Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02959:Il24'

365277

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Il24

Ensembl Gene

ENSMUSG00000026420

Gene Name

interleukin 24

Synonyms

FISP, Mda-7

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02959

Quality Score

Status

Chromosome

Chromosomal Location

130809801-130815153 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 130813470 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Stop codon at position 42 (W42*)

Ref Sequence

ENSEMBL: ENSMUSP00000140821 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038829] [ENSMUST00000121040] [ENSMUST00000187650] [ENSMUST00000188148] [ENSMUST00000191279]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000038829

SMART Domains

Protein: ENSMUSP00000048303
Gene: ENSMUSG00000042474

Domain	Start	End	E-Value	Type
signal peptide	1	16	N/A	INTRINSIC
Pfam:V-set	21	122	1.3e-10	PFAM
low complexity region	212	223	N/A	INTRINSIC
transmembrane domain	264	283	N/A	INTRINSIC
low complexity region	285	311	N/A	INTRINSIC
low complexity region	344	363	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000121040
AA Change: W42*

SMART Domains

Protein: ENSMUSP00000113064
Gene: ENSMUSG00000026420
AA Change: W42*

Domain	Start	End	E-Value	Type
low complexity region	44	56	N/A	INTRINSIC
IL10	76	219	1.14e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126821

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145446

Predicted Effect

probably null
Transcript: ENSMUST00000187650
AA Change: W3*

SMART Domains

Protein: ENSMUSP00000140149
Gene: ENSMUSG00000026420
AA Change: W3*

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
IL10	37	180	5.4e-4	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000188148
AA Change: G33R

SMART Domains

Protein: ENSMUSP00000139907
Gene: ENSMUSG00000026420
AA Change: G33R

Domain	Start	End	E-Value	Type
low complexity region	37	50	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000191279
AA Change: W42*

