Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02938:Nedd1'

364429

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Nedd1

Ensembl Gene

ENSMUSG00000019988

Gene Name

neural precursor cell expressed, developmentally down-regulated gene 1

Synonyms

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.966) question?

Stock #

IGL02938

Quality Score

Status

Chromosome

Chromosomal Location

92684746-92722420 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 92689657 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 597 (Q597*)

Ref Sequence

ENSEMBL: ENSMUSP00000020163 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020163]

AlphaFold

P33215

Predicted Effect

probably null
Transcript: ENSMUST00000020163
AA Change: Q597*

SMART Domains

Protein: ENSMUSP00000020163
Gene: ENSMUSG00000019988
AA Change: Q597*

Domain	Start	End	E-Value	Type
WD40	21	63	5.97e-1	SMART
WD40	67	105	9.75e-3	SMART
WD40	108	147	6.19e-5	SMART
WD40	149	191	6.42e-1	SMART
WD40	194	235	9.1e-3	SMART
WD40	238	276	2.24e-2	SMART
low complexity region	555	568	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000157787

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214417

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc5	T	C	16: 20,362,229	T1152A	possibly damaging	Het
Adgra3	T	C	5: 49,961,317	D963G	probably benign	Het
Adrm1	T	A	2: 180,175,602	D287E	probably damaging	Het
Agxt	A	G	1: 93,145,109	D396G	probably damaging	Het
Ankle1	C	T	8: 71,406,252	A43V	probably damaging	Het
Apc	A	G	18: 34,315,228	I1692V	probably damaging	Het
Arhgef18	T	C	8: 3,450,802	V588A	probably benign	Het
Ccdc62	T	A	5: 123,934,184	V4E	probably benign	Het
Cdh16	A	T	8: 104,616,929		probably benign	Het
Cr2	A	T	1: 195,166,388	C276S	probably damaging	Het
Cyp2c29	T	A	19: 39,287,123	D2E	probably damaging	Het
Ddx31	T	A	2: 28,859,023	V277E	possibly damaging	Het
Defa35	C	T	8: 21,065,914		probably benign	Het
Dhx9	A	T	1: 153,464,630	D707E	probably benign	Het
Dnmt1	A	G	9: 20,941,373	S28P	probably benign	Het
Dock5	A	T	14: 67,757,218		probably benign	Het
Dpp6	T	C	5: 27,723,367		probably benign	Het
Egln1	A	G	8: 124,914,015		probably null	Het
Esr1	T	A	10: 4,783,872	M224K	probably damaging	Het
Flt1	A	G	5: 147,678,299	I279T	possibly damaging	Het
Fzd6	T	C	15: 39,033,890	I478T	probably benign	Het
Glb1l3	A	G	9: 26,826,759	V368A	probably benign	Het
Gltpd2	T	C	11: 70,519,811	F5S	probably damaging	Het
Helz	G	A	11: 107,686,438	E1872K	unknown	Het
Irak3	A	G	10: 120,182,524		probably null	Het
Itsn2	A	T	12: 4,697,216	I1206F	probably damaging	Het
Lingo3	A	T	10: 80,835,154	V314E	probably benign	Het
Lrrc8a	C	T	2: 30,255,686	R171W	probably damaging	Het
Lsg1	T	C	16: 30,571,206	T364A	probably benign	Het
Mks1	T	C	11: 87,862,652		probably null	Het
Mov10l1	T	A	15: 88,988,526	F89Y	probably damaging	Het
Myo1b	A	C	1: 51,801,178		probably null	Het
Myo1h	T	C	5: 114,358,939	Y819H	probably damaging	Het
Nrn1	C	A	13: 36,730,106		probably null	Het
Olfr1431	A	G	19: 12,209,682	T39A	probably benign	Het
Pbrm1	T	C	14: 31,067,804	S792P	probably damaging	Het
Pccb	T	C	9: 100,984,396	N457S	probably benign	Het
Plekho2	T	C	9: 65,558,620	E162G	possibly damaging	Het
Pou1f1	A	T	16: 65,523,544	T40S	probably benign	Het
Pwwp2b	T	C	7: 139,256,143	V500A	probably damaging	Het
Pygo1	C	T	9: 72,944,738	A69V	probably damaging	Het
Slc18a3	A	C	14: 32,463,815	Y204D	probably damaging	Het
Stab2	A	G	10: 86,871,921	V261A	possibly damaging	Het
Tacc2	A	T	7: 130,728,941	K208N	probably damaging	Het
Tbc1d4	T	C	14: 101,501,100	D403G	probably damaging	Het
Tbc1d9	T	A	8: 83,269,067		probably benign	Het
Tdrkh	T	C	3: 94,429,350		probably benign	Het
Tktl2	T	A	8: 66,512,330	L180H	probably damaging	Het
Tm4sf19	T	A	16: 32,405,915	L27Q	probably damaging	Het
Tmtc2	A	G	10: 105,413,296	V192A	probably damaging	Het
Ttn	C	A	2: 76,712,984	M33219I	probably damaging	Het
Vmn1r52	A	T	6: 90,179,313	M200L	possibly damaging	Het
Vmn2r114	T	A	17: 23,291,289	H739L	probably benign	Het
Wdr20rt	T	C	12: 65,225,918	F52L	probably benign	Het
Zbtb38	C	T	9: 96,687,174	G619D	probably benign	Het
Zfyve19	T	C	2: 119,211,518	V156A	probably benign	Het

