Mutagenetix > Incidental Mutation

Incidental Mutation 'R0409:Chil6'

36504

Institutional Source

Beutler Lab

Gene Symbol

Chil6

Ensembl Gene

ENSMUSG00000027902

Gene Name

chitinase-like 6

Synonyms

BYm, BC051070

MMRRC Submission

038611-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

R0409 (G1)

Quality Score

213

Status

Validated

Chromosome

Chromosomal Location

106294700-106313498 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 106311492 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Aspartic acid at position 96 (G96D)

Ref Sequence

ENSEMBL: ENSMUSP00000029510 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029510]

AlphaFold

Q80W26

Predicted Effect

probably benign
Transcript: ENSMUST00000029510
AA Change: G96D

PolyPhen 2 Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000029510
Gene: ENSMUSG00000027902
AA Change: G96D

Domain	Start	End	E-Value	Type
Glyco_18	39	382	3.04e-122	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 96.9%
20x: 94.8%

Validation Efficiency

100% (55/55)

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700113H08Rik	G	T	10: 87,061,816 (GRCm39)	A89S	probably damaging	Het
Alkbh3	T	A	2: 93,831,793 (GRCm39)	I146F	possibly damaging	Het
Aox1	A	T	1: 58,375,783 (GRCm39)	I871F	possibly damaging	Het
Birc2	A	C	9: 7,819,385 (GRCm39)	V509G	possibly damaging	Het
Car7	G	A	8: 105,275,056 (GRCm39)	A165T	probably damaging	Het
Ccdc81	A	G	7: 89,535,423 (GRCm39)	V271A	probably benign	Het
Cdc40	G	T	10: 40,723,164 (GRCm39)	H302N	probably damaging	Het
Cep104	C	T	4: 154,067,510 (GRCm39)		probably benign	Het
Cfap54	C	A	10: 92,612,075 (GRCm39)	S3161I	probably benign	Het
Chil5	A	G	3: 105,942,282 (GRCm39)		probably benign	Het
Cnot1	T	C	8: 96,475,483 (GRCm39)	K531E	probably damaging	Het
Colgalt2	G	T	1: 152,384,312 (GRCm39)	A551S	possibly damaging	Het
Disp3	T	G	4: 148,356,416 (GRCm39)	E148A	probably damaging	Het
Eps8l2	A	G	7: 140,922,893 (GRCm39)	Y52C	probably damaging	Het
Exph5	C	A	9: 53,285,643 (GRCm39)	T908K	probably benign	Het
Fat4	C	T	3: 39,031,562 (GRCm39)	S2449F	probably damaging	Het
Faxc	T	A	4: 21,948,751 (GRCm39)	N154K	probably benign	Het
Fbxo43	C	T	15: 36,162,503 (GRCm39)	A235T	probably benign	Het
Fnip1	A	G	11: 54,371,180 (GRCm39)		probably null	Het
Fsd1l	T	C	4: 53,679,932 (GRCm39)	L210P	probably benign	Het
Gm6420	A	C	1: 23,295,119 (GRCm39)	S123R	unknown	Het
Gm8801	T	G	17: 36,258,268 (GRCm39)		noncoding transcript	Het
Gmfb	T	C	14: 47,053,679 (GRCm39)	I36V	probably benign	Het
Gsap	G	A	5: 21,427,443 (GRCm39)		probably benign	Het
Hectd1	T	A	12: 51,829,339 (GRCm39)	I969L	possibly damaging	Het
Il21r	G	T	7: 125,229,012 (GRCm39)		probably benign	Het
Lrrc7	A	G	3: 157,867,063 (GRCm39)	F893L	possibly damaging	Het
Map2	A	G	1: 66,472,739 (GRCm39)	I1715V	probably damaging	Het
Mlh3	A	G	12: 85,287,628 (GRCm39)	I1339T	possibly damaging	Het
Nacad	T	C	11: 6,549,810 (GRCm39)	D1127G	probably benign	Het
Noc3l	A	G	19: 38,806,371 (GRCm39)		probably benign	Het
Nup93	A	G	8: 95,030,293 (GRCm39)	D384G	probably damaging	Het
Or5m9b	T	A	2: 85,905,646 (GRCm39)	C187*	probably null	Het
Or5p54	T	C	7: 107,554,433 (GRCm39)	I195T	probably benign	Het
Or8b40	C	T	9: 38,027,547 (GRCm39)	L152F	probably benign	Het
Pls1	A	T	9: 95,668,972 (GRCm39)		probably benign	Het
Prkcb	A	T	7: 122,024,200 (GRCm39)	H75L	probably damaging	Het
Rev1	A	T	1: 38,113,449 (GRCm39)	Y539*	probably null	Het
Rnf10	A	T	5: 115,393,506 (GRCm39)		probably benign	Het
Rnpepl1	A	G	1: 92,843,582 (GRCm39)	Y234C	probably damaging	Het
Sdk2	T	C	11: 113,741,717 (GRCm39)		probably benign	Het
Sec23b	T	A	2: 144,409,832 (GRCm39)	M240K	probably benign	Het
Sema5a	A	T	15: 32,681,755 (GRCm39)	N945Y	probably damaging	Het
Snapc4	C	A	2: 26,257,228 (GRCm39)	R799L	probably benign	Het
Spata31g1	A	C	4: 42,972,203 (GRCm39)	K512T	probably damaging	Het
Tctn3	T	C	19: 40,599,860 (GRCm39)		probably benign	Het
Tex56	A	T	13: 35,108,532 (GRCm39)	I5L	probably benign	Het
Tfpt	G	A	7: 3,623,898 (GRCm39)	Q50*	probably null	Het
Trim80	T	C	11: 115,332,039 (GRCm39)	V77A	probably damaging	Het
Trp73	T	A	4: 154,148,841 (GRCm39)	D256V	possibly damaging	Het
Utrn	G	T	10: 12,519,345 (GRCm39)	N2202K	probably benign	Het
Vps13c	T	A	9: 67,858,926 (GRCm39)	F2792Y	probably benign	Het

