Incidental Mutation 'IGL02932:Olfr1184'
ID364138
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1184
Ensembl Gene ENSMUSG00000051424
Gene Nameolfactory receptor 1184
SynonymsGA_x6K02T2Q125-49974190-49975125, MOR225-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.068) question?
Stock #IGL02932
Quality Score
Status
Chromosome2
Chromosomal Location88483598-88489284 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 88487175 bp
ZygosityHeterozygous
Amino Acid Change Valine to Phenylalanine at position 148 (V148F)
Ref Sequence ENSEMBL: ENSMUSP00000149649 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050038] [ENSMUST00000216675]
Predicted Effect probably benign
Transcript: ENSMUST00000050038
AA Change: V148F

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000058679
Gene: ENSMUSG00000051424
AA Change: V148F

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.2e-47 PFAM
Pfam:7tm_1 39 285 2.3e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216675
AA Change: V148F

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap42 T A 9: 9,115,708 E122D probably damaging Het
Asb3 G A 11: 31,029,067 probably null Het
Avl9 T C 6: 56,736,551 S265P probably benign Het
Cep44 C T 8: 56,547,424 R18Q probably damaging Het
Clec10a T C 11: 70,169,728 probably benign Het
Cog4 A G 8: 110,852,433 I115V probably benign Het
Coq3 C T 4: 21,900,430 A219V probably benign Het
Cry2 G A 2: 92,413,117 R460* probably null Het
Ddx39b A G 17: 35,253,361 probably benign Het
Dhx40 G A 11: 86,771,929 R646C probably damaging Het
Ears2 G A 7: 122,063,061 R55C probably damaging Het
Eif3m C T 2: 105,014,869 G26R probably damaging Het
Exo5 A G 4: 120,922,545 L41P probably benign Het
Fut10 A G 8: 31,259,937 H417R probably damaging Het
Gars T A 6: 55,060,944 L296Q probably damaging Het
Gpr143 A T X: 152,793,443 probably benign Het
Htr1b C A 9: 81,631,636 R306L probably damaging Het
Lama3 G A 18: 12,528,801 A2185T probably damaging Het
Mbd5 C A 2: 49,279,448 Q1544K possibly damaging Het
Mccc1 T C 3: 35,960,029 E713G possibly damaging Het
Mttp A G 3: 138,111,744 F415S probably benign Het
Mug1 A G 6: 121,887,427 T1428A probably benign Het
Mup6 A C 4: 60,006,009 D159A probably damaging Het
Nsd2 T C 5: 33,880,128 L698P probably damaging Het
Olfr1361 A T 13: 21,658,831 M164K probably damaging Het
Olfr495 A G 7: 108,395,513 N131S probably benign Het
Olfr815 A T 10: 129,902,418 C97* probably null Het
Osgepl1 G A 1: 53,321,516 R372H probably benign Het
Pias2 C T 18: 77,145,103 H537Y probably damaging Het
Slc38a7 A C 8: 95,846,155 I149M probably damaging Het
Smn1 A G 13: 100,127,964 T68A probably benign Het
Syde2 A G 3: 146,001,476 K657R possibly damaging Het
Tdrd5 A T 1: 156,270,620 H625Q possibly damaging Het
Tead3 T C 17: 28,341,351 Y2C probably damaging Het
Tmem255a T A X: 38,208,063 T280S probably benign Het
Ttpa A G 4: 20,021,215 T128A possibly damaging Het
Wdhd1 A G 14: 47,272,134 probably null Het
Other mutations in Olfr1184
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01286:Olfr1184 APN 2 88487248 missense probably damaging 1.00
IGL01288:Olfr1184 APN 2 88487248 missense probably damaging 1.00
IGL01790:Olfr1184 APN 2 88486926 missense possibly damaging 0.65
IGL02070:Olfr1184 APN 2 88487002 missense probably damaging 1.00
IGL02247:Olfr1184 APN 2 88487427 missense probably benign 0.00
IGL02997:Olfr1184 APN 2 88487388 missense probably damaging 0.99
IGL03161:Olfr1184 APN 2 88487448 missense probably benign 0.01
PIT4531001:Olfr1184 UTSW 2 88487257 missense possibly damaging 0.95
R3713:Olfr1184 UTSW 2 88487443 missense probably damaging 1.00
R3715:Olfr1184 UTSW 2 88487443 missense probably damaging 1.00
R4421:Olfr1184 UTSW 2 88487241 missense probably damaging 1.00
R4514:Olfr1184 UTSW 2 88487365 missense probably benign 0.05
R5096:Olfr1184 UTSW 2 88487302 missense possibly damaging 0.89
R5661:Olfr1184 UTSW 2 88487097 missense probably damaging 0.98
R5851:Olfr1184 UTSW 2 88486860 missense possibly damaging 0.54
R6458:Olfr1184 UTSW 2 88487218 missense possibly damaging 0.90
R7073:Olfr1184 UTSW 2 88487307 missense probably benign 0.00
R7102:Olfr1184 UTSW 2 88487148 missense probably damaging 1.00
R7145:Olfr1184 UTSW 2 88487377 missense probably damaging 1.00
R7221:Olfr1184 UTSW 2 88487629 missense probably damaging 0.97
X0063:Olfr1184 UTSW 2 88487490 missense probably benign 0.23
Posted On2015-12-18