Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02948:Ptgfrn'

364852

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ptgfrn

Ensembl Gene

ENSMUSG00000027864

Gene Name

prostaglandin F2 receptor negative regulator

Synonyms

4833445A08Rik, CD9P-1

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02948

Quality Score

Status

Chromosome

Chromosomal Location

100947548-101017594 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 100980135 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 402 (T402A)

Ref Sequence

ENSEMBL: ENSMUSP00000099755 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102694]

AlphaFold

Q9WV91

Predicted Effect

probably benign
Transcript: ENSMUST00000102694
AA Change: T402A

PolyPhen 2 Score 0.209 (Sensitivity: 0.92; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000099755
Gene: ENSMUSG00000027864
AA Change: T402A

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGv	38	121	3.01e-7	SMART
IG	154	264	1.54e-4	SMART
IG	284	390	1.11e-5	SMART
IG	414	532	1.72e-2	SMART
IG	556	676	9.71e-2	SMART
IG	696	822	5.21e-2	SMART
transmembrane domain	831	853	N/A	INTRINSIC
low complexity region	862	872	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198037

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000200065

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mice for a null gene trap mutation exhibit a decreased depressive-like response during tail suspension testing when compared with their wild-type littermates, [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aass	A	T	6: 23,094,318 (GRCm39)		probably benign	Het
Ano3	A	T	2: 110,527,363 (GRCm39)		probably benign	Het
Arpp21	T	C	9: 112,005,268 (GRCm39)	Y193C	probably damaging	Het
Atm	G	A	9: 53,364,740 (GRCm39)		probably benign	Het
Ceacam13	C	T	7: 17,744,988 (GRCm39)		probably benign	Het
Cenpi	T	A	X: 133,250,017 (GRCm39)	C599S	possibly damaging	Het
Clec7a	A	C	6: 129,442,441 (GRCm39)	D195E	possibly damaging	Het
Cnksr1	T	C	4: 133,962,417 (GRCm39)		probably null	Het
Cntn1	A	G	15: 92,143,891 (GRCm39)	T285A	probably benign	Het
Dusp4	G	T	8: 35,285,726 (GRCm39)	G329V	probably damaging	Het
Emb	C	A	13: 117,409,602 (GRCm39)		probably benign	Het
Esyt1	A	T	10: 128,355,040 (GRCm39)	S496T	probably damaging	Het
Evpl	T	C	11: 116,112,648 (GRCm39)	T1681A	probably damaging	Het
Fam131b	A	C	6: 42,297,926 (GRCm39)		probably benign	Het
Fam162b	T	C	10: 51,463,392 (GRCm39)	M92V	probably damaging	Het
Fbxw2	T	C	2: 34,695,723 (GRCm39)	*455W	probably null	Het
Gm12886	A	G	4: 121,280,234 (GRCm39)	L14P	unknown	Het
Gpc4	A	T	X: 51,163,178 (GRCm39)	V235E	probably damaging	Het
Gss	A	G	2: 155,419,541 (GRCm39)	L170P	probably damaging	Het
Hbs1l	C	T	10: 21,217,610 (GRCm39)		probably benign	Het
Hhatl	T	C	9: 121,618,857 (GRCm39)	M92V	probably benign	Het
Hhla1	A	T	15: 65,814,542 (GRCm39)	L194H	probably damaging	Het
Hivep2	C	A	10: 14,004,757 (GRCm39)	R452S	probably benign	Het
Homer2	C	A	7: 81,299,393 (GRCm39)	W24L	probably damaging	Het
Lhcgr	A	T	17: 89,050,050 (GRCm39)	L492H	probably damaging	Het
Lrba	C	A	3: 86,217,691 (GRCm39)		probably null	Het
Lrp2	G	T	2: 69,318,181 (GRCm39)	P2090Q	probably damaging	Het
Lyl1	C	T	8: 85,429,300 (GRCm39)	P3L	possibly damaging	Het
Madd	T	A	2: 90,973,172 (GRCm39)	M1497L	probably benign	Het
Naprt	C	T	15: 75,764,206 (GRCm39)	R336Q	probably damaging	Het
Nars1	A	G	18: 64,638,266 (GRCm39)	C266R	possibly damaging	Het
Or10v1	T	A	19: 11,874,145 (GRCm39)	Y253*	probably null	Het
Or5k8	T	A	16: 58,644,451 (GRCm39)	Q207L	probably benign	Het
Pard3	A	T	8: 128,032,975 (GRCm39)	T190S	probably benign	Het
Pstpip2	A	G	18: 77,942,507 (GRCm39)	N86S	probably benign	Het
Rnf130	T	C	11: 49,943,598 (GRCm39)		probably benign	Het
Ropn1l	T	C	15: 31,451,325 (GRCm39)	D53G	possibly damaging	Het
Rps6ka2	G	A	17: 7,521,849 (GRCm39)		probably null	Het
Rtn2	T	C	7: 19,027,036 (GRCm39)	S17P	probably damaging	Het
Shank2	T	C	7: 143,963,373 (GRCm39)	V327A	probably benign	Het
Slc22a16	T	G	10: 40,449,958 (GRCm39)	Y131*	probably null	Het
Slc28a2	T	A	2: 122,288,458 (GRCm39)	M583K	possibly damaging	Het
Slco1a6	G	T	6: 142,078,961 (GRCm39)		probably null	Het
Slfn8	T	A	11: 82,894,078 (GRCm39)	I854F	probably damaging	Het
Strip1	T	C	3: 107,520,582 (GRCm39)	R823G	probably benign	Het
Stxbp2	A	T	8: 3,691,971 (GRCm39)	I538F	probably benign	Het
Tcl1b5	C	T	12: 105,145,273 (GRCm39)	T79M	probably benign	Het
Tmem104	G	T	11: 115,088,122 (GRCm39)	A36S	probably damaging	Het
Trim55	T	A	3: 19,725,116 (GRCm39)	L211Q	probably damaging	Het
Trim80	T	C	11: 115,332,419 (GRCm39)	W204R	possibly damaging	Het
Ttbk1	G	A	17: 46,757,256 (GRCm39)	T1126I	probably benign	Het
Ubqln2	C	T	X: 152,282,692 (GRCm39)	Q415*	probably null	Het
Unc13a	C	T	8: 72,103,193 (GRCm39)	R931H	possibly damaging	Het
Utp4	T	A	8: 107,621,273 (GRCm39)	S17T	probably benign	Het

