Incidental Mutation 'IGL02946:Or2t26'
ID 364724
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2t26
Ensembl Gene ENSMUSG00000050763
Gene Name olfactory receptor family 2 subfamily T member 26
Synonyms GA_x6K02T2QP88-6286247-6285294, Olfr1395, MOR277-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # IGL02946
Quality Score
Status
Chromosome 11
Chromosomal Location 49039086-49040039 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 49039719 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Valine at position 212 (F212V)
Ref Sequence ENSEMBL: ENSMUSP00000150679 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059379] [ENSMUST00000203377] [ENSMUST00000214195]
AlphaFold Q8VGD7
Predicted Effect probably damaging
Transcript: ENSMUST00000059379
AA Change: F212V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000050142
Gene: ENSMUSG00000050763
AA Change: F212V

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 1e-50 PFAM
Pfam:7TM_GPCR_Srsx 36 252 4.8e-6 PFAM
Pfam:7tm_1 42 291 1.9e-28 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000203377
AA Change: F212V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000145357
Gene: ENSMUSG00000050763
AA Change: F212V

DomainStartEndE-ValueType
Pfam:7tm_1 1 219 1.9e-18 PFAM
Pfam:7tm_4 1 237 2.4e-38 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214195
AA Change: F212V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a G A 11: 109,919,041 (GRCm39) probably benign Het
Actr3b T C 5: 26,053,481 (GRCm39) I270T possibly damaging Het
Adgrf2 T C 17: 43,021,384 (GRCm39) Y480C probably damaging Het
Arhgap27 T C 11: 103,229,174 (GRCm39) T514A probably damaging Het
BC031181 C T 18: 75,141,736 (GRCm39) probably benign Het
Cckbr C T 7: 105,083,238 (GRCm39) A147V probably damaging Het
Ccm2 G A 11: 6,546,195 (GRCm39) R335H probably damaging Het
Ces1d C A 8: 93,896,346 (GRCm39) probably null Het
Crabp1 T C 9: 54,672,232 (GRCm39) F16S possibly damaging Het
Crmp1 C T 5: 37,441,424 (GRCm39) A502V probably damaging Het
Ehhadh A T 16: 21,581,672 (GRCm39) V440D probably damaging Het
Galnt3 T A 2: 65,925,562 (GRCm39) I392L probably damaging Het
Gm12689 T A 4: 99,184,490 (GRCm39) N114K unknown Het
Hspa2 A G 12: 76,451,947 (GRCm39) T214A probably damaging Het
Itga7 T C 10: 128,769,952 (GRCm39) I32T probably benign Het
Itgal A G 7: 126,913,540 (GRCm39) S682G probably damaging Het
Kctd1 C T 18: 15,107,036 (GRCm39) probably null Het
Lrp1b T A 2: 41,202,571 (GRCm39) D439V probably damaging Het
Mdn1 A G 4: 32,734,366 (GRCm39) K3258E probably damaging Het
Mgat4c T C 10: 102,225,114 (GRCm39) S443P probably benign Het
Mylk G A 16: 34,742,158 (GRCm39) G890E probably benign Het
Mylk2 T A 2: 152,761,130 (GRCm39) L446* probably null Het
Niban1 A T 1: 151,525,176 (GRCm39) I194F probably damaging Het
Pi4k2b T C 5: 52,910,549 (GRCm39) F278L probably damaging Het
Pitpnm3 A G 11: 71,983,378 (GRCm39) S84P probably benign Het
Plxna2 T C 1: 194,431,617 (GRCm39) probably benign Het
Prr5l C A 2: 101,602,529 (GRCm39) probably null Het
Ptprs T C 17: 56,731,032 (GRCm39) T719A probably benign Het
Rasa3 T C 8: 13,648,280 (GRCm39) H128R probably benign Het
Rhox13 A G X: 37,218,652 (GRCm39) K205E probably damaging Het
Rif1 C A 2: 52,000,137 (GRCm39) S1197* probably null Het
Sgta A G 10: 80,885,612 (GRCm39) probably benign Het
Slc25a5 T A X: 36,061,506 (GRCm39) M239K probably damaging Het
Stil T A 4: 114,887,110 (GRCm39) H734Q probably benign Het
Stk32b T C 5: 37,688,883 (GRCm39) probably benign Het
Ubr4 T G 4: 139,152,606 (GRCm39) F1999C probably damaging Het
Wfdc2 A C 2: 164,406,009 (GRCm39) T86P probably benign Het
Zfp407 T C 18: 84,578,834 (GRCm39) S760G probably damaging Het
Zfp668 A T 7: 127,465,690 (GRCm39) L498Q possibly damaging Het
Other mutations in Or2t26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02413:Or2t26 APN 11 49,039,384 (GRCm39) missense probably damaging 1.00
R0030:Or2t26 UTSW 11 49,039,867 (GRCm39) missense possibly damaging 0.81
R1013:Or2t26 UTSW 11 49,039,977 (GRCm39) missense probably damaging 1.00
R1577:Or2t26 UTSW 11 49,040,016 (GRCm39) missense probably benign 0.05
R1908:Or2t26 UTSW 11 49,039,101 (GRCm39) missense possibly damaging 0.95
R3715:Or2t26 UTSW 11 49,039,642 (GRCm39) missense probably damaging 0.99
R4386:Or2t26 UTSW 11 49,039,842 (GRCm39) missense probably damaging 1.00
R4496:Or2t26 UTSW 11 49,039,214 (GRCm39) missense possibly damaging 0.86
R5030:Or2t26 UTSW 11 49,039,188 (GRCm39) missense probably benign 0.01
R6044:Or2t26 UTSW 11 49,039,522 (GRCm39) missense probably benign 0.29
R6226:Or2t26 UTSW 11 49,039,660 (GRCm39) missense possibly damaging 0.81
R7177:Or2t26 UTSW 11 49,040,012 (GRCm39) nonsense probably null
R7282:Or2t26 UTSW 11 49,039,945 (GRCm39) missense probably damaging 1.00
R7391:Or2t26 UTSW 11 49,039,806 (GRCm39) missense probably damaging 1.00
R7411:Or2t26 UTSW 11 49,039,821 (GRCm39) missense probably benign 0.01
R7888:Or2t26 UTSW 11 49,039,266 (GRCm39) missense probably damaging 1.00
R8869:Or2t26 UTSW 11 49,039,483 (GRCm39) missense probably damaging 1.00
R8944:Or2t26 UTSW 11 49,039,266 (GRCm39) missense probably damaging 1.00
R9048:Or2t26 UTSW 11 49,039,830 (GRCm39) missense probably damaging 1.00
R9253:Or2t26 UTSW 11 49,039,822 (GRCm39) missense probably damaging 0.98
R9445:Or2t26 UTSW 11 49,039,879 (GRCm39) missense probably benign 0.25
R9752:Or2t26 UTSW 11 49,039,681 (GRCm39) missense probably benign 0.27
Posted On 2015-12-18