Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02938:Vmn2r114'

364394

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r114

Ensembl Gene

ENSMUSG00000091945

Gene Name

vomeronasal 2, receptor 114

Synonyms

EG666002

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.131) question?

Stock #

IGL02938

Quality Score

Status

Chromosome

Chromosomal Location

23509908-23531287 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 23510263 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 739 (H739L)

Ref Sequence

ENSEMBL: ENSMUSP00000127505 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168033]

AlphaFold

E9Q281

Predicted Effect

probably benign
Transcript: ENSMUST00000168033
AA Change: H739L

PolyPhen 2 Score 0.097 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000127505
Gene: ENSMUSG00000091945
AA Change: H739L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	154	470	1.5e-24	PFAM
Pfam:NCD3G	511	564	1.5e-18	PFAM
Pfam:7tm_3	597	832	1.4e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc5	T	C	16: 20,180,979 (GRCm39)	T1152A	possibly damaging	Het
Adgra3	T	C	5: 50,118,659 (GRCm39)	D963G	probably benign	Het
Adrm1	T	A	2: 179,817,395 (GRCm39)	D287E	probably damaging	Het
Agxt	A	G	1: 93,072,831 (GRCm39)	D396G	probably damaging	Het
Ankle1	C	T	8: 71,858,896 (GRCm39)	A43V	probably damaging	Het
Apc	A	G	18: 34,448,281 (GRCm39)	I1692V	probably damaging	Het
Arhgef18	T	C	8: 3,500,802 (GRCm39)	V588A	probably benign	Het
Ccdc62	T	A	5: 124,072,247 (GRCm39)	V4E	probably benign	Het
Cdh16	A	T	8: 105,343,561 (GRCm39)		probably benign	Het
Cr2	A	T	1: 194,848,696 (GRCm39)	C276S	probably damaging	Het
Cyp2c29	T	A	19: 39,275,567 (GRCm39)	D2E	probably damaging	Het
Ddx31	T	A	2: 28,749,035 (GRCm39)	V277E	possibly damaging	Het
Defa35	C	T	8: 21,555,930 (GRCm39)		probably benign	Het
Dhx9	A	T	1: 153,340,376 (GRCm39)	D707E	probably benign	Het
Dnmt1	A	G	9: 20,852,669 (GRCm39)	S28P	probably benign	Het
Dock5	A	T	14: 67,994,667 (GRCm39)		probably benign	Het
Dpp6	T	C	5: 27,928,365 (GRCm39)		probably benign	Het
Egln1	A	G	8: 125,640,754 (GRCm39)		probably null	Het
Esr1	T	A	10: 4,733,872 (GRCm39)	M224K	probably damaging	Het
Flt1	A	G	5: 147,615,109 (GRCm39)	I279T	possibly damaging	Het
Fzd6	T	C	15: 38,897,285 (GRCm39)	I478T	probably benign	Het
Glb1l3	A	G	9: 26,738,055 (GRCm39)	V368A	probably benign	Het
Gltpd2	T	C	11: 70,410,637 (GRCm39)	F5S	probably damaging	Het
Helz	G	A	11: 107,577,264 (GRCm39)	E1872K	unknown	Het
Irak3	A	G	10: 120,018,429 (GRCm39)		probably null	Het
Itsn2	A	T	12: 4,747,216 (GRCm39)	I1206F	probably damaging	Het
Lingo3	A	T	10: 80,670,988 (GRCm39)	V314E	probably benign	Het
Lrrc8a	C	T	2: 30,145,698 (GRCm39)	R171W	probably damaging	Het
Lsg1	T	C	16: 30,390,024 (GRCm39)	T364A	probably benign	Het
Mks1	T	C	11: 87,753,478 (GRCm39)		probably null	Het
Mov10l1	T	A	15: 88,872,729 (GRCm39)	F89Y	probably damaging	Het
Myo1b	A	C	1: 51,840,337 (GRCm39)		probably null	Het
Myo1h	T	C	5: 114,497,000 (GRCm39)	Y819H	probably damaging	Het
Nedd1	G	A	10: 92,525,519 (GRCm39)	Q597*	probably null	Het
Nrn1	C	A	13: 36,914,080 (GRCm39)		probably null	Het
Or5an9	A	G	19: 12,187,046 (GRCm39)	T39A	probably benign	Het
Pbrm1	T	C	14: 30,789,761 (GRCm39)	S792P	probably damaging	Het
Pccb	T	C	9: 100,866,449 (GRCm39)	N457S	probably benign	Het
Plekho2	T	C	9: 65,465,902 (GRCm39)	E162G	possibly damaging	Het
Pou1f1	A	T	16: 65,320,430 (GRCm39)	T40S	probably benign	Het
Pwwp2b	T	C	7: 138,836,059 (GRCm39)	V500A	probably damaging	Het
Pygo1	C	T	9: 72,852,020 (GRCm39)	A69V	probably damaging	Het
Slc18a3	A	C	14: 32,185,772 (GRCm39)	Y204D	probably damaging	Het
Stab2	A	G	10: 86,707,785 (GRCm39)	V261A	possibly damaging	Het
Tacc2	A	T	7: 130,330,671 (GRCm39)	K208N	probably damaging	Het
Tbc1d4	T	C	14: 101,738,536 (GRCm39)	D403G	probably damaging	Het
Tbc1d9	T	A	8: 83,995,696 (GRCm39)		probably benign	Het
Tdrkh	T	C	3: 94,336,657 (GRCm39)		probably benign	Het
Tktl2	T	A	8: 66,964,982 (GRCm39)	L180H	probably damaging	Het
Tm4sf19	T	A	16: 32,224,733 (GRCm39)	L27Q	probably damaging	Het
Tmtc2	A	G	10: 105,249,157 (GRCm39)	V192A	probably damaging	Het
Ttn	C	A	2: 76,543,328 (GRCm39)	M33219I	probably damaging	Het
Vmn1r52	A	T	6: 90,156,295 (GRCm39)	M200L	possibly damaging	Het
Wdr20rt	T	C	12: 65,272,692 (GRCm39)	F52L	probably benign	Het
Zbtb38	C	T	9: 96,569,227 (GRCm39)	G619D	probably benign	Het
Zfyve19	T	C	2: 119,041,999 (GRCm39)	V156A	probably benign	Het

