Het
Tac1	A	T	6: 7,562,410	N106I	possibly damaging	Het
Tspan31	T	G	10: 127,068,909		probably null	Het
Usp36	C	T	11: 118,264,783	V723M	probably benign	Het
Utrn	A	T	10: 12,690,760	N1219K	probably damaging	Het
Vcan	G	T	13: 89,688,623	T2934K	probably damaging	Het

Other mutations in Trim13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00788:Trim13	APN	14	61605670	missense	probably benign
IGL00811:Trim13	APN	14	61604857	splice site	probably null
IGL01760:Trim13	APN	14	61605723	missense	probably benign	0.06
IGL02411:Trim13	APN	14	61605149	missense	probably damaging	1.00
IGL02625:Trim13	APN	14	61605550	missense	probably benign	0.00
IGL03231:Trim13	APN	14	61605545	missense	probably benign	0.11
R0089:Trim13	UTSW	14	61604717	missense	possibly damaging	0.95
R0811:Trim13	UTSW	14	61605700	missense	probably benign
R0812:Trim13	UTSW	14	61605700	missense	probably benign
R1515:Trim13	UTSW	14	61605659	missense	probably benign	0.03
R1778:Trim13	UTSW	14	61605619	missense	probably benign	0.13
R2018:Trim13	UTSW	14	61604886	nonsense	probably null
R2019:Trim13	UTSW	14	61604886	nonsense	probably null
R4865:Trim13	UTSW	14	61605517	missense	probably benign
R5456:Trim13	UTSW	14	61605074	missense	possibly damaging	0.91
R5860:Trim13	UTSW	14	61604739	missense	probably damaging	0.96
R5921:Trim13	UTSW	14	61605089	missense	probably benign	0.00
R7026:Trim13	UTSW	14	61605113	nonsense	probably null
R7147:Trim13	UTSW	14	61604631	missense	probably damaging	1.00
R8461:Trim13	UTSW	14	61605472	missense	probably benign
R9181:Trim13	UTSW	14	61604597	missense	possibly damaging	0.94

Posted On

2015-12-18