Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02954:Vmn1r8'

365033

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r8

Ensembl Gene

ENSMUSG00000061208

Gene Name

vomeronasal 1 receptor 8

Synonyms

V1rc32

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL02954

Quality Score

Status

Chromosome

Chromosomal Location

57012898-57014110 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 57013315 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 122 (Y122C)

Ref Sequence

ENSEMBL: ENSMUSP00000154298 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078186] [ENSMUST00000227706] [ENSMUST00000228690]

AlphaFold

Q8R2C2

Predicted Effect

probably benign
Transcript: ENSMUST00000078186
AA Change: Y122C

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000093561
Gene: ENSMUSG00000061208
AA Change: Y122C

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	1.2e-58	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000227706
AA Change: Y122C

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

Predicted Effect

probably benign
Transcript: ENSMUST00000228690
AA Change: Y122C

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1a	G	T	5: 8,782,341 (GRCm39)	R908L	probably benign	Het
Abcc9	T	C	6: 142,592,007 (GRCm39)	N774S	probably damaging	Het
Alpk2	C	T	18: 65,439,207 (GRCm39)	V729I	probably benign	Het
Atf3	T	C	1: 190,903,852 (GRCm39)	N125D	probably damaging	Het
Bcat1	C	T	6: 144,964,945 (GRCm39)	G215D	probably damaging	Het
Bptf	G	T	11: 106,945,575 (GRCm39)	Q2555K	possibly damaging	Het
Cthrc1	A	G	15: 38,940,389 (GRCm39)		probably benign	Het
Cyp2c38	A	G	19: 39,379,520 (GRCm39)	M443T	probably damaging	Het
D6Wsu163e	C	T	6: 126,951,441 (GRCm39)		probably benign	Het
Dgkg	T	A	16: 22,441,003 (GRCm39)	E3D	probably benign	Het
Dnah8	G	T	17: 30,923,809 (GRCm39)	R1259L	probably benign	Het
Dnah9	A	G	11: 66,009,793 (GRCm39)	L698P	probably damaging	Het
Ebag9	A	C	15: 44,493,601 (GRCm39)	H141P	probably benign	Het
Emilin2	T	C	17: 71,563,526 (GRCm39)	R840G	probably benign	Het
Faap100	A	T	11: 120,262,957 (GRCm39)	H800Q	probably damaging	Het
Fh1	A	T	1: 175,437,301 (GRCm39)	I266N	probably damaging	Het
Fkbp15	A	G	4: 62,239,302 (GRCm39)		probably benign	Het
Gm17334	A	G	11: 53,663,654 (GRCm39)		probably benign	Het
Gm5773	G	T	3: 93,680,358 (GRCm39)	W10L	probably benign	Het
Gng13	T	C	17: 25,937,726 (GRCm39)	Y18H	probably damaging	Het
Hivep3	T	C	4: 119,990,838 (GRCm39)	S2113P	probably damaging	Het
Ift81	A	T	5: 122,748,248 (GRCm39)		probably benign	Het
Irak3	A	C	10: 120,012,147 (GRCm39)	L206V	probably damaging	Het
Kcng4	C	T	8: 120,359,792 (GRCm39)	A195T	probably benign	Het
Lrrc40	G	A	3: 157,747,302 (GRCm39)		probably benign	Het
Nars2	T	G	7: 96,689,100 (GRCm39)		probably null	Het
Nol8	T	C	13: 49,814,648 (GRCm39)	V234A	probably benign	Het
Or12j4	A	T	7: 140,046,353 (GRCm39)	K80*	probably null	Het
Or1o4	T	A	17: 37,591,195 (GRCm39)	N39Y	probably damaging	Het
Patz1	A	G	11: 3,241,761 (GRCm39)	Y383C	probably damaging	Het
Pdcd5	T	C	7: 35,343,089 (GRCm39)	Y152C	probably damaging	Het
Phkg1	A	G	5: 129,894,910 (GRCm39)	W214R	probably damaging	Het
Plxna1	A	G	6: 89,301,649 (GRCm39)	L1459P	probably damaging	Het
Pspc1	G	A	14: 57,009,217 (GRCm39)	P206S	probably benign	Het
St7	A	T	6: 17,848,030 (GRCm39)	N198I	probably damaging	Het
Supt3	A	G	17: 45,349,015 (GRCm39)	D249G	probably damaging	Het
Taf1c	T	C	8: 120,327,225 (GRCm39)	Y418C	probably damaging	Het
Tdrd6	A	G	17: 43,938,153 (GRCm39)	V965A	possibly damaging	Het
Ugt2b35	A	G	5: 87,159,180 (GRCm39)	N458S	probably benign	Het

