Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02948:Olfr1420'

364818

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr1420

Ensembl Gene

ENSMUSG00000060878

Gene Name

olfactory receptor 1420

Synonyms

MOR266-4, GA_x6K02T2RE5P-2247227-2248156

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.133) question?

Stock #

IGL02948

Quality Score

Status

Chromosome

Chromosomal Location

11886565-11898079 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 11896781 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 253 (Y253*)

Ref Sequence

ENSEMBL: ENSMUSP00000149208 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072784] [ENSMUST00000217281]

Predicted Effect

probably null
Transcript: ENSMUST00000072784
AA Change: Y253*

SMART Domains

Protein: ENSMUSP00000072563
Gene: ENSMUSG00000060878
AA Change: Y253*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	5.3e-54	PFAM
Pfam:7tm_1	41	291	3.4e-23	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215766

Predicted Effect

probably null
Transcript: ENSMUST00000217281
AA Change: Y253*

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aass	A	T	6: 23,094,319		probably benign	Het
Ano3	A	T	2: 110,697,018		probably benign	Het
Arpp21	T	C	9: 112,176,200	Y193C	probably damaging	Het
Atm	G	A	9: 53,453,440		probably benign	Het
Ceacam13	C	T	7: 18,011,063		probably benign	Het
Cenpi	T	A	X: 134,349,268	C599S	possibly damaging	Het
Clec7a	A	C	6: 129,465,478	D195E	possibly damaging	Het
Cnksr1	T	C	4: 134,235,106		probably null	Het
Cntn1	A	G	15: 92,246,010	T285A	probably benign	Het
Dusp4	G	T	8: 34,818,572	G329V	probably damaging	Het
Emb	C	A	13: 117,273,066		probably benign	Het
Esyt1	A	T	10: 128,519,171	S496T	probably damaging	Het
Evpl	T	C	11: 116,221,822	T1681A	probably damaging	Het
Fam131b	A	C	6: 42,320,992		probably benign	Het
Fam162b	T	C	10: 51,587,296	M92V	probably damaging	Het
Fbxw2	T	C	2: 34,805,711	*455W	probably null	Het
Gm12886	A	G	4: 121,423,037	L14P	unknown	Het
Gpc4	A	T	X: 52,074,301	V235E	probably damaging	Het
Gss	A	G	2: 155,577,621	L170P	probably damaging	Het
Hbs1l	C	T	10: 21,341,711		probably benign	Het
Hhatl	T	C	9: 121,789,791	M92V	probably benign	Het
Hhla1	A	T	15: 65,942,693	L194H	probably damaging	Het
Hivep2	C	A	10: 14,129,013	R452S	probably benign	Het
Homer2	C	A	7: 81,649,645	W24L	probably damaging	Het
Lhcgr	A	T	17: 88,742,622	L492H	probably damaging	Het
Lrba	C	A	3: 86,310,384		probably null	Het
Lrp2	G	T	2: 69,487,837	P2090Q	probably damaging	Het
Lyl1	C	T	8: 84,702,671	P3L	possibly damaging	Het
Madd	T	A	2: 91,142,827	M1497L	probably benign	Het
Naprt	C	T	15: 75,892,357	R336Q	probably damaging	Het
Nars	A	G	18: 64,505,195	C266R	possibly damaging	Het
Olfr175-ps1	T	A	16: 58,824,088	Q207L	probably benign	Het
Pard3	A	T	8: 127,306,494	T190S	probably benign	Het
Pstpip2	A	G	18: 77,854,807	N86S	probably benign	Het
Ptgfrn	T	C	3: 101,072,819	T402A	probably benign	Het
Rnf130	T	C	11: 50,052,771		probably benign	Het
Ropn1l	T	C	15: 31,451,179	D53G	possibly damaging	Het
Rps6ka2	G	A	17: 7,254,450		probably null	Het
Rtn2	T	C	7: 19,293,111	S17P	probably damaging	Het
Shank2	T	C	7: 144,409,636	V327A	probably benign	Het
Slc22a16	T	G	10: 40,573,962	Y131*	probably null	Het
Slc28a2	T	A	2: 122,457,977	M583K	possibly damaging	Het
Slco1a6	G	T	6: 142,133,235		probably null	Het
Slfn8	T	A	11: 83,003,252	I854F	probably damaging	Het
Strip1	T	C	3: 107,613,266	R823G	probably benign	Het
Stxbp2	A	T	8: 3,641,971	I538F	probably benign	Het
Tcl1b5	C	T	12: 105,179,014	T79M	probably benign	Het
Tmem104	G	T	11: 115,197,296	A36S	probably damaging	Het
Trim55	T	A	3: 19,670,952	L211Q	probably damaging	Het
Trim80	T	C	11: 115,441,593	W204R	possibly damaging	Het
Ttbk1	G	A	17: 46,446,330	T1126I	probably benign	Het
Ubqln2	C	T	X: 153,499,696	Q415*	probably null	Het
Unc13a	C	T	8: 71,650,549	R931H	possibly damaging	Het
Utp4	T	A	8: 106,894,641	S17T	probably benign	Het

Other mutations in Olfr1420

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02419:Olfr1420	APN	19	11896822	missense	probably benign	0.06
IGL02703:Olfr1420	APN	19	11896242	missense	possibly damaging	0.96
R1514:Olfr1420	UTSW	19	11896614	missense	probably benign
R1539:Olfr1420	UTSW	19	11896491	missense	possibly damaging	0.88
R1852:Olfr1420	UTSW	19	11896885	missense	probably damaging	1.00
R1903:Olfr1420	UTSW	19	11896549	missense	probably benign	0.24
R2061:Olfr1420	UTSW	19	11896557	missense	probably damaging	0.98
R3768:Olfr1420	UTSW	19	11896312	missense	probably damaging	0.99
R3977:Olfr1420	UTSW	19	11896516	missense	probably damaging	1.00
R4479:Olfr1420	UTSW	19	11896558	missense	probably damaging	0.99
R4592:Olfr1420	UTSW	19	11896762	missense	probably benign
R5934:Olfr1420	UTSW	19	11896929	missense	probably benign
R6058:Olfr1420	UTSW	19	11896024	start codon destroyed	probably null	1.00
R6536:Olfr1420	UTSW	19	11896396	missense	probably benign	0.05
R7752:Olfr1420	UTSW	19	11896534	missense	probably benign	0.01
R7901:Olfr1420	UTSW	19	11896534	missense	probably benign	0.01
R8250:Olfr1420	UTSW	19	11896377	missense	probably damaging	1.00

Posted On

2015-12-18