Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02934:Vmn2r97'

364209

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r97

Ensembl Gene

ENSMUSG00000091491

Gene Name

vomeronasal 2, receptor 97

Synonyms

EG627367

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

IGL02934

Quality Score

Status

Chromosome

Chromosomal Location

18914300-18958087 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 18929685 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 445 (V445A)

Ref Sequence

ENSEMBL: ENSMUSP00000129313 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168710] [ENSMUST00000232219]

AlphaFold

K7N6Z2

Predicted Effect

probably benign
Transcript: ENSMUST00000168710
AA Change: V445A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: V445A

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	82	442	2.9e-36	PFAM
Pfam:NCD3G	513	566	4.9e-21	PFAM
Pfam:7tm_3	599	834	1.7e-52	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000232219
AA Change: V445A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232325

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	A	T	3: 122,162,359	R716*	probably null	Het
Abca8a	A	T	11: 110,040,588	N1246K	probably damaging	Het
Acadl	A	G	1: 66,836,975	Y396H	probably benign	Het
Apol7c	A	T	15: 77,526,118	S209R	possibly damaging	Het
Atp1a1	A	T	3: 101,576,992	C990*	probably null	Het
Cachd1	C	T	4: 100,968,098	S583L	probably damaging	Het
Cbfa2t3	T	C	8: 122,647,758	T48A	probably benign	Het
Ccdc138	G	T	10: 58,573,580		probably benign	Het
Cenpe	A	G	3: 135,264,351	E2231G	probably damaging	Het
Cog3	T	C	14: 75,741,689	I206V	probably damaging	Het
Cr2	A	G	1: 195,154,325		probably benign	Het
Ctdspl2	T	C	2: 121,979,009	V147A	probably damaging	Het
Cyp4f13	A	G	17: 32,929,871	V300A	probably damaging	Het
Dkk3	A	T	7: 112,150,747	M72K	probably damaging	Het
Dock3	A	T	9: 107,023,745	F340L	probably benign	Het
Fut1	A	G	7: 45,618,703	H27R	possibly damaging	Het
Igkv4-80	A	G	6: 69,016,856	V17A	probably benign	Het
Igkv9-123	G	A	6: 67,954,396	P62L	possibly damaging	Het
Kmt2e	T	C	5: 23,497,884	S1021P	probably damaging	Het
Krt13	A	C	11: 100,119,084	L320R	probably damaging	Het
Ldhal6b	T	C	17: 5,417,544	T372A	probably benign	Het
Manba	T	C	3: 135,544,749	V379A	probably benign	Het
Map1b	C	T	13: 99,435,131	V361I	probably benign	Het
Map4k1	A	G	7: 28,994,106	S399G	probably benign	Het
Mff	G	A	1: 82,747,094	R229H	probably damaging	Het
Naga	T	C	15: 82,330,200	N370S	possibly damaging	Het
Ncor2	A	T	5: 125,025,557	M2045K	probably benign	Het
Nipal1	T	C	5: 72,647,907	L7P	probably damaging	Het
Olfr9	T	A	10: 128,990,089	M59K	probably damaging	Het
Pcmt1	A	T	10: 7,640,727	M187K	probably benign	Het
Perp	A	T	10: 18,855,772	T160S	probably damaging	Het
Rapgef6	G	A	11: 54,625,864	D169N	probably damaging	Het
Sel1l	G	A	12: 91,809,936	Q711*	probably null	Het
Sept5	T	C	16: 18,629,831	Y7C	probably damaging	Het
Spdya	A	T	17: 71,556,400	N48I	probably benign	Het
Stard6	T	A	18: 70,496,104		probably benign	Het
Sytl2	T	C	7: 90,375,992	V396A	probably benign	Het
Tcaf3	T	G	6: 42,593,898	M307L	probably benign	Het
Tdrd6	T	C	17: 43,627,887	N757D	probably benign	Het
Tgm1	T	A	14: 55,709,989	D305V	probably damaging	Het
Themis2	T	A	4: 132,789,551	M213L	probably damaging	Het
Tmem184c	A	G	8: 77,597,820	V347A	probably damaging	Het
Tmem214	A	G	5: 30,871,544	E159G	probably benign	Het
Trim58	C	T	11: 58,640,466		probably benign	Het
Tshz1	A	T	18: 84,013,090	S1064R	probably damaging	Het
Ubr2	C	T	17: 46,957,340	E983K	possibly damaging	Het
Vmn1r23	A	T	6: 57,925,929	I288N	probably benign	Het
Whrn	G	A	4: 63,416,105	T813M	probably damaging	Het
Xirp2	C	T	2: 67,515,676	H2754Y	probably benign	Het