Other mutations in Vmn2r114

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Vmn2r114	APN	17	23,510,639 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r114	APN	17	23,510,212 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r114	APN	17	23,509,957 (GRCm39)	missense	probably benign	0.23
IGL00990:Vmn2r114	APN	17	23,509,939 (GRCm39)	missense	probably benign
IGL01838:Vmn2r114	APN	17	23,515,956 (GRCm39)	missense	probably benign	0.44
IGL01990:Vmn2r114	APN	17	23,529,355 (GRCm39)	missense	probably benign	0.22
IGL01994:Vmn2r114	APN	17	23,529,451 (GRCm39)	missense	probably damaging	1.00
IGL02153:Vmn2r114	APN	17	23,510,782 (GRCm39)	missense	probably benign	0.01
IGL02453:Vmn2r114	APN	17	23,530,108 (GRCm39)	missense	probably benign	0.00
IGL02621:Vmn2r114	APN	17	23,529,494 (GRCm39)	missense	probably damaging	0.98
IGL03130:Vmn2r114	APN	17	23,515,970 (GRCm39)	splice site	probably benign
IGL03325:Vmn2r114	APN	17	23,510,652 (GRCm39)	missense	probably damaging	1.00
BB004:Vmn2r114	UTSW	17	23,510,619 (GRCm39)	missense	probably damaging	1.00
R0109:Vmn2r114	UTSW	17	23,529,549 (GRCm39)	nonsense	probably null
R0164:Vmn2r114	UTSW	17	23,528,800 (GRCm39)	critical splice donor site	probably null
R0310:Vmn2r114	UTSW	17	23,509,917 (GRCm39)	missense	probably benign	0.23
R0583:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R0677:Vmn2r114	UTSW	17	23,529,568 (GRCm39)	missense	probably damaging	1.00
R1127:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R1147:Vmn2r114	UTSW	17	23,530,037 (GRCm39)	missense	probably benign	0.00
R1147:Vmn2r114	UTSW	17	23,530,037 (GRCm39)	missense	probably benign	0.00
R1157:Vmn2r114	UTSW	17	23,529,314 (GRCm39)	missense	possibly damaging	0.60
R1323:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R1347:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R1435:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R1437:Vmn2r114	UTSW	17	23,510,185 (GRCm39)	missense	probably damaging	1.00
R1585:Vmn2r114	UTSW	17	23,510,675 (GRCm39)	missense	probably damaging	0.98
R1641:Vmn2r114	UTSW	17	23,515,962 (GRCm39)	missense	probably benign	0.00
R1748:Vmn2r114	UTSW	17	23,527,035 (GRCm39)	missense	probably benign	0.17
R1954:Vmn2r114	UTSW	17	23,530,086 (GRCm39)	missense	probably benign	0.32
R2081:Vmn2r114	UTSW	17	23,510,083 (GRCm39)	missense	possibly damaging	0.91
R2103:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R2113:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R2134:Vmn2r114	UTSW	17	23,510,737 (GRCm39)	missense	probably damaging	1.00
R2149:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R2424:Vmn2r114	UTSW	17	23,515,842 (GRCm39)	missense	possibly damaging	0.90
R2847:Vmn2r114	UTSW	17	23,509,948 (GRCm39)	missense	probably benign	0.00
R2848:Vmn2r114	UTSW	17	23,509,948 (GRCm39)	missense	probably benign	0.00
R2893:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R3017:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R3018:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R3019:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R3020:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R3021:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R4628:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R4668:Vmn2r114	UTSW	17	23,529,447 (GRCm39)	missense	possibly damaging	0.83
