Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02945:Tmem255b'

364696

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem255b

Ensembl Gene

ENSMUSG00000038457

Gene Name

transmembrane protein 255B

Synonyms

Fam70b, LOC272465

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL02945

Quality Score

Status

Chromosome

Chromosomal Location

13435189-13468473 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 13455141 bp

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 149 (S149P)

Ref Sequence

ENSEMBL: ENSMUSP00000130504 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167071] [ENSMUST00000167505] [ENSMUST00000210804]

Predicted Effect

probably benign
Transcript: ENSMUST00000167071
AA Change: S128P

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000127421
Gene: ENSMUSG00000038457
AA Change: S128P

Domain	Start	End	E-Value	Type
Pfam:FAM70	1	68	8.2e-28	PFAM
Pfam:FAM70	66	307	1.8e-119	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000167505
AA Change: S149P

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000130504
Gene: ENSMUSG00000038457
AA Change: S149P

Domain	Start	End	E-Value	Type
Pfam:FAM70	6	328	6e-166	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000209950

Predicted Effect

probably benign
Transcript: ENSMUST00000210804

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211356

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933411G06Rik	A	T	10: 51,756,999		noncoding transcript	Het
Adgrf4	T	C	17: 42,667,366	Q362R	probably benign	Het
Akap6	A	G	12: 52,880,837	N177D	probably damaging	Het
Alms1	A	G	6: 85,620,933	I914V	probably damaging	Het
Arhgap11a	A	T	2: 113,837,473	S394R	possibly damaging	Het
Cacna1h	C	T	17: 25,388,059	V962I	probably damaging	Het
Calr3	A	T	8: 72,438,557	L91Q	probably damaging	Het
Ccnf	T	C	17: 24,224,916	E626G	probably damaging	Het
Clec10a	A	T	11: 70,170,542	I295F	possibly damaging	Het
Cop1	A	T	1: 159,306,689	N167I	probably benign	Het
Csmd1	G	T	8: 16,271,570	Q505K	possibly damaging	Het
Ctrc	A	C	4: 141,846,252	V6G	possibly damaging	Het
Cyp2c69	T	C	19: 39,886,647	R21G	possibly damaging	Het
Dnah5	A	G	15: 28,270,426	H958R	probably benign	Het
Egfr	T	A	11: 16,752,514	L11Q	probably damaging	Het
Erich2	A	G	2: 70,534,394	T371A	probably damaging	Het
Fbxl21	T	A	13: 56,527,170	F111L	probably damaging	Het
Grik4	G	T	9: 42,597,879	T416N	possibly damaging	Het
Grin3a	A	G	4: 49,792,971	V254A	possibly damaging	Het
Hat1	G	A	2: 71,420,693	R195K	probably benign	Het
Hmgb4	A	C	4: 128,260,594	Y60*	probably null	Het
Ighv12-3	A	G	12: 114,366,717	W53R	probably damaging	Het
Irs2	C	A	8: 11,007,781	C217F	probably damaging	Het
Kcnb1	T	C	2: 167,188,388	E79G	probably benign	Het
Lingo3	A	G	10: 80,834,698	I466T	probably damaging	Het
Lyst	T	C	13: 13,761,198	S3665P	possibly damaging	Het
Myh9	A	T	15: 77,762,005	L1926Q	probably benign	Het
Myom1	A	G	17: 71,092,093		probably benign	Het
Nbeal1	T	C	1: 60,206,410	F198L	probably damaging	Het
Nktr	A	G	9: 121,728,631	T63A	probably damaging	Het
Nle1	A	T	11: 82,904,084		probably benign	Het
Nr3c2	A	T	8: 76,909,659	D463V	probably damaging	Het
Olfr181	A	T	16: 58,926,340	I77N	probably damaging	Het
Olfr902	A	G	9: 38,449,516	I215V	probably benign	Het
Pcdhb18	T	C	18: 37,489,995	I126T	probably benign	Het
Pgm2	A	G	4: 99,961,534	I127V	probably benign	Het
Rai14	A	G	15: 10,574,709	I721T	probably benign	Het
Rps6ka1	A	G	4: 133,867,199	Y57H	probably damaging	Het
Scara3	T	A	14: 65,931,211	D319V	probably damaging	Het
Selp	G	A	1: 164,133,929	G404S	probably damaging	Het
Serinc3	A	G	2: 163,630,916		probably benign	Het
Slc4a8	A	G	15: 100,807,199		probably null	Het
Spen	G	T	4: 141,494,313	L325I	unknown	Het
Sphkap	A	T	1: 83,276,831	S779T	probably damaging	Het
Stxbp2	A	T	8: 3,641,971	I538F	probably benign	Het
Thumpd1	A	T	7: 119,716,747	S326R	possibly damaging	Het
Tnni3k	A	T	3: 155,037,438	S95T	possibly damaging	Het
Trim66	G	A	7: 109,460,176	Q954*	probably null	Het
Ttn	A	T	2: 76,751,972	I22859N	probably damaging	Het
Zfp319	A	T	8: 95,323,818		probably benign	Het

Other mutations in Tmem255b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00823:Tmem255b	APN	8	13457054	missense	probably benign
IGL02635:Tmem255b	APN	8	13455195	missense	probably damaging	1.00
IGL02679:Tmem255b	APN	8	13457055	missense	probably benign	0.04
IGL03007:Tmem255b	APN	8	13457066	missense	possibly damaging	0.94
IGL03146:Tmem255b	APN	8	13454174	missense	probably damaging	1.00
R2278:Tmem255b	UTSW	8	13451081	missense	probably damaging	1.00
R2410:Tmem255b	UTSW	8	13441278	missense	probably benign	0.22
R3081:Tmem255b	UTSW	8	13451048	missense	probably damaging	0.99
R4498:Tmem255b	UTSW	8	13455998	missense	probably damaging	1.00
R4612:Tmem255b	UTSW	8	13454228	missense	probably benign	0.00
R6018:Tmem255b	UTSW	8	13455138	missense	probably benign	0.00
R6073:Tmem255b	UTSW	8	13456958	missense	probably damaging	0.98
R6240:Tmem255b	UTSW	8	13454216	missense	probably damaging	1.00
R6737:Tmem255b	UTSW	8	13457096	critical splice donor site	probably null
R8231:Tmem255b	UTSW	8	13454225	missense	probably damaging	0.97

Posted On

2015-12-18