Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02959:Or6d15'

365273

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or6d15

Ensembl Gene

ENSMUSG00000050654

Gene Name

olfactory receptor family 6 subfamily D member 15

Synonyms

GA_x54KRFPKN04-58217732-58216800, MOR119-2, Olfr215

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.078) question?

Stock #

IGL02959

Quality Score

Status

Chromosome

Chromosomal Location

116558973-116559905 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 116559505 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 134 (M134K)

Ref Sequence

ENSEMBL: ENSMUSP00000052425 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061723]

AlphaFold

Q8VF82

Predicted Effect

probably damaging
Transcript: ENSMUST00000061723
AA Change: M134K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000052425
Gene: ENSMUSG00000050654
AA Change: M134K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	5e-47	PFAM
Pfam:7TM_GPCR_Srsx	33	258	1.8e-5	PFAM
Pfam:7tm_1	39	288	2.9e-15	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	G	T	6: 128,544,023 (GRCm39)	A506D	probably benign	Het
Agap1	G	T	1: 89,770,913 (GRCm39)	V635L	possibly damaging	Het
Akr1c12	T	C	13: 4,329,331 (GRCm39)	K9E	probably benign	Het
Alms1	T	A	6: 85,606,034 (GRCm39)	Y2561*	probably null	Het
Atm	T	C	9: 53,382,718 (GRCm39)	H1957R	probably damaging	Het
Bcr	T	C	10: 74,996,222 (GRCm39)	F922S	probably benign	Het
Cfap44	T	A	16: 44,291,230 (GRCm39)		probably benign	Het
Chil5	A	G	3: 105,926,906 (GRCm39)	V243A	probably damaging	Het
Csmd1	A	G	8: 15,960,465 (GRCm39)	C3317R	probably damaging	Het
Dsc1	T	C	18: 20,241,942 (GRCm39)	K133R	probably damaging	Het
Ecm1	T	A	3: 95,644,989 (GRCm39)	Q136L	probably damaging	Het
Fscn3	C	A	6: 28,435,997 (GRCm39)	A431E	possibly damaging	Het
Gas7	C	T	11: 67,565,061 (GRCm39)		probably benign	Het
Gbx2	A	G	1: 89,856,517 (GRCm39)	V291A	probably damaging	Het
Hipk3	G	A	2: 104,301,604 (GRCm39)	T196M	probably damaging	Het
Il20ra	T	A	10: 19,634,789 (GRCm39)	N343K	probably benign	Het
Il24	C	T	1: 130,813,470 (GRCm39)	W42*	probably null	Het
Kif13b	A	T	14: 65,005,166 (GRCm39)	I1153F	probably damaging	Het
Krt1c	A	T	15: 101,719,763 (GRCm39)	S636T	unknown	Het
Or11g24	A	T	14: 50,662,389 (GRCm39)	M138L	possibly damaging	Het
Or13a25	C	T	7: 140,247,463 (GRCm39)	P81S	probably damaging	Het
Or14c40	T	C	7: 86,313,737 (GRCm39)	F289S	probably damaging	Het
Or4k52	T	A	2: 111,610,955 (GRCm39)	C97S	probably damaging	Het
Osmr	T	C	15: 6,845,378 (GRCm39)	D796G	possibly damaging	Het
Peli2	A	T	14: 48,477,754 (GRCm39)	T99S	probably benign	Het
Pi4k2a	A	T	19: 42,101,510 (GRCm39)	K317N	probably benign	Het
Pik3r1	T	G	13: 101,894,037 (GRCm39)	D44A	probably benign	Het
Pkhd1	G	T	1: 20,678,640 (GRCm39)	S96*	probably null	Het
Plekha5	A	G	6: 140,489,904 (GRCm39)	E9G	probably damaging	Het
Plekha8	T	C	6: 54,592,254 (GRCm39)	F71S	probably damaging	Het
Polq	G	T	16: 36,906,928 (GRCm39)	L2296F	probably damaging	Het
Rbm5	G	A	9: 107,631,384 (GRCm39)		probably benign	Het
Rc3h2	T	C	2: 37,295,366 (GRCm39)	K217E	probably damaging	Het
Scrib	A	G	15: 75,937,056 (GRCm39)	L350P	probably damaging	Het
Slc4a10	T	A	2: 62,098,487 (GRCm39)	S540R	probably damaging	Het
Smc3	G	T	19: 53,611,988 (GRCm39)	V354L	probably benign	Het
Smurf1	T	A	5: 144,836,199 (GRCm39)	I105F	probably damaging	Het
Stx7	G	T	10: 24,031,247 (GRCm39)	R17L	probably benign	Het
Tbca	C	T	13: 94,979,203 (GRCm39)	R74C	probably benign	Het
Tmem92	T	C	11: 94,669,504 (GRCm39)	Q153R	possibly damaging	Het
Trim41	C	A	11: 48,698,307 (GRCm39)	G553V	probably damaging	Het
Trim75	A	T	8: 65,435,417 (GRCm39)	N344K	possibly damaging	Het
Tsr1	A	G	11: 74,791,075 (GRCm39)	D218G	probably benign	Het
Ubr2	A	C	17: 47,286,877 (GRCm39)	V474G	probably damaging	Het
Unc45a	T	G	7: 79,982,721 (GRCm39)		probably benign	Het
Zfp609	C	T	9: 65,610,675 (GRCm39)	A763T	probably benign	Het

Other mutations in Or6d15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01666:Or6d15	APN	6	116,559,296 (GRCm39)	missense	possibly damaging	0.93
IGL03053:Or6d15	APN	6	116,559,206 (GRCm39)	missense	possibly damaging	0.50
R0078:Or6d15	UTSW	6	116,559,701 (GRCm39)	missense	probably damaging	0.96
R0277:Or6d15	UTSW	6	116,559,562 (GRCm39)	missense	probably damaging	0.99
R0323:Or6d15	UTSW	6	116,559,562 (GRCm39)	missense	probably damaging	0.99
R0399:Or6d15	UTSW	6	116,559,742 (GRCm39)	missense	probably benign	0.00
R0545:Or6d15	UTSW	6	116,559,617 (GRCm39)	missense	probably benign	0.01
R1213:Or6d15	UTSW	6	116,559,827 (GRCm39)	missense	probably benign	0.00
R1775:Or6d15	UTSW	6	116,559,925 (GRCm39)	start gained	probably benign
R1789:Or6d15	UTSW	6	116,559,658 (GRCm39)	missense	probably damaging	1.00
R4724:Or6d15	UTSW	6	116,559,898 (GRCm39)	missense	probably damaging	1.00
R5391:Or6d15	UTSW	6	116,559,808 (GRCm39)	missense	probably damaging	1.00
R5392:Or6d15	UTSW	6	116,559,379 (GRCm39)	missense	probably damaging	1.00
R5686:Or6d15	UTSW	6	116,559,890 (GRCm39)	missense	probably benign	0.00
R6124:Or6d15	UTSW	6	116,559,446 (GRCm39)	missense	probably benign	0.05
R7080:Or6d15	UTSW	6	116,559,314 (GRCm39)	missense	probably damaging	1.00
R7355:Or6d15	UTSW	6	116,559,916 (GRCm39)	start gained	probably benign
R9084:Or6d15	UTSW	6	116,559,232 (GRCm39)	missense	probably benign	0.03
Z1177:Or6d15	UTSW	6	116,559,514 (GRCm39)	missense	probably benign	0.01

Posted On

2015-12-18