R4840:Vmn2r114	UTSW	17	23,510,353 (GRCm39)	missense	probably damaging	0.97
R4841:Vmn2r114	UTSW	17	23,529,336 (GRCm39)	missense	probably benign	0.04
R4842:Vmn2r114	UTSW	17	23,529,336 (GRCm39)	missense	probably benign	0.04
R4856:Vmn2r114	UTSW	17	23,527,008 (GRCm39)	missense	probably benign	0.11
R4886:Vmn2r114	UTSW	17	23,527,008 (GRCm39)	missense	probably benign	0.11
R4992:Vmn2r114	UTSW	17	23,510,765 (GRCm39)	missense	probably benign	0.03
R5182:Vmn2r114	UTSW	17	23,510,632 (GRCm39)	missense	probably damaging	0.96
R5223:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R5405:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R5449:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R5615:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R5834:Vmn2r114	UTSW	17	23,529,599 (GRCm39)	missense	possibly damaging	0.90
R6150:Vmn2r114	UTSW	17	23,510,269 (GRCm39)	missense	probably benign	0.03
R6277:Vmn2r114	UTSW	17	23,509,954 (GRCm39)	missense	possibly damaging	0.93
R6403:Vmn2r114	UTSW	17	23,528,939 (GRCm39)	missense	probably damaging	0.99
R6589:Vmn2r114	UTSW	17	23,510,642 (GRCm39)	missense	probably damaging	1.00
R6613:Vmn2r114	UTSW	17	23,529,220 (GRCm39)	missense	possibly damaging	0.82
R6747:Vmn2r114	UTSW	17	23,528,850 (GRCm39)	missense	probably benign	0.00
R6837:Vmn2r114	UTSW	17	23,529,176 (GRCm39)	missense	probably benign	0.10
R6911:Vmn2r114	UTSW	17	23,510,104 (GRCm39)	missense	probably damaging	0.98
R6950:Vmn2r114	UTSW	17	23,529,137 (GRCm39)	missense	probably benign	0.03
R7276:Vmn2r114	UTSW	17	23,509,934 (GRCm39)	missense	probably damaging	0.97
R7482:Vmn2r114	UTSW	17	23,510,468 (GRCm39)	missense	probably damaging	1.00
R7514:Vmn2r114	UTSW	17	23,527,035 (GRCm39)	missense	probably null	0.96
R7523:Vmn2r114	UTSW	17	23,529,611 (GRCm39)	missense	probably benign	0.01
R7563:Vmn2r114	UTSW	17	23,510,000 (GRCm39)	missense	probably benign	0.01
R7585:Vmn2r114	UTSW	17	23,510,239 (GRCm39)	missense	probably damaging	1.00
R7593:Vmn2r114	UTSW	17	23,510,817 (GRCm39)	nonsense	probably null
R7611:Vmn2r114	UTSW	17	23,515,944 (GRCm39)	missense	probably damaging	0.97
R7641:Vmn2r114	UTSW	17	23,527,177 (GRCm39)	missense	possibly damaging	0.53
R7651:Vmn2r114	UTSW	17	23,509,986 (GRCm39)	nonsense	probably null
R7970:Vmn2r114	UTSW	17	23,530,186 (GRCm39)	missense	probably benign	0.00
R8737:Vmn2r114	UTSW	17	23,529,142 (GRCm39)	missense	probably benign	0.36
R8802:Vmn2r114	UTSW	17	23,528,836 (GRCm39)	missense	possibly damaging	0.65
R8847:Vmn2r114	UTSW	17	23,528,986 (GRCm39)	missense	probably damaging	1.00
R8991:Vmn2r114	UTSW	17	23,529,286 (GRCm39)	missense	probably damaging	1.00
R9138:Vmn2r114	UTSW	17	23,510,578 (GRCm39)	missense	probably damaging	1.00
R9173:Vmn2r114	UTSW	17	23,510,527 (GRCm39)	missense	probably damaging	0.99
R9175:Vmn2r114	UTSW	17	23,527,212 (GRCm39)	missense	probably damaging	1.00
R9657:Vmn2r114	UTSW	17	23,510,690 (GRCm39)	missense	probably damaging	1.00
R9670:Vmn2r114	UTSW	17	23,531,098 (GRCm39)	missense
X0065:Vmn2r114	UTSW	17	23,529,931 (GRCm39)	missense	probably benign	0.34
Z1088:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null

Posted On

2015-12-18