Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02948:Gm12886'

364821

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm12886

Ensembl Gene

ENSMUSG00000078576

Gene Name

predicted gene 12886

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

IGL02948

Quality Score

Status

Chromosome

Chromosomal Location

121414735-121423099 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 121423037 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 14 (L14P)

Ref Sequence

ENSEMBL: ENSMUSP00000101873 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000106266]

AlphaFold

B1AZM5

Predicted Effect

unknown
Transcript: ENSMUST00000106266
AA Change: L14P

SMART Domains

Protein: ENSMUSP00000101873
Gene: ENSMUSG00000078576
AA Change: L14P

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aass	A	T	6: 23,094,319		probably benign	Het
Ano3	A	T	2: 110,697,018		probably benign	Het
Arpp21	T	C	9: 112,176,200	Y193C	probably damaging	Het
Atm	G	A	9: 53,453,440		probably benign	Het
Ceacam13	C	T	7: 18,011,063		probably benign	Het
Cenpi	T	A	X: 134,349,268	C599S	possibly damaging	Het
Clec7a	A	C	6: 129,465,478	D195E	possibly damaging	Het
Cnksr1	T	C	4: 134,235,106		probably null	Het
Cntn1	A	G	15: 92,246,010	T285A	probably benign	Het
Dusp4	G	T	8: 34,818,572	G329V	probably damaging	Het
Emb	C	A	13: 117,273,066		probably benign	Het
Esyt1	A	T	10: 128,519,171	S496T	probably damaging	Het
Evpl	T	C	11: 116,221,822	T1681A	probably damaging	Het
Fam131b	A	C	6: 42,320,992		probably benign	Het
Fam162b	T	C	10: 51,587,296	M92V	probably damaging	Het
Fbxw2	T	C	2: 34,805,711	*455W	probably null	Het
Gpc4	A	T	X: 52,074,301	V235E	probably damaging	Het
Gss	A	G	2: 155,577,621	L170P	probably damaging	Het
Hbs1l	C	T	10: 21,341,711		probably benign	Het
Hhatl	T	C	9: 121,789,791	M92V	probably benign	Het
Hhla1	A	T	15: 65,942,693	L194H	probably damaging	Het
Hivep2	C	A	10: 14,129,013	R452S	probably benign	Het
Homer2	C	A	7: 81,649,645	W24L	probably damaging	Het
Lhcgr	A	T	17: 88,742,622	L492H	probably damaging	Het
Lrba	C	A	3: 86,310,384		probably null	Het
Lrp2	G	T	2: 69,487,837	P2090Q	probably damaging	Het
Lyl1	C	T	8: 84,702,671	P3L	possibly damaging	Het
Madd	T	A	2: 91,142,827	M1497L	probably benign	Het
Naprt	C	T	15: 75,892,357	R336Q	probably damaging	Het
Nars	A	G	18: 64,505,195	C266R	possibly damaging	Het
Olfr1420	T	A	19: 11,896,781	Y253*	probably null	Het
Olfr175-ps1	T	A	16: 58,824,088	Q207L	probably benign	Het
Pard3	A	T	8: 127,306,494	T190S	probably benign	Het
Pstpip2	A	G	18: 77,854,807	N86S	probably benign	Het
Ptgfrn	T	C	3: 101,072,819	T402A	probably benign	Het
Rnf130	T	C	11: 50,052,771		probably benign	Het
Ropn1l	T	C	15: 31,451,179	D53G	possibly damaging	Het
Rps6ka2	G	A	17: 7,254,450		probably null	Het
Rtn2	T	C	7: 19,293,111	S17P	probably damaging	Het
Shank2	T	C	7: 144,409,636	V327A	probably benign	Het
Slc22a16	T	G	10: 40,573,962	Y131*	probably null	Het
Slc28a2	T	A	2: 122,457,977	M583K	possibly damaging	Het
Slco1a6	G	T	6: 142,133,235		probably null	Het
Slfn8	T	A	11: 83,003,252	I854F	probably damaging	Het
Strip1	T	C	3: 107,613,266	R823G	probably benign	Het
Stxbp2	A	T	8: 3,641,971	I538F	probably benign	Het
Tcl1b5	C	T	12: 105,179,014	T79M	probably benign	Het
Tmem104	G	T	11: 115,197,296	A36S	probably damaging	Het
Trim55	T	A	3: 19,670,952	L211Q	probably damaging	Het
Trim80	T	C	11: 115,441,593	W204R	possibly damaging	Het
Ttbk1	G	A	17: 46,446,330	T1126I	probably benign	Het
Ubqln2	C	T	X: 153,499,696	Q415*	probably null	Het
Unc13a	C	T	8: 71,650,549	R931H	possibly damaging	Het
Utp4	T	A	8: 106,894,641	S17T	probably benign	Het

Other mutations in Gm12886

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02369:Gm12886	APN	4	121423032	missense	unknown
IGL03077:Gm12886	APN	4	121415500	utr 3 prime	probably benign
R1793:Gm12886	UTSW	4	121422977	missense	probably benign	0.22
R3722:Gm12886	UTSW	4	121417470	missense	probably damaging	1.00
R4581:Gm12886	UTSW	4	121416683	missense	probably damaging	0.98
R6847:Gm12886	UTSW	4	121416719	nonsense	probably null
R7169:Gm12886	UTSW	4	121416751	missense	probably damaging	0.97
R7452:Gm12886	UTSW	4	121417474	nonsense	probably null
R7699:Gm12886	UTSW	4	121416679	missense	possibly damaging	0.92
R9135:Gm12886	UTSW	4	121417546	missense	probably benign	0.01
Z1177:Gm12886	UTSW	4	121416719	nonsense	probably null

Posted On

2015-12-18