Incidental Mutation 'IGL02942:Tas2r117'
ID364549
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r117
Ensembl Gene ENSMUSG00000058349
Gene Nametaste receptor, type 2, member 117
SynonymsTas2r17, T2R17, mt2r54, mGR17
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.055) question?
Stock #IGL02942
Quality Score
Status
Chromosome6
Chromosomal Location132802818-132803975 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 132803694 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 265 (L265P)
Ref Sequence ENSEMBL: ENSMUSP00000069768 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068302]
Predicted Effect probably benign
Transcript: ENSMUST00000068302
AA Change: L265P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000069768
Gene: ENSMUSG00000058349
AA Change: L265P

DomainStartEndE-ValueType
Pfam:TAS2R 8 307 1.2e-85 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd2 A C 15: 91,149,175 D679E probably damaging Het
Adh6a A T 3: 138,324,881 D88V probably damaging Het
Ank3 G A 10: 69,973,877 V1123I probably damaging Het
Apba1 T C 19: 23,944,971 V801A possibly damaging Het
Bcl2a1a C T 9: 88,957,042 probably benign Het
Brd8 A G 18: 34,610,627 V215A possibly damaging Het
Cdk17 G A 10: 93,238,968 V454I probably benign Het
Chd5 G A 4: 152,385,725 G1876D probably damaging Het
Clec4g T C 8: 3,718,356 E125G probably damaging Het
Col24a1 G A 3: 145,541,665 G1602D probably damaging Het
Depdc7 A C 2: 104,728,094 L194R probably damaging Het
Dgke T G 11: 89,055,369 N202H probably benign Het
Dkk2 T A 3: 132,178,037 C233S probably damaging Het
Dmpk A C 7: 19,092,241 D542A probably damaging Het
Epb41l4a G A 18: 33,874,201 R246W probably damaging Het
Frmpd1 A T 4: 45,285,493 Q1438L probably damaging Het
Gcgr A G 11: 120,536,817 probably null Het
Gm10295 T C 7: 71,350,502 K110R unknown Het
Ifrd1 A G 12: 40,217,376 probably null Het
Inpp5f A G 7: 128,694,900 T365A probably benign Het
Kcnn3 A G 3: 89,652,076 K551R probably benign Het
Lama2 A T 10: 27,041,220 N2236K probably damaging Het
Larp7 A T 3: 127,544,195 I405N possibly damaging Het
Meltf C A 16: 31,890,778 Y432* probably null Het
Mst1r C A 9: 107,913,153 T655K possibly damaging Het
Myh1 C T 11: 67,202,482 P133L probably damaging Het
Nrn1 C A 13: 36,730,106 probably null Het
Olfr1454 A T 19: 13,064,188 Q259L probably benign Het
Olfr2 A G 7: 107,001,354 S169P possibly damaging Het
Olfr584 A T 7: 103,086,198 M222L probably benign Het
Pfkl A T 10: 78,000,133 probably null Het
Plekhb2 T C 1: 34,876,992 M204T probably damaging Het
Ptp4a2 G A 4: 129,845,193 probably null Het
Rtp4 A G 16: 23,612,954 T79A probably benign Het
Senp3 T C 11: 69,677,989 D410G probably benign Het
Slc16a5 T C 11: 115,469,350 F120L possibly damaging Het
Snrpe T C 1: 133,608,931 E37G probably damaging Het
Sorcs1 T C 19: 50,475,437 T192A probably damaging Het
Spef2 T A 15: 9,668,874 H742L possibly damaging Het
Syt12 T C 19: 4,447,830 S375G probably benign Het
Tcp10a T A 17: 7,329,919 D158E probably damaging Het
Tesk2 A T 4: 116,771,820 H122L probably damaging Het
Unc93b1 T A 19: 3,948,686 M535K probably damaging Het
Vangl1 C A 3: 102,184,031 R246S probably damaging Het
Xpo5 C T 17: 46,208,133 T166I probably damaging Het
Zcchc6 T G 13: 59,811,521 N378H probably damaging Het
Zmiz2 T C 11: 6,399,500 probably benign Het
Other mutations in Tas2r117
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01611:Tas2r117 APN 6 132803484 missense probably benign 0.00
IGL01611:Tas2r117 APN 6 132803487 missense probably damaging 0.96
IGL02140:Tas2r117 APN 6 132803595 missense probably benign 0.15
IGL02154:Tas2r117 APN 6 132803715 missense probably benign 0.00
IGL02466:Tas2r117 APN 6 132803000 missense probably benign 0.12
IGL03328:Tas2r117 APN 6 132803078 missense probably benign 0.40
PIT4480001:Tas2r117 UTSW 6 132803051 missense possibly damaging 0.91
R0380:Tas2r117 UTSW 6 132803588 nonsense probably null
R0456:Tas2r117 UTSW 6 132803391 missense probably benign 0.12
R0699:Tas2r117 UTSW 6 132803198 missense probably damaging 1.00
R2118:Tas2r117 UTSW 6 132803166 missense probably damaging 0.96
R2265:Tas2r117 UTSW 6 132803225 missense probably benign 0.06
R4420:Tas2r117 UTSW 6 132803349 nonsense probably null
R4861:Tas2r117 UTSW 6 132803129 missense probably benign 0.00
R4861:Tas2r117 UTSW 6 132803129 missense probably benign 0.00
R5233:Tas2r117 UTSW 6 132803622 missense possibly damaging 0.95
R5384:Tas2r117 UTSW 6 132803154 missense probably benign 0.04
R6750:Tas2r117 UTSW 6 132802854 start gained probably benign
R6852:Tas2r117 UTSW 6 132802929 missense probably benign 0.00
R6902:Tas2r117 UTSW 6 132803325 missense probably damaging 0.98
R6946:Tas2r117 UTSW 6 132803325 missense probably damaging 0.98
R7129:Tas2r117 UTSW 6 132803387 missense probably benign 0.01
R7412:Tas2r117 UTSW 6 132803229 missense probably damaging 1.00
R7733:Tas2r117 UTSW 6 132803175 missense probably benign 0.02
Posted On2015-12-18