Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02960:Gpr137c'

365312

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr137c

Ensembl Gene

ENSMUSG00000049092

Gene Name

G protein-coupled receptor 137C

Synonyms

LOC380893, 6330416L11Rik, TM7SF1L2

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

IGL02960

Quality Score

Status

Chromosome

Chromosomal Location

45219717-45282725 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 45246433 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 206 (F206L)

Ref Sequence

ENSEMBL: ENSMUSP00000120015 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000146150]

AlphaFold

E9Q343

Predicted Effect

possibly damaging
Transcript: ENSMUST00000146150
AA Change: F206L

PolyPhen 2 Score 0.924 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000120015
Gene: ENSMUSG00000049092
AA Change: F206L

Domain	Start	End	E-Value	Type
low complexity region	4	17	N/A	INTRINSIC
low complexity region	23	39	N/A	INTRINSIC
transmembrane domain	44	66	N/A	INTRINSIC
transmembrane domain	78	100	N/A	INTRINSIC
Blast:G_alpha	121	286	9e-17	BLAST
transmembrane domain	294	316	N/A	INTRINSIC
low complexity region	376	389	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700129C05Rik	G	A	14: 59,142,808	R14C	probably benign	Het
Adam29	A	T	8: 55,872,666	L251*	probably null	Het
Atpaf2	T	C	11: 60,405,824	E161G	probably damaging	Het
Brwd1	T	C	16: 96,057,466	D381G	probably damaging	Het
Cept1	T	A	3: 106,539,396	R45*	probably null	Het
Col3a1	A	G	1: 45,328,455	E273G	unknown	Het
Cuzd1	T	C	7: 131,320,103	N57D	probably benign	Het
Cyp2b13	A	G	7: 26,061,676	K53E	probably benign	Het
Fadd	T	C	7: 144,580,539	E203G	probably benign	Het
Gm14548	T	C	7: 3,897,079	T175A	possibly damaging	Het
Gm3159	G	A	14: 4,400,552		probably null	Het
Hephl1	G	T	9: 15,084,319	T471N	probably damaging	Het
Ido1	A	T	8: 24,593,329		probably benign	Het
Krt40	C	T	11: 99,539,867		probably null	Het
Lrp2	T	A	2: 69,455,453		probably benign	Het
Lrrc8a	T	A	2: 30,257,013	L613H	probably damaging	Het
Mettl14	A	G	3: 123,374,885	Y169H	probably damaging	Het
Nlrp4a	A	G	7: 26,449,730	Q254R	probably benign	Het
Olfr1211	A	C	2: 88,929,784	M177R	possibly damaging	Het
Olfr1356	A	T	10: 78,847,537	I126N	probably damaging	Het
Pkhd1	A	T	1: 20,377,446	M2241K	possibly damaging	Het
Ptprd	G	A	4: 76,128,868	S387L	probably damaging	Het
Ryr1	A	C	7: 29,060,053	L3264R	probably damaging	Het
Serpina16	G	A	12: 103,675,379	T29I	probably benign	Het
Slc9a7	A	G	X: 20,186,143	M237T	probably benign	Het
Tbck	A	G	3: 132,722,783	T300A	probably benign	Het
Tcaf1	A	C	6: 42,686,459	D162E	probably benign	Het
Unc80	G	A	1: 66,678,058		probably benign	Het
Usp17le	A	C	7: 104,768,740	H398Q	probably benign	Het
Utp15	G	A	13: 98,252,881	T303M	probably benign	Het
Vmn2r86	A	C	10: 130,453,767	D86E	possibly damaging	Het
Zmym2	T	A	14: 56,938,413	C822S	probably benign	Het
Zp3r	T	C	1: 130,583,438	D336G	possibly damaging	Het
Zpr1	A	G	9: 46,273,551	H82R	probably damaging	Het

Other mutations in Gpr137c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00478:Gpr137c	APN	14	45278745	missense	probably damaging	0.97
IGL02167:Gpr137c	APN	14	45279955	missense	probably damaging	0.98
IGL02203:Gpr137c	APN	14	45277487	missense	possibly damaging	0.86
R0731:Gpr137c	UTSW	14	45246349	missense	probably damaging	1.00
R1162:Gpr137c	UTSW	14	45244158	missense	possibly damaging	0.89
R1245:Gpr137c	UTSW	14	45279065	utr 3 prime	probably benign
R1983:Gpr137c	UTSW	14	45279971	missense	probably benign	0.01
R2060:Gpr137c	UTSW	14	45244159	missense	probably damaging	1.00
R2428:Gpr137c	UTSW	14	45278963	missense	probably damaging	1.00
R3034:Gpr137c	UTSW	14	45220276	missense	probably damaging	0.99
R3911:Gpr137c	UTSW	14	45278935	missense	probably benign	0.31
R4037:Gpr137c	UTSW	14	45220230	missense	probably damaging	0.99
R4038:Gpr137c	UTSW	14	45220230	missense	probably damaging	0.99
R4213:Gpr137c	UTSW	14	45246508	missense	probably damaging	0.99
R4986:Gpr137c	UTSW	14	45246286	critical splice acceptor site	probably null
R5521:Gpr137c	UTSW	14	45278694	missense	possibly damaging	0.92
R6028:Gpr137c	UTSW	14	45277481	missense	probably damaging	0.96
R7117:Gpr137c	UTSW	14	45279027	missense	probably damaging	1.00
R7238:Gpr137c	UTSW	14	45278691	missense	probably damaging	1.00
R7365:Gpr137c	UTSW	14	45279014	missense	probably damaging	1.00
R9515:Gpr137c	UTSW	14	45278772	nonsense	probably null
R9539:Gpr137c	UTSW	14	45278730	missense	probably damaging	0.97
X0027:Gpr137c	UTSW	14	45278669	missense	probably benign	0.14

Posted On

2015-12-18