Other mutations in Chil6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01411:Chil6	APN	3	106,296,141 (GRCm39)	missense	probably damaging	1.00
IGL01735:Chil6	APN	3	106,296,004 (GRCm39)	critical splice donor site	probably null
IGL01795:Chil6	APN	3	106,296,108 (GRCm39)	missense	probably damaging	0.96
IGL02505:Chil6	APN	3	106,313,278 (GRCm39)	missense	probably benign
IGL03164:Chil6	APN	3	106,301,714 (GRCm39)	missense	probably benign	0.04
cold_cut	UTSW	3	106,297,290 (GRCm39)	missense	probably damaging	1.00
R1761:Chil6	UTSW	3	106,301,654 (GRCm39)	missense	probably damaging	1.00
R1967:Chil6	UTSW	3	106,298,470 (GRCm39)	missense	possibly damaging	0.84
R2571:Chil6	UTSW	3	106,297,709 (GRCm39)	nonsense	probably null
R3024:Chil6	UTSW	3	106,296,086 (GRCm39)	missense	probably damaging	1.00
R3829:Chil6	UTSW	3	106,313,274 (GRCm39)	missense	probably benign	0.00
R4835:Chil6	UTSW	3	106,313,290 (GRCm39)	nonsense	probably null
R4851:Chil6	UTSW	3	106,297,244 (GRCm39)	missense	possibly damaging	0.61
R4948:Chil6	UTSW	3	106,295,988 (GRCm39)	intron	probably benign
R5056:Chil6	UTSW	3	106,301,659 (GRCm39)	missense	probably damaging	1.00
R5244:Chil6	UTSW	3	106,297,290 (GRCm39)	missense	probably damaging	1.00
R5555:Chil6	UTSW	3	106,297,268 (GRCm39)	missense	possibly damaging	0.87
R5594:Chil6	UTSW	3	106,301,745 (GRCm39)	splice site	probably null
R5633:Chil6	UTSW	3	106,296,068 (GRCm39)	missense	probably damaging	1.00
R6194:Chil6	UTSW	3	106,312,192 (GRCm39)	critical splice donor site	probably null
R6587:Chil6	UTSW	3	106,312,197 (GRCm39)	missense	probably benign
R6613:Chil6	UTSW	3	106,297,191 (GRCm39)	missense	probably benign	0.25
R6641:Chil6	UTSW	3	106,296,240 (GRCm39)	missense	possibly damaging	0.61
R6651:Chil6	UTSW	3	106,311,576 (GRCm39)	missense	probably damaging	1.00
R7094:Chil6	UTSW	3	106,311,486 (GRCm39)	missense	probably damaging	0.96
R7161:Chil6	UTSW	3	106,301,728 (GRCm39)	missense	probably benign	0.01
R7653:Chil6	UTSW	3	106,301,641 (GRCm39)	missense	possibly damaging	0.82
R8802:Chil6	UTSW	3	106,312,208 (GRCm39)	missense	probably damaging	1.00
R9217:Chil6	UTSW	3	106,313,411 (GRCm39)	start gained	probably benign
R9584:Chil6	UTSW	3	106,301,672 (GRCm39)	missense	probably damaging	1.00
R9782:Chil6	UTSW	3	106,296,121 (GRCm39)	nonsense	probably null
X0026:Chil6	UTSW	3	106,296,284 (GRCm39)	missense	probably benign	0.02
X0064:Chil6	UTSW	3	106,311,635 (GRCm39)	nonsense	probably null

Predicted Primers

Posted On

2013-05-09