Other mutations in Nedd1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00764:Nedd1	APN	10	92694974	splice site	probably benign
IGL00988:Nedd1	APN	10	92689686	missense	possibly damaging	0.71
IGL01563:Nedd1	APN	10	92698169	critical splice donor site	probably null
IGL01588:Nedd1	APN	10	92686262	missense	probably benign	0.12
IGL01988:Nedd1	APN	10	92714159	missense	probably benign	0.39
IGL02706:Nedd1	APN	10	92686285	missense	possibly damaging	0.88
IGL03011:Nedd1	APN	10	92689641	missense	possibly damaging	0.92
Brainless	UTSW	10	92690773	missense	probably benign	0.01
R0125:Nedd1	UTSW	10	92691929	missense	possibly damaging	0.93
R0173:Nedd1	UTSW	10	92698883	missense	probably benign	0.30
R0244:Nedd1	UTSW	10	92716265	intron	probably benign
R0645:Nedd1	UTSW	10	92691831	splice site	probably null
R0791:Nedd1	UTSW	10	92719614	missense	probably damaging	1.00
R1490:Nedd1	UTSW	10	92700798	missense	probably damaging	1.00
R1522:Nedd1	UTSW	10	92719614	missense	probably damaging	1.00
R1797:Nedd1	UTSW	10	92698739	missense	possibly damaging	0.46
R1984:Nedd1	UTSW	10	92714160	missense	possibly damaging	0.63
R2474:Nedd1	UTSW	10	92719603	missense	probably damaging	0.99
R2877:Nedd1	UTSW	10	92714126	missense	possibly damaging	0.89
R2883:Nedd1	UTSW	10	92694998	missense	probably damaging	0.98
R4694:Nedd1	UTSW	10	92719582	missense	probably benign	0.00
R4798:Nedd1	UTSW	10	92698910	missense	probably benign	0.00
R4830:Nedd1	UTSW	10	92686258	missense	probably damaging	1.00
R4963:Nedd1	UTSW	10	92695031	missense	probably damaging	1.00
R5174:Nedd1	UTSW	10	92711212	missense	possibly damaging	0.77
R5329:Nedd1	UTSW	10	92686240	missense	probably damaging	1.00
R5404:Nedd1	UTSW	10	92716192	missense	probably benign	0.04
R5534:Nedd1	UTSW	10	92695032	missense	probably benign	0.01
R6045:Nedd1	UTSW	10	92695100	nonsense	probably null
R6154:Nedd1	UTSW	10	92698242	missense	possibly damaging	0.65
R6512:Nedd1	UTSW	10	92691875	missense	probably benign
R6692:Nedd1	UTSW	10	92698337	missense	possibly damaging	0.88
R6693:Nedd1	UTSW	10	92698337	missense	possibly damaging	0.88
R6943:Nedd1	UTSW	10	92711306	missense	probably damaging	1.00
R7011:Nedd1	UTSW	10	92690773	missense	probably benign	0.01
R7406:Nedd1	UTSW	10	92711323	splice site	probably null
R7455:Nedd1	UTSW	10	92700925	missense	probably benign	0.01
R7587:Nedd1	UTSW	10	92698730	missense	probably benign	0.01
R7745:Nedd1	UTSW	10	92714172	missense	probably benign
R8104:Nedd1	UTSW	10	92691916	missense	probably damaging	1.00
R8209:Nedd1	UTSW	10	92691935	missense	probably benign
R8226:Nedd1	UTSW	10	92691935	missense	probably benign
R8925:Nedd1	UTSW	10	92722396	start gained	probably benign
R8927:Nedd1	UTSW	10	92722396	start gained	probably benign

Posted On

2015-12-18