Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02936:Fbxw24'

364336

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fbxw24

Ensembl Gene

ENSMUSG00000062275

Gene Name

F-box and WD-40 domain protein 24

Synonyms

Gm5162

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

IGL02936

Quality Score

Status

Chromosome

Chromosomal Location

109430184-109455125 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 109454026 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000073617 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073962]

AlphaFold

E9PXM9

Predicted Effect

probably null
Transcript: ENSMUST00000073962

SMART Domains

Protein: ENSMUSP00000073617
Gene: ENSMUSG00000062275

Domain	Start	End	E-Value	Type
FBOX	8	45	3.25e-4	SMART
SCOP:d1gxra_	87	227	8e-7	SMART
Blast:WD40	137	176	1e-6	BLAST

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017B05Rik	G	A	9: 57,165,687 (GRCm39)	T229I	possibly damaging	Het
Acad11	T	C	9: 103,990,711 (GRCm39)	S439P	probably benign	Het
Acer2	A	T	4: 86,818,796 (GRCm39)	N148I	possibly damaging	Het
Adgre1	A	G	17: 57,785,833 (GRCm39)	I860V	probably benign	Het
Asb2	A	G	12: 103,302,173 (GRCm39)	I125T	probably benign	Het
Atp13a2	G	T	4: 140,729,260 (GRCm39)	L614F	probably benign	Het
Car7	A	G	8: 105,274,854 (GRCm39)	T132A	possibly damaging	Het
Cfap221	T	C	1: 119,912,482 (GRCm39)	D135G	probably damaging	Het
Crtc3	A	G	7: 80,239,511 (GRCm39)	F614L	probably damaging	Het
Csn3	T	G	5: 88,077,992 (GRCm39)	I166S	possibly damaging	Het
Dna2	T	G	10: 62,792,879 (GRCm39)	L298R	probably damaging	Het
Ece1	T	C	4: 137,673,612 (GRCm39)	S387P	probably benign	Het
Fbxo28	C	T	1: 182,169,093 (GRCm39)	G15D	unknown	Het
Foxd3	T	A	4: 99,545,052 (GRCm39)	V64E	probably benign	Het
Galnt7	A	C	8: 58,037,248 (GRCm39)	V47G	probably benign	Het
Gcc2	A	T	10: 58,131,962 (GRCm39)	L1453F	probably damaging	Het
Gcnt4	G	A	13: 97,082,919 (GRCm39)	V72I	probably benign	Het
Gm10269	A	C	18: 20,816,010 (GRCm39)		probably null	Het
Hmcn1	T	G	1: 150,573,273 (GRCm39)	Q2125H	probably damaging	Het
Iho1	T	C	9: 108,289,702 (GRCm39)	I173M	possibly damaging	Het
Llcfc1	T	A	6: 41,661,593 (GRCm39)	S48T	probably benign	Het
Met	G	T	6: 17,553,396 (GRCm39)	V1061F	probably damaging	Het
Mthfd2	G	A	6: 83,288,342 (GRCm39)	H138Y	probably damaging	Het
Mtus1	A	T	8: 41,452,554 (GRCm39)	D1041E	possibly damaging	Het
Mug2	G	A	6: 122,058,346 (GRCm39)		probably null	Het
Nos3	C	T	5: 24,585,991 (GRCm39)	T878I	probably damaging	Het
Or4c15	A	G	2: 88,760,128 (GRCm39)	M177T	probably benign	Het
Or52b1	A	T	7: 104,979,212 (GRCm39)	Y62*	probably null	Het
Pbrm1	T	A	14: 30,783,470 (GRCm39)	V497D	probably damaging	Het
Plcd1	T	C	9: 118,903,267 (GRCm39)	E471G	probably damaging	Het
Poc1a	A	G	9: 106,162,226 (GRCm39)	T84A	probably damaging	Het
Ppm1f	A	G	16: 16,733,100 (GRCm39)	H209R	probably damaging	Het
Rccd1	T	A	7: 79,966,794 (GRCm39)	K329N	probably damaging	Het
Serpinb9g	A	T	13: 33,678,865 (GRCm39)	N245I	possibly damaging	Het
Slc22a26	A	C	19: 7,768,470 (GRCm39)	F196V	probably damaging	Het
Tial1	G	A	7: 128,044,387 (GRCm39)		probably benign	Het
Trpa1	A	T	1: 14,946,193 (GRCm39)		probably null	Het
Vmn1r15	A	T	6: 57,235,803 (GRCm39)	K224*	probably null	Het
Wdr72	A	T	9: 74,059,862 (GRCm39)	D424V	probably damaging	Het
Wt1	A	G	2: 104,999,384 (GRCm39)	K308E	probably damaging	Het
Zwint	T	C	10: 72,492,956 (GRCm39)	S193P	probably damaging	Het

