Incidental Mutation 'IGL02932:Fut10'
ID364156
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fut10
Ensembl Gene ENSMUSG00000046152
Gene Namefucosyltransferase 10
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.101) question?
Stock #IGL02932
Quality Score
Status
Chromosome8
Chromosomal Location31187331-31261738 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 31259937 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Arginine at position 417 (H417R)
Ref Sequence ENSEMBL: ENSMUSP00000125265 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066173] [ENSMUST00000110527] [ENSMUST00000161502]
Predicted Effect probably damaging
Transcript: ENSMUST00000066173
AA Change: H417R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000069816
Gene: ENSMUSG00000046152
AA Change: H417R

DomainStartEndE-ValueType
transmembrane domain 9 31 N/A INTRINSIC
Pfam:Glyco_tran_10_N 79 184 5e-13 PFAM
Pfam:Glyco_transf_10 209 410 7.9e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110527
SMART Domains Protein: ENSMUSP00000106156
Gene: ENSMUSG00000046152

DomainStartEndE-ValueType
Pfam:Glyco_transf_10 7 134 3e-9 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000161502
AA Change: H417R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000125265
Gene: ENSMUSG00000046152
AA Change: H417R

DomainStartEndE-ValueType
Pfam:Glyco_transf_10 7 412 4.1e-92 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap42 T A 9: 9,115,708 E122D probably damaging Het
Asb3 G A 11: 31,029,067 probably null Het
Avl9 T C 6: 56,736,551 S265P probably benign Het
Cep44 C T 8: 56,547,424 R18Q probably damaging Het
Clec10a T C 11: 70,169,728 probably benign Het
Cog4 A G 8: 110,852,433 I115V probably benign Het
Coq3 C T 4: 21,900,430 A219V probably benign Het
Cry2 G A 2: 92,413,117 R460* probably null Het
Ddx39b A G 17: 35,253,361 probably benign Het
Dhx40 G A 11: 86,771,929 R646C probably damaging Het
Ears2 G A 7: 122,063,061 R55C probably damaging Het
Eif3m C T 2: 105,014,869 G26R probably damaging Het
Exo5 A G 4: 120,922,545 L41P probably benign Het
Gars T A 6: 55,060,944 L296Q probably damaging Het
Gpr143 A T X: 152,793,443 probably benign Het
Htr1b C A 9: 81,631,636 R306L probably damaging Het
Lama3 G A 18: 12,528,801 A2185T probably damaging Het
Mbd5 C A 2: 49,279,448 Q1544K possibly damaging Het
Mccc1 T C 3: 35,960,029 E713G possibly damaging Het
Mttp A G 3: 138,111,744 F415S probably benign Het
Mug1 A G 6: 121,887,427 T1428A probably benign Het
Mup6 A C 4: 60,006,009 D159A probably damaging Het
Nsd2 T C 5: 33,880,128 L698P probably damaging Het
Olfr1184 G T 2: 88,487,175 V148F probably benign Het
Olfr1361 A T 13: 21,658,831 M164K probably damaging Het
Olfr495 A G 7: 108,395,513 N131S probably benign Het
Olfr815 A T 10: 129,902,418 C97* probably null Het
Osgepl1 G A 1: 53,321,516 R372H probably benign Het
Pias2 C T 18: 77,145,103 H537Y probably damaging Het
Slc38a7 A C 8: 95,846,155 I149M probably damaging Het
Smn1 A G 13: 100,127,964 T68A probably benign Het
Syde2 A G 3: 146,001,476 K657R possibly damaging Het
Tdrd5 A T 1: 156,270,620 H625Q possibly damaging Het
Tead3 T C 17: 28,341,351 Y2C probably damaging Het
Tmem255a T A X: 38,208,063 T280S probably benign Het
Ttpa A G 4: 20,021,215 T128A possibly damaging Het
Wdhd1 A G 14: 47,272,134 probably null Het
Other mutations in Fut10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Fut10 APN 8 31195291 critical splice donor site probably null
IGL00566:Fut10 APN 8 31235684 missense probably damaging 1.00
IGL00858:Fut10 APN 8 31235705 missense probably damaging 0.97
IGL00861:Fut10 APN 8 31235705 missense probably damaging 0.97
IGL00862:Fut10 APN 8 31235705 missense probably damaging 0.97
IGL01916:Fut10 APN 8 31235706 missense probably benign 0.01
IGL02030:Fut10 APN 8 31235978 nonsense probably null
IGL02318:Fut10 APN 8 31236258 missense probably damaging 1.00
IGL02354:Fut10 APN 8 31201370 missense probably damaging 0.99
IGL02361:Fut10 APN 8 31201370 missense probably damaging 0.99
IGL03345:Fut10 APN 8 31260041 missense probably damaging 1.00
R0234:Fut10 UTSW 8 31236197 missense probably damaging 1.00
R0234:Fut10 UTSW 8 31236197 missense probably damaging 1.00
R1728:Fut10 UTSW 8 31201390 missense probably benign 0.00
R1729:Fut10 UTSW 8 31201390 missense probably benign 0.00
R1845:Fut10 UTSW 8 31236300 missense probably damaging 1.00
R2173:Fut10 UTSW 8 31236131 missense probably damaging 1.00
R2518:Fut10 UTSW 8 31236467 missense probably benign 0.19
R3692:Fut10 UTSW 8 31236020 missense possibly damaging 0.94
R4449:Fut10 UTSW 8 31236257 missense probably damaging 1.00
R5015:Fut10 UTSW 8 31236120 missense probably damaging 0.96
R5942:Fut10 UTSW 8 31201457 missense possibly damaging 0.62
R6497:Fut10 UTSW 8 31236250 missense probably damaging 0.99
R7566:Fut10 UTSW 8 31259922 missense probably benign 0.00
R7645:Fut10 UTSW 8 31236204 missense possibly damaging 0.92
R8127:Fut10 UTSW 8 31194971 start gained probably benign
R8241:Fut10 UTSW 8 31260006 nonsense probably null
Posted On2015-12-18