Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02952:Vmn2r3'

364942

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r3

Ensembl Gene

ENSMUSG00000091572

Gene Name

vomeronasal 2, receptor 3

Synonyms

EG637004

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02952

Quality Score

Status

Chromosome

Chromosomal Location

64166225-64197130 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 64186256 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 143 (E143G)

Ref Sequence

ENSEMBL: ENSMUSP00000134891 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170244] [ENSMUST00000176328]

AlphaFold

H3BJ88

Predicted Effect

probably damaging
Transcript: ENSMUST00000170244
AA Change: E115G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000126165
Gene: ENSMUSG00000091572
AA Change: E115G

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	64	479	4e-64	PFAM
Pfam:NCD3G	521	574	1.1e-17	PFAM
Pfam:7tm_3	605	842	2.9e-75	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000176328
AA Change: E143G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000134891
Gene: ENSMUSG00000091572
AA Change: E143G

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	92	507	9.5e-66	PFAM
Pfam:NCD3G	549	602	8.8e-17	PFAM
Pfam:7tm_3	635	869	8.5e-48	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	A	T	6: 121,654,984 (GRCm39)	D1436V	probably damaging	Het
Abca7	G	T	10: 79,843,242 (GRCm39)	R1239L	probably damaging	Het
Acp2	T	C	2: 91,038,788 (GRCm39)		probably benign	Het
Adamts4	A	G	1: 171,078,917 (GRCm39)	N179S	probably damaging	Het
Adgrv1	T	C	13: 81,581,755 (GRCm39)	D4763G	probably benign	Het
Atp11b	T	C	3: 35,882,844 (GRCm39)	V633A	probably damaging	Het
Cadm2	A	T	16: 66,461,338 (GRCm39)	I342K	probably damaging	Het
Capn10	T	C	1: 92,872,896 (GRCm39)	S541P	probably damaging	Het
Ccnf	A	G	17: 24,450,299 (GRCm39)	L462P	possibly damaging	Het
Cdc27	T	C	11: 104,408,290 (GRCm39)	Y546C	probably damaging	Het
Cep120	G	T	18: 53,816,300 (GRCm39)		probably benign	Het
Cetn2	T	C	X: 71,957,808 (GRCm39)		probably null	Het
Cyp1a1	C	T	9: 57,609,993 (GRCm39)	S469L	probably benign	Het
Dnah17	G	A	11: 117,979,094 (GRCm39)	T1766I	probably benign	Het
Doc2g	G	A	19: 4,056,719 (GRCm39)	G345D	possibly damaging	Het
Dock4	T	C	12: 40,760,902 (GRCm39)		probably null	Het
Dop1a	T	A	9: 86,414,975 (GRCm39)		probably benign	Het
Emilin2	C	A	17: 71,587,816 (GRCm39)	V99F	probably damaging	Het
Exoc8	A	G	8: 125,624,275 (GRCm39)	S31P	probably benign	Het
Gask1b	T	C	3: 79,793,646 (GRCm39)	L38P	probably damaging	Het
Gm3115	T	C	14: 4,084,302 (GRCm38)		probably benign	Het
Gm9742	T	A	13: 8,079,930 (GRCm39)		noncoding transcript	Het
Gpr160	T	C	3: 30,950,443 (GRCm39)	Y172H	probably benign	Het
Ifnk	T	A	4: 35,152,495 (GRCm39)	L141Q	probably damaging	Het
Klhl36	A	G	8: 120,597,223 (GRCm39)	E308G	probably benign	Het
Lrp1b	T	C	2: 41,396,715 (GRCm39)	I450M	probably benign	Het
Noxa1	T	C	2: 24,981,773 (GRCm39)	Y110C	probably damaging	Het
Or10ad1	T	C	15: 98,105,470 (GRCm39)	Y265C	probably damaging	Het
Pkd2	A	T	5: 104,628,026 (GRCm39)	T367S	possibly damaging	Het
Polg2	T	C	11: 106,663,539 (GRCm39)	I385V	possibly damaging	Het
Ppp1r14bl	A	T	1: 23,141,071 (GRCm39)	I81N	probably damaging	Het
Prr14l	A	G	5: 32,993,014 (GRCm39)	S17P	unknown	Het
Prss22	C	A	17: 24,215,697 (GRCm39)	C75F	probably damaging	Het
Ptgs1	A	G	2: 36,141,253 (GRCm39)	K567E	probably benign	Het
Ptprz1	A	G	6: 23,036,925 (GRCm39)	I1141M	probably damaging	Het
R3hcc1l	A	G	19: 42,552,433 (GRCm39)	K477E	probably damaging	Het
Riok1	A	G	13: 38,232,866 (GRCm39)	Y194C	probably damaging	Het
Smr2	T	A	5: 88,236,095 (GRCm39)	C16S	possibly damaging	Het
Stk25	A	T	1: 93,553,798 (GRCm39)	I187N	probably damaging	Het
Trhde	T	C	10: 114,636,478 (GRCm39)	E243G	probably damaging	Het