Other mutations in Fbxw24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01093:Fbxw24	APN	9	109,434,041 (GRCm39)	missense	probably benign	0.00
IGL01373:Fbxw24	APN	9	109,452,701 (GRCm39)	missense	probably damaging	0.98
IGL01996:Fbxw24	APN	9	109,434,440 (GRCm39)	missense	possibly damaging	0.84
IGL02179:Fbxw24	APN	9	109,438,973 (GRCm39)	nonsense	probably null
IGL02718:Fbxw24	APN	9	109,453,858 (GRCm39)	missense	possibly damaging	0.55
IGL03010:Fbxw24	APN	9	109,452,678 (GRCm39)	missense	probably benign	0.07
IGL03350:Fbxw24	APN	9	109,436,081 (GRCm39)	missense	probably damaging	1.00
IGL03402:Fbxw24	APN	9	109,430,316 (GRCm39)	missense	probably damaging	1.00
R0140:Fbxw24	UTSW	9	109,434,482 (GRCm39)	missense	possibly damaging	0.73
R0718:Fbxw24	UTSW	9	109,452,577 (GRCm39)	splice site	probably benign
R1166:Fbxw24	UTSW	9	109,436,066 (GRCm39)	missense	probably benign	0.00
R1550:Fbxw24	UTSW	9	109,436,112 (GRCm39)	missense	probably benign	0.00
R1950:Fbxw24	UTSW	9	109,434,481 (GRCm39)	missense	probably benign	0.02
R1986:Fbxw24	UTSW	9	109,436,124 (GRCm39)	missense	probably damaging	0.97
R2244:Fbxw24	UTSW	9	109,434,117 (GRCm39)	missense	possibly damaging	0.66
R3683:Fbxw24	UTSW	9	109,437,110 (GRCm39)	missense	possibly damaging	0.51
R4324:Fbxw24	UTSW	9	109,434,013 (GRCm39)	critical splice donor site	probably null
R4387:Fbxw24	UTSW	9	109,439,053 (GRCm39)	missense	probably damaging	1.00
R4409:Fbxw24	UTSW	9	109,437,256 (GRCm39)	missense	probably damaging	1.00
R4410:Fbxw24	UTSW	9	109,437,256 (GRCm39)	missense	probably damaging	1.00
R4803:Fbxw24	UTSW	9	109,453,910 (GRCm39)	missense	probably benign	0.02
R5571:Fbxw24	UTSW	9	109,436,066 (GRCm39)	missense	probably benign	0.00
R6042:Fbxw24	UTSW	9	109,436,079 (GRCm39)	missense	probably benign	0.09
R6523:Fbxw24	UTSW	9	109,434,048 (GRCm39)	nonsense	probably null
R6799:Fbxw24	UTSW	9	109,453,998 (GRCm39)	missense	probably damaging	1.00
R7122:Fbxw24	UTSW	9	109,430,328 (GRCm39)	missense	probably benign	0.03
R7239:Fbxw24	UTSW	9	109,434,598 (GRCm39)	missense	possibly damaging	0.71
R7405:Fbxw24	UTSW	9	109,436,136 (GRCm39)	missense	possibly damaging	0.46
R7705:Fbxw24	UTSW	9	109,437,516 (GRCm39)	splice site	probably null
R8536:Fbxw24	UTSW	9	109,452,599 (GRCm39)	missense	probably damaging	1.00
R8873:Fbxw24	UTSW	9	109,453,996 (GRCm39)	missense	probably damaging	1.00
R9332:Fbxw24	UTSW	9	109,452,681 (GRCm39)	missense	probably damaging	1.00
R9430:Fbxw24	UTSW	9	109,439,038 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-12-18