Incidental Mutation 'IGL02934:Vmn2r97'
ID 364209
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r97
Ensembl Gene ENSMUSG00000091491
Gene Name vomeronasal 2, receptor 97
Synonyms EG627367
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # IGL02934
Quality Score
Status
Chromosome 17
Chromosomal Location 19134584-19168333 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 19149947 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 445 (V445A)
Ref Sequence ENSEMBL: ENSMUSP00000129313 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168710] [ENSMUST00000232219]
AlphaFold K7N6Z2
Predicted Effect probably benign
Transcript: ENSMUST00000168710
AA Change: V445A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: V445A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 82 442 2.9e-36 PFAM
Pfam:NCD3G 513 566 4.9e-21 PFAM
Pfam:7tm_3 599 834 1.7e-52 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000232219
AA Change: V445A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232325
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 A T 3: 121,956,008 (GRCm39) R716* probably null Het
Abca8a A T 11: 109,931,414 (GRCm39) N1246K probably damaging Het
Acadl A G 1: 66,876,134 (GRCm39) Y396H probably benign Het
Apol7c A T 15: 77,410,318 (GRCm39) S209R possibly damaging Het
Atp1a1 A T 3: 101,484,308 (GRCm39) C990* probably null Het
Cachd1 C T 4: 100,825,295 (GRCm39) S583L probably damaging Het
Cbfa2t3 T C 8: 123,374,497 (GRCm39) T48A probably benign Het
Ccdc138 G T 10: 58,409,402 (GRCm39) probably benign Het
Cenpe A G 3: 134,970,112 (GRCm39) E2231G probably damaging Het
Cog3 T C 14: 75,979,129 (GRCm39) I206V probably damaging Het
Cr2 A G 1: 194,836,633 (GRCm39) probably benign Het
Ctdspl2 T C 2: 121,809,490 (GRCm39) V147A probably damaging Het
Cyp4f13 A G 17: 33,148,845 (GRCm39) V300A probably damaging Het
Dkk3 A T 7: 111,749,954 (GRCm39) M72K probably damaging Het
Dock3 A T 9: 106,900,944 (GRCm39) F340L probably benign Het
Fut1 A G 7: 45,268,127 (GRCm39) H27R possibly damaging Het
Igkv4-80 A G 6: 68,993,840 (GRCm39) V17A probably benign Het
Igkv9-123 G A 6: 67,931,380 (GRCm39) P62L possibly damaging Het
Kmt2e T C 5: 23,702,882 (GRCm39) S1021P probably damaging Het
Krt13 A C 11: 100,009,910 (GRCm39) L320R probably damaging Het
Ldhal6b T C 17: 5,467,819 (GRCm39) T372A probably benign Het
Manba T C 3: 135,250,510 (GRCm39) V379A probably benign Het
Map1b C T 13: 99,571,639 (GRCm39) V361I probably benign Het
Map4k1 A G 7: 28,693,531 (GRCm39) S399G probably benign Het
Mff G A 1: 82,724,815 (GRCm39) R229H probably damaging Het
Naga T C 15: 82,214,401 (GRCm39) N370S possibly damaging Het
Ncor2 A T 5: 125,102,621 (GRCm39) M2045K probably benign Het
Nipal1 T C 5: 72,805,250 (GRCm39) L7P probably damaging Het
Or10p22 T A 10: 128,825,958 (GRCm39) M59K probably damaging Het
Pcmt1 A T 10: 7,516,491 (GRCm39) M187K probably benign Het
Perp A T 10: 18,731,520 (GRCm39) T160S probably damaging Het
Rapgef6 G A 11: 54,516,690 (GRCm39) D169N probably damaging Het
Sel1l G A 12: 91,776,710 (GRCm39) Q711* probably null Het
Septin5 T C 16: 18,448,581 (GRCm39) Y7C probably damaging Het
