Incidental Mutation 'IGL02949:Zfp282'
ID 364889
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp282
Ensembl Gene ENSMUSG00000025821
Gene Name zinc finger protein 282
Synonyms HUB1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # IGL02949
Quality Score
Status
Chromosome 6
Chromosomal Location 47854138-47885419 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 47874848 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 351 (T351I)
Ref Sequence ENSEMBL: ENSMUSP00000053643 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061890]
AlphaFold E9PVC2
Predicted Effect probably damaging
Transcript: ENSMUST00000061890
AA Change: T351I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000053643
Gene: ENSMUSG00000025821
AA Change: T351I

DomainStartEndE-ValueType
low complexity region 11 20 N/A INTRINSIC
low complexity region 66 75 N/A INTRINSIC
Pfam:DUF3669 98 168 1.8e-12 PFAM
KRAB 198 260 1.04e-21 SMART
internal_repeat_1 317 372 1.1e-13 PROSPERO
low complexity region 387 399 N/A INTRINSIC
low complexity region 403 420 N/A INTRINSIC
low complexity region 457 499 N/A INTRINSIC
ZnF_C2H2 514 536 8.94e-3 SMART
ZnF_C2H2 542 564 4.72e-2 SMART
ZnF_C2H2 570 592 1.04e-3 SMART
ZnF_C2H2 598 620 4.24e-4 SMART
ZnF_C2H2 626 648 1.06e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4 G A 4: 144,344,490 (GRCm39) V89I probably damaging Het
Abhd5 T C 9: 122,206,980 (GRCm39) F89L possibly damaging Het
Akr1c13 T A 13: 4,248,593 (GRCm39) V266E probably damaging Het
B4galt2 C T 4: 117,738,602 (GRCm39) A72T probably benign Het
Ccdc141 T C 2: 76,857,938 (GRCm39) Y1081C probably damaging Het
Coq8b T C 7: 26,956,038 (GRCm39) V405A possibly damaging Het
Ddah2 A G 17: 35,280,776 (GRCm39) K251E probably damaging Het
Dnah5 T C 15: 28,272,331 (GRCm39) V1045A probably benign Het
Dpy19l1 A T 9: 24,332,476 (GRCm39) M662K probably benign Het
Dpys A G 15: 39,690,279 (GRCm39) V358A probably damaging Het
H2-D1 A G 17: 35,483,064 (GRCm39) N198S probably benign Het
Hnrnpa1 T C 15: 103,150,538 (GRCm39) V163A probably damaging Het
Hr C T 14: 70,797,225 (GRCm39) R543C possibly damaging Het
Lct C T 1: 128,240,869 (GRCm39) V245M probably benign Het
Lpl G A 8: 69,345,400 (GRCm39) V135M probably damaging Het
Mblac1 T A 5: 138,193,119 (GRCm39) C154S probably benign Het
Mmp9 T C 2: 164,793,039 (GRCm39) F396S probably damaging Het
Mroh1 A T 15: 76,293,168 (GRCm39) H314L probably damaging Het
Msantd4 T A 9: 4,385,196 (GRCm39) L307Q probably damaging Het
Nol8 A G 13: 49,815,878 (GRCm39) D662G probably benign Het
Nynrin G A 14: 56,109,837 (GRCm39) S1648N probably damaging Het
Or52a20 A G 7: 103,366,427 (GRCm39) I209V probably benign Het
Plcb2 C T 2: 118,549,590 (GRCm39) probably null Het
Scyl2 T A 10: 89,496,163 (GRCm39) N229I possibly damaging Het
Spryd3 C T 15: 102,026,544 (GRCm39) E376K probably benign Het
Srr T G 11: 74,799,563 (GRCm39) E304A probably benign Het
Srsf1 A G 11: 87,940,352 (GRCm39) probably benign Het
Txnrd2 T G 16: 18,296,456 (GRCm39) S473A probably benign Het
Wdr18 T A 10: 79,800,889 (GRCm39) C151S probably benign Het
Other mutations in Zfp282
