Incidental Mutation 'IGL02960:Ido1'
ID365326
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ido1
Ensembl Gene ENSMUSG00000031551
Gene Nameindoleamine 2,3-dioxygenase 1
SynonymsIndo, Ido
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02960
Quality Score
Status
Chromosome8
Chromosomal Location24584136-24597009 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 24593329 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000106295 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033956] [ENSMUST00000110667]
Predicted Effect probably benign
Transcript: ENSMUST00000033956
SMART Domains Protein: ENSMUSP00000033956
Gene: ENSMUSG00000031551

DomainStartEndE-ValueType
Pfam:IDO 15 402 4.7e-124 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110667
SMART Domains Protein: ENSMUSP00000106295
Gene: ENSMUSG00000031551

DomainStartEndE-ValueType
Pfam:IDO 1 313 6e-111 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for a null allele fail to induce IFN-alpha production by dendritic cells after B7 ligation, and show epididymal inflammation, teratospermia, and elevated caudal epididymal sperm counts along with higher protein and cytokine levels and reduced leukocyte count and proteasome activity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700129C05Rik G A 14: 59,142,808 R14C probably benign Het
Adam29 A T 8: 55,872,666 L251* probably null Het
Atpaf2 T C 11: 60,405,824 E161G probably damaging Het
Brwd1 T C 16: 96,057,466 D381G probably damaging Het
Cept1 T A 3: 106,539,396 R45* probably null Het
Col3a1 A G 1: 45,328,455 E273G unknown Het
Cuzd1 T C 7: 131,320,103 N57D probably benign Het
Cyp2b13 A G 7: 26,061,676 K53E probably benign Het
Fadd T C 7: 144,580,539 E203G probably benign Het
Gm14548 T C 7: 3,897,079 T175A possibly damaging Het
Gm3159 G A 14: 4,400,552 probably null Het
Gpr137c T C 14: 45,246,433 F206L possibly damaging Het
Hephl1 G T 9: 15,084,319 T471N probably damaging Het
Krt40 C T 11: 99,539,867 probably null Het
Lrp2 T A 2: 69,455,453 probably benign Het
Lrrc8a T A 2: 30,257,013 L613H probably damaging Het
Mettl14 A G 3: 123,374,885 Y169H probably damaging Het
Nlrp4a A G 7: 26,449,730 Q254R probably benign Het
Olfr1211 A C 2: 88,929,784 M177R possibly damaging Het
Olfr1356 A T 10: 78,847,537 I126N probably damaging Het
Pkhd1 A T 1: 20,377,446 M2241K possibly damaging Het
Ptprd G A 4: 76,128,868 S387L probably damaging Het
Ryr1 A C 7: 29,060,053 L3264R probably damaging Het
Serpina16 G A 12: 103,675,379 T29I probably benign Het
Slc9a7 A G X: 20,186,143 M237T probably benign Het
Tbck A G 3: 132,722,783 T300A probably benign Het
Tcaf1 A C 6: 42,686,459 D162E probably benign Het
Unc80 G A 1: 66,678,058 probably benign Het
Usp17le A C 7: 104,768,740 H398Q probably benign Het
Utp15 G A 13: 98,252,881 T303M probably benign Het
Vmn2r86 A C 10: 130,453,767 D86E possibly damaging Het
Zmym2 T A 14: 56,938,413 C822S probably benign Het
Zp3r T C 1: 130,583,438 D336G possibly damaging Het
Zpr1 A G 9: 46,273,551 H82R probably damaging Het
Other mutations in Ido1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00832:Ido1 APN 8 24584559 missense possibly damaging 0.93
IGL01987:Ido1 APN 8 24593143 missense probably benign 0.02
R0180:Ido1 UTSW 8 24593140 missense possibly damaging 0.87
R0652:Ido1 UTSW 8 24585244 missense probably damaging 1.00
R1102:Ido1 UTSW 8 24593140 missense probably damaging 1.00
R1474:Ido1 UTSW 8 24584446 missense probably damaging 0.97
R1925:Ido1 UTSW 8 24585290 missense possibly damaging 0.82
R2509:Ido1 UTSW 8 24584485 nonsense probably null
R4913:Ido1 UTSW 8 24584517 missense probably benign
R4962:Ido1 UTSW 8 24584549 missense probably benign 0.00
R5313:Ido1 UTSW 8 24587778 missense probably damaging 1.00
R5654:Ido1 UTSW 8 24587803 missense probably damaging 1.00
R5660:Ido1 UTSW 8 24591542 missense probably damaging 1.00
R6144:Ido1 UTSW 8 24585290 missense possibly damaging 0.82
R7436:Ido1 UTSW 8 24586916 missense probably benign 0.00
R7615:Ido1 UTSW 8 24593188 missense probably damaging 1.00
R7873:Ido1 UTSW 8 24584742 missense probably damaging 0.98
R7956:Ido1 UTSW 8 24584742 missense probably damaging 0.98
Posted On2015-12-18