Incidental Mutation 'IGL02937:Dach1'
| ID |
364392 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Dach1
|
| Ensembl Gene |
ENSMUSG00000055639 |
| Gene Name |
dachshund family transcription factor 1 |
| Synonyms |
Dac, E130112M23Rik |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
IGL02937
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
14 |
| Chromosomal Location |
98024289-98407201 bp(-) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
A to G
at 98153231 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000071464
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000069334]
[ENSMUST00000071533]
|
| AlphaFold |
Q9QYB2 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000069334
|
| SMART Domains |
Protein: ENSMUSP00000064970
Gene: ENSMUSG00000055639
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
53 |
N/A |
INTRINSIC |
|
low complexity region
|
61 |
97 |
N/A |
INTRINSIC |
|
low complexity region
|
102 |
156 |
N/A |
INTRINSIC |
|
Pfam:Ski_Sno
|
159 |
275 |
4.8e-53 |
PFAM |
|
low complexity region
|
318 |
334 |
N/A |
INTRINSIC |
|
low complexity region
|
443 |
470 |
N/A |
INTRINSIC |
|
SCOP:d1eq1a_
|
556 |
674 |
1e-3 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000071533
|
| SMART Domains |
Protein: ENSMUSP00000071464
Gene: ENSMUSG00000055639
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
53 |
N/A |
INTRINSIC |
|
low complexity region
|
61 |
97 |
N/A |
INTRINSIC |
|
low complexity region
|
102 |
156 |
N/A |
INTRINSIC |
|
Pfam:Ski_Sno
|
164 |
274 |
6.5e-42 |
PFAM |
|
low complexity region
|
318 |
334 |
N/A |
INTRINSIC |
|
low complexity region
|
495 |
522 |
N/A |
INTRINSIC |
|
SCOP:d1eq1a_
|
608 |
726 |
6e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156684
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
PHENOTYPE: In spite of normal gross morphology, mice homozygous for targeted mutations that inactivate this gene die within 1 day of birth. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 53 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931406C07Rik |
C |
T |
9: 15,206,049 (GRCm39) |
C21Y |
probably damaging |
Het |
| 4933427D06Rik |
T |
C |
6: 89,085,127 (GRCm39) |
|
noncoding transcript |
Het |
| 5730480H06Rik |
A |
G |
5: 48,536,783 (GRCm39) |
I160V |
probably benign |
Het |
| Arhgap29 |
G |
A |
3: 121,767,698 (GRCm39) |
E47K |
probably damaging |
Het |
| Arhgef12 |
T |
A |
9: 42,927,216 (GRCm39) |
S303C |
probably damaging |
Het |
| Bap1 |
A |
G |
14: 30,980,284 (GRCm39) |
N644S |
probably benign |
Het |
| Cc2d1b |
A |
G |
4: 108,489,091 (GRCm39) |
E796G |
probably damaging |
Het |
| Cfh |
C |
A |
1: 140,033,180 (GRCm39) |
R788L |
probably benign |
Het |
| Cldn1 |
A |
G |
16: 26,179,623 (GRCm39) |
F148S |
probably damaging |
Het |
| Cryzl1 |
A |
G |
16: 91,487,619 (GRCm39) |
M292T |
possibly damaging |
Het |
| Cyp11b1 |
T |
C |
15: 74,708,408 (GRCm39) |
R385G |
possibly damaging |
Het |
| Cyp4f37 |
T |
C |
17: 32,844,163 (GRCm39) |
L89P |
probably benign |
Het |
| Dhtkd1 |
A |
G |
2: 5,922,716 (GRCm39) |
I481T |
possibly damaging |
Het |
| Dlx5 |
A |
T |
6: 6,881,755 (GRCm39) |
D44E |
probably damaging |
Het |
| Dsg1a |
T |
A |
18: 20,464,591 (GRCm39) |
I362N |
possibly damaging |
Het |
| Ecm2 |
T |
A |
13: 49,671,952 (GRCm39) |
I151N |
probably damaging |
Het |
| Far1 |
T |
A |
7: 113,139,855 (GRCm39) |
I101N |
probably damaging |
Het |
| Gm21985 |
T |
C |
