Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02947:Or6c202'

364778

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or6c202

Ensembl Gene

ENSMUSG00000061367

Gene Name

olfactory receptor family 6 subfamily C member 202

Synonyms

GA_x6K02T2PULF-10846420-10845467, Olfr771, MOR114-8

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL02947

Quality Score

Status

Chromosome

Chromosomal Location

128995898-128996851 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 128996439 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Phenylalanine at position 138 (C138F)

Ref Sequence

ENSEMBL: ENSMUSP00000151108 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078914] [ENSMUST00000214271]

AlphaFold

Q8VFH6

Predicted Effect

probably damaging
Transcript: ENSMUST00000078914
AA Change: C138F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000077948
Gene: ENSMUSG00000061367
AA Change: C138F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	28	304	8.9e-48	PFAM
Pfam:7tm_1	38	287	3e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000214271
AA Change: C138F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aasdh	A	G	5: 77,049,957 (GRCm39)	V13A	probably benign	Het
Atp8b5	T	A	4: 43,305,774 (GRCm39)	I106K	possibly damaging	Het
Cdh15	T	C	8: 123,592,111 (GRCm39)	S633P	probably benign	Het
Celsr3	A	G	9: 108,723,134 (GRCm39)	T228A	probably benign	Het
Cfap90	T	A	13: 68,759,312 (GRCm39)	F95L	probably benign	Het
Chrng	A	G	1: 87,137,606 (GRCm39)		probably null	Het
Coprs	T	C	8: 13,935,782 (GRCm39)	E79G	probably damaging	Het
Cpb2	A	C	14: 75,520,758 (GRCm39)	Y391S	probably damaging	Het
Cyp2j8	A	T	4: 96,358,815 (GRCm39)	I368N	probably damaging	Het
Ddah1	T	C	3: 145,464,842 (GRCm39)	F76L	probably benign	Het
Eif2ak4	A	G	2: 118,261,514 (GRCm39)	T573A	probably benign	Het
Exoc6b	T	A	6: 84,835,411 (GRCm39)	M375L	probably benign	Het
Fasn	T	C	11: 120,706,502 (GRCm39)	E994G	probably damaging	Het
Fem1a	T	A	17: 56,565,640 (GRCm39)	C578S	probably benign	Het
Garnl3	A	G	2: 32,936,606 (GRCm39)	S188P	probably damaging	Het
Gpn3	T	C	5: 122,516,551 (GRCm39)	V60A	possibly damaging	Het
Hnrnpr	A	G	4: 136,043,690 (GRCm39)	D59G	probably damaging	Het
Hydin	A	T	8: 111,145,094 (GRCm39)	E815V	probably damaging	Het
Itga9	C	T	9: 118,487,601 (GRCm39)	T228M	probably damaging	Het
Kpna7	T	C	5: 144,930,884 (GRCm39)	I320M	probably damaging	Het
Lnpep	T	C	17: 17,791,234 (GRCm39)	T437A	probably damaging	Het
Ltf	C	T	9: 110,868,015 (GRCm39)	T48I	probably benign	Het
Masp1	T	G	16: 23,313,476 (GRCm39)	D153A	probably damaging	Het
Mcpt9	T	A	14: 56,264,373 (GRCm39)	R241*	probably null	Het
Msantd4	T	A	9: 4,384,787 (GRCm39)	S171T	probably damaging	Het
Nos1	G	A	5: 118,081,382 (GRCm39)	V1229M	probably damaging	Het
Npc1l1	A	G	11: 6,179,246 (GRCm39)	S55P	probably benign	Het
Oc90	T	C	15: 65,759,983 (GRCm39)	K212R	probably benign	Het
Or2a12	A	G	6: 42,904,830 (GRCm39)	I222V	probably benign	Het
Or5t15	C	T	2: 86,681,130 (GRCm39)	R304K	probably benign	Het
Prr12	T	A	7: 44,697,980 (GRCm39)	Q645L	unknown	Het
Psmd9	A	G	5: 123,384,278 (GRCm39)	I145V	probably benign	Het
Rbks	T	C	5: 31,817,407 (GRCm39)	I121V	probably benign	Het
Rnase2b	A	T	14: 51,400,264 (GRCm39)	Y115F	probably damaging	Het
Sarnp	A	G	10: 128,675,723 (GRCm39)	E78G	probably benign	Het
Sltm	A	G	9: 70,498,946 (GRCm39)	S1007G	probably benign	Het
Spata31d1c	T	A	13: 65,182,759 (GRCm39)	Y100*	probably null	Het
Srrm2	T	C	17: 24,029,720 (GRCm39)	S222P	probably benign	Het
Sult3a1	G	A	10: 33,740,046 (GRCm39)	R35Q	possibly damaging	Het
Tfap4	T	C	16: 4,369,224 (GRCm39)	D132G	probably damaging	Het
Tmem53	C	T	4: 117,125,285 (GRCm39)	Q111*	probably null	Het
Togaram1	T	A	12: 65,068,274 (GRCm39)	V1709D	probably damaging	Het
Trpm3	A	T	19: 22,878,483 (GRCm39)	D628V	probably damaging	Het
Ttn	T	A	2: 76,544,838 (GRCm39)	K31009*	probably null	Het
Vldlr	A	G	19: 27,217,120 (GRCm39)	I58V	probably benign	Het
Vmn1r4	T	C	6: 56,934,231 (GRCm39)	F245S	probably benign	Het
Vrtn	T	A	12: 84,695,258 (GRCm39)	S3T	probably damaging	Het
Vwa7	A	G	17: 35,242,476 (GRCm39)		probably null	Het
Wrnip1	T	A	13: 33,006,053 (GRCm39)	Y632N	probably damaging	Het