Other mutations in Vmn2r3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01019:Vmn2r3	APN	3	64,167,304 (GRCm39)	missense	probably damaging	1.00
IGL01468:Vmn2r3	APN	3	64,182,382 (GRCm39)	missense	possibly damaging	0.57
IGL02032:Vmn2r3	APN	3	64,182,476 (GRCm39)	missense	possibly damaging	0.95
IGL02405:Vmn2r3	APN	3	64,178,620 (GRCm39)	splice site	probably benign
IGL02640:Vmn2r3	APN	3	64,194,816 (GRCm39)	missense	probably benign
IGL02719:Vmn2r3	APN	3	64,183,031 (GRCm39)	missense	probably damaging	1.00
IGL02746:Vmn2r3	APN	3	64,167,239 (GRCm39)	missense	possibly damaging	0.74
IGL03390:Vmn2r3	APN	3	64,182,767 (GRCm39)	missense	possibly damaging	0.55
G1citation:Vmn2r3	UTSW	3	64,194,876 (GRCm39)	missense	probably benign	0.30
R0023:Vmn2r3	UTSW	3	64,182,787 (GRCm39)	missense	probably damaging	0.99
R0433:Vmn2r3	UTSW	3	64,183,054 (GRCm39)	missense	possibly damaging	0.51
R0647:Vmn2r3	UTSW	3	64,183,046 (GRCm39)	missense	probably damaging	1.00
R1071:Vmn2r3	UTSW	3	64,182,697 (GRCm39)	missense	possibly damaging	0.79
R1536:Vmn2r3	UTSW	3	64,182,538 (GRCm39)	missense	probably damaging	1.00
R1806:Vmn2r3	UTSW	3	64,194,810 (GRCm39)	missense	possibly damaging	0.73
R1806:Vmn2r3	UTSW	3	64,182,893 (GRCm39)	missense	probably benign	0.03
R1852:Vmn2r3	UTSW	3	64,166,815 (GRCm39)	missense	probably damaging	1.00
R1868:Vmn2r3	UTSW	3	64,166,537 (GRCm39)	missense	probably damaging	1.00
R2072:Vmn2r3	UTSW	3	64,182,493 (GRCm39)	missense	possibly damaging	0.87
R2240:Vmn2r3	UTSW	3	64,166,483 (GRCm39)	missense	probably benign	0.44
R2446:Vmn2r3	UTSW	3	64,182,733 (GRCm39)	missense	probably damaging	0.98
R4133:Vmn2r3	UTSW	3	64,183,138 (GRCm39)	missense	probably damaging	0.99
R4159:Vmn2r3	UTSW	3	64,194,850 (GRCm39)	nonsense	probably null
R4494:Vmn2r3	UTSW	3	64,182,692 (GRCm39)	missense	probably damaging	1.00
R4860:Vmn2r3	UTSW	3	64,183,022 (GRCm39)	missense	probably benign	0.00
R4895:Vmn2r3	UTSW	3	64,167,182 (GRCm39)	missense	probably benign	0.00
R4912:Vmn2r3	UTSW	3	64,166,618 (GRCm39)	missense	probably damaging	1.00
R5018:Vmn2r3	UTSW	3	64,178,774 (GRCm39)	missense	probably benign
R5033:Vmn2r3	UTSW	3	64,167,220 (GRCm39)	missense	probably benign	0.09
R5126:Vmn2r3	UTSW	3	64,166,740 (GRCm39)	missense	probably damaging	1.00
R5148:Vmn2r3	UTSW	3	64,186,247 (GRCm39)	missense	probably damaging	1.00
R5414:Vmn2r3	UTSW	3	64,166,978 (GRCm39)	nonsense	probably null
R5785:Vmn2r3	UTSW	3	64,166,444 (GRCm39)	missense	possibly damaging	0.89
R5905:Vmn2r3	UTSW	3	64,182,698 (GRCm39)	missense	probably benign	0.19
