Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02947:Mcpt9'

364768

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mcpt9

Ensembl Gene

ENSMUSG00000071361

Gene Name

mast cell protease 9

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

IGL02947

Quality Score

Status

Chromosome

Chromosomal Location

56264321-56267952 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 56264373 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 241 (R241*)

Ref Sequence

ENSEMBL: ENSMUSP00000093476 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095798]

AlphaFold

O35164

Predicted Effect

probably null
Transcript: ENSMUST00000095798
AA Change: R241*

SMART Domains

Protein: ENSMUSP00000093476
Gene: ENSMUSG00000071361
AA Change: R241*

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Tryp_SPc	20	239	1.18e-80	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aasdh	A	G	5: 77,049,957 (GRCm39)	V13A	probably benign	Het
Atp8b5	T	A	4: 43,305,774 (GRCm39)	I106K	possibly damaging	Het
Cdh15	T	C	8: 123,592,111 (GRCm39)	S633P	probably benign	Het
Celsr3	A	G	9: 108,723,134 (GRCm39)	T228A	probably benign	Het
Cfap90	T	A	13: 68,759,312 (GRCm39)	F95L	probably benign	Het
Chrng	A	G	1: 87,137,606 (GRCm39)		probably null	Het
Coprs	T	C	8: 13,935,782 (GRCm39)	E79G	probably damaging	Het
Cpb2	A	C	14: 75,520,758 (GRCm39)	Y391S	probably damaging	Het
Cyp2j8	A	T	4: 96,358,815 (GRCm39)	I368N	probably damaging	Het
Ddah1	T	C	3: 145,464,842 (GRCm39)	F76L	probably benign	Het
Eif2ak4	A	G	2: 118,261,514 (GRCm39)	T573A	probably benign	Het
Exoc6b	T	A	6: 84,835,411 (GRCm39)	M375L	probably benign	Het
Fasn	T	C	11: 120,706,502 (GRCm39)	E994G	probably damaging	Het
Fem1a	T	A	17: 56,565,640 (GRCm39)	C578S	probably benign	Het
Garnl3	A	G	2: 32,936,606 (GRCm39)	S188P	probably damaging	Het
Gpn3	T	C	5: 122,516,551 (GRCm39)	V60A	possibly damaging	Het
Hnrnpr	A	G	4: 136,043,690 (GRCm39)	D59G	probably damaging	Het
Hydin	A	T	8: 111,145,094 (GRCm39)	E815V	probably damaging	Het
Itga9	C	T	9: 118,487,601 (GRCm39)	T228M	probably damaging	Het
Kpna7	T	C	5: 144,930,884 (GRCm39)	I320M	probably damaging	Het
Lnpep	T	C	17: 17,791,234 (GRCm39)	T437A	probably damaging	Het
Ltf	C	T	9: 110,868,015 (GRCm39)	T48I	probably benign	Het
Masp1	T	G	16: 23,313,476 (GRCm39)	D153A	probably damaging	Het
Msantd4	T	A	9: 4,384,787 (GRCm39)	S171T	probably damaging	Het
Nos1	G	A	5: 118,081,382 (GRCm39)	V1229M	probably damaging	Het
Npc1l1	A	G	11: 6,179,246 (GRCm39)	S55P	probably benign	Het
Oc90	T	C	15: 65,759,983 (GRCm39)	K212R	probably benign	Het
Or2a12	A	G	6: 42,904,830 (GRCm39)	I222V	probably benign	Het
Or5t15	C	T	2: 86,681,130 (GRCm39)	R304K	probably benign	Het
Or6c202	C	A	10: 128,996,439 (GRCm39)	C138F	probably damaging	Het
Prr12	T	A	7: 44,697,980 (GRCm39)	Q645L	unknown	Het
Psmd9	A	G	5: 123,384,278 (GRCm39)	I145V	probably benign	Het
Rbks	T	C	5: 31,817,407 (GRCm39)	I121V	probably benign	Het
Rnase2b	A	T	14: 51,400,264 (GRCm39)	Y115F	probably damaging	Het
Sarnp	A	G	10: 128,675,723 (GRCm39)	E78G	probably benign	Het
Sltm	A	G	9: 70,498,946 (GRCm39)	S1007G	probably benign	Het
Spata31d1c	T	A	13: 65,182,759 (GRCm39)	Y100*	probably null	Het
Srrm2	T	C	17: 24,029,720 (GRCm39)	S222P	probably benign	Het
Sult3a1	G	A	10: 33,740,046 (GRCm39)	R35Q	possibly damaging	Het
Tfap4	T	C	16: 4,369,224 (GRCm39)	D132G	probably damaging	Het
Tmem53	C	T	4: 117,125,285 (GRCm39)	Q111*	probably null	Het
Togaram1	T	A	12: 65,068,274 (GRCm39)	V1709D	probably damaging	Het
Trpm3	A	T	19: 22,878,483 (GRCm39)	D628V	probably damaging	Het
Ttn	T	A	2: 76,544,838 (GRCm39)	K31009*	probably null	Het
Vldlr	A	G	19: 27,217,120 (GRCm39)	I58V	probably benign	Het
Vmn1r4	T	C	6: 56,934,231 (GRCm39)	F245S	probably benign	Het
Vrtn	T	A	12: 84,695,258 (GRCm39)	S3T	probably damaging	Het
Vwa7	A	G	17: 35,242,476 (GRCm39)		probably null	Het
Wrnip1	T	A	13: 33,006,053 (GRCm39)	Y632N	probably damaging	Het

Other mutations in Mcpt9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03200:Mcpt9	APN	14	56,264,390 (GRCm39)	missense	probably benign	0.01
IGL03218:Mcpt9	APN	14	56,264,908 (GRCm39)	missense	probably damaging	1.00
IGL03412:Mcpt9	APN	14	56,265,484 (GRCm39)	missense	probably damaging	1.00
PIT4434001:Mcpt9	UTSW	14	56,266,686 (GRCm39)	missense	probably benign	0.03
R0196:Mcpt9	UTSW	14	56,265,453 (GRCm39)	missense	probably benign	0.43
R1218:Mcpt9	UTSW	14	56,266,125 (GRCm39)	nonsense	probably null
R1489:Mcpt9	UTSW	14	56,264,976 (GRCm39)	missense	probably benign	0.00
R1962:Mcpt9	UTSW	14	56,265,024 (GRCm39)	missense	probably benign	0.01
R2232:Mcpt9	UTSW	14	56,265,445 (GRCm39)	missense	probably benign	0.00
R3911:Mcpt9	UTSW	14	56,265,136 (GRCm39)	missense	probably benign	0.29
R4441:Mcpt9	UTSW	14	56,265,009 (GRCm39)	missense	probably damaging	1.00
R4600:Mcpt9	UTSW	14	56,266,049 (GRCm39)	missense	probably damaging	1.00
R4603:Mcpt9	UTSW	14	56,266,049 (GRCm39)	missense	probably damaging	1.00
R4610:Mcpt9	UTSW	14	56,266,049 (GRCm39)	missense	probably damaging	1.00
R4611:Mcpt9	UTSW	14	56,266,049 (GRCm39)	missense	probably damaging	1.00
R4738:Mcpt9	UTSW	14	56,264,456 (GRCm39)	missense	probably damaging	0.98
R7146:Mcpt9	UTSW	14	56,264,445 (GRCm39)	missense	probably damaging	1.00
R7475:Mcpt9	UTSW	14	56,264,400 (GRCm39)	missense	probably damaging	1.00
R8885:Mcpt9	UTSW	14	56,265,153 (GRCm39)	missense	probably benign	0.01

Posted On

2015-12-18