Incidental Mutation 'IGL02946:Zfp668'
ID 364740
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp668
Ensembl Gene ENSMUSG00000049728
Gene Name zinc finger protein 668
Synonyms E130018B19Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.147) question?
Stock # IGL02946
Quality Score
Status
Chromosome 7
Chromosomal Location 127462219-127476000 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 127465690 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 498 (L498Q)
Ref Sequence ENSEMBL: ENSMUSP00000101870 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054415] [ENSMUST00000106261] [ENSMUST00000106262] [ENSMUST00000106263] [ENSMUST00000144721]
AlphaFold Q8K2R5
Predicted Effect possibly damaging
Transcript: ENSMUST00000054415
AA Change: L498Q

PolyPhen 2 Score 0.703 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000056105
Gene: ENSMUSG00000049728
AA Change: L498Q

DomainStartEndE-ValueType
ZnF_C2H2 22 44 7.67e-2 SMART
ZnF_C2H2 84 106 9.44e-2 SMART
ZnF_C2H2 112 134 3.63e-3 SMART
ZnF_C2H2 140 162 2.36e-2 SMART
ZnF_C2H2 168 190 1.98e-4 SMART
ZnF_C2H2 196 218 2.91e-2 SMART
ZnF_C2H2 224 246 1.26e-2 SMART
ZnF_C2H2 252 274 5.21e-4 SMART
ZnF_C2H2 280 302 2.57e-3 SMART
ZnF_C2H2 308 330 5.59e-4 SMART
ZnF_C2H2 336 358 1.79e-2 SMART
ZnF_C2H2 364 386 7.9e-4 SMART
ZnF_C2H2 392 414 5.5e-3 SMART
low complexity region 428 470 N/A INTRINSIC
ZnF_C2H2 516 538 3.63e-3 SMART
ZnF_C2H2 544 566 1.3e-4 SMART
ZnF_C2H2 572 594 5.59e-4 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000106261
AA Change: L498Q

PolyPhen 2 Score 0.703 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000101868
Gene: ENSMUSG00000049728
AA Change: L498Q

DomainStartEndE-ValueType
ZnF_C2H2 22 44 7.67e-2 SMART
ZnF_C2H2 84 106 9.44e-2 SMART
ZnF_C2H2 112 134 3.63e-3 SMART
ZnF_C2H2 140 162 2.36e-2 SMART
ZnF_C2H2 168 190 1.98e-4 SMART
ZnF_C2H2 196 218 2.91e-2 SMART
ZnF_C2H2 224 246 1.26e-2 SMART
ZnF_C2H2 252 274 5.21e-4 SMART
ZnF_C2H2 280 302 2.57e-3 SMART
ZnF_C2H2 308 330 5.59e-4 SMART
ZnF_C2H2 336 358 1.79e-2 SMART
ZnF_C2H2 364 386 7.9e-4 SMART
ZnF_C2H2 392 414 5.5e-3 SMART
low complexity region 428 470 N/A INTRINSIC
ZnF_C2H2 516 538 3.63e-3 SMART
ZnF_C2H2 544 566 1.3e-4 SMART
ZnF_C2H2 572 594 5.59e-4 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000106262
AA Change: L498Q

PolyPhen 2 Score 0.703 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000101869
Gene: ENSMUSG00000049728
AA Change: L498Q

DomainStartEndE-ValueType
ZnF_C2H2 22 44 7.67e-2 SMART
ZnF_C2H2 84 106 9.44e-2 SMART
ZnF_C2H2 112 134 3.63e-3 SMART
ZnF_C2H2 140 162 2.36e-2 SMART
ZnF_C2H2 168 190 1.98e-4 SMART
ZnF_C2H2 196 218 2.91e-2 SMART
ZnF_C2H2 224 246 1.26e-2 SMART
ZnF_C2H2 252 274 5.21e-4 SMART
ZnF_C2H2 280 302 2.57e-3 SMART
ZnF_C2H2 308 330 5.59e-4 SMART
ZnF_C2H2 336 358 1.79e-2 SMART
ZnF_C2H2 364 386 7.9e-4 SMART
ZnF_C2H2 392 414 5.5e-3 SMART
low complexity region 428 470 N/A INTRINSIC
ZnF_C2H2 516 538 3.63e-3 SMART
ZnF_C2H2 544 566 1.3e-4 SMART
ZnF_C2H2 572 594 5.59e-4 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000106263
AA Change: L498Q

