Incidental Mutation 'IGL02929:Kras'
ID 364029
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kras
Ensembl Gene ENSMUSG00000030265
Gene Name Kirsten rat sarcoma viral oncogene homolog
Synonyms Kras2, Kras-2, K-ras, Ki-ras
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02929
Quality Score
Status
Chromosome 6
Chromosomal Location 145162425-145195965 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to G at 145177815 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000145294 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032399] [ENSMUST00000111710] [ENSMUST00000156486] [ENSMUST00000203147]
AlphaFold P32883
Predicted Effect probably benign
Transcript: ENSMUST00000032399
SMART Domains Protein: ENSMUSP00000032399
Gene: ENSMUSG00000030265

DomainStartEndE-ValueType
RAS 1 166 1.14e-123 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000111710
SMART Domains Protein: ENSMUSP00000107339
Gene: ENSMUSG00000030265

DomainStartEndE-ValueType
RAS 1 166 3.7e-123 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123972
Predicted Effect probably benign
Transcript: ENSMUST00000156486
Predicted Effect probably benign
Transcript: ENSMUST00000203147
SMART Domains Protein: ENSMUSP00000145294
Gene: ENSMUSG00000030265

DomainStartEndE-ValueType
small_GTPase 1 53 3.1e-8 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality, decreased fetal growth, pericardial edema, anemia, and liver hypoplasia. Mice heterozygous for various knock-in alleles exhibit increased tumorigenesis. [provided by MGI curators]
Allele List at MGI

All alleles(26) : Targeted, knock-out(3) Targeted, other(7) Gene trapped(14) Other(2)
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A330070K13Rik A G 5: 130,413,252 (GRCm39) probably null Het
Abcb5 T C 12: 118,908,674 (GRCm39) Y90C probably damaging Het
Accs T C 2: 93,674,566 (GRCm39) D112G probably damaging Het
Adam32 C A 8: 25,362,659 (GRCm39) V13L possibly damaging Het
Adgrb3 A G 1: 25,592,905 (GRCm39) V294A probably benign Het
Agt G T 8: 125,283,829 (GRCm39) A430E probably benign Het
Agxt2 T C 15: 10,388,379 (GRCm39) probably benign Het
Atp2a1 A T 7: 126,056,116 (GRCm39) I235N probably damaging Het
Atp8b1 T C 18: 64,694,733 (GRCm39) I516M possibly damaging Het
Atrx T C X: 104,923,512 (GRCm39) probably null Het
Brcc3 T C X: 74,479,105 (GRCm39) V117A possibly damaging Het
Casp8ap2 T C 4: 32,624,105 (GRCm39) probably benign Het
Ceacam3 T A 7: 16,892,115 (GRCm39) V286D probably damaging Het
Cpb1 T C 3: 20,329,630 (GRCm39) D32G probably benign Het
Cpsf1 C A 15: 76,486,327 (GRCm39) probably null Het
Dnai4 C T 4: 102,917,188 (GRCm39) W552* probably null Het
Dock2 A T 11: 34,218,048 (GRCm39) V1174E probably damaging Het
Dqx1 A G 6: 83,037,465 (GRCm39) probably benign Het
Ercc1 T C 7: 19,089,288 (GRCm39) probably null Het
Fn1 A G 1: 71,634,821 (GRCm39) probably null Het
Garre1 A T 7: 33,944,507 (GRCm39) M75K possibly damaging Het
Ice1 A G 13: 70,744,322 (GRCm39) L2087P probably damaging Het
Ift122 A G 6: 115,879,838 (GRCm39) D612G probably damaging Het
Igkv6-25 A G 6: 70,192,929 (GRCm39) Y112C probably damaging Het
Kit C A 5: 75,801,429 (GRCm39) P572Q probably damaging Het
Ltv1 T C 10: 13,067,970 (GRCm39) K6R possibly damaging Het
Man1a C T 10: 53,801,531 (GRCm39) V443I probably benign Het
Mat2b A C 11: 40,575,540 (GRCm39) D154E probably benign Het
Mtrf1 A G 14: 79,640,273 (GRCm39) K143E probably benign Het
Myh13 A C 11: 67,257,991 (GRCm39) I95L probably damaging Het
Myo7b A T 18: 32,127,978 (GRCm39) D571E probably benign Het
Nek10 T A 14: 14,821,119 (GRCm38) D28E possibly damaging Het
Npm2 T A 14: 70,889,678 (GRCm39) probably null Het
Pkd1l2 G A 8: 117,792,484 (GRCm39) T436I probably benign Het
Plcb2 G A 2: 118,543,715 (GRCm39) probably benign Het
Ppp1r3a A G 6: 14,719,810 (GRCm39) M368T probably benign Het
Rnf123 G T 9: 107,946,275 (GRCm39) T300K probably benign Het
Sbspon A G 1: 15,954,069 (GRCm39) probably benign Het
Slc52a2 G A 15: 76,424,776 (GRCm39) C338Y probably benign Het
Tdrd6 T A 17: 43,940,604 (GRCm39) Q148L possibly damaging Het
Tle5 T A 10: 81,400,672 (GRCm39) probably null Het
Trpc3 T A 3: 36,692,623 (GRCm39) K790* probably null Het
Ushbp1 C T 8: 71,847,120 (GRCm39) A171T probably damaging Het
Usp32 T C 11: 84,879,198 (GRCm39) T1504A probably benign Het
Other mutations in Kras
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00808:Kras APN 6 145,192,474 (GRCm39) missense probably damaging 1.00
N/A - 293:Kras UTSW 6 145,177,940 (GRCm39) missense probably benign 0.01
R1463:Kras UTSW 6 145,170,787 (GRCm39) intron probably benign
R1518:Kras UTSW 6 145,177,977 (GRCm39) missense probably benign 0.00
R1603:Kras UTSW 6 145,170,871 (GRCm39) nonsense probably null
R1885:Kras UTSW 6 145,177,843 (GRCm39) missense probably damaging 1.00
R5089:Kras UTSW 6 145,170,869 (GRCm39) missense probably benign 0.00
R5133:Kras UTSW 6 145,177,879 (GRCm39) missense probably benign 0.00
R7710:Kras UTSW 6 145,166,354 (GRCm39) missense probably benign
R7876:Kras UTSW 6 145,170,848 (GRCm39) missense probably benign
R8151:Kras UTSW 6 145,166,360 (GRCm39) small deletion probably benign
R8944:Kras UTSW 6 145,170,853 (GRCm39) missense probably benign
R8951:Kras UTSW 6 145,166,338 (GRCm39) missense probably benign
R9345:Kras UTSW 6 145,192,442 (GRCm39) missense probably benign 0.00
Z1177:Kras UTSW 6 145,192,498 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18