2: 112,172,207 (GRCm39) |
S384P |
probably benign |
Het |
| Gnb5 |
T |
C |
9: 75,247,471 (GRCm39) |
Y247H |
probably damaging |
Het |
| Golgb1 |
A |
G |
16: 36,736,572 (GRCm39) |
K1940E |
probably damaging |
Het |
| Gprc5b |
A |
G |
7: 118,583,017 (GRCm39) |
V284A |
probably benign |
Het |
| Idh2 |
T |
C |
7: 79,748,661 (GRCm39) |
Y179C |
probably damaging |
Het |
| Kalrn |
G |
A |
16: 34,040,500 (GRCm39) |
Q737* |
probably null |
Het |
| Kcnj13 |
T |
C |
1: 87,314,175 (GRCm39) |
D349G |
probably damaging |
Het |
| Lgsn |
A |
T |
1: 31,243,318 (GRCm39) |
T467S |
possibly damaging |
Het |
| Map9 |
T |
A |
3: 82,270,819 (GRCm39) |
S128T |
possibly damaging |
Het |
| Mroh5 |
A |
G |
15: 73,661,827 (GRCm39) |
C455R |
probably damaging |
Het |
| Nes |
A |
G |
3: 87,887,186 (GRCm39) |
H1771R |
probably benign |
Het |
| Nkain2 |
T |
C |
10: 32,205,840 (GRCm39) |
Y65C |
probably damaging |
Het |
| Or51a43 |
T |
A |
7: 103,718,056 (GRCm39) |
M61L |
probably damaging |
Het |
| Or51b6b |
A |
T |
7: 103,310,112 (GRCm39) |
V115D |
probably damaging |
Het |
| Or6aa1 |
T |
C |
7: 86,043,798 (GRCm39) |
K303E |
possibly damaging |
Het |
| Pabpc4l |
A |
C |
3: 46,400,725 (GRCm39) |
D306E |
probably benign |
Het |
| Parp12 |
A |
T |
6: 39,079,515 (GRCm39) |
Y332N |
probably damaging |
Het |
| Parvb |
A |
T |
15: 84,193,154 (GRCm39) |
K316M |
probably damaging |
Het |
| Pde8a |
T |
A |
7: 80,945,519 (GRCm39) |
|
probably benign |
Het |
| Polq |
A |
G |
16: 36,833,471 (GRCm39) |
T55A |
probably benign |
Het |
| Ppp2r5b |
T |
A |
19: 6,281,016 (GRCm39) |
K271M |
probably damaging |
Het |
| Ralgapb |
A |
G |
2: 158,334,936 (GRCm39) |
|
probably null |
Het |
| Rigi |
C |
T |
4: 40,229,661 (GRCm39) |
C86Y |
probably benign |
Het |
| Skap2 |
T |
C |
6: 51,886,351 (GRCm39) |
N175D |
probably benign |
Het |
| Slc44a3 |
A |
G |
3: 121,303,970 (GRCm39) |
|
probably benign |
Het |
| Smurf2 |
G |
A |
11: 106,736,873 (GRCm39) |
H318Y |
probably damaging |
Het |
| Tbc1d23 |
T |
C |
16: 57,004,778 (GRCm39) |
T460A |
possibly damaging |
Het |
| Tcerg1 |
T |
C |
18: 42,657,414 (GRCm39) |
S299P |
unknown |
Het |
| Tll1 |
A |
C |
8: 64,658,319 (GRCm39) |
Y33* |
probably null |
Het |
| Tmem59 |
A |
T |
4: 107,054,782 (GRCm39) |
T196S |
probably damaging |
Het |
| Ttll4 |
C |
A |
1: 74,718,662 (GRCm39) |
A171D |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,641,513 (GRCm39) |
T13528A |
possibly damaging |
Het |
| Ttn |
A |
G |
2: 76,717,621 (GRCm39) |
|
probably benign |
Het |
| Xpc |
C |
A |
6: 91,477,119 (GRCm39) |
G327W |
probably damaging |
Het |
| Zbtb7a |
A |
G |
10: 80,980,132 (GRCm39) |
S109G |
probably benign |
Het |
| Zfyve26 |
T |
C |
12: 79,285,794 (GRCm39) |
M2328V |
probably benign |
Het |
|
| Other mutations in Dach1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00780:Dach1
|
APN |
14 |
98,138,858 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01101:Dach1
|
APN |
14 |
98,077,640 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL02033:Dach1
|
APN |
14 |
98,138,865 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02116:Dach1
|
APN |
14 |
98,138,859 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02583:Dach1
|
APN |
14 |
98,065,830 (GRCm39) |
splice site |
probably benign |
|
|
IGL03120:Dach1
|
APN |
14 |
98,065,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0016:Dach1
|
UTSW |
14 |
98,406,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0017:Dach1
