Incidental Mutation 'IGL02932:Olfr1361'
ID364136
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1361
Ensembl Gene ENSMUSG00000049737
Gene Nameolfactory receptor 1361
SynonymsGA_x6K02T2QHY8-11577590-11578528, MOR256-12
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.094) question?
Stock #IGL02932
Quality Score
Status
Chromosome13
Chromosomal Location21656880-21663386 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 21658831 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 164 (M164K)
Ref Sequence ENSEMBL: ENSMUSP00000150315 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055615] [ENSMUST00000214321]
Predicted Effect probably damaging
Transcript: ENSMUST00000055615
AA Change: M164K

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000062356
Gene: ENSMUSG00000049737
AA Change: M164K

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 30 312 4.2e-10 PFAM
Pfam:7tm_4 36 313 7.7e-52 PFAM
Pfam:7tm_1 46 295 1.5e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214321
AA Change: M164K

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap42 T A 9: 9,115,708 E122D probably damaging Het
Asb3 G A 11: 31,029,067 probably null Het
Avl9 T C 6: 56,736,551 S265P probably benign Het
Cep44 C T 8: 56,547,424 R18Q probably damaging Het
Clec10a T C 11: 70,169,728 probably benign Het
Cog4 A G 8: 110,852,433 I115V probably benign Het
Coq3 C T 4: 21,900,430 A219V probably benign Het
Cry2 G A 2: 92,413,117 R460* probably null Het
Ddx39b A G 17: 35,253,361 probably benign Het
Dhx40 G A 11: 86,771,929 R646C probably damaging Het
Ears2 G A 7: 122,063,061 R55C probably damaging Het
Eif3m C T 2: 105,014,869 G26R probably damaging Het
Exo5 A G 4: 120,922,545 L41P probably benign Het
Fut10 A G 8: 31,259,937 H417R probably damaging Het
Gars T A 6: 55,060,944 L296Q probably damaging Het
Gpr143 A T X: 152,793,443 probably benign Het
Htr1b C A 9: 81,631,636 R306L probably damaging Het
Lama3 G A 18: 12,528,801 A2185T probably damaging Het
Mbd5 C A 2: 49,279,448 Q1544K possibly damaging Het
Mccc1 T C 3: 35,960,029 E713G possibly damaging Het
Mttp A G 3: 138,111,744 F415S probably benign Het
Mug1 A G 6: 121,887,427 T1428A probably benign Het
Mup6 A C 4: 60,006,009 D159A probably damaging Het
Nsd2 T C 5: 33,880,128 L698P probably damaging Het
Olfr1184 G T 2: 88,487,175 V148F probably benign Het
Olfr495 A G 7: 108,395,513 N131S probably benign Het
Olfr815 A T 10: 129,902,418 C97* probably null Het
Osgepl1 G A 1: 53,321,516 R372H probably benign Het
Pias2 C T 18: 77,145,103 H537Y probably damaging Het
Slc38a7 A C 8: 95,846,155 I149M probably damaging Het
Smn1 A G 13: 100,127,964 T68A probably benign Het
Syde2 A G 3: 146,001,476 K657R possibly damaging Het
Tdrd5 A T 1: 156,270,620 H625Q possibly damaging Het
Tead3 T C 17: 28,341,351 Y2C probably damaging Het
Tmem255a T A X: 38,208,063 T280S probably benign Het
Ttpa A G 4: 20,021,215 T128A possibly damaging Het
Wdhd1 A G 14: 47,272,134 probably null Het
Other mutations in Olfr1361
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01878:Olfr1361 APN 13 21658783 missense possibly damaging 0.63
IGL02025:Olfr1361 APN 13 21659263 missense possibly damaging 0.92
IGL02275:Olfr1361 APN 13 21659000 missense probably benign 0.01
IGL02831:Olfr1361 APN 13 21658904 missense probably benign
R0102:Olfr1361 UTSW 13 21658735 missense probably damaging 1.00
R0597:Olfr1361 UTSW 13 21659146 missense probably damaging 0.96
R1669:Olfr1361 UTSW 13 21659286 missense possibly damaging 0.91
R2006:Olfr1361 UTSW 13 21658472 missense possibly damaging 0.94
R2292:Olfr1361 UTSW 13 21658831 missense probably damaging 1.00
R4894:Olfr1361 UTSW 13 21659182 missense probably damaging 1.00
R4919:Olfr1361 UTSW 13 21658624 missense possibly damaging 0.59
R5339:Olfr1361 UTSW 13 21659234 missense probably benign 0.37
R5815:Olfr1361 UTSW 13 21658537 missense probably damaging 1.00
R6248:Olfr1361 UTSW 13 21659074 missense possibly damaging 0.72
R8273:Olfr1361 UTSW 13 21659207 missense probably damaging 1.00
R8323:Olfr1361 UTSW 13 21659132 missense possibly damaging 0.95
Posted On2015-12-18