R5992:Vmn2r3	UTSW	3	64,167,068 (GRCm39)	missense	probably damaging	1.00
R6028:Vmn2r3	UTSW	3	64,182,698 (GRCm39)	missense	probably benign	0.19
R6331:Vmn2r3	UTSW	3	64,186,182 (GRCm39)	missense	probably damaging	1.00
R6378:Vmn2r3	UTSW	3	64,182,517 (GRCm39)	missense	probably damaging	1.00
R6775:Vmn2r3	UTSW	3	64,183,039 (GRCm39)	missense	possibly damaging	0.88
R6822:Vmn2r3	UTSW	3	64,194,876 (GRCm39)	missense	probably benign	0.30
R6826:Vmn2r3	UTSW	3	64,182,327 (GRCm39)	nonsense	probably null
R6886:Vmn2r3	UTSW	3	64,166,927 (GRCm39)	missense	probably damaging	1.00
R6971:Vmn2r3	UTSW	3	64,166,668 (GRCm39)	missense	probably damaging	0.99
R7154:Vmn2r3	UTSW	3	64,194,732 (GRCm39)	missense	probably benign	0.02
R7192:Vmn2r3	UTSW	3	64,167,364 (GRCm39)	missense	probably benign	0.24
R7282:Vmn2r3	UTSW	3	64,168,825 (GRCm39)	missense	possibly damaging	0.90
R7472:Vmn2r3	UTSW	3	64,182,953 (GRCm39)	missense	probably benign	0.00
R7563:Vmn2r3	UTSW	3	64,182,770 (GRCm39)	missense	possibly damaging	0.60
R7726:Vmn2r3	UTSW	3	64,182,939 (GRCm39)	nonsense	probably null
R7966:Vmn2r3	UTSW	3	64,186,235 (GRCm39)	missense	probably damaging	0.99
R8025:Vmn2r3	UTSW	3	64,182,871 (GRCm39)	missense	possibly damaging	0.91
R8050:Vmn2r3	UTSW	3	64,178,714 (GRCm39)	missense	probably damaging	0.99
R8300:Vmn2r3	UTSW	3	64,182,347 (GRCm39)	missense	probably benign	0.00
R8402:Vmn2r3	UTSW	3	64,178,617 (GRCm39)	splice site	probably benign
R8486:Vmn2r3	UTSW	3	64,186,370 (GRCm39)	missense	probably damaging	1.00
R8523:Vmn2r3	UTSW	3	64,182,311 (GRCm39)	missense	probably benign	0.03
R8678:Vmn2r3	UTSW	3	64,166,896 (GRCm39)	missense	possibly damaging	0.76
R8885:Vmn2r3	UTSW	3	64,182,383 (GRCm39)	missense	probably benign	0.00
R8886:Vmn2r3	UTSW	3	64,194,892 (GRCm39)	missense	possibly damaging	0.47
R8905:Vmn2r3	UTSW	3	64,166,695 (GRCm39)	missense	probably damaging	0.99
R8937:Vmn2r3	UTSW	3	64,166,673 (GRCm39)	missense	probably damaging	1.00
R8955:Vmn2r3	UTSW	3	64,168,803 (GRCm39)	missense	possibly damaging	0.56
R9172:Vmn2r3	UTSW	3	64,186,403 (GRCm39)	missense	possibly damaging	0.79
R9485:Vmn2r3	UTSW	3	64,183,046 (GRCm39)	missense	probably damaging	1.00
R9575:Vmn2r3	UTSW	3	64,178,735 (GRCm39)	missense	probably benign	0.01
R9618:Vmn2r3	UTSW	3	64,178,724 (GRCm39)	missense	probably damaging	0.98
X0022:Vmn2r3	UTSW	3	64,182,389 (GRCm39)	missense	probably damaging	1.00
X0022:Vmn2r3	UTSW	3	64,178,669 (GRCm39)	missense	possibly damaging	0.62

Posted On

2015-12-18