Other mutations in Vmn2r97

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r97	APN	17	18947659	missense	probably benign	0.37
IGL00962:Vmn2r97	APN	17	18929228	missense	probably damaging	1.00
IGL01704:Vmn2r97	APN	17	18947811	missense	probably damaging	0.99
IGL01888:Vmn2r97	APN	17	18929024	nonsense	probably null
IGL02429:Vmn2r97	APN	17	18930334	missense	possibly damaging	0.94
IGL02742:Vmn2r97	APN	17	18929170	missense	probably damaging	0.97
IGL02978:Vmn2r97	APN	17	18948036	missense	probably benign	0.01
IGL03230:Vmn2r97	APN	17	18929406	missense	probably benign	0.10
IGL03241:Vmn2r97	APN	17	18928176	missense	probably benign	0.11
IGL03050:Vmn2r97	UTSW	17	18947638	missense	possibly damaging	0.84
PIT4469001:Vmn2r97	UTSW	17	18929616	missense	probably benign	0.00
R0482:Vmn2r97	UTSW	17	18947668	missense	probably damaging	1.00
R0514:Vmn2r97	UTSW	17	18914472	missense	probably benign	0.25
R0944:Vmn2r97	UTSW	17	18947403	missense	probably benign	0.13
R1061:Vmn2r97	UTSW	17	18928178	nonsense	probably null
R1546:Vmn2r97	UTSW	17	18947848	missense	probably damaging	1.00
R1725:Vmn2r97	UTSW	17	18929135	missense	probably benign	0.43
R1860:Vmn2r97	UTSW	17	18947386	missense	probably benign	0.01
R1938:Vmn2r97	UTSW	17	18929331	missense	probably benign	0.01
R1944:Vmn2r97	UTSW	17	18940238	missense	probably benign	0.00
R2027:Vmn2r97	UTSW	17	18929682	missense	unknown
R2106:Vmn2r97	UTSW	17	18947838	missense	probably damaging	1.00
R2151:Vmn2r97	UTSW	17	18947322	nonsense	probably null
R2153:Vmn2r97	UTSW	17	18947322	nonsense	probably null
R2154:Vmn2r97	UTSW	17	18947322	nonsense	probably null
R2516:Vmn2r97	UTSW	17	18947552	missense	probably benign
R3739:Vmn2r97	UTSW	17	18928151	missense	probably damaging	1.00
R3744:Vmn2r97	UTSW	17	18929628	missense	probably benign
R3885:Vmn2r97	UTSW	17	18928334	missense	possibly damaging	0.90
R3899:Vmn2r97	UTSW	17	18947611	missense	probably damaging	0.96
R4115:Vmn2r97	UTSW	17	18928070	missense	probably benign	0.01
R4247:Vmn2r97	UTSW	17	18947280	missense	possibly damaging	0.83
R4287:Vmn2r97	UTSW	17	18948075	intron	probably benign
R4439:Vmn2r97	UTSW	17	18930354	missense	probably benign	0.00
R4523:Vmn2r97	UTSW	17	18929071	missense	probably benign	0.03
R4783:Vmn2r97	UTSW	17	18929288	missense	probably benign
R4948:Vmn2r97	UTSW	17	18947299	missense	possibly damaging	0.95
R4981:Vmn2r97	UTSW	17	18940174	nonsense	probably null
R5029:Vmn2r97	UTSW	17	18947911	missense	probably damaging	1.00
R5200:Vmn2r97	UTSW	17	18928353	missense	probably damaging	1.00
R5541:Vmn2r97	UTSW	17	18928355	nonsense	probably null
R5637:Vmn2r97	UTSW	17	18947366	nonsense	probably null
R5765:Vmn2r97	UTSW	17	18947180	nonsense	probably null
R5885:Vmn2r97	UTSW	17	18947773	missense	possibly damaging	0.50
R6272:Vmn2r97	UTSW	17	18947599	missense	possibly damaging	0.70
R6553:Vmn2r97	UTSW	17	18930304	nonsense	probably null
R6818:Vmn2r97	UTSW	17	18947931	missense	possibly damaging	0.95
R6880:Vmn2r97	UTSW	17	18914508	missense	probably benign	0.00
R7012:Vmn2r97	UTSW	17	18947494	missense	probably damaging	0.99
R7023:Vmn2r97	UTSW	17	18914401	missense	probably damaging	1.00
R7044:Vmn2r97	UTSW	17	18914367	missense	probably benign	0.05
R7191:Vmn2r97	UTSW	17	18930286	missense	probably damaging	1.00
R7503:Vmn2r97	UTSW	17	18928208	missense	probably benign
R7862:Vmn2r97	UTSW	17	18947154	missense	probably damaging	1.00
R7876:Vmn2r97	UTSW	17	18929064	missense	probably damaging	0.97
R7890:Vmn2r97	UTSW	17	18929540	missense	probably benign	0.00
R7936:Vmn2r97	UTSW	17	18930400	missense	probably damaging	1.00
R7978:Vmn2r97	UTSW	17	18947592	missense	probably damaging	1.00
R8405:Vmn2r97	UTSW	17	18914540	critical splice donor site	probably null
R8755:Vmn2r97	UTSW	17	18947842	missense	probably damaging	1.00
R8790:Vmn2r97	UTSW	17	18940210	missense	probably damaging	1.00
R8850:Vmn2r97	UTSW	17	18929345	missense	probably benign	0.00
R9060:Vmn2r97	UTSW	17	18914323	start codon destroyed	probably null	0.94
R9079:Vmn2r97	UTSW	17	18929378	missense	probably benign
R9252:Vmn2r97	UTSW	17	18947587	missense	probably benign	0.00
R9278:Vmn2r97	UTSW	17	18914500	missense	probably benign	0.00
R9342:Vmn2r97	UTSW	17	18929106	missense	probably benign
R9422:Vmn2r97	UTSW	17	18929071	missense	probably benign	0.03
R9496:Vmn2r97	UTSW	17	18928965	missense	probably damaging	1.00
R9571:Vmn2r97	UTSW	17	18929657	missense	probably benign
R9601:Vmn2r97	UTSW	17	18914508	missense	probably benign
R9672:Vmn2r97	UTSW	17	18929180	missense	probably benign	0.00
R9773:Vmn2r97	UTSW	17	18947959	missense	probably benign	0.01
R9795:Vmn2r97	UTSW	17	18947299	missense	probably damaging	1.00

Posted On

2015-12-18