Other mutations in Vmn1r8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01569:Vmn1r8	APN	6	57,013,272 (GRCm39)	missense	possibly damaging	0.70
IGL01820:Vmn1r8	APN	6	57,013,653 (GRCm39)	missense	possibly damaging	0.94
IGL02416:Vmn1r8	APN	6	57,013,605 (GRCm39)	missense	probably damaging	0.97
IGL02496:Vmn1r8	APN	6	57,013,556 (GRCm39)	missense	probably damaging	1.00
IGL02930:Vmn1r8	APN	6	57,013,579 (GRCm39)	missense	probably benign	0.03
IGL03235:Vmn1r8	APN	6	57,013,746 (GRCm39)	nonsense	probably null
IGL03353:Vmn1r8	APN	6	57,013,776 (GRCm39)	missense	probably benign	0.03
PIT4494001:Vmn1r8	UTSW	6	57,013,712 (GRCm39)	missense	probably benign	0.01
R0656:Vmn1r8	UTSW	6	57,013,573 (GRCm39)	missense	probably benign	0.35
R1328:Vmn1r8	UTSW	6	57,013,278 (GRCm39)	missense	possibly damaging	0.94
R1846:Vmn1r8	UTSW	6	57,013,413 (GRCm39)	missense	probably benign	0.06
R2083:Vmn1r8	UTSW	6	57,013,325 (GRCm39)	missense	probably benign	0.21
R3683:Vmn1r8	UTSW	6	57,013,260 (GRCm39)	missense	probably damaging	1.00
R4134:Vmn1r8	UTSW	6	57,013,705 (GRCm39)	missense	probably benign
R4754:Vmn1r8	UTSW	6	57,012,952 (GRCm39)	start codon destroyed	probably null	1.00
R4857:Vmn1r8	UTSW	6	57,013,338 (GRCm39)	missense	probably benign	0.00
R5787:Vmn1r8	UTSW	6	57,013,244 (GRCm39)	missense	probably damaging	1.00
R6158:Vmn1r8	UTSW	6	57,013,274 (GRCm39)	missense	probably benign	0.00
R6711:Vmn1r8	UTSW	6	57,013,444 (GRCm39)	missense	probably damaging	1.00
R6971:Vmn1r8	UTSW	6	57,013,400 (GRCm39)	missense	probably damaging	1.00
R8066:Vmn1r8	UTSW	6	57,013,419 (GRCm39)	missense	probably benign	0.03
R8261:Vmn1r8	UTSW	6	57,013,158 (GRCm39)	missense	probably benign	0.00
R8526:Vmn1r8	UTSW	6	57,013,362 (GRCm39)	missense	probably benign	0.05
R8552:Vmn1r8	UTSW	6	57,013,138 (GRCm39)	missense	possibly damaging	0.76
R8692:Vmn1r8	UTSW	6	57,013,557 (GRCm39)	missense	probably benign	0.01
R8712:Vmn1r8	UTSW	6	57,013,665 (GRCm39)	missense	probably benign	0.07
R9306:Vmn1r8	UTSW	6	57,013,713 (GRCm39)	missense	probably benign	0.12

Posted On

2015-12-18