Incidental Mutation 'IGL02962:Wars'
ID365386
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wars
Ensembl Gene ENSMUSG00000021266
Gene Nametryptophanyl-tRNA synthetase
Synonyms
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL02962
Quality Score
Status
Chromosome12
Chromosomal Location108860030-108894174 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 108875780 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 147 (M147K)
Ref Sequence ENSEMBL: ENSMUSP00000125320 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109848] [ENSMUST00000160477] [ENSMUST00000161154] [ENSMUST00000161410] [ENSMUST00000162748]
Predicted Effect probably damaging
Transcript: ENSMUST00000109848
AA Change: M147K

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000105474
Gene: ENSMUSG00000021266
AA Change: M147K

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 447 5.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000160477
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160974
Predicted Effect probably damaging
Transcript: ENSMUST00000161154
AA Change: M147K

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000124625
Gene: ENSMUSG00000021266
AA Change: M147K

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 446 1.4e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000161410
AA Change: M147K

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000125320
Gene: ENSMUSG00000021266
AA Change: M147K

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 447 5.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000162748
SMART Domains Protein: ENSMUSP00000125102
Gene: ENSMUSG00000021266

DomainStartEndE-ValueType
PDB:2QUK|A 4 37 1e-8 PDB
SCOP:d1fyja_ 14 37 8e-7 SMART
Blast:WHEP 16 37 3e-7 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162952
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221779
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik T A 10: 100,610,593 probably null Het
9530068E07Rik T C 11: 52,403,535 V209A possibly damaging Het
Abca3 T A 17: 24,400,409 V907E probably damaging Het
Acvrl1 T C 15: 101,135,501 Y90H probably benign Het
Aff3 T C 1: 38,535,656 D81G probably damaging Het
Amn G T 12: 111,274,517 V152L probably damaging Het
Arhgap44 A G 11: 65,067,161 probably benign Het
Atad5 T A 11: 80,108,579 V895D possibly damaging Het
Card9 T G 2: 26,358,017 probably null Het
Ccer1 T C 10: 97,693,840 S122P unknown Het
Ccr2 A G 9: 124,105,675 probably benign Het
Dsg1a T A 18: 20,340,324 I818N possibly damaging Het
Ear10 G T 14: 43,923,317 L18I probably damaging Het
Gm13089 T A 4: 143,697,340 E293V probably benign Het
Mertk A G 2: 128,777,454 Y544C probably damaging Het
Miga1 A T 3: 152,285,341 probably benign Het
Myo18a T C 11: 77,778,235 V307A probably damaging Het
Olfr1354 T A 10: 78,916,939 L33H probably damaging Het
Olfr488 A T 7: 108,255,703 I145N possibly damaging Het
Pou2f3 T C 9: 43,125,089 probably benign Het
Prickle2 A C 6: 92,376,422 S744A probably benign Het
Prkcb T A 7: 122,425,047 probably null Het
Prkd2 A G 7: 16,869,832 T813A probably benign Het
Prkra G A 2: 76,633,547 T257M probably damaging Het
Rbm18 C T 2: 36,122,874 R102Q probably damaging Het
Rbsn A G 6: 92,190,326 S446P probably benign Het
Rpgrip1l A T 8: 91,270,362 V28D possibly damaging Het
Sdccag8 A T 1: 176,948,362 K613I probably damaging Het
Serbp1 G A 6: 67,267,119 G8D probably damaging Het
Slc6a2 T A 8: 92,972,762 Y139* probably null Het
Slc7a2 T A 8: 40,905,584 F321L probably damaging Het
Slco1b2 G A 6: 141,648,553 S48N probably damaging Het
Ssbp2 G T 13: 91,642,371 V118L possibly damaging Het
Sugp1 T A 8: 70,059,862 probably benign Het
Taar5 C A 10: 23,970,985 R94S possibly damaging Het
Tgs1 G T 4: 3,586,181 A353S probably benign Het
Trav1 A G 14: 52,428,642 E32G probably damaging Het
Trp53bp2 T C 1: 182,431,595 V71A probably benign Het
Vmn2r50 T C 7: 10,050,325 Y74C probably damaging Het
Other mutations in Wars
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01961:Wars APN 12 108866170 missense probably damaging 1.00
IGL02327:Wars APN 12 108866301 critical splice acceptor site probably null
IGL02864:Wars APN 12 108882865 missense probably benign
R0271:Wars UTSW 12 108875193 missense probably benign
R0485:Wars UTSW 12 108875157 missense probably damaging 1.00
R0669:Wars UTSW 12 108866018 missense probably benign 0.00
R1144:Wars UTSW 12 108888365 nonsense probably null
R1581:Wars UTSW 12 108875709 nonsense probably null
R1730:Wars UTSW 12 108875741 missense probably damaging 1.00
R1783:Wars UTSW 12 108875741 missense probably damaging 1.00
R1990:Wars UTSW 12 108888433 missense possibly damaging 0.94
R5382:Wars UTSW 12 108882780 missense probably benign
R5703:Wars UTSW 12 108875121 missense probably damaging 1.00
R6299:Wars UTSW 12 108861383 missense probably benign 0.00
R7186:Wars UTSW 12 108881056 missense probably damaging 0.99
R7508:Wars UTSW 12 108882875 missense probably benign 0.01
R7919:Wars UTSW 12 108881104 missense probably benign 0.11
Posted On2015-12-18