Spdya A T 17: 71,863,395 (GRCm39) N48I probably benign Het
Stard6 T A 18: 70,629,175 (GRCm39) probably benign Het
Sytl2 T C 7: 90,025,200 (GRCm39) V396A probably benign Het
Tcaf3 T G 6: 42,570,832 (GRCm39) M307L probably benign Het
Tdrd6 T C 17: 43,938,778 (GRCm39) N757D probably benign Het
Tgm1 T A 14: 55,947,446 (GRCm39) D305V probably damaging Het
Themis2 T A 4: 132,516,862 (GRCm39) M213L probably damaging Het
Tmem184c A G 8: 78,324,449 (GRCm39) V347A probably damaging Het
Tmem214 A G 5: 31,028,888 (GRCm39) E159G probably benign Het
Trim58 C T 11: 58,531,292 (GRCm39) probably benign Het
Tshz1 A T 18: 84,031,215 (GRCm39) S1064R probably damaging Het
Ubr2 C T 17: 47,268,266 (GRCm39) E983K possibly damaging Het
Vmn1r23 A T 6: 57,902,914 (GRCm39) I288N probably benign Het
Whrn G A 4: 63,334,342 (GRCm39) T813M probably damaging Het
Xirp2 C T 2: 67,346,020 (GRCm39) H2754Y probably benign Het
Other mutations in Vmn2r97
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00897:Vmn2r97 APN 17 19,167,921 (GRCm39) missense probably benign 0.37
IGL00962:Vmn2r97 APN 17 19,149,490 (GRCm39) missense probably damaging 1.00
IGL01704:Vmn2r97 APN 17 19,168,073 (GRCm39) missense probably damaging 0.99
IGL01888:Vmn2r97 APN 17 19,149,286 (GRCm39) nonsense probably null
IGL02429:Vmn2r97 APN 17 19,150,596 (GRCm39) missense possibly damaging 0.94
IGL02742:Vmn2r97 APN 17 19,149,432 (GRCm39) missense probably damaging 0.97
IGL02978:Vmn2r97 APN 17 19,168,298 (GRCm39) missense probably benign 0.01
IGL03230:Vmn2r97 APN 17 19,149,668 (GRCm39) missense probably benign 0.10
IGL03241:Vmn2r97 APN 17 19,148,438 (GRCm39) missense probably benign 0.11
IGL03050:Vmn2r97 UTSW 17 19,167,900 (GRCm39) missense possibly damaging 0.84
PIT4469001:Vmn2r97 UTSW 17 19,149,878 (GRCm39) missense probably benign 0.00
R0482:Vmn2r97 UTSW 17 19,167,930 (GRCm39) missense probably damaging 1.00
R0514:Vmn2r97 UTSW 17 19,134,734 (GRCm39) missense probably benign 0.25
R0944:Vmn2r97 UTSW 17 19,167,665 (GRCm39) missense probably benign 0.13
R1061:Vmn2r97 UTSW 17 19,148,440 (GRCm39) nonsense probably null
R1546:Vmn2r97 UTSW 17 19,168,110 (GRCm39) missense probably damaging 1.00
R1725:Vmn2r97 UTSW 17 19,149,397 (GRCm39) missense probably benign 0.43
R1860:Vmn2r97 UTSW 17 19,167,648 (GRCm39) missense probably benign 0.01
R1938:Vmn2r97 UTSW 17 19,149,593 (GRCm39) missense probably benign 0.01
R1944:Vmn2r97 UTSW 17 19,160,500 (GRCm39) missense probably benign 0.00
R2027:Vmn2r97 UTSW 17 19,149,944 (GRCm39) missense unknown
R2106:Vmn2r97 UTSW 17 19,168,100 (GRCm39) missense probably damaging 1.00
R2151:Vmn2r97 UTSW 17 19,167,584 (GRCm39) nonsense probably null
R2153:Vmn2r97 UTSW 17 19,167,584 (GRCm39) nonsense probably null
R2154:Vmn2r97 UTSW 17 19,167,584 (GRCm39) nonsense probably null
R2516:Vmn2r97 UTSW 17 19,167,814 (GRCm39) missense probably benign
R3739:Vmn2r97 UTSW 17 19,148,413 (GRCm39) missense probably damaging 1.00
R3744:Vmn2r97 UTSW 17 19,149,890 (GRCm39) missense probably benign
R3885:Vmn2r97 UTSW 17 19,148,596 (GRCm39) missense possibly damaging 0.90
R3899:Vmn2r97 UTSW 17 19,167,873 (GRCm39) missense probably damaging 0.96
