Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02936:Trpa1'

364338

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trpa1

Ensembl Gene

ENSMUSG00000032769

Gene Name

transient receptor potential cation channel, subfamily A, member 1

Synonyms

ANKTM1

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.163) question?

Stock #

IGL02936

Quality Score

Status

Chromosome

Chromosomal Location

14872648-14918862 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 14875969 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000043594 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041447] [ENSMUST00000041447] [ENSMUST00000041447]

Predicted Effect

probably null
Transcript: ENSMUST00000041447

SMART Domains

Protein: ENSMUSP00000043594
Gene: ENSMUSG00000032769

Domain	Start	End	E-Value	Type
ANK	63	94	1.01e2	SMART
ANK	98	127	9.7e-8	SMART
ANK	131	161	1.36e-2	SMART
ANK	165	194	5.45e-2	SMART
ANK	198	226	3.07e2	SMART
ANK	239	268	1.99e-4	SMART
ANK	272	302	1.33e2	SMART
ANK	309	338	4.19e-3	SMART
ANK	342	371	2.34e-1	SMART
ANK	413	442	3.41e-3	SMART
ANK	446	475	5.75e-1	SMART
ANK	482	511	4.1e-6	SMART
ANK	514	543	1.68e-2	SMART
ANK	548	577	4.97e-5	SMART
Blast:ANK	580	609	2e-11	BLAST
Pfam:Ion_trans	736	975	1.8e-11	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000041447

SMART Domains

Protein: ENSMUSP00000043594
Gene: ENSMUSG00000032769

Domain	Start	End	E-Value	Type
ANK	63	94	1.01e2	SMART
ANK	98	127	9.7e-8	SMART
ANK	131	161	1.36e-2	SMART
ANK	165	194	5.45e-2	SMART
ANK	198	226	3.07e2	SMART
ANK	239	268	1.99e-4	SMART
ANK	272	302	1.33e2	SMART
ANK	309	338	4.19e-3	SMART
ANK	342	371	2.34e-1	SMART
ANK	413	442	3.41e-3	SMART
ANK	446	475	5.75e-1	SMART
ANK	482	511	4.1e-6	SMART
ANK	514	543	1.68e-2	SMART
ANK	548	577	4.97e-5	SMART
Blast:ANK	580	609	2e-11	BLAST
Pfam:Ion_trans	736	975	1.8e-11	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000041447