PolyPhen 2 Score 0.703 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000101870
Gene: ENSMUSG00000049728
AA Change: L498Q

DomainStartEndE-ValueType
ZnF_C2H2 22 44 7.67e-2 SMART
ZnF_C2H2 84 106 9.44e-2 SMART
ZnF_C2H2 112 134 3.63e-3 SMART
ZnF_C2H2 140 162 2.36e-2 SMART
ZnF_C2H2 168 190 1.98e-4 SMART
ZnF_C2H2 196 218 2.91e-2 SMART
ZnF_C2H2 224 246 1.26e-2 SMART
ZnF_C2H2 252 274 5.21e-4 SMART
ZnF_C2H2 280 302 2.57e-3 SMART
ZnF_C2H2 308 330 5.59e-4 SMART
ZnF_C2H2 336 358 1.79e-2 SMART
ZnF_C2H2 364 386 7.9e-4 SMART
ZnF_C2H2 392 414 5.5e-3 SMART
low complexity region 428 470 N/A INTRINSIC
ZnF_C2H2 516 538 3.63e-3 SMART
ZnF_C2H2 544 566 1.3e-4 SMART
ZnF_C2H2 572 594 5.59e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000144721
SMART Domains Protein: ENSMUSP00000116730
Gene: ENSMUSG00000049728