SMART Domains

Protein: ENSMUSP00000140821
Gene: ENSMUSG00000026420
AA Change: W42*

Domain	Start	End	E-Value	Type
low complexity region	44	56	N/A	INTRINSIC
Blast:IL10	76	118	2e-21	BLAST
SCOP:d2ilk__	80	119	2e-9	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele display normal induction of epidermal hyperplasia in response to intradermal IL-23 treatment. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	G	T	6: 128,544,023 (GRCm39)	A506D	probably benign	Het
Agap1	G	T	1: 89,770,913 (GRCm39)	V635L	possibly damaging	Het
Akr1c12	T	C	13: 4,329,331 (GRCm39)	K9E	probably benign	Het
Alms1	T	A	6: 85,606,034 (GRCm39)	Y2561*	probably null	Het
Atm	T	C	9: 53,382,718 (GRCm39)	H1957R	probably damaging	Het
Bcr	T	C	10: 74,996,222 (GRCm39)	F922S	probably benign	Het
Cfap44	T	A	16: 44,291,230 (GRCm39)		probably benign	Het
Chil5	A	G	3: 105,926,906 (GRCm39)	V243A	probably damaging	Het
Csmd1	A	G	8: 15,960,465 (GRCm39)	C3317R	probably damaging	Het
Dsc1	T	C	18: 20,241,942 (GRCm39)	K133R	probably damaging	Het
Ecm1	T	A	3: 95,644,989 (GRCm39)	Q136L	probably damaging	Het
Fscn3	C	A	6: 28,435,997 (GRCm39)	A431E	possibly damaging	Het
Gas7	C	T	11: 67,565,061 (GRCm39)		probably benign	Het
Gbx2	A	G	1: 89,856,517 (GRCm39)	V291A	probably damaging	Het
Hipk3	G	A	2: 104,301,604 (GRCm39)	T196M	probably damaging	Het
Il20ra	T	A	10: 19,634,789 (GRCm39)	N343K	probably benign	Het
Kif13b	A	T	14: 65,005,166 (GRCm39)	I1153F	probably damaging	Het
Krt1c	A	T	15: 101,719,763 (GRCm39)	S636T	unknown	Het
Or11g24	A	T	14: 50,662,389 (GRCm39)	M138L	possibly damaging	Het
Or13a25	C	T	7: 140,247,463 (GRCm39)	P81S	probably damaging	Het
Or14c40	T	C	7: 86,313,737 (GRCm39)	F289S	probably damaging	Het
Or4k52	T	A	2: 111,610,955 (GRCm39)	C97S	probably damaging	Het
Or6d15	A	T	6: 116,559,505 (GRCm39)	M134K	probably damaging	Het
Osmr	T	C	15: 6,845,378 (GRCm39)	D796G	possibly damaging	Het
Peli2	A	T	14: 48,477,754 (GRCm39)	T99S	probably benign	Het
Pi4k2a	A	T	19: 42,101,510 (GRCm39)	K317N	probably benign	Het
Pik3r1	T	G	13: 101,894,037 (GRCm39)	D44A	probably benign	Het
Pkhd1	G	T	1: 20,678,640 (GRCm39)	S96*	probably null	Het
Plekha5	A	G	6: 140,489,904 (GRCm39)	E9G	probably damaging	Het
Plekha8	T	C	6: 54,592,254 (GRCm39)	F71S	probably damaging	Het
Polq	G	T	16: 36,906,928 (GRCm39)	L2296F	probably damaging	Het
Rbm5	G	A	9: 107,631,384 (GRCm39)		probably benign	Het
Rc3h2	T	C	2: 37,295,366 (GRCm39)	K217E	probably damaging	Het
Scrib	A	G	15: 75,937,056 (GRCm39)	L350P	probably damaging	Het
Slc4a10	T	A	2: 62,098,487 (GRCm39)	S540R	probably damaging	Het
Smc3	G	T	19: 53,611,988 (GRCm39)	V354L	probably benign	Het
Smurf1	T	A	5: 144,836,199 (GRCm39)	I105F	probably damaging	Het
Stx7	G	T	10: 24,031,247 (GRCm39)	R17L	probably benign	Het
Tbca	C	T	13: 94,979,203 (GRCm39)	R74C	probably benign	Het
Tmem92	T	C	11: 94,669,504 (GRCm39)	Q153R	possibly damaging	Het
Trim41	C	A	11: 48,698,307 (GRCm39)	G553V	probably damaging	Het
Trim75	A	T	8: 65,435,417 (GRCm39)	N344K	possibly damaging	Het
Tsr1	A	G	11: 74,791,075 (GRCm39)	D218G	probably benign	Het
Ubr2	A	C	17: 47,286,877 (GRCm39)	V474G	probably damaging	Het
Unc45a	T	G	7: 79,982,721 (GRCm39)		probably benign	Het
Zfp609	C	T	9: 65,610,675 (GRCm39)	A763T	probably benign	Het

Other mutations in Il24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01934:Il24	APN	1	130,811,614 (GRCm39)	missense	probably damaging	1.00
IGL02540:Il24	APN	1	130,815,040 (GRCm39)	unclassified	probably benign
IGL03191:Il24	APN	1	130,812,584 (GRCm39)	missense	probably benign	0.06
R0360:Il24	UTSW	1	130,811,674 (GRCm39)	missense	probably damaging	1.00
R1738:Il24	UTSW	1	130,815,099 (GRCm39)	splice site	probably null
R1755:Il24	UTSW	1	130,811,680 (GRCm39)	missense	possibly damaging	0.58
R1984:Il24	UTSW	1	130,810,268 (GRCm39)	missense	probably benign	0.01
R1985:Il24	UTSW	1	130,810,268 (GRCm39)	missense	probably benign	0.01
R1986:Il24	UTSW	1	130,810,268 (GRCm39)	missense	probably benign	0.01
R2090:Il24	UTSW	1	130,812,574 (GRCm39)	missense	possibly damaging	0.90
R4970:Il24	UTSW	1	130,811,179 (GRCm39)	splice site	probably null
R5112:Il24	UTSW	1	130,811,179 (GRCm39)	splice site	probably null
R5590:Il24	UTSW	1	130,810,253 (GRCm39)	missense	possibly damaging	0.72
R6128:Il24	UTSW	1	130,813,435 (GRCm39)	missense	probably damaging	0.97
R7061:Il24	UTSW	1	130,811,108 (GRCm39)	missense	possibly damaging	0.81
R9114:Il24	UTSW	1	130,813,483 (GRCm39)	missense	possibly damaging	0.86
R9465:Il24	UTSW	1	130,813,462 (GRCm39)	missense	probably benign	0.18
X0021:Il24	UTSW	1	130,813,322 (GRCm39)	missense	probably benign	0.06

Posted On

2015-12-18