Other mutations in Or6c202

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02341:Or6c202	APN	10	128,996,302 (GRCm39)	missense	probably benign	0.30
IGL02366:Or6c202	APN	10	128,996,494 (GRCm39)	missense	probably damaging	1.00
R0040:Or6c202	UTSW	10	128,996,608 (GRCm39)	missense	probably benign	0.10
R0081:Or6c202	UTSW	10	128,996,707 (GRCm39)	missense	possibly damaging	0.55
R1179:Or6c202	UTSW	10	128,995,927 (GRCm39)	missense	probably benign	0.00
R1328:Or6c202	UTSW	10	128,996,293 (GRCm39)	missense	possibly damaging	0.54
R1701:Or6c202	UTSW	10	128,995,974 (GRCm39)	missense	probably damaging	1.00
R4470:Or6c202	UTSW	10	128,996,383 (GRCm39)	missense	probably benign	0.16
R4814:Or6c202	UTSW	10	128,996,245 (GRCm39)	missense	possibly damaging	0.77
R5106:Or6c202	UTSW	10	128,996,106 (GRCm39)	missense	probably damaging	0.99
R5109:Or6c202	UTSW	10	128,996,106 (GRCm39)	missense	probably damaging	0.99
R5209:Or6c202	UTSW	10	128,996,801 (GRCm39)	missense	possibly damaging	0.74
R5646:Or6c202	UTSW	10	128,996,706 (GRCm39)	missense	possibly damaging	0.55
R6114:Or6c202	UTSW	10	128,996,202 (GRCm39)	missense	probably benign
R6133:Or6c202	UTSW	10	128,996,752 (GRCm39)	missense	possibly damaging	0.55
R6879:Or6c202	UTSW	10	128,996,848 (GRCm39)	missense	probably benign	0.04
R7358:Or6c202	UTSW	10	128,995,939 (GRCm39)	missense	probably benign
R7426:Or6c202	UTSW	10	128,996,620 (GRCm39)	missense	possibly damaging	0.67
R7699:Or6c202	UTSW	10	128,995,924 (GRCm39)	missense	probably benign
R7700:Or6c202	UTSW	10	128,995,924 (GRCm39)	missense	probably benign
R8232:Or6c202	UTSW	10	128,996,097 (GRCm39)	missense	probably damaging	1.00
R8695:Or6c202	UTSW	10	128,996,233 (GRCm39)	missense	probably damaging	0.99
R8885:Or6c202	UTSW	10	128,996,334 (GRCm39)	missense	probably benign	0.00
R8959:Or6c202	UTSW	10	128,996,484 (GRCm39)	missense	probably damaging	1.00
R9338:Or6c202	UTSW	10	128,996,610 (GRCm39)	missense	probably benign	0.02
R9497:Or6c202	UTSW	10	128,996,464 (GRCm39)	missense	probably benign	0.01
Z1177:Or6c202	UTSW	10	128,996,271 (GRCm39)	missense	probably benign	0.07

Posted On

2015-12-18