Other mutations in Ptgfrn

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00949:Ptgfrn	APN	3	100,980,161 (GRCm39)	missense	probably benign	0.01
IGL01710:Ptgfrn	APN	3	100,980,404 (GRCm39)	missense	probably damaging	0.98
IGL02557:Ptgfrn	APN	3	100,967,952 (GRCm39)	critical splice donor site	probably null
IGL02740:Ptgfrn	APN	3	100,980,253 (GRCm39)	missense	possibly damaging	0.84
IGL02817:Ptgfrn	APN	3	100,968,068 (GRCm39)	missense	probably benign
R1540:Ptgfrn	UTSW	3	100,967,970 (GRCm39)	missense	probably benign	0.41
R1563:Ptgfrn	UTSW	3	100,967,967 (GRCm39)	missense	possibly damaging	0.67
R1730:Ptgfrn	UTSW	3	100,963,758 (GRCm39)	missense	possibly damaging	0.71
R1766:Ptgfrn	UTSW	3	100,957,438 (GRCm39)	missense	probably benign	0.00
R1783:Ptgfrn	UTSW	3	100,963,758 (GRCm39)	missense	possibly damaging	0.71
R1918:Ptgfrn	UTSW	3	100,963,623 (GRCm39)	missense	probably benign
R2113:Ptgfrn	UTSW	3	100,984,625 (GRCm39)	missense	probably benign	0.00
R2290:Ptgfrn	UTSW	3	100,984,677 (GRCm39)	missense	possibly damaging	0.77
R3522:Ptgfrn	UTSW	3	100,950,718 (GRCm39)	missense	probably damaging	1.00
R5223:Ptgfrn	UTSW	3	100,952,909 (GRCm39)	missense	probably benign	0.13
R5600:Ptgfrn	UTSW	3	100,963,566 (GRCm39)	missense	probably damaging	0.99
R5642:Ptgfrn	UTSW	3	100,950,678 (GRCm39)	missense	probably damaging	1.00
R5927:Ptgfrn	UTSW	3	100,967,968 (GRCm39)	missense	possibly damaging	0.92
R5984:Ptgfrn	UTSW	3	100,957,459 (GRCm39)	missense	probably damaging	0.99
R6124:Ptgfrn	UTSW	3	100,980,405 (GRCm39)	missense	probably damaging	0.98
R6331:Ptgfrn	UTSW	3	100,952,936 (GRCm39)	missense	possibly damaging	0.64
R6363:Ptgfrn	UTSW	3	100,952,894 (GRCm39)	missense	possibly damaging	0.93
R6473:Ptgfrn	UTSW	3	100,952,955 (GRCm39)	missense	probably damaging	1.00
R6856:Ptgfrn	UTSW	3	100,952,762 (GRCm39)	missense	probably damaging	1.00
R7151:Ptgfrn	UTSW	3	100,987,511 (GRCm39)	nonsense	probably null
R7313:Ptgfrn	UTSW	3	100,980,363 (GRCm39)	missense	possibly damaging	0.84
R7361:Ptgfrn	UTSW	3	100,984,760 (GRCm39)	missense	probably benign	0.03
R7806:Ptgfrn	UTSW	3	100,984,448 (GRCm39)	missense	possibly damaging	0.50
R7823:Ptgfrn	UTSW	3	100,950,725 (GRCm39)	missense	probably damaging	1.00
R7841:Ptgfrn	UTSW	3	100,968,126 (GRCm39)	missense	probably damaging	0.98
R8093:Ptgfrn	UTSW	3	100,980,257 (GRCm39)	missense	probably benign	0.09
R8093:Ptgfrn	UTSW	3	100,963,753 (GRCm39)	missense	probably benign	0.19
R8490:Ptgfrn	UTSW	3	100,963,686 (GRCm39)	missense	probably damaging	0.99
R8856:Ptgfrn	UTSW	3	100,963,927 (GRCm39)	missense	possibly damaging	0.86
Z1088:Ptgfrn	UTSW	3	100,963,753 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-12-18