Incidental Mutation 'IGL02947:Olfr771'
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ID364778
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr771
Ensembl Gene ENSMUSG00000061367
Gene Nameolfactory receptor 771
SynonymsMOR114-8, GA_x6K02T2PULF-10846420-10845467
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.055) question?
Stock #IGL02947
Quality Score
Status
Chromosome10
Chromosomal Location129160003-129164751 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 129160570 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Phenylalanine at position 138 (C138F)
Ref Sequence ENSEMBL: ENSMUSP00000151108 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078914] [ENSMUST00000214271]
Predicted Effect probably damaging
Transcript: ENSMUST00000078914
AA Change: C138F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000077948
Gene: ENSMUSG00000061367
AA Change: C138F

DomainStartEndE-ValueType
Pfam:7tm_4 28 304 8.9e-48 PFAM
Pfam:7tm_1 38 287 3e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214271
AA Change: C138F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001L19Rik T A 13: 68,611,193 F95L probably benign Het
Aasdh A G 5: 76,902,110 V13A probably benign Het
Atp8b5 T A 4: 43,305,774 I106K possibly damaging Het
Cdh15 T C 8: 122,865,372 S633P probably benign Het
Celsr3 A G 9: 108,845,935 T228A probably benign Het
Chrng A G 1: 87,209,884 probably null Het
Coprs T C 8: 13,885,782 E79G probably damaging Het
Cpb2 A C 14: 75,283,318 Y391S probably damaging Het
Cyp2j8 A T 4: 96,470,578 I368N probably damaging Het
Ddah1 T C 3: 145,759,087 F76L probably benign Het
Eif2ak4 A G 2: 118,431,033 T573A probably benign Het
Exoc6b T A 6: 84,858,429 M375L probably benign Het
Fasn T C 11: 120,815,676 E994G probably damaging Het
Fem1a T A 17: 56,258,640 C578S probably benign Het
Garnl3 A G 2: 33,046,594 S188P probably damaging Het
Gpn3 T C 5: 122,378,488 V60A possibly damaging Het
Hnrnpr A G 4: 136,316,379 D59G probably damaging Het
Hydin A T 8: 110,418,462 E815V probably damaging Het
Itga9 C T 9: 118,658,533 T228M probably damaging Het
Kpna7 T C 5: 144,994,074 I320M probably damaging Het
Lnpep T C 17: 17,570,972 T437A probably damaging Het
Ltf C T 9: 111,038,947 T48I probably benign Het
Masp1 T G 16: 23,494,726 D153A probably damaging Het
Mcpt9 T A 14: 56,026,916 R241* probably null Het
Msantd4 T A 9: 4,384,787 S171T probably damaging Het
Nos1 G A 5: 117,943,317 V1229M probably damaging Het
Npc1l1 A G 11: 6,229,246 S55P probably benign Het
Oc90 T C 15: 65,888,134 K212R probably benign Het
Olfr1095 C T 2: 86,850,786 R304K probably benign Het
Olfr446 A G 6: 42,927,896 I222V probably benign Het
Prr12 T A 7: 45,048,556 Q645L unknown Het
Psmd9 A G 5: 123,246,215 I145V probably benign Het
Rbks T C 5: 31,660,063 I121V probably benign Het
Rnase2b A T 14: 51,162,807 Y115F probably damaging Het
Sarnp A G 10: 128,839,854 E78G probably benign Het
Sltm A G 9: 70,591,664 S1007G probably benign Het
Spata31d1c T A 13: 65,034,945 Y100* probably null Het
Srrm2 T C 17: 23,810,746 S222P probably benign Het
Sult3a1 G A 10: 33,864,050 R35Q possibly damaging Het
Tfap4 T C 16: 4,551,360 D132G probably damaging Het
Tmem53 C T 4: 117,268,088 Q111* probably null Het
Togaram1 T A 12: 65,021,500 V1709D probably damaging Het
Trpm3 A T 19: 22,901,119 D628V probably damaging Het
Ttn T A 2: 76,714,494 K31009* probably null Het
Vldlr A G 19: 27,239,720 I58V probably benign Het
Vmn1r4 T C 6: 56,957,246 F245S probably benign Het
Vrtn T A 12: 84,648,484 S3T probably damaging Het
Vwa7 A G 17: 35,023,500 probably null Het
Wrnip1 T A 13: 32,822,070 Y632N probably damaging Het
Other mutations in Olfr771
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02341:Olfr771 APN 10 129160433 missense probably benign 0.30
IGL02366:Olfr771 APN 10 129160625 missense probably damaging 1.00
R0040:Olfr771 UTSW 10 129160739 missense probably benign 0.10
R0081:Olfr771 UTSW 10 129160838 missense possibly damaging 0.55
R1179:Olfr771 UTSW 10 129160058 missense probably benign 0.00
R1328:Olfr771 UTSW 10 129160424 missense possibly damaging 0.54
R1701:Olfr771 UTSW 10 129160105 missense probably damaging 1.00
R4470:Olfr771 UTSW 10 129160514 missense probably benign 0.16
R4814:Olfr771 UTSW 10 129160376 missense possibly damaging 0.77
R5106:Olfr771 UTSW 10 129160237 missense probably damaging 0.99
R5109:Olfr771 UTSW 10 129160237 missense probably damaging 0.99
R5209:Olfr771 UTSW 10 129160932 missense possibly damaging 0.74
R5646:Olfr771 UTSW 10 129160837 missense possibly damaging 0.55
R6114:Olfr771 UTSW 10 129160333 missense probably benign
R6133:Olfr771 UTSW 10 129160883 missense possibly damaging 0.55
R6879:Olfr771 UTSW 10 129160979 missense probably benign 0.04
R7358:Olfr771 UTSW 10 129160070 missense probably benign
R7426:Olfr771 UTSW 10 129160751 missense possibly damaging 0.67
R7699:Olfr771 UTSW 10 129160055 missense probably benign
R7700:Olfr771 UTSW 10 129160055 missense probably benign
R8232:Olfr771 UTSW 10 129160228 missense probably damaging 1.00
R8695:Olfr771 UTSW 10 129160364 missense probably damaging 0.99
R8885:Olfr771 UTSW 10 129160465 missense probably benign 0.00
Z1177:Olfr771 UTSW 10 129160402 missense probably benign 0.07
Posted On2015-12-18