Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02938:Or5an9'

364399

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5an9

Ensembl Gene

ENSMUSG00000094133

Gene Name

olfactory receptor family 5 subfamily AN member 9

Synonyms

MOR214-5, Olfr1431, GA_x6K02T2RE5P-2573738-2574676

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL02938

Quality Score

Status

Chromosome

Chromosomal Location

12186932-12187870 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 12187046 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 39 (T39A)

Ref Sequence

ENSEMBL: ENSMUSP00000150967 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072316] [ENSMUST00000213759]

AlphaFold

Q8VF59

Predicted Effect

probably benign
Transcript: ENSMUST00000072316
AA Change: T39A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000072158
Gene: ENSMUSG00000094133
AA Change: T39A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	309	8.4e-56	PFAM
Pfam:7tm_1	42	309	2.4e-18	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213759
AA Change: T39A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214138

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc5	T	C	16: 20,180,979 (GRCm39)	T1152A	possibly damaging	Het
Adgra3	T	C	5: 50,118,659 (GRCm39)	D963G	probably benign	Het
Adrm1	T	A	2: 179,817,395 (GRCm39)	D287E	probably damaging	Het
Agxt	A	G	1: 93,072,831 (GRCm39)	D396G	probably damaging	Het
Ankle1	C	T	8: 71,858,896 (GRCm39)	A43V	probably damaging	Het
Apc	A	G	18: 34,448,281 (GRCm39)	I1692V	probably damaging	Het
Arhgef18	T	C	8: 3,500,802 (GRCm39)	V588A	probably benign	Het
Ccdc62	T	A	5: 124,072,247 (GRCm39)	V4E	probably benign	Het
Cdh16	A	T	8: 105,343,561 (GRCm39)		probably benign	Het
Cr2	A	T	1: 194,848,696 (GRCm39)	C276S	probably damaging	Het
Cyp2c29	T	A	19: 39,275,567 (GRCm39)	D2E	probably damaging	Het
Ddx31	T	A	2: 28,749,035 (GRCm39)	V277E	possibly damaging	Het
Defa35	C	T	8: 21,555,930 (GRCm39)		probably benign	Het
Dhx9	A	T	1: 153,340,376 (GRCm39)	D707E	probably benign	Het
Dnmt1	A	G	9: 20,852,669 (GRCm39)	S28P	probably benign	Het
Dock5	A	T	14: 67,994,667 (GRCm39)		probably benign	Het
Dpp6	T	C	5: 27,928,365 (GRCm39)		probably benign	Het
Egln1	A	G	8: 125,640,754 (GRCm39)		probably null	Het
Esr1	T	A	10: 4,733,872 (GRCm39)	M224K	probably damaging	Het
Flt1	A	G	5: 147,615,109 (GRCm39)	I279T	possibly damaging	Het
Fzd6	T	C	15: 38,897,285 (GRCm39)	I478T	probably benign	Het
Glb1l3	A	G	9: 26,738,055 (GRCm39)	V368A	probably benign	Het
Gltpd2	T	C	11: 70,410,637 (GRCm39)	F5S	probably damaging	Het
Helz	G	A	11: 107,577,264 (GRCm39)	E1872K	unknown	Het
Irak3	A	G	10: 120,018,429 (GRCm39)		probably null	Het
Itsn2	A	T	12: 4,747,216 (GRCm39)	I1206F	probably damaging	Het
Lingo3	A	T	10: 80,670,988 (GRCm39)	V314E	probably benign	Het
Lrrc8a	C	T	2: 30,145,698 (GRCm39)	R171W	probably damaging	Het
Lsg1	T	C	16: 30,390,024 (GRCm39)	T364A	probably benign	Het
Mks1	T	C	11: 87,753,478 (GRCm39)		probably null	Het
Mov10l1	T	A	15: 88,872,729 (GRCm39)	F89Y	probably damaging	Het
Myo1b	A	C	1: 51,840,337 (GRCm39)		probably null	Het
Myo1h	T	C	5: 114,497,000 (GRCm39)	Y819H	probably damaging	Het
Nedd1	G	A	10: 92,525,519 (GRCm39)	Q597*	probably null	Het
Nrn1	C	A	13: 36,914,080 (GRCm39)		probably null	Het
Pbrm1	T	C	14: 30,789,761 (GRCm39)	S792P	probably damaging	Het
Pccb	T	C	9: 100,866,449 (GRCm39)	N457S	probably benign	Het
Plekho2	T	C	9: 65,465,902 (GRCm39)	E162G	possibly damaging	Het
Pou1f1	A	T	16: 65,320,430 (GRCm39)	T40S	probably benign	Het
Pwwp2b	T	C	7: 138,836,059 (GRCm39)	V500A	probably damaging	Het
Pygo1	C	T	9: 72,852,020 (GRCm39)	A69V	probably damaging	Het
Slc18a3	A	C	14: 32,185,772 (GRCm39)	Y204D	probably damaging	Het
Stab2	A	G	10: 86,707,785 (GRCm39)	V261A	possibly damaging	Het
Tacc2	A	T	7: 130,330,671 (GRCm39)	K208N	probably damaging	Het
Tbc1d4	T	C	14: 101,738,536 (GRCm39)	D403G	probably damaging	Het
Tbc1d9	T	A	8: 83,995,696 (GRCm39)		probably benign	Het
Tdrkh	T	C	3: 94,336,657 (GRCm39)		probably benign	Het
Tktl2	T	A	8: 66,964,982 (GRCm39)	L180H	probably damaging	Het
Tm4sf19	T	A	16: 32,224,733 (GRCm39)	L27Q	probably damaging	Het
Tmtc2	A	G	10: 105,249,157 (GRCm39)	V192A	probably damaging	Het
Ttn	C	A	2: 76,543,328 (GRCm39)	M33219I	probably damaging	Het
Vmn1r52	A	T	6: 90,156,295 (GRCm39)	M200L	possibly damaging	Het
Vmn2r114	T	A	17: 23,510,263 (GRCm39)	H739L	probably benign	Het
Wdr20rt	T	C	12: 65,272,692 (GRCm39)	F52L	probably benign	Het
Zbtb38	C	T	9: 96,569,227 (GRCm39)	G619D	probably benign	Het
Zfyve19	T	C	2: 119,041,999 (GRCm39)	V156A	probably benign	Het

