Incidental Mutation 'IGL02941:Olfr339'
ID364488
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr339
Ensembl Gene ENSMUSG00000094464
Gene Nameolfactory receptor 339
SynonymsMOR136-3, GA_x6K02T2NLDC-33116096-33117025
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.115) question?
Stock #IGL02941
Quality Score
Status
Chromosome2
Chromosomal Location36418947-36426123 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 36422120 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Arginine at position 241 (C241R)
Ref Sequence ENSEMBL: ENSMUSP00000149068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071437] [ENSMUST00000216645]
Predicted Effect probably damaging
Transcript: ENSMUST00000071437
AA Change: C241R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000071383
Gene: ENSMUSG00000094464
AA Change: C241R

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.9e-55 PFAM
Pfam:7tm_1 41 290 5e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216645
AA Change: C241R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933405O20Rik G A 7: 50,599,536 R106Q probably damaging Het
Amhr2 T C 15: 102,447,289 V223A probably damaging Het
Aqr T A 2: 114,113,354 H1101L probably damaging Het
Arnt T A 3: 95,460,370 probably benign Het
Cacnb2 G A 2: 14,958,829 V85I probably benign Het
Cast A T 13: 74,700,687 D727E probably damaging Het
Ccdc134 C T 15: 82,140,950 R217W probably damaging Het
Col5a3 A G 9: 20,804,666 S360P unknown Het
Cyp4f16 T C 17: 32,537,087 I30T possibly damaging Het
Dopey2 T C 16: 93,755,473 F267L probably benign Het
Fbxo3 A G 2: 104,050,294 T250A probably damaging Het
Gm4953 C T 1: 159,168,393 noncoding transcript Het
Gm9242 T C 16: 97,491,079 probably benign Het
Gsr G A 8: 33,689,425 V354I probably damaging Het
Hecw1 T A 13: 14,377,726 D96V probably damaging Het
Hist2h2be A G 3: 96,221,416 Y84C possibly damaging Het
Il18r1 A G 1: 40,498,551 Y492C probably damaging Het
Itgb5 T G 16: 33,944,095 probably benign Het
Lars2 T G 9: 123,459,585 L832R probably damaging Het
Ms4a6c A G 19: 11,471,102 probably benign Het
Nrxn1 T C 17: 90,208,383 S1227G probably damaging Het
Olfr15 T C 16: 3,839,816 V281A possibly damaging Het
Olfr584 A G 7: 103,086,321 T263A probably benign Het
Pcdh17 A G 14: 84,448,307 Y738C probably damaging Het
Pcsk5 C A 19: 17,447,501 C1646F probably damaging Het
Pirb A G 7: 3,717,378 V332A probably damaging Het
Pkd1l2 G A 8: 117,065,745 T436I probably benign Het
Polrmt A T 10: 79,737,258 probably benign Het
Saxo1 G T 4: 86,445,584 R221S probably damaging Het
Specc1l A G 10: 75,241,188 I93V probably benign Het
St8sia2 T A 7: 73,976,649 probably benign Het
Tep1 A T 14: 50,866,037 N265K probably damaging Het
Thbd A T 2: 148,407,034 Y305N probably damaging Het
Tmem120a T C 5: 135,735,751 T325A probably damaging Het
Tmem2 G A 19: 21,823,843 D775N possibly damaging Het
Vill G A 9: 119,066,887 probably benign Het
Wdr35 A G 12: 9,027,507 D1060G probably damaging Het
Xrn2 T A 2: 147,026,524 F166I probably damaging Het
Zc3h7a T G 16: 11,158,594 probably null Het
Zdhhc13 G A 7: 48,817,138 probably benign Het
Zfp808 T A 13: 62,173,130 N724K possibly damaging Het
Other mutations in Olfr339
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01296:Olfr339 APN 2 36421704 missense probably benign 0.44
IGL01447:Olfr339 APN 2 36421454 missense probably damaging 0.97
IGL01845:Olfr339 APN 2 36422093 missense probably benign 0.27
IGL02728:Olfr339 APN 2 36422144 missense possibly damaging 0.95
R0128:Olfr339 UTSW 2 36422287 missense probably benign 0.16
R0130:Olfr339 UTSW 2 36422287 missense probably benign 0.16
R1432:Olfr339 UTSW 2 36421643 missense probably damaging 1.00
R1451:Olfr339 UTSW 2 36421865 missense probably benign 0.01
R1656:Olfr339 UTSW 2 36421646 missense probably benign 0.00
R1854:Olfr339 UTSW 2 36421874 missense probably damaging 0.97
R2012:Olfr339 UTSW 2 36421919 missense probably benign 0.00
R2093:Olfr339 UTSW 2 36421929 missense probably benign 0.00
R2136:Olfr339 UTSW 2 36421938 missense probably damaging 1.00
R2282:Olfr339 UTSW 2 36422000 missense probably benign 0.00
R4363:Olfr339 UTSW 2 36421532 missense probably damaging 1.00
R4466:Olfr339 UTSW 2 36422296 missense probably benign 0.00
R4628:Olfr339 UTSW 2 36421857 nonsense probably null
R4839:Olfr339 UTSW 2 36422000 missense probably benign 0.00
R6023:Olfr339 UTSW 2 36421511 missense probably damaging 0.98
R6305:Olfr339 UTSW 2 36421622 missense probably damaging 1.00
R6486:Olfr339 UTSW 2 36421544 missense probably damaging 1.00
R6851:Olfr339 UTSW 2 36421820 missense probably damaging 0.97
R6864:Olfr339 UTSW 2 36421820 missense probably damaging 0.97
R7771:Olfr339 UTSW 2 36422144 missense possibly damaging 0.95
Posted On2015-12-18