Incidental Mutation 'IGL02961:Olfr646'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr646
Ensembl Gene ENSMUSG00000073931
Gene Nameolfactory receptor 646
SynonymsGA_x6K02T2PBJ9-6841330-6842268, MOR33-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.132) question?
Stock #IGL02961
Quality Score
Chromosomal Location104104873-104109766 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to A at 104107150 bp
Amino Acid Change Tyrosine to Stop codon at position 290 (Y290*)
Ref Sequence ENSEMBL: ENSMUSP00000149102 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098182] [ENSMUST00000138055] [ENSMUST00000214099]
Predicted Effect probably null
Transcript: ENSMUST00000098182
AA Change: Y290*
SMART Domains Protein: ENSMUSP00000095784
Gene: ENSMUSG00000073931
AA Change: Y290*

Pfam:7tm_4 28 307 1.9e-109 PFAM
Pfam:7TM_GPCR_Srsx 32 225 6.1e-10 PFAM
Pfam:7tm_1 38 290 3.3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138055
SMART Domains Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

transmembrane domain 29 51 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000214099
AA Change: Y290*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214291
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A G 13: 81,523,612 V2288A probably damaging Het
Agbl4 T A 4: 110,580,121 N76K probably damaging Het
AI182371 A T 2: 35,086,112 V258E possibly damaging Het
Alg1 T A 16: 5,234,997 N80K probably benign Het
Ambra1 A G 2: 91,911,448 M963V possibly damaging Het
Avil C A 10: 127,008,306 Q245K probably benign Het
Caml A G 13: 55,631,882 N256S probably benign Het
Ccdc102a A C 8: 94,903,350 I521S possibly damaging Het
Ccm2l A G 2: 153,078,601 T393A probably benign Het
Cdh16 A G 8: 104,615,205 V91A probably damaging Het
Chd7 A G 4: 8,751,542 D13G probably damaging Het
Chsy1 T A 7: 66,171,782 D588E probably benign Het
Cilp T A 9: 65,278,609 V662E possibly damaging Het
Cog8 A G 8: 107,056,253 probably benign Het
Cpb2 T C 14: 75,265,383 V134A probably benign Het
Ctcfl T A 2: 173,101,919 H546L possibly damaging Het
Dclre1c A G 2: 3,437,033 D136G probably damaging Het
Dnah2 T A 11: 69,518,414 E379D probably damaging Het
Extl3 A G 14: 65,056,959 Y808H possibly damaging Het
Gm7247 T A 14: 51,365,355 N49K probably damaging Het
Gm8882 A T 6: 132,361,408 F282L unknown Het
Insr T C 8: 3,258,785 I84V probably benign Het
Ipo7 C T 7: 110,047,016 P541S probably benign Het
Kcnc3 T C 7: 44,591,492 S203P probably damaging Het
Myo5a A G 9: 75,215,120 D1732G probably benign Het
Olfr1419 T A 19: 11,870,331 N295I probably damaging Het
Olfr153 A G 2: 87,532,684 Y217C probably damaging Het
Olfr493 T C 7: 108,346,127 I285V probably benign Het
Olfr986 T C 9: 40,187,601 V162A probably benign Het
Pde3a T A 6: 141,459,700 L426* probably null Het
Pkd1 T A 17: 24,578,115 D8E possibly damaging Het
Polr3a A T 14: 24,467,040 Y714* probably null Het
Pramef25 T C 4: 143,949,147 T370A probably damaging Het
Rasgrf1 T C 9: 89,981,649 V556A possibly damaging Het
Rev3l T C 10: 39,827,945 Y1996H possibly damaging Het
Rttn T C 18: 89,053,573 L1248P probably damaging Het
Slc11a1 T C 1: 74,377,173 L53P probably damaging Het
Slc22a27 T C 19: 7,926,521 R84G probably damaging Het
Sptbn4 A G 7: 27,397,967 L1302P probably damaging Het
Srm T C 4: 148,594,129 V271A possibly damaging Het
Sycp2 A G 2: 178,380,862 I492T probably benign Het
Tmprss13 A G 9: 45,345,003 T472A probably damaging Het
Togaram1 A G 12: 64,966,710 D245G probably damaging Het
Vmn1r184 A T 7: 26,267,650 I274L probably benign Het
Vmn1r21 T C 6: 57,843,989 M157V probably benign Het
Wdr90 C A 17: 25,848,675 E1420* probably null Het
Zfp518a A T 19: 40,915,018 R1130S probably benign Het
Other mutations in Olfr646
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01779:Olfr646 APN 7 104106633 missense probably damaging 1.00
IGL02454:Olfr646 APN 7 104106612 missense probably damaging 0.96
IGL02588:Olfr646 APN 7 104107053 missense possibly damaging 0.94
IGL03092:Olfr646 APN 7 104106647 missense probably damaging 0.99
PIT4402001:Olfr646 UTSW 7 104106450 missense probably damaging 1.00
R0006:Olfr646 UTSW 7 104106320 missense probably benign 0.00
R0109:Olfr646 UTSW 7 104106605 missense probably damaging 1.00
R0109:Olfr646 UTSW 7 104106605 missense probably damaging 1.00
R0601:Olfr646 UTSW 7 104107142 missense possibly damaging 0.83
R0732:Olfr646 UTSW 7 104106294 missense probably damaging 1.00
R1320:Olfr646 UTSW 7 104106480 missense probably damaging 1.00
R1468:Olfr646 UTSW 7 104106689 missense possibly damaging 0.82
R1468:Olfr646 UTSW 7 104106689 missense possibly damaging 0.82
R1513:Olfr646 UTSW 7 104106464 missense probably benign 0.02
R5486:Olfr646 UTSW 7 104106498 missense probably damaging 0.99
R6110:Olfr646 UTSW 7 104106572 missense probably damaging 1.00
R6497:Olfr646 UTSW 7 104107215 intron probably benign
R6856:Olfr646 UTSW 7 104106791 missense probably benign 0.00
R7766:Olfr646 UTSW 7 104106994 nonsense probably null
R7789:Olfr646 UTSW 7 104106988 missense probably damaging 0.99
R7844:Olfr646 UTSW 7 104106483 missense probably damaging 1.00
R7927:Olfr646 UTSW 7 104106483 missense probably damaging 1.00
Posted On2015-12-18