Other mutations in Or5an9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01330:Or5an9	APN	19	12,187,404 (GRCm39)	missense	possibly damaging	0.65
IGL02206:Or5an9	APN	19	12,187,824 (GRCm39)	missense	probably damaging	1.00
PIT4812001:Or5an9	UTSW	19	12,187,617 (GRCm39)	missense	probably damaging	1.00
R0402:Or5an9	UTSW	19	12,186,953 (GRCm39)	missense	probably damaging	1.00
R0661:Or5an9	UTSW	19	12,187,068 (GRCm39)	missense	probably damaging	1.00
R1193:Or5an9	UTSW	19	12,187,803 (GRCm39)	missense	probably damaging	1.00
R1483:Or5an9	UTSW	19	12,187,114 (GRCm39)	nonsense	probably null
R4091:Or5an9	UTSW	19	12,187,143 (GRCm39)	missense	probably damaging	1.00
R4280:Or5an9	UTSW	19	12,187,302 (GRCm39)	missense	probably damaging	1.00
R5028:Or5an9	UTSW	19	12,187,518 (GRCm39)	missense	possibly damaging	0.94
R5540:Or5an9	UTSW	19	12,187,824 (GRCm39)	missense	probably damaging	1.00
R6042:Or5an9	UTSW	19	12,187,286 (GRCm39)	missense	probably damaging	0.99
R6045:Or5an9	UTSW	19	12,187,659 (GRCm39)	missense	probably damaging	1.00
R7104:Or5an9	UTSW	19	12,187,242 (GRCm39)	missense	possibly damaging	0.82
R9068:Or5an9	UTSW	19	12,187,703 (GRCm39)	missense	probably damaging	1.00
R9165:Or5an9	UTSW	19	12,187,286 (GRCm39)	missense	probably damaging	0.99
Z1088:Or5an9	UTSW	19	12,187,854 (GRCm39)	missense	possibly damaging	0.55

Posted On

2015-12-18