Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02947:Cyp2j8'

364767

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2j8

Ensembl Gene

ENSMUSG00000082932

Gene Name

cytochrome P450, family 2, subfamily j, polypeptide 8

Synonyms

Cyp2j8-ps, OTTMUSG00000007938

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

IGL02947

Quality Score

Status

Chromosome

Chromosomal Location

96444596-96507386 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 96470578 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 368 (I368N)

Ref Sequence

ENSEMBL: ENSMUSP00000134591 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000124729]

Predicted Effect

probably damaging
Transcript: ENSMUST00000124729
AA Change: I368N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000134591
Gene: ENSMUSG00000082932
AA Change: I368N

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
Pfam:p450	44	500	1.2e-134	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001L19Rik	T	A	13: 68,611,193	F95L	probably benign	Het
Aasdh	A	G	5: 76,902,110	V13A	probably benign	Het
Atp8b5	T	A	4: 43,305,774	I106K	possibly damaging	Het
Cdh15	T	C	8: 122,865,372	S633P	probably benign	Het
Celsr3	A	G	9: 108,845,935	T228A	probably benign	Het
Chrng	A	G	1: 87,209,884		probably null	Het
Coprs	T	C	8: 13,885,782	E79G	probably damaging	Het
Cpb2	A	C	14: 75,283,318	Y391S	probably damaging	Het
Ddah1	T	C	3: 145,759,087	F76L	probably benign	Het
Eif2ak4	A	G	2: 118,431,033	T573A	probably benign	Het
Exoc6b	T	A	6: 84,858,429	M375L	probably benign	Het
Fasn	T	C	11: 120,815,676	E994G	probably damaging	Het
Fem1a	T	A	17: 56,258,640	C578S	probably benign	Het
Garnl3	A	G	2: 33,046,594	S188P	probably damaging	Het
Gpn3	T	C	5: 122,378,488	V60A	possibly damaging	Het
Hnrnpr	A	G	4: 136,316,379	D59G	probably damaging	Het
Hydin	A	T	8: 110,418,462	E815V	probably damaging	Het
Itga9	C	T	9: 118,658,533	T228M	probably damaging	Het
Kpna7	T	C	5: 144,994,074	I320M	probably damaging	Het
Lnpep	T	C	17: 17,570,972	T437A	probably damaging	Het
Ltf	C	T	9: 111,038,947	T48I	probably benign	Het
Masp1	T	G	16: 23,494,726	D153A	probably damaging	Het
Mcpt9	T	A	14: 56,026,916	R241*	probably null	Het
Msantd4	T	A	9: 4,384,787	S171T	probably damaging	Het
Nos1	G	A	5: 117,943,317	V1229M	probably damaging	Het
Npc1l1	A	G	11: 6,229,246	S55P	probably benign	Het
Oc90	T	C	15: 65,888,134	K212R	probably benign	Het
Olfr1095	C	T	2: 86,850,786	R304K	probably benign	Het
Olfr446	A	G	6: 42,927,896	I222V	probably benign	Het
Olfr771	C	A	10: 129,160,570	C138F	probably damaging	Het
Prr12	T	A	7: 45,048,556	Q645L	unknown	Het
Psmd9	A	G	5: 123,246,215	I145V	probably benign	Het
Rbks	T	C	5: 31,660,063	I121V	probably benign	Het
Rnase2b	A	T	14: 51,162,807	Y115F	probably damaging	Het
Sarnp	A	G	10: 128,839,854	E78G	probably benign	Het
Sltm	A	G	9: 70,591,664	S1007G	probably benign	Het
Spata31d1c	T	A	13: 65,034,945	Y100*	probably null	Het
Srrm2	T	C	17: 23,810,746	S222P	probably benign	Het
Sult3a1	G	A	10: 33,864,050	R35Q	possibly damaging	Het
Tfap4	T	C	16: 4,551,360	D132G	probably damaging	Het
Tmem53	C	T	4: 117,268,088	Q111*	probably null	Het
Togaram1	T	A	12: 65,021,500	V1709D	probably damaging	Het
Trpm3	A	T	19: 22,901,119	D628V	probably damaging	Het
Ttn	T	A	2: 76,714,494	K31009*	probably null	Het
Vldlr	A	G	19: 27,239,720	I58V	probably benign	Het
Vmn1r4	T	C	6: 56,957,246	F245S	probably benign	Het
Vrtn	T	A	12: 84,648,484	S3T	probably damaging	Het
Vwa7	A	G	17: 35,023,500		probably null	Het
Wrnip1	T	A	13: 32,822,070	Y632N	probably damaging	Het