R4115:Vmn2r97 UTSW 17 19,148,332 (GRCm39) missense probably benign 0.01
R4247:Vmn2r97 UTSW 17 19,167,542 (GRCm39) missense possibly damaging 0.83
R4287:Vmn2r97 UTSW 17 19,168,337 (GRCm39) intron probably benign
R4439:Vmn2r97 UTSW 17 19,150,616 (GRCm39) missense probably benign 0.00
R4523:Vmn2r97 UTSW 17 19,149,333 (GRCm39) missense probably benign 0.03
R4783:Vmn2r97 UTSW 17 19,149,550 (GRCm39) missense probably benign
R4948:Vmn2r97 UTSW 17 19,167,561 (GRCm39) missense possibly damaging 0.95
R4981:Vmn2r97 UTSW 17 19,160,436 (GRCm39) nonsense probably null
R5029:Vmn2r97 UTSW 17 19,168,173 (GRCm39) missense probably damaging 1.00
R5200:Vmn2r97 UTSW 17 19,148,615 (GRCm39) missense probably damaging 1.00
R5541:Vmn2r97 UTSW 17 19,148,617 (GRCm39) nonsense probably null
R5637:Vmn2r97 UTSW 17 19,167,628 (GRCm39) nonsense probably null
R5765:Vmn2r97 UTSW 17 19,167,442 (GRCm39) nonsense probably null
R5885:Vmn2r97 UTSW 17 19,168,035 (GRCm39) missense possibly damaging 0.50
R6272:Vmn2r97 UTSW 17 19,167,861 (GRCm39) missense possibly damaging 0.70
R6553:Vmn2r97 UTSW 17 19,150,566 (GRCm39) nonsense probably null
R6818:Vmn2r97 UTSW 17 19,168,193 (GRCm39) missense possibly damaging 0.95
R6880:Vmn2r97 UTSW 17 19,134,770 (GRCm39) missense probably benign 0.00
R7012:Vmn2r97 UTSW 17 19,167,756 (GRCm39) missense probably damaging 0.99
R7023:Vmn2r97 UTSW 17 19,134,663 (GRCm39) missense probably damaging 1.00
R7044:Vmn2r97 UTSW 17 19,134,629 (GRCm39) missense probably benign 0.05
R7191:Vmn2r97 UTSW 17 19,150,548 (GRCm39) missense probably damaging 1.00
R7503:Vmn2r97 UTSW 17 19,148,470 (GRCm39) missense probably benign
R7862:Vmn2r97 UTSW 17 19,167,416 (GRCm39) missense probably damaging 1.00
R7876:Vmn2r97 UTSW 17 19,149,326 (GRCm39) missense probably damaging 0.97
R7890:Vmn2r97 UTSW 17 19,149,802 (GRCm39) missense probably benign 0.00
R7936:Vmn2r97 UTSW 17 19,150,662 (GRCm39) missense probably damaging 1.00
R7978:Vmn2r97 UTSW 17 19,167,854 (GRCm39) missense probably damaging 1.00
R8405:Vmn2r97 UTSW 17 19,134,802 (GRCm39) critical splice donor site probably null
R8755:Vmn2r97 UTSW 17 19,168,104 (GRCm39) missense probably damaging 1.00
R8790:Vmn2r97 UTSW 17 19,160,472 (GRCm39) missense probably damaging 1.00
R8850:Vmn2r97 UTSW 17 19,149,607 (GRCm39) missense probably benign 0.00
R9060:Vmn2r97 UTSW 17 19,134,585 (GRCm39) start codon destroyed probably null 0.94
R9079:Vmn2r97 UTSW 17 19,149,640 (GRCm39) missense probably benign
R9252:Vmn2r97 UTSW 17 19,167,849 (GRCm39) missense probably benign 0.00
R9278:Vmn2r97 UTSW 17 19,134,762 (GRCm39) missense probably benign 0.00
R9342:Vmn2r97 UTSW 17 19,149,368 (GRCm39) missense probably benign
R9422:Vmn2r97 UTSW 17 19,149,333 (GRCm39) missense probably benign 0.03
R9496:Vmn2r97 UTSW 17 19,149,227 (GRCm39) missense probably damaging 1.00
R9571:Vmn2r97 UTSW 17 19,149,919 (GRCm39) missense probably benign
R9601:Vmn2r97 UTSW 17 19,134,770 (GRCm39) missense probably benign
R9672:Vmn2r97 UTSW 17 19,149,442 (GRCm39) missense probably benign 0.00
R9773:Vmn2r97 UTSW 17 19,168,221 (GRCm39) missense probably benign 0.01
R9795:Vmn2r97 UTSW 17 19,167,561 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18