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00732:Zfp282 APN 6 47,857,324 (GRCm39) missense probably damaging 1.00
IGL00755:Zfp282 APN 6 47,857,324 (GRCm39) missense probably damaging 1.00
IGL01402:Zfp282 APN 6 47,874,770 (GRCm39) missense probably damaging 0.99
IGL01404:Zfp282 APN 6 47,874,770 (GRCm39) missense probably damaging 0.99
IGL01484:Zfp282 APN 6 47,867,054 (GRCm39) missense possibly damaging 0.76
IGL01560:Zfp282 APN 6 47,857,211 (GRCm39) missense probably damaging 1.00
FR4304:Zfp282 UTSW 6 47,881,731 (GRCm39) small insertion probably benign
FR4589:Zfp282 UTSW 6 47,881,725 (GRCm39) small insertion probably benign
FR4737:Zfp282 UTSW 6 47,881,733 (GRCm39) small insertion probably benign
FR4737:Zfp282 UTSW 6 47,881,724 (GRCm39) small insertion probably benign
FR4976:Zfp282 UTSW 6 47,881,724 (GRCm39) small insertion probably benign
R0020:Zfp282 UTSW 6 47,856,943 (GRCm39) missense probably damaging 1.00
R0020:Zfp282 UTSW 6 47,856,943 (GRCm39) missense probably damaging 1.00
R0118:Zfp282 UTSW 6 47,869,866 (GRCm39) missense probably benign 0.34
R0415:Zfp282 UTSW 6 47,881,987 (GRCm39) missense possibly damaging 0.88
R0415:Zfp282 UTSW 6 47,874,815 (GRCm39) missense probably damaging 0.99
R0607:Zfp282 UTSW 6 47,857,303 (GRCm39) missense probably damaging 1.00
R0710:Zfp282 UTSW 6 47,857,318 (GRCm39) missense probably damaging 1.00
R0946:Zfp282 UTSW 6 47,856,943 (GRCm39) missense probably damaging 1.00
R1054:Zfp282 UTSW 6 47,881,533 (GRCm39) missense probably benign 0.00
R1401:Zfp282 UTSW 6 47,867,108 (GRCm39) nonsense probably null
R1572:Zfp282 UTSW 6 47,869,801 (GRCm39) missense probably damaging 1.00
R2016:Zfp282 UTSW 6 47,874,721 (GRCm39) splice site probably null
R2971:Zfp282 UTSW 6 47,874,866 (GRCm39) splice site probably null
R4064:Zfp282 UTSW 6 47,857,028 (GRCm39) missense probably damaging 0.99
R4478:Zfp282 UTSW 6 47,867,630 (GRCm39) nonsense probably null
R4530:Zfp282 UTSW 6 47,867,567 (GRCm39) missense probably benign 0.00
R4532:Zfp282 UTSW 6 47,867,567 (GRCm39) missense probably benign 0.00
R5068:Zfp282 UTSW 6 47,854,637 (GRCm39) missense probably benign 0.01
R5261:Zfp282 UTSW 6 47,874,824 (GRCm39) missense probably damaging 0.99
R5326:Zfp282 UTSW 6 47,882,261 (GRCm39) missense probably benign
R5551:Zfp282 UTSW 6 47,867,579 (GRCm39) missense possibly damaging 0.59
R6046:Zfp282 UTSW 6 47,857,102 (GRCm39) missense probably damaging 1.00
R6408:Zfp282 UTSW 6 47,857,319 (GRCm39) missense probably damaging 1.00
R7535:Zfp282 UTSW 6 47,881,878 (GRCm39) missense probably benign 0.03
R8098:Zfp282 UTSW 6 47,867,652 (GRCm39) missense probably benign 0.00
R8158:Zfp282 UTSW 6 47,867,626 (GRCm39) missense possibly damaging 0.61
R8304:Zfp282 UTSW 6 47,881,722 (GRCm39) small deletion probably benign
R8385:Zfp282 UTSW 6 47,882,023 (GRCm39) missense possibly damaging 0.88
R8543:Zfp282 UTSW 6 47,881,561 (GRCm39) missense probably benign 0.40
R8817:Zfp282 UTSW 6 47,881,760 (GRCm39) missense probably benign 0.00
S24628:Zfp282 UTSW 6 47,881,987 (GRCm39) missense possibly damaging 0.88
S24628:Zfp282 UTSW 6 47,874,815 (GRCm39) missense probably damaging 0.99
Z1177:Zfp282 UTSW 6 47,867,571 (GRCm39) missense probably benign 0.00
Posted On 2015-12-18