Other mutations in Cyp2j8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00088:Cyp2j8	APN	4	96503842	missense	probably benign	0.06
IGL00418:Cyp2j8	APN	4	96444616	missense	possibly damaging	0.85
IGL01577:Cyp2j8	APN	4	96479071	missense	probably damaging	0.96
IGL01629:Cyp2j8	APN	4	96499603	missense	probably damaging	1.00
IGL01928:Cyp2j8	APN	4	96470476	splice site	probably benign
IGL01978:Cyp2j8	APN	4	96504009	splice site	probably null
IGL02053:Cyp2j8	APN	4	96470654	missense	probably damaging	1.00
IGL02500:Cyp2j8	APN	4	96470650	missense	probably damaging	1.00
cyprus	UTSW	4	96499603	missense	probably damaging	1.00
R0558:Cyp2j8	UTSW	4	96444634	missense	probably benign	0.01
R0718:Cyp2j8	UTSW	4	96501196	missense	probably benign
R1553:Cyp2j8	UTSW	4	96475557	missense	probably benign
R1557:Cyp2j8	UTSW	4	96470476	splice site	probably benign
R1632:Cyp2j8	UTSW	4	96447324	missense	probably benign	0.02
R1708:Cyp2j8	UTSW	4	96499595	missense	probably damaging	1.00
R2119:Cyp2j8	UTSW	4	96507201	missense	probably benign
R2220:Cyp2j8	UTSW	4	96444625	missense	probably benign	0.03
R3123:Cyp2j8	UTSW	4	96501213	splice site	probably benign
R3735:Cyp2j8	UTSW	4	96444599	missense	probably damaging	1.00
R3736:Cyp2j8	UTSW	4	96444599	missense	probably damaging	1.00
R4326:Cyp2j8	UTSW	4	96507329	missense	probably benign	0.10
R4327:Cyp2j8	UTSW	4	96507329	missense	probably benign	0.10
R4762:Cyp2j8	UTSW	4	96470649	missense	probably damaging	1.00
R4901:Cyp2j8	UTSW	4	96479086	missense	probably benign	0.16
R4960:Cyp2j8	UTSW	4	96507377	missense	probably benign
R5260:Cyp2j8	UTSW	4	96501064	missense	possibly damaging	0.65
R5562:Cyp2j8	UTSW	4	96470653	missense	probably damaging	1.00
R5596:Cyp2j8	UTSW	4	96507341	missense	probably benign	0.00
R5741:Cyp2j8	UTSW	4	96444643	missense	probably benign	0.00
R5825:Cyp2j8	UTSW	4	96507214	missense	probably benign	0.01
R5903:Cyp2j8	UTSW	4	96507277	missense	possibly damaging	0.46
R6122:Cyp2j8	UTSW	4	96444640	missense	probably benign
R6232:Cyp2j8	UTSW	4	96507190	missense	possibly damaging	0.94
R6748:Cyp2j8	UTSW	4	96475545	missense	probably benign	0.01
R6931:Cyp2j8	UTSW	4	96444781	splice site	probably null
R7000:Cyp2j8	UTSW	4	96447351	missense	probably benign	0.06
R7183:Cyp2j8	UTSW	4	96479181	missense	probably damaging	0.97
R7186:Cyp2j8	UTSW	4	96475550	missense	probably benign	0.00
R7348:Cyp2j8	UTSW	4	96444640	missense	probably benign	0.00
R7575:Cyp2j8	UTSW	4	96470548	missense	possibly damaging	0.63
R7648:Cyp2j8	UTSW	4	96499603	missense	probably damaging	1.00
R7975:Cyp2j8	UTSW	4	96470539	missense	possibly damaging	0.65
R7993:Cyp2j8	UTSW	4	96447219	critical splice donor site	probably null

Posted On

2015-12-18