|
UTSW |
14 |
98,406,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0117:Dach1
|
UTSW |
14 |
98,406,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0334:Dach1
|
UTSW |
14 |
98,406,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0336:Dach1
|
UTSW |
14 |
98,406,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0371:Dach1
|
UTSW |
14 |
98,207,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0511:Dach1
|
UTSW |
14 |
98,138,765 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0538:Dach1
|
UTSW |
14 |
98,140,715 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0799:Dach1
|
UTSW |
14 |
98,406,051 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0928:Dach1
|
UTSW |
14 |
98,153,268 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0939:Dach1
|
UTSW |
14 |
98,153,360 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1512:Dach1
|
UTSW |
14 |
98,138,835 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1646:Dach1
|
UTSW |
14 |
98,406,550 (GRCm39) |
missense |
unknown |
|
|
R1865:Dach1
|
UTSW |
14 |
98,077,645 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1881:Dach1
|
UTSW |
14 |
98,138,832 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1909:Dach1
|
UTSW |
14 |
98,138,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1980:Dach1
|
UTSW |
14 |
98,068,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2215:Dach1
|
UTSW |
14 |
98,405,917 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2570:Dach1
|
UTSW |
14 |
98,138,847 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3924:Dach1
|
UTSW |
14 |
98,153,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3957:Dach1
|
UTSW |
14 |
98,077,545 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4095:Dach1
|
UTSW |
14 |
98,138,815 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4373:Dach1
|
UTSW |
14 |
98,065,186 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5350:Dach1
|
UTSW |
14 |
98,207,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5428:Dach1
|
UTSW |
14 |
98,406,705 (GRCm39) |
missense |
unknown |
|
|
R5818:Dach1
|
UTSW |
14 |
98,406,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6824:Dach1
|
UTSW |
14 |
98,256,328 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6967:Dach1
|
UTSW |
14 |
98,140,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7263:Dach1
|
UTSW |
14 |
98,406,295 (GRCm39) |
missense |
probably benign |
|
|
R7701:Dach1
|
UTSW |
14 |
98,140,670 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8176:Dach1
|
UTSW |
14 |
98,153,916 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8196:Dach1
|
UTSW |
14 |
98,256,370 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8419:Dach1
|
UTSW |
14 |
98,406,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8434:Dach1
|
UTSW |
14 |
98,406,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8510:Dach1
|
UTSW |
14 |
98,140,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8748:Dach1
|
UTSW |
14 |
98,065,770 (GRCm39) |
nonsense |
probably null |
|
|
R8909:Dach1
|
UTSW |
14 |
98,406,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9087:Dach1
|
UTSW |
14 |
98,406,267 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9200:Dach1
|
UTSW |
14 |
98,065,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1192:Dach1
|
UTSW |
14 |
98,140,587 (GRCm39) |
missense |
probably benign |
0.30 |
|
| Posted On |
2015-12-18 |
Incidental Mutation