SMART Domains

Protein: ENSMUSP00000043594
Gene: ENSMUSG00000032769

Domain	Start	End	E-Value	Type
ANK	63	94	1.01e2	SMART
ANK	98	127	9.7e-8	SMART
ANK	131	161	1.36e-2	SMART
ANK	165	194	5.45e-2	SMART
ANK	198	226	3.07e2	SMART
ANK	239	268	1.99e-4	SMART
ANK	272	302	1.33e2	SMART
ANK	309	338	4.19e-3	SMART
ANK	342	371	2.34e-1	SMART
ANK	413	442	3.41e-3	SMART
ANK	446	475	5.75e-1	SMART
ANK	482	511	4.1e-6	SMART
ANK	514	543	1.68e-2	SMART
ANK	548	577	4.97e-5	SMART
Blast:ANK	580	609	2e-11	BLAST
Pfam:Ion_trans	736	975	1.8e-11	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in altered nociception and neuron responses to isothiocyanate or thiosulfinate compounds like those found in mustard oil and garlic. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017B05Rik	G	A	9: 57,258,404	T229I	possibly damaging	Het
Acad11	T	C	9: 104,113,512	S439P	probably benign	Het
Acer2	A	T	4: 86,900,559	N148I	possibly damaging	Het
Adgre1	A	G	17: 57,478,833	I860V	probably benign	Het
Asb2	A	G	12: 103,335,914	I125T	probably benign	Het
Atp13a2	G	T	4: 141,001,949	L614F	probably benign	Het
Car7	A	G	8: 104,548,222	T132A	possibly damaging	Het
Ccdc36	T	C	9: 108,412,503	I173M	possibly damaging	Het
Cfap221	T	C	1: 119,984,752	D135G	probably damaging	Het
Crtc3	A	G	7: 80,589,763	F614L	probably damaging	Het
Csn3	T	G	5: 87,930,133	I166S	possibly damaging	Het
Dna2	T	G	10: 62,957,100	L298R	probably damaging	Het
Ece1	T	C	4: 137,946,301	S387P	probably benign	Het
Fbxo28	C	T	1: 182,341,528	G15D	unknown	Het
Fbxw24	A	T	9: 109,624,958		probably null	Het
Foxd3	T	A	4: 99,656,815	V64E	probably benign	Het
Galnt7	A	C	8: 57,584,214	V47G	probably benign	Het
Gcc2	A	T	10: 58,296,140	L1453F	probably damaging	Het
Gcnt4	G	A	13: 96,946,411	V72I	probably benign	Het
Gm10269	A	C	18: 20,682,953		probably null	Het
Hmcn1	T	G	1: 150,697,522	Q2125H	probably damaging	Het
Llcfc1	T	A	6: 41,684,659	S48T	probably benign	Het
Met	G	T	6: 17,553,397	V1061F	probably damaging	Het
Mthfd2	G	A	6: 83,311,360	H138Y	probably damaging	Het
Mtus1	A	T	8: 40,999,517	D1041E	possibly damaging	Het
Mug2	G	A	6: 122,081,387		probably null	Het
Nos3	C	T	5: 24,380,993	T878I	probably damaging	Het
Olfr1211	A	G	2: 88,929,784	M177T	probably benign	Het
Olfr690	A	T	7: 105,330,005	Y62*	probably null	Het
Pbrm1	T	A	14: 31,061,513	V497D	probably damaging	Het
Plcd1	T	C	9: 119,074,199	E471G	probably damaging	Het
Poc1a	A	G	9: 106,285,027	T84A	probably damaging	Het
Ppm1f	A	G	16: 16,915,236	H209R	probably damaging	Het
Rccd1	T	A	7: 80,317,046	K329N	probably damaging	Het
Serpinb9g	A	T	13: 33,494,882	N245I	possibly damaging	Het
Slc22a26	A	C	19: 7,791,105	F196V	probably damaging	Het
Tial1	G	A	7: 128,442,663		probably benign	Het
Vmn1r15	A	T	6: 57,258,818	K224*	probably null	Het
Wdr72	A	T	9: 74,152,580	D424V	probably damaging	Het
Wt1	A	G	2: 105,169,039	K308E	probably damaging	Het
Zwint	T	C	10: 72,657,124	S193P	probably damaging	Het

Other mutations in Trpa1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00801:Trpa1	APN	1	14891333	missense	probably damaging	0.97
IGL00937:Trpa1	APN	1	14880277	splice site	probably benign
IGL00957:Trpa1	APN	1	14881668	missense	probably damaging	0.99
IGL01307:Trpa1	APN	1	14896547	missense	probably benign	0.23
IGL01336:Trpa1	APN	1	14886880	splice site	probably benign
IGL01408:Trpa1	APN	1	14889413	missense	probably benign	0.03
IGL01504:Trpa1	APN	1	14882219	missense	possibly damaging	0.79
IGL01543:Trpa1	APN	1	14900076	missense	probably damaging	1.00
IGL01609:Trpa1	APN	1	14912383	missense	probably damaging	0.99
IGL01895:Trpa1	APN	1	14887643	missense	possibly damaging	0.87
IGL02449:Trpa1	APN	1	14898157	missense	probably damaging	1.00
fear-2	UTSW	1	14891303	critical splice donor site	probably null
petrified	UTSW	1	14884116	missense	probably damaging	1.00
R0008:Trpa1	UTSW	1	14903215	missense	possibly damaging	0.53
R0008:Trpa1	UTSW	1	14903215	missense	possibly damaging	0.53
R0317:Trpa1	UTSW	1	14881632	missense	probably benign	0.03
R0454:Trpa1	UTSW	1	14885748	critical splice donor site	probably null
R0828:Trpa1	UTSW	1	14875884	missense	probably damaging	1.00
R0944:Trpa1	UTSW	1	14912361	splice site	probably null
R0962:Trpa1	UTSW	1	14898163	missense	possibly damaging	0.61
R1025:Trpa1	UTSW	1	14904183	missense	probably benign	0.01
R1035:Trpa1	UTSW	1	14891303	critical splice donor site	probably null
R1134:Trpa1	UTSW	1	14881748	missense	possibly damaging	0.95
R1278:Trpa1	UTSW	1	14918723	critical splice donor site	probably null
R1497:Trpa1	UTSW	1	14885812	missense	probably benign	0.30
R1617:Trpa1	UTSW	1	14873675	missense	probably damaging	1.00
R1800:Trpa1	UTSW	1	14874424	missense	probably benign	0.04
R1856:Trpa1	UTSW	1	14899388	nonsense	probably null
R1886:Trpa1	UTSW	1	14889425	missense	probably benign	0.00
R2004:Trpa1	UTSW	1	14905983	missense	possibly damaging	0.83
R2152:Trpa1	UTSW	1	14899401	missense	probably damaging	1.00
R2172:Trpa1	UTSW	1	14881656	missense	probably benign	0.01
R2198:Trpa1	UTSW	1	14910746	missense	probably benign
R2221:Trpa1	UTSW	1	14903256	missense	probably null	0.12
R2223:Trpa1	UTSW	1	14903256	missense	probably null	0.12
R2307:Trpa1	UTSW	1	14912381	missense	probably benign	0.00
R2338:Trpa1	UTSW	1	14884245	missense	probably damaging	0.97
R2698:Trpa1	UTSW	1	14905998	missense	probably damaging	1.00
R2872:Trpa1	UTSW	1	14887620	missense	probably damaging	1.00
R2872:Trpa1	UTSW	1	14887620	missense	probably damaging	1.00
R2873:Trpa1	UTSW	1	14887620	missense	probably damaging	1.00
R2874:Trpa1	UTSW	1	14887620	missense	probably damaging	1.00
R3418:Trpa1	UTSW	1	14874381	missense	probably benign	0.01
R3419:Trpa1	UTSW	1	14874381	missense	probably benign	0.01
R3796:Trpa1	UTSW	1	14893264	missense	possibly damaging	0.74
R3799:Trpa1	UTSW	1	14893264	missense	possibly damaging	0.74
R4238:Trpa1	UTSW	1	14884116	missense	probably damaging	1.00
R4320:Trpa1	UTSW	1	14874452	missense	probably benign	0.00
R4591:Trpa1	UTSW	1	14882108	splice site	probably null
R4834:Trpa1	UTSW	1	14896523	missense	possibly damaging	0.72
R4991:Trpa1	UTSW	1	14910746	missense	probably benign	0.00
R4999:Trpa1	UTSW	1	14875861	missense	probably benign	0.05
R5038:Trpa1	UTSW	1	14910866	missense	probably damaging	1.00
R5055:Trpa1	UTSW	1	14875959	missense	probably damaging	1.00
R5158:Trpa1	UTSW	1	14881661	missense	probably benign	0.01
R5193:Trpa1	UTSW	1	14875917	missense	possibly damaging	0.92
R5558:Trpa1	UTSW	1	14898268	missense	probably damaging	1.00
R5578:Trpa1	UTSW	1	14887008	missense	probably damaging	1.00
R5680:Trpa1	UTSW	1	14875854	missense	probably benign	0.00
R5738:Trpa1	UTSW	1	14875950	missense	probably damaging	1.00
R5801:Trpa1	UTSW	1	14898078	missense	probably damaging	1.00
R5945:Trpa1	UTSW	1	14898135	missense	probably benign	0.03
R6092:Trpa1	UTSW	1	14889486	missense	probably damaging	1.00
R6776:Trpa1	UTSW	1	14912377	missense	probably benign
R7126:Trpa1	UTSW	1	14890424	missense	probably benign	0.00
R7154:Trpa1	UTSW	1	14882233	missense	possibly damaging	0.46
R7175:Trpa1	UTSW	1	14893207	missense	possibly damaging	0.90
R7258:Trpa1	UTSW	1	14903249	missense	probably damaging	1.00
R7358:Trpa1	UTSW	1	14898110	missense	probably damaging	1.00
R7412:Trpa1	UTSW	1	14884198	missense	probably benign	0.43
R7639:Trpa1	UTSW	1	14886913	missense	probably benign	0.00
R7740:Trpa1	UTSW	1	14912401	missense	possibly damaging	0.72
R7815:Trpa1	UTSW	1	14904262	missense	probably benign	0.01
R7854:Trpa1	UTSW	1	14881694	missense	probably benign	0.00
R8112:Trpa1	UTSW	1	14904266	missense	probably benign
R8217:Trpa1	UTSW	1	14887023	missense	probably damaging	0.97
X0028:Trpa1	UTSW	1	14890420	missense	probably benign	0.16
Z1176:Trpa1	UTSW	1	14881692	missense	probably damaging	1.00
Z1176:Trpa1	UTSW	1	14891306	missense	possibly damaging	0.80
Z1176:Trpa1	UTSW	1	14898350	missense	probably damaging	1.00

Posted On

2015-12-18