DomainStartEndE-ValueType
ZnF_C2H2 22 44 7.67e-2 SMART
ZnF_C2H2 84 106 9.44e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a G A 11: 109,919,041 (GRCm39) probably benign Het
Actr3b T C 5: 26,053,481 (GRCm39) I270T possibly damaging Het
Adgrf2 T C 17: 43,021,384 (GRCm39) Y480C probably damaging Het
Arhgap27 T C 11: 103,229,174 (GRCm39) T514A probably damaging Het
BC031181 C T 18: 75,141,736 (GRCm39) probably benign Het
Cckbr C T 7: 105,083,238 (GRCm39) A147V probably damaging Het
Ccm2 G A 11: 6,546,195 (GRCm39) R335H probably damaging Het
Ces1d C A 8: 93,896,346 (GRCm39) probably null Het
Crabp1 T C 9: 54,672,232 (GRCm39) F16S possibly damaging Het
Crmp1 C T 5: 37,441,424 (GRCm39) A502V probably damaging Het
Ehhadh A T 16: 21,581,672 (GRCm39) V440D probably damaging Het
Galnt3 T A 2: 65,925,562 (GRCm39) I392L probably damaging Het
Gm12689 T A 4: 99,184,490 (GRCm39) N114K unknown Het
Hspa2 A G 12: 76,451,947 (GRCm39) T214A probably damaging Het
Itga7 T C 10: 128,769,952 (GRCm39) I32T probably benign Het
Itgal A G 7: 126,913,540 (GRCm39) S682G probably damaging Het
Kctd1 C T 18: 15,107,036 (GRCm39) probably null Het
Lrp1b T A 2: 41,202,571 (GRCm39) D439V probably damaging Het
Mdn1 A G 4: 32,734,366 (GRCm39) K3258E probably damaging Het
Mgat4c T C 10: 102,225,114 (GRCm39) S443P probably benign Het
Mylk G A 16: 34,742,158 (GRCm39) G890E probably benign Het
Mylk2 T A 2: 152,761,130 (GRCm39) L446* probably null Het
Niban1 A T 1: 151,525,176 (GRCm39) I194F probably damaging Het
Or2t26 T G 11: 49,039,719 (GRCm39) F212V probably damaging Het
Pi4k2b T C 5: 52,910,549 (GRCm39) F278L probably damaging Het
Pitpnm3 A G 11: 71,983,378 (GRCm39) S84P probably benign Het
Plxna2 T C 1: 194,431,617 (GRCm39) probably benign Het
Prr5l C A 2: 101,602,529 (GRCm39) probably null Het
Ptprs T C 17: 56,731,032 (GRCm39) T719A probably benign Het
Rasa3 T C 8: 13,648,280 (GRCm39) H128R probably benign Het
Rhox13 A G X: 37,218,652 (GRCm39) K205E probably damaging Het
Rif1 C A 2: 52,000,137 (GRCm39) S1197* probably null Het
Sgta A G 10: 80,885,612 (GRCm39) probably benign Het
Slc25a5 T A X: 36,061,506 (GRCm39) M239K probably damaging Het
Stil T A 4: 114,887,110 (GRCm39) H734Q probably benign Het
Stk32b T C 5: 37,688,883 (GRCm39) probably benign Het
Ubr4 T G 4: 139,152,606 (GRCm39) F1999C probably damaging Het
Wfdc2 A C 2: 164,406,009 (GRCm39) T86P probably benign Het
Zfp407 T C 18: 84,578,834 (GRCm39) S760G probably damaging Het
Other mutations in Zfp668
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00944:Zfp668 APN 7 127,467,079 (GRCm39) missense probably damaging 1.00
IGL01063:Zfp668 APN 7 127,465,454 (GRCm39) missense probably damaging 1.00
IGL01909:Zfp668 APN 7 127,465,994 (GRCm39) missense probably damaging 1.00
IGL02404:Zfp668 APN 7 127,465,532 (GRCm39) missense probably damaging 1.00
IGL02543:Zfp668 APN 7 127,467,494 (GRCm39) nonsense probably null
R0078:Zfp668 UTSW 7 127,467,210 (GRCm39) missense possibly damaging 0.94
R1521:Zfp668 UTSW 7 127,466,252 (GRCm39) missense probably benign 0.09
R1775:Zfp668 UTSW 7 127,465,778 (GRCm39) missense possibly damaging 0.75
R1873:Zfp668 UTSW 7 127,465,654 (GRCm39) splice site probably null
R1875:Zfp668 UTSW 7 127,465,654 (GRCm39) splice site probably null
R2066:Zfp668 UTSW 7 127,466,203 (GRCm39) missense probably damaging 0.98
R2068:Zfp668 UTSW 7 127,465,837 (GRCm39) missense probably benign 0.06
R2278:Zfp668 UTSW 7 127,465,998 (GRCm39) missense probably benign 0.05
R5516:Zfp668 UTSW 7 127,466,318 (GRCm39) missense probably damaging 1.00
R5569:Zfp668 UTSW 7 127,466,995 (GRCm39) nonsense probably null
R5875:Zfp668 UTSW 7 127,465,474 (GRCm39) missense possibly damaging 0.61
R6663:Zfp668 UTSW 7 127,466,941 (GRCm39) missense probably damaging 1.00
R8543:Zfp668 UTSW 7 127,466,392 (GRCm39) missense probably damaging 1.00
R8822:Zfp668 UTSW 7 127,466,315 (GRCm39) missense probably damaging 1.00
R8905:Zfp668 UTSW 7 127,465,598 (GRCm39) missense probably benign 0.04
R9191:Zfp668 UTSW 7 127,465,658 (GRCm39) missense probably benign
R9217:Zfp668 UTSW 7 127,465,804 (GRCm39) nonsense probably null
R9655:Zfp668 UTSW 7 127,466,113 (GRCm39) missense possibly damaging 0.70
Posted On 2015-12-18