Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02937:Cyp4f37'

364342

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp4f37

Ensembl Gene

ENSMUSG00000062464

Gene Name

cytochrome P450, family 4, subfamily f, polypeptide 37

Synonyms

Gm9705

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.222) question?

Stock #

IGL02937

Quality Score

Status

Chromosome

Chromosomal Location

32840283-32855158 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 32844163 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 89 (L89P)

Ref Sequence

ENSEMBL: ENSMUSP00000076827 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077639]

AlphaFold

Q3V1F1

Predicted Effect

probably benign
Transcript: ENSMUST00000077639
AA Change: L89P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000076827
Gene: ENSMUSG00000062464
AA Change: L89P

Domain	Start	End	E-Value	Type
Pfam:p450	52	515	1.1e-136	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931406C07Rik	C	T	9: 15,206,049 (GRCm39)	C21Y	probably damaging	Het
4933427D06Rik	T	C	6: 89,085,127 (GRCm39)		noncoding transcript	Het
5730480H06Rik	A	G	5: 48,536,783 (GRCm39)	I160V	probably benign	Het
Arhgap29	G	A	3: 121,767,698 (GRCm39)	E47K	probably damaging	Het
Arhgef12	T	A	9: 42,927,216 (GRCm39)	S303C	probably damaging	Het
Bap1	A	G	14: 30,980,284 (GRCm39)	N644S	probably benign	Het
Cc2d1b	A	G	4: 108,489,091 (GRCm39)	E796G	probably damaging	Het
Cfh	C	A	1: 140,033,180 (GRCm39)	R788L	probably benign	Het
Cldn1	A	G	16: 26,179,623 (GRCm39)	F148S	probably damaging	Het
Cryzl1	A	G	16: 91,487,619 (GRCm39)	M292T	possibly damaging	Het
Cyp11b1	T	C	15: 74,708,408 (GRCm39)	R385G	possibly damaging	Het
Dach1	A	G	14: 98,153,231 (GRCm39)		probably null	Het
Dhtkd1	A	G	2: 5,922,716 (GRCm39)	I481T	possibly damaging	Het
Dlx5	A	T	6: 6,881,755 (GRCm39)	D44E	probably damaging	Het
Dsg1a	T	A	18: 20,464,591 (GRCm39)	I362N	possibly damaging	Het
Ecm2	T	A	13: 49,671,952 (GRCm39)	I151N	probably damaging	Het
Far1	T	A	7: 113,139,855 (GRCm39)	I101N	probably damaging	Het
Gm21985	T	C	2: 112,172,207 (GRCm39)	S384P	probably benign	Het
Gnb5	T	C	9: 75,247,471 (GRCm39)	Y247H	probably damaging	Het
Golgb1	A	G	16: 36,736,572 (GRCm39)	K1940E	probably damaging	Het
Gprc5b	A	G	7: 118,583,017 (GRCm39)	V284A	probably benign	Het
Idh2	T	C	7: 79,748,661 (GRCm39)	Y179C	probably damaging	Het
Kalrn	G	A	16: 34,040,500 (GRCm39)	Q737*	probably null	Het
Kcnj13	T	C	1: 87,314,175 (GRCm39)	D349G	probably damaging	Het
Lgsn	A	T	1: 31,243,318 (GRCm39)	T467S	possibly damaging	Het
Map9	T	A	3: 82,270,819 (GRCm39)	S128T	possibly damaging	Het
Mroh5	A	G	15: 73,661,827 (GRCm39)	C455R	probably damaging	Het
Nes	A	G	3: 87,887,186 (GRCm39)	H1771R	probably benign	Het
Nkain2	T	C	10: 32,205,840 (GRCm39)	Y65C	probably damaging	Het
Or51a43	T	A	7: 103,718,056 (GRCm39)	M61L	probably damaging	Het
Or51b6b	A	T	7: 103,310,112 (GRCm39)	V115D	probably damaging	Het
Or6aa1	T	C	7: 86,043,798 (GRCm39)	K303E	possibly damaging	Het
Pabpc4l	A	C	3: 46,400,725 (GRCm39)	D306E	probably benign	Het
Parp12	A	T	6: 39,079,515 (GRCm39)	Y332N	probably damaging	Het
Parvb	A	T	15: 84,193,154 (GRCm39)	K316M	probably damaging	Het
Pde8a	T	A	7: 80,945,519 (GRCm39)		probably benign	Het
Polq	A	G	16: 36,833,471 (GRCm39)	T55A	probably benign	Het
Ppp2r5b	T	A	19: 6,281,016 (GRCm39)	K271M	probably damaging	Het
Ralgapb	A	G	2: 158,334,936 (GRCm39)		probably null	Het
Rigi	C	T	4: 40,229,661 (GRCm39)	C86Y	probably benign	Het
Skap2	T	C	6: 51,886,351 (GRCm39)	N175D	probably benign	Het
Slc44a3	A	G	3: 121,303,970 (GRCm39)		probably benign	Het
Smurf2	G	A	11: 106,736,873 (GRCm39)	H318Y	probably damaging	Het
Tbc1d23	T	C	16: 57,004,778 (GRCm39)	T460A	possibly damaging	Het
Tcerg1	T	C	18: 42,657,414 (GRCm39)	S299P	unknown	Het
Tll1	A	C	8: 64,658,319 (GRCm39)	Y33*	probably null	Het
Tmem59	A	T	4: 107,054,782 (GRCm39)	T196S	probably damaging	Het
Ttll4	C	A	1: 74,718,662 (GRCm39)	A171D	possibly damaging	Het
Ttn	T	C	2: 76,641,513 (GRCm39)	T13528A	possibly damaging	Het
Ttn	A	G	2: 76,717,621 (GRCm39)		probably benign	Het
Xpc	C	A	6: 91,477,119 (GRCm39)	G327W	probably damaging	Het
Zbtb7a	A	G	10: 80,980,132 (GRCm39)	S109G	probably benign	Het
Zfyve26	T	C	12: 79,285,794 (GRCm39)	M2328V	probably benign	Het

Other mutations in Cyp4f37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01140:Cyp4f37	APN	17	32,848,027 (GRCm39)	missense	probably benign	0.20
IGL01994:Cyp4f37	APN	17	32,844,150 (GRCm39)	nonsense	probably null
IGL02073:Cyp4f37	APN	17	32,846,825 (GRCm39)	missense	possibly damaging	0.59
IGL02145:Cyp4f37	APN	17	32,849,009 (GRCm39)	missense	probably benign	0.43
IGL02814:Cyp4f37	APN	17	32,853,645 (GRCm39)	missense	probably benign	0.01
IGL02873:Cyp4f37	APN	17	32,844,142 (GRCm39)	missense	probably benign	0.00
IGL03170:Cyp4f37	APN	17	32,844,093 (GRCm39)	splice site	probably benign
R0625:Cyp4f37	UTSW	17	32,853,652 (GRCm39)	missense	probably damaging	1.00
R1774:Cyp4f37	UTSW	17	32,848,864 (GRCm39)	missense	possibly damaging	0.59
R1871:Cyp4f37	UTSW	17	32,853,639 (GRCm39)	missense	probably damaging	1.00
R2232:Cyp4f37	UTSW	17	32,853,244 (GRCm39)	missense	probably benign	0.23
R2847:Cyp4f37	UTSW	17	32,848,099 (GRCm39)	missense	probably damaging	1.00
R2848:Cyp4f37	UTSW	17	32,848,099 (GRCm39)	missense	probably damaging	1.00
R4027:Cyp4f37	UTSW	17	32,850,646 (GRCm39)	missense	probably benign	0.00
R4463:Cyp4f37	UTSW	17	32,846,710 (GRCm39)	critical splice acceptor site	probably null
R4517:Cyp4f37	UTSW	17	32,850,566 (GRCm39)	missense	probably benign	0.00
R4573:Cyp4f37	UTSW	17	32,848,061 (GRCm39)	missense	probably benign	0.23
R4670:Cyp4f37	UTSW	17	32,844,126 (GRCm39)	missense	probably benign
R5752:Cyp4f37	UTSW	17	32,850,306 (GRCm39)	missense	probably damaging	1.00
R5930:Cyp4f37	UTSW	17	32,848,957 (GRCm39)	missense	possibly damaging	0.79
R6248:Cyp4f37	UTSW	17	32,848,864 (GRCm39)	missense	possibly damaging	0.59
R7412:Cyp4f37	UTSW	17	32,848,818 (GRCm39)	missense	possibly damaging	0.87
R7969:Cyp4f37	UTSW	17	32,844,181 (GRCm39)	missense	probably benign	0.00
R8066:Cyp4f37	UTSW	17	32,854,047 (GRCm39)	missense	probably benign	0.21
R8187:Cyp4f37	UTSW	17	32,854,171 (GRCm39)	missense	probably benign
R8303:Cyp4f37	UTSW	17	32,853,152 (GRCm39)	critical splice acceptor site	probably null
R8309:Cyp4f37	UTSW	17	32,853,952 (GRCm39)	missense	probably damaging	1.00
R8407:Cyp4f37	UTSW	17	32,853,158 (GRCm39)	missense	probably damaging	1.00
R8869:Cyp4f37	UTSW	17	32,844,096 (GRCm39)	missense	probably benign	0.01
R9054:Cyp4f37	UTSW	17	32,853,253 (GRCm39)	missense	probably benign	0.25
R9565:Cyp4f37	UTSW	17	32,844,205 (GRCm39)	missense	possibly damaging	0.79
R9674:Cyp4f37	UTSW	17	32,846,841 (GRCm39)	critical splice donor site	probably null
X0057:Cyp4f37	UTSW	17	32,844,198 (GRCm39)	missense	probably benign	0.01

Posted On

2015-12-18