Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02941:Pirb'

364499

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Pirb

Ensembl Gene

ENSMUSG00000058818

Gene Name

paired Ig-like receptor B

Synonyms

Lilrb3, Gp91

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02941

Quality Score

Status

Chromosome

Chromosomal Location

3711409-3720391 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 3717378 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 332 (V332A)

Ref Sequence

ENSEMBL: ENSMUSP00000077546 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078451]

AlphaFold

P97484

Predicted Effect

probably damaging
Transcript: ENSMUST00000078451
AA Change: V332A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000077546
Gene: ENSMUSG00000058818
AA Change: V332A

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
IG	34	118	1.8e-3	SMART
IG	129	315	1.2e-4	SMART
IG_like	237	302	6.2e-4	SMART
IG_like	328	415	3.4e-2	SMART
IG_like	435	502	1e-2	SMART
IG	529	618	3.6e-5	SMART
low complexity region	624	637	N/A	INTRINSIC
transmembrane domain	641	663	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129493

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136238

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137474

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155131

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for disruptions of this gene display abnormalities in both B and T lymphocytes. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933405O20Rik	G	A	7: 50,599,536	R106Q	probably damaging	Het
Amhr2	T	C	15: 102,447,289	V223A	probably damaging	Het
Aqr	T	A	2: 114,113,354	H1101L	probably damaging	Het
Arnt	T	A	3: 95,460,370		probably benign	Het
Cacnb2	G	A	2: 14,958,829	V85I	probably benign	Het
Cast	A	T	13: 74,700,687	D727E	probably damaging	Het
Ccdc134	C	T	15: 82,140,950	R217W	probably damaging	Het
Col5a3	A	G	9: 20,804,666	S360P	unknown	Het
Cyp4f16	T	C	17: 32,537,087	I30T	possibly damaging	Het
Dopey2	T	C	16: 93,755,473	F267L	probably benign	Het
Fbxo3	A	G	2: 104,050,294	T250A	probably damaging	Het
Gm4953	C	T	1: 159,168,393		noncoding transcript	Het
Gm9242	T	C	16: 97,491,079		probably benign	Het
Gsr	G	A	8: 33,689,425	V354I	probably damaging	Het
Hecw1	T	A	13: 14,377,726	D96V	probably damaging	Het
Hist2h2be	A	G	3: 96,221,416	Y84C	possibly damaging	Het
Il18r1	A	G	1: 40,498,551	Y492C	probably damaging	Het
Itgb5	T	G	16: 33,944,095		probably benign	Het
Lars2	T	G	9: 123,459,585	L832R	probably damaging	Het
Ms4a6c	A	G	19: 11,471,102		probably benign	Het
Nrxn1	T	C	17: 90,208,383	S1227G	probably damaging	Het
Olfr15	T	C	16: 3,839,816	V281A	possibly damaging	Het
Olfr339	T	C	2: 36,422,120	C241R	probably damaging	Het
Olfr584	A	G	7: 103,086,321	T263A	probably benign	Het
Pcdh17	A	G	14: 84,448,307	Y738C	probably damaging	Het
Pcsk5	C	A	19: 17,447,501	C1646F	probably damaging	Het
Pkd1l2	G	A	8: 117,065,745	T436I	probably benign	Het
Polrmt	A	T	10: 79,737,258		probably benign	Het
Saxo1	G	T	4: 86,445,584	R221S	probably damaging	Het
Specc1l	A	G	10: 75,241,188	I93V	probably benign	Het
St8sia2	T	A	7: 73,976,649		probably benign	Het
Tep1	A	T	14: 50,866,037	N265K	probably damaging	Het
Thbd	A	T	2: 148,407,034	Y305N	probably damaging	Het
Tmem120a	T	C	5: 135,735,751	T325A	probably damaging	Het
Tmem2	G	A	19: 21,823,843	D775N	possibly damaging	Het
Vill	G	A	9: 119,066,887		probably benign	Het
Wdr35	A	G	12: 9,027,507	D1060G	probably damaging	Het
Xrn2	T	A	2: 147,026,524	F166I	probably damaging	Het
Zc3h7a	T	G	16: 11,158,594		probably null	Het
Zdhhc13	G	A	7: 48,817,138		probably benign	Het
Zfp808	T	A	13: 62,173,130	N724K	possibly damaging	Het

Other mutations in Pirb

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01295:Pirb	APN	7	3717406	missense	probably damaging	0.99
IGL01744:Pirb	APN	7	3717176	nonsense	probably null
IGL01755:Pirb	APN	7	3717170	missense	probably benign	0.16
IGL02580:Pirb	APN	7	3714206	splice site	probably null
R0394:Pirb	UTSW	7	3719248	missense	probably benign	0.08
R0680:Pirb	UTSW	7	3717361	missense	possibly damaging	0.94
R0787:Pirb	UTSW	7	3717638	missense	probably benign
R0790:Pirb	UTSW	7	3717638	missense	probably benign
R0832:Pirb	UTSW	7	3717638	missense	probably benign
R1124:Pirb	UTSW	7	3719732	missense	probably benign	0.02
R1178:Pirb	UTSW	7	3717638	missense	probably benign
R1180:Pirb	UTSW	7	3717638	missense	probably benign
R1181:Pirb	UTSW	7	3717638	missense	probably benign
R1281:Pirb	UTSW	7	3717190	missense	probably damaging	1.00
R1343:Pirb	UTSW	7	3717638	missense	probably benign
R1579:Pirb	UTSW	7	3717638	missense	probably benign
R1699:Pirb	UTSW	7	3717638	missense	probably benign
R1768:Pirb	UTSW	7	3717190	missense	probably damaging	1.00
R1909:Pirb	UTSW	7	3714588	missense	probably benign	0.33
R1965:Pirb	UTSW	7	3717638	missense	probably benign
R1966:Pirb	UTSW	7	3717638	missense	probably benign
R2004:Pirb	UTSW	7	3717638	missense	probably benign
R2305:Pirb	UTSW	7	3712991	missense	probably benign	0.00
R2931:Pirb	UTSW	7	3717206	missense	probably benign	0.08
R3858:Pirb	UTSW	7	3717663	missense	possibly damaging	0.54
R3928:Pirb	UTSW	7	3717638	missense	probably benign
R3938:Pirb	UTSW	7	3717638	missense	probably benign
R4119:Pirb	UTSW	7	3717575	missense	probably damaging	1.00
R4174:Pirb	UTSW	7	3716032	critical splice donor site	probably null
R4248:Pirb	UTSW	7	3719298	missense	probably damaging	1.00
R4827:Pirb	UTSW	7	3717603	missense	probably benign
R4828:Pirb	UTSW	7	3717603	missense	probably benign
R4829:Pirb	UTSW	7	3717603	missense	probably benign
R4830:Pirb	UTSW	7	3717603	missense	probably benign
R4870:Pirb	UTSW	7	3712662	missense	probably benign	0.00
R4909:Pirb	UTSW	7	3719362	nonsense	probably null
R5146:Pirb	UTSW	7	3712621	utr 3 prime	probably benign
R5244:Pirb	UTSW	7	3716063	missense	probably benign	0.32
R5323:Pirb	UTSW	7	3716599	missense	possibly damaging	0.85
R5921:Pirb	UTSW	7	3716694	nonsense	probably null
R6316:Pirb	UTSW	7	3717823	missense	probably damaging	1.00
R6502:Pirb	UTSW	7	3717393	missense	probably benign	0.00
R6811:Pirb	UTSW	7	3719642	missense	possibly damaging	0.91
R7216:Pirb	UTSW	7	3716274	missense	probably benign	0.00
R7275:Pirb	UTSW	7	3716178	missense	probably benign	0.00
R7327:Pirb	UTSW	7	3717188	nonsense	probably null
R7582:Pirb	UTSW	7	3713818	critical splice donor site	probably null
R7717:Pirb	UTSW	7	3717783	missense	not run
R7717:Pirb	UTSW	7	3717801	missense	not run
R7807:Pirb	UTSW	7	3719865	missense	possibly damaging	0.55
R7844:Pirb	UTSW	7	3719411	nonsense	probably null
R7947:Pirb	UTSW	7	3719858	missense	probably damaging	0.96
R8206:Pirb	UTSW	7	3712906	critical splice donor site	probably null
R8397:Pirb	UTSW	7	3716046	missense	probably damaging	1.00
R8774:Pirb	UTSW	7	3717729	missense	probably damaging	1.00
R8774-TAIL:Pirb	UTSW	7	3717729	missense	probably damaging	1.00
R9033:Pirb	UTSW	7	3717585	missense	probably benign
R9275:Pirb	UTSW	7	3716860	missense	probably benign
R9452:Pirb	UTSW	7	3717618	missense	possibly damaging	0.68
R9595:Pirb	UTSW	7	3719407	missense	possibly damaging	0.78
R9605:Pirb	UTSW	7	3717618	missense	possibly damaging	0.68
R9607:Pirb	UTSW	7	3717618	missense	possibly damaging	0.68
X0025:Pirb	UTSW	7	3717268	missense	probably benign